OpenURL Connection Search

Select item for more details and to access through your institution.

Preclinical and translational evaluation of coagulation factor IXa as a novel therapeutic target.
Published in:
Pharmacology Research & Perspectives, 2016, v. 4, n. 1, p. n/a, doi. 10.1002/prp2.207
By:
- Ankrom, Wendy;
- Wood, Harold B.;
- Xu, Jiayi;
- Geissler, Wayne;
- Bateman, Tom;
- Chatterjee, Manash S.;
- Feng, Kung‐I;
- Metzger, Joseph M.;
- Strapps, Walter R.;
- Tadin‐Strapps, Marija;
- Seiffert, Dietmar;
- Andre, Patrick
Publication type:
Article
Safety, pharmacokinetics, and pharmacodynamics of milvexian in healthy Japanese participants.
Published in:
Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-08768-y
By:
- Perera, Vidya;
- Wang, Zhaoqing;
- Lubin, Susan;
- Ueno, Takayo;
- Shiozaki, Tomomi;
- Chen, Wei;
- Xu, Xiaohui;
- Seiffert, Dietmar;
- DeSouza, Mary;
- Murthy, Bindu
Publication type:
Article
Abnormalities in the Fibrinolytic System of the Vascular Wall Associated with Atherosclerosis.
Published in:
Annals of the New York Academy of Sciences, 1994, v. 748, n. 1, p. 177, doi. 10.1111/j.1749-6632.1994.tb17317.x
By:
- LOSKUTOFF, DAVID J.;
- AKEN, BENIGNA E.;
- SEIFFERT, DIETMAR
Publication type:
Article
Accumulation of Type 1 Plasminogen Activator Inhibitor and Vitronectin at Sites of Cellular Necrosis and Inflammation.
Published in:
Annals of the New York Academy of Sciences, 1992, v. 667, n. 1, p. 173, doi. 10.1111/j.1749-6632.1992.tb51609.x
By:
- PODOR, THOMAS J.;
- JOSHUA, PENNY;
- BUTCHER, MARTIN;
- SEIFFERT, DIETMAR;
- LOSKUTOFF, DAVID;
- GAULDIE, JACK
Publication type:
Article
Effects of rifampin on the pharmacokinetics and pharmacodynamics of milvexian, a potent, selective, oral small molecule factor XIa inhibitor.
Published in:
Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-25936-2
By:
- Perera, Vidya;
- Wang, Zhaoqing;
- Lubin, Susan;
- Christopher, Lisa J.;
- Chen, Wei;
- Xu, Sophia;
- Seiffert, Dietmar;
- DeSouza, Mary;
- Murthy, Bindu
Publication type:
Article
Effects of Itraconazole and Diltiazem on the Pharmacokinetics and Pharmacodynamics of Milvexian, A Factor XIa Inhibitor.
Published in:
Cardiology & Therapy, 2022, v. 11, n. 3, p. 407, doi. 10.1007/s40119-022-00266-6
By:
- Perera, Vidya;
- Wang, Zhaoqing;
- Lubin, Susan;
- Christopher, Lisa J.;
- Chen, Wei;
- Xu, Sophia;
- Seiffert, Dietmar;
- DeSouza, Mary;
- Murthy, Bindu
Publication type:
Article
Gamma-secretase inhibitors have intrinsically different potencies against Aβ production and Notch signaling
Published in:
2010
By:
- Burton, Catherine R.;
- Meredith, Jere E.;
- Toyn, Jeremy H.;
- Bradley, Jodi D.;
- Wang, Qian;
- Sharp, Diane;
- Sisk, Lisa;
- Guss, Valerie;
- Polson, Craig;
- Krause, Carol M.;
- Wardwell-Swanson, Judith;
- Guo, Qi;
- Fitzgerald, Kevin;
- Seiffert, Dietmar E.;
- Stern, Andrew M.;
- Olson, Richard E.;
- Macor, John E.;
- Zaczek, Robert;
- Houston, John G.;
- Albright, Charles F.
Publication type:
Abstract
Distribution of vitronectin mRNA during murine development.
Published in:
Developmental Dynamics, 1995, v. 203, n. 1, p. 71, doi. 10.1002/aja.1002030108
By:
- Seiffert, Dietmar;
- Iruela-Arispe, Maria Luisa;
- Sage, E. Helene;
- Loskutoff, David J.
Publication type:
Article
Rapid Loss of Microvascular Integrin Expression During Focal Brain Ischemia Reflects Neuron Injury.
Published in:
Journal of Cerebral Blood Flow & Metabolism, 2001, v. 21, n. 7, p. 835, doi. 10.1097/00004647-200107000-00009
By:
- Tagaya, Masafumi;
- Haring, Hans-Peter;
- Stuiver, Ingrid;
- Wagner, Simone;
- Abumiya, Takeo;
- Lucero, Jacinta;
- Lee, Pauline;
- Copeland, Brian R;
- Seiffert, Dietmar;
- del Zoppo, Gregory J
Publication type:
Article
First‐in‐human study to assess the safety, pharmacokinetics and pharmacodynamics of BMS‐962212, a direct, reversible, small molecule factor XIa inhibitor in non‐Japanese and Japanese healthy subjects.
Published in:
British Journal of Clinical Pharmacology, 2018, v. 84, n. 5, p. 876, doi. 10.1111/bcp.13520
By:
- Perera, Vidya;
- Luettgen, Joseph M.;
- Wang, Zhaoqing;
- Frost, Charles E.;
- Yones, Cynthia;
- Russo, Cesare;
- Lee, John;
- Zhao, Yue;
- LaCreta, Frank P.;
- Ma, Xuewen;
- Knabb, Robert M.;
- Seiffert, Dietmar;
- DeSouza, Mary;
- Mugnier, Pierre;
- Cirincione, Brenda;
- Ueno, Takayo;
- Frost, Robert J. A.
Publication type:
Article
Haemodynamic effects of the nitroxyl donor cimlanod (BMS-986231) in chronic heart failure: a randomized trial.
Published in:
2021
By:
- Lang, Ninian N.;
- Ahmad, Faheem A.;
- Cleland, John G.;
- O'Connor, Christopher M.;
- Teerlink, John R.;
- Voors, Adriaan A.;
- Taubel, Jorg;
- Hodes, Anke R.;
- Anwar, Mohamed;
- Karra, Ravi;
- Sakata, Yasushi;
- Ishihara, Shiro;
- Senior, Roxy;
- Khemka, Abhishek;
- Prasad, Narayana G.;
- DeSouza, Mary M.;
- Seiffert, Dietmar;
- Ye, June Y.;
- Kessler, Paul D.;
- Borentain, Maria
Publication type:
journal article
Rationale and design for the development of a novel nitroxyl donor in patients with acute heart failure.
Published in:
2019
By:
- Felker, G. Michael;
- Borentain, Maria;
- Cleland, John G.;
- DeSouza, Mary M.;
- Kessler, Paul D.;
- O'Connor, Christopher M.;
- Seiffert, Dietmar;
- Teerlink, John R.;
- Voors, Adriaan A.;
- McMurray, John J.V.
Publication type:
journal article
Blockade of protease-activated receptor-4 (PAR4) provides robust antithrombotic activity with low bleeding.
Published in:
Science Translational Medicine, 2017, v. 9, n. 371, p. 1, doi. 10.1126/scitranslmed.aaf5294
By:
- Wong, Pancras C.;
- Seiffert, Dietmar;
- Bird, J. Eileen;
- Watson, Carol A.;
- Bostwick, Jeffrey S.;
- Giancarli, Mary;
- Allegretto, Nick;
- Ji Hua;
- Harden, David;
- Guay, Jocelyne;
- Callejo, Mario;
- Miller, Michael M.;
- Lawrence, R. Michael;
- Banville, Jacques;
- Guy, Julia;
- Maxwell, Brad D.;
- Priestley, E. Scott;
- Marinier, Anne;
- Wexler, Ruth R.;
- Bouvier, Michel
Publication type:
Article
First‐in‐human study of milvexian, an oral, direct, small molecule factor XIa inhibitor.
Published in:
CTS: Clinical & Translational Science, 2022, v. 15, n. 2, p. 330, doi. 10.1111/cts.13148
By:
- Perera, Vidya;
- Wang, Zhaoqing;
- Luettgen, Joseph;
- Li, Danshi;
- DeSouza, Mary;
- Cerra, Michael;
- Seiffert, Dietmar
Publication type:
Article
In vitro, antithrombotic and bleeding time studies of BMS-654457, a small-molecule, reversible and direct inhibitor of factor XIa.
Published in:
Journal of Thrombosis & Thrombolysis, 2015, v. 40, n. 4, p. 416, doi. 10.1007/s11239-015-1258-7
By:
- Wong, Pancras;
- Quan, Mimi;
- Watson, Carol;
- Crain, Earl;
- Harpel, Mark;
- Rendina, Alan;
- Luettgen, Joseph;
- Wexler, Ruth;
- Schumacher, William;
- Seiffert, Dietmar
Publication type:
Article
4-Benzothiazole-7-hydroxyindolinyl Diaryl Ureas Are Potent P2Y<sub>1</sub> Antagonists with Favorable Pharmacokinetics: Low Clearance and Small Volume of Distribution.
Published in:
ChemMedChem, 2014, v. 9, n. 10, p. 2327, doi. 10.1002/cmdc.201402141
By:
- Qiao, Jennifer X.;
- Wang, Tammy C.;
- Hiebert, Sheldon;
- Hu, Carol H.;
- Schumacher, William A.;
- Spronk, Steven A.;
- Clark, Charles G.;
- Han, Ying;
- Hua, Ji;
- Price, Laura A.;
- Shen, Hong;
- Chacko, Silvi A.;
- Everlof, Gerry;
- Bostwick, Jeffrey S.;
- Steinbacher, Thomas E.;
- Li, Yi‐Xin;
- Huang, Christine S.;
- Seiffert, Dietmar A.;
- Rehfuss, Robert;
- Wexler, Ruth R.
Publication type:
Article
Oxidative stress-inducible protein tyrosine phosphatase in glomerulonephritis.
Published in:
Kidney International, 1995, v. 48, n. 6, p. 1920, doi. 10.1038/ki.1995.492
By:
- Lili Feng;
- Yiyang Xia;
- Seiffert, Dietmar;
- Wilson, Curtis B.
Publication type:
Article

Found: 17