Found: 22
Select item for more details and to access through your institution.
Targeting protein prenylation for cancer therapy.
- Published in:
- 2011
- By:
- Publication type:
- journal article
Loss of the cell cycle inhibitors p21<sup>Cip1</sup> and p27<sup>Kip1</sup> enhances tumorigenesis in knockout mouse models.
- Published in:
- Oncogene, 2002, v. 21, n. 55, p. 8486, doi. 10.1038/sj.onc.1205946
- By:
- Publication type:
- Article
Ras and RhoA suppress whereas RhoB enhances cytokine-induced transcription of nitric oxide synthase-2 in human normal liver AKN-1 cells and lung cancer A-549 cells.
- Published in:
- Oncogene, 2001, v. 20, n. 45, p. 6531, doi. 10.1038/sj.onc.1204801
- By:
- Publication type:
- Article
Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: Lessons from mechanism and bench-to-bedside translational studies.
- Published in:
- Oncogene, 2000, v. 19, n. 56, p. 6584, doi. 10.1038/sj.onc.1204146
- By:
- Publication type:
- Article
Design of growth factor antagonists with antiangiogenic and antitumor properties.
- Published in:
- Oncogene, 2000, v. 19, n. 56, p. 6566, doi. 10.1038/sj.onc.1204121
- By:
- Publication type:
- Article
Inhibition of farnesyltransferase increases TGFβ type II receptor expression and enhances the responsiveness of human cancer cells to TGFβ.
- Published in:
- Oncogene, 2000, v. 19, n. 48, p. 5525, doi. 10.1038/sj.onc.1203920
- By:
- Publication type:
- Article
Loss of p21<sup>WAF1/CIP1</sup> accelerates Ras oncogenesis in a transgenic/knockout mammary cancer model.
- Published in:
- Oncogene, 2000, v. 19, n. 47, p. 5338, doi. 10.1038/sj.onc.1203956
- By:
- Publication type:
- Article
Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts.
- Published in:
- Oncogene, 1998, v. 16, n. 11, p. 1467, doi. 10.1038/sj.onc.1201656
- By:
- Publication type:
- Article
Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines.
- Published in:
- Oncogene, 1997, v. 15, n. 11, p. 1283, doi. 10.1038/sj.onc.1201296
- By:
- Publication type:
- Article
Farnesyltransferase as a target for anticancer drug design.
- Published in:
- Biopolymers, 1997, v. 43, n. 1, p. 25, doi. 10.1002/(SICI)1097-0282(1997)43:1<25::AID-BIP4>3.0.CO;2-2
- By:
- Publication type:
- Article
Inhibiting angiogenesis and tumorigenesis by a synthetic molecule that blocks binding of both VEGF and PDGF to their receptors.
- Published in:
- Oncogene, 2005, v. 24, n. 29, p. 4701, doi. 10.1038/sj.onc.1208391
- By:
- Publication type:
- Article
Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity.
- Published in:
- Oncogene, 2005, v. 24, n. 20, p. 3236, doi. 10.1038/sj.onc.1208470
- By:
- Publication type:
- Article
EGFR, ErbB2 and Ras but not Src suppress RhoB expression while ectopic expression of RhoB antagonizes oncogene-mediated transformation.
- Published in:
- Oncogene, 2004, v. 23, n. 5, p. 1136, doi. 10.1038/sj.onc.1207236
- By:
- Publication type:
- Article
Structurally Simple Farnesyltransferase Inhibitors Arrest the Growth of Malaria ParasitesThis work was supported by the Medicines for Malaria Venture (MMV) and NIH grants CA67771 and AI054384. S.-Y.C. thanks the Postdoctoral Fellowship Program of Korea Science & Engineering Foundation (KOSEF). O.H. gratefully acknowledges a postdoctoral fellowship of the German Academy of Natural Scientists Leopoldina (BMBF-LPD 9901/8-77). We thank David Floyd, Lou Lombardo and David Williams from Bristol-Myers Squibb for helpful suggestions.
- Published in:
- Angewandte Chemie, 2005, v. 117, n. 31, p. 4981, doi. 10.1002/ange.200500674
- By:
- Publication type:
- Article
GSK<sub>3</sub> suppression upregulates β-catenin and c-Myc to abrogate KRas-dependent tumors
- Published in:
- Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-07644-6
- By:
- Publication type:
- Article
Design of GFB-111, a platelet-derived growth factor binding molecule with antiangiogenic and anticancer activity against human tumors in mice.
- Published in:
- Nature Biotechnology, 2000, v. 18, n. 10, p. 1065, doi. 10.1038/80257
- By:
- Publication type:
- Article
Lysophosphatidic Acid Acyltransferase Beta Regulates mTOR Signaling.
- Published in:
- PLoS ONE, 2013, v. 8, n. 10, p. 1, doi. 10.1371/journal.pone.0078632
- By:
- Publication type:
- Article
Module Assembly for Protein-Surface Recognition: Geranylgeranyltransferase I Bivalent Inhibitors for Simultaneous Targeting of Interior and Exterior Protein Surfaces.
- Published in:
- Chemistry - A European Journal, 2008, v. 14, n. 5, p. 1392, doi. 10.1002/chem.200701634
- By:
- Publication type:
- Article
Searching for the elusive targets of farnesyltransferase inhibitors.
- Published in:
- Nature Reviews Cancer, 2003, v. 3, n. 12, p. 945, doi. 10.1038/nrc1234
- By:
- Publication type:
- Article
Targeting Protein-Protein Interactions: Suppression of Stat3 Dimerization with Rationally Designed Small-Molecule, Nonpeptidic SH2 Domain Binders.
- Published in:
- ChemBioChem, 2008, v. 9, n. 17, p. 2800, doi. 10.1002/cbic.200800291
- By:
- Publication type:
- Article
Geranylgeraniol potentiates lovastatin inhibition of oncogenic H-Ras processing and signaling while preventing cytotoxicity.
- Published in:
- Oncogene, 1997, v. 14, n. 3, p. 305, doi. 10.1038/sj.onc.1200819
- By:
- Publication type:
- Article
Structurally Simple Farnesyltransferase Inhibitors Arrest the Growth of Malaria ParasitesThis work was supported by the Medicines for Malaria Venture (MMV) and NIH grants CA67771 and AI054384. S.-Y.C. thanks the Postdoctoral Fellowship Program of Korea Science & Engineering Foundation (KOSEF). O.H. gratefully acknowledges a postdoctoral fellowship of the German Academy of Natural Scientists Leopoldina (BMBF-LPD 9901/8-77). We thank David Floyd, Lou Lombardo and David Williams from Bristol-Myers Squibb for helpful suggestions.
- Published in:
- Angewandte Chemie International Edition, 2005, v. 44, n. 31, p. 4903, doi. 10.1002/anie.200500674
- By:
- Publication type:
- Article