Works by Seabra, Miguel C.

Results: 61

Deacidification of endolysosomes by neuronal aging drives synapse loss.

Published in:

Traffic, 2023, v. 24, n. 8, p. 334, doi. 10.1111/tra.12889

By:

Burrinha, Tatiana;
Cunha, César;
Hall, Michael J.;
Lopes‐da‐Silva, Mafalda;
Seabra, Miguel C.;
Guimas Almeida, Cláudia

Publication type:

Article

Melanocore uptake by keratinocytes occurs through phagocytosis and involves protease‐activated receptor‐2 internalization.

Published in:

Traffic, 2022, v. 23, n. 6, p. 331, doi. 10.1111/tra.12843

By:

Moreiras, Hugo;
Bento‐Lopes, Liliana;
Neto, Matilde V.;
Escrevente, Cristina;
Cabaço, Luís C.;
Hall, Michael J.;
Ramalho, José S.;
Seabra, Miguel C.;
Barral, Duarte C.

Publication type:

Article

Melanin processing by keratinocytes: A non‐microbial type of host‐pathogen interaction?

Published in:

Traffic, 2019, v. 20, n. 4, p. 301, doi. 10.1111/tra.12638

By:

Moreiras, Hugo;
Lopes‐da‐Silva, Mafalda;
Seabra, Miguel C.;
Barral, Duarte C.

Publication type:

Article

Host PI(3,5)P2 Activity Is Required for Plasmodium berghei Growth During Liver Stage Infection.

Published in:

Traffic, 2014, v. 15, n. 10, p. 1066, doi. 10.1111/tra.12190

By:

Thieleke‐Matos, Carolina;
da Silva, Mafalda Lopes;
Cabrita‐Santos, Laura;
Pires, Cristiana F.;
Ramalho, José S.;
Ikonomov, Ognian;
Seixas, Elsa;
Shisheva, Assia;
Seabra, Miguel C.;
Barral, Duarte C.

Publication type:

Article

Rab and Arf Proteins in Genetic Diseases.

Published in:

Traffic, 2013, v. 14, n. 8, p. 871, doi. 10.1111/tra.12072

By:

Seixas, Elsa;
Barros, Mafalda;
Seabra, Miguel C.;
Barral, Duarte C.

Publication type:

Article

The Host Endocytic Pathway is Essential for Plasmodium berghei Late Liver Stage Development.

Published in:

Traffic, 2012, v. 13, n. 10, p. 1351, doi. 10.1111/j.1600-0854.2012.01398.x

By:

Lopes da Silva, Mafalda;
Thieleke-Matos, Carolina;
Cabrita-Santos, Laura;
Ramalho, José S.;
Wavre-Shapton, Silène T.;
Futter, Clare E.;
Barral, Duarte C.;
Seabra, Miguel C.

Publication type:

Article

Semi-Automated Analysis of Organelle Movement and Membrane Content: Understanding Rab-Motor Complex Transport Function.

Published in:

Traffic, 2011, v. 12, n. 12, p. 1686, doi. 10.1111/j.1600-0854.2011.01283.x

By:

Hume, Alistair N.;
Wilson, Miranda S.;
Ushakov, Dmitry S.;
Ferenczi, Michael A.;
Seabra, Miguel C.

Publication type:

Article

Myosin Va Acts in Concert with Rab27a and MyRIP to Regulate Acute Von-Willebrand Factor Release from Endothelial Cells.

Published in:

Traffic, 2011, v. 12, n. 10, p. 1371, doi. 10.1111/j.1600-0854.2011.01248.x

By:

Rojo Pulido, Inés;
Nightingale, Thomas D.;
Darchen, François;
Seabra, Miguel C.;
Cutler, Daniel F.;
Gerke, Volker

Publication type:

Article

Rab27a Targeting to Melanosomes Requires Nucleotide Exchange but Not Effector Binding.

Published in:

Traffic, 2011, v. 12, n. 8, p. 1056, doi. 10.1111/j.1600-0854.2011.01216.x

By:

Tarafder, Abul K.;
Wasmeier, Christina;
Figueiredo, Ana C.;
Booth, Antonia E. G.;
Orihara, Asumi;
Ramalho, Jose S.;
Hume, Alistair N.;
Seabra, Miguel C.

Publication type:

Article

Rab27a and Rab27b Regulate Neutrophil Azurophilic Granule Exocytosis and NADPH oxidase Activity by Independent Mechanisms.

Published in:

Traffic, 2010, v. 11, n. 4, p. 533, doi. 10.1111/j.1600-0854.2009.01029.x

By:

Johnson, Jennifer L.;
Brzezinska, Agnieszka A.;
Tolmachova, Tanya;
Munafo, Daniela B.;
Ellis, Beverly A.;
Seabra, Miguel C.;
Hong, Hong;
Catz, Sergio D.

Publication type:

Article

Rab27b Regulates Mast Cell Granule Dynamics and Secretion.

Published in:

Traffic, 2007, v. 8, n. 7, p. 883, doi. 10.1111/j.1600-0854.2007.00571.x

By:

Mizuno, Kouichi;
Tolmachova, Tanya;
Ushakov, Dmitry S.;
Romao, Maryse;
Åbrink, Magnus;
Ferenczi, Michael A.;
Raposo, Graça;
Seabra, Miguel C.

Publication type:

Article

The Ternary Rab27a–Myrip–Myosin VIIa Complex Regulates Melanosome Motility in the Retinal Pigment Epithelium.

Published in:

Traffic, 2007, v. 8, n. 5, p. 486, doi. 10.1111/j.1600-0854.2007.00548.x

By:

Lopes, Vanda S.;
Ramalho, José S.;
Owen, Dylan M.;
Karl, Mike O.;
Strauss, Olaf;
Futter, Clare E.;
Seabra, Miguel C.

Publication type:

Article

Host cell autophagy contributes to Plasmodium liver development.

Published in:

Cellular Microbiology, 2016, v. 18, n. 3, p. 437, doi. 10.1111/cmi.12524

By:

Thieleke‐Matos, Carolina;
Lopes da Silva, Mafalda;
Cabrita‐Santos, Laura;
Portal, Martim D.;
Rodrigues, Inês P.;
Zuzarte‐Luis, Vanessa;
Ramalho, José S.;
Futter, Clare E.;
Mota, Maria M.;
Barral, Duarte C.;
Seabra, Miguel C.

Publication type:

Article

Impaired prenylation of Rab GTPases in the gunmetal mouse causes defects in bone cell function.

Published in:

Small GTPases, 2011, v. 2, n. 3, p. 131, doi. 10.4161/sgtp.2.3.16488

By:

Taylor, Adam;
Mules, Emilie H.;
Seabra, Miguel C.;
Helfrich, Miep H.;
Rogers, Michael J.;
Coxon, Fraser P.

Publication type:

Article

CHM/REP1 cDNA delivery by lentiviral vectors provides functional expression of the transgene in the retinal pigment epithelium of choroideremia mice.

Published in:

Journal of Gene Medicine, 2012, v. 14, n. 3, p. 158, doi. 10.1002/jgm.1652

By:

Tolmachova, Tanya;
Tolmachov, Oleg E.;
Wavre-Shapton, Silene T.;
Tracey-White, Dhani;
Futter, Clare E.;
Seabra, Miguel C.

Publication type:

Article

Rab27a Is Required for Regulated Secretion in Cytotoxic T Lymphocytes.

Published in:

Journal of Cell Biology, 2001, v. 152, n. 4, p. 825, doi. 10.1083/jcb.152.4.825

By:

Stinchcombe, Jane C.;
Barral, Duarte C.;
Mules, Emilie H.;
Booth, Sarah;
Hume, Alistair N.;
Machesky, Laura M.;
Seabra, Miguel C.;
Griffiths, Gillian M.

Publication type:

Article

Rab27a Regulates the Peripheral Distribution of Melanosomes in Melanocytes.

Published in:

Journal of Cell Biology, 2001, v. 152, n. 4, p. 795, doi. 10.1083/jcb.152.4.795

By:

Hume, Alistair N.;
Collinson, Lucy M.;
Rapak, Andrzej;
Gomes, Anita Q.;
Hopkins, Colin R.;
Seabra, Miguel C.

Publication type:

Article

Rab27a and Rab27b control different steps of the exosome secretion pathway.

Published in:

Nature Cell Biology, 2010, v. 12, n. 1, p. 19, doi. 10.1038/ncb2000

By:

Ostrowski, Matias;
Carmo, Nuno B.;
Krumeich, Sophie;
Fanget, Isabelle;
Raposo, Graça;
Savina, Ariel;
Moita, Catarina F.;
Schauer, Kristine;
Hume, Alistair N.;
Freitas, Rui P.;
Goud, Bruno;
Benaroch, Philippe;
Hacohen, Nir;
Fukuda, Mitsunori;
Desnos, Claire;
Seabra, Miguel C.;
Darchen, François;
Amigorena, Sebastian;
Moita, Luis F.;
Thery, Clotilde

Publication type:

Article

Rab27a regulates phagosomal pH and NADPH oxidase recruitment to dendritic cell phagosomes.

Published in:

Nature Cell Biology, 2007, v. 9, n. 4, p. 367, doi. 10.1038/ncb1552

By:

Jancic, Carolina;
Savina, Ariel;
Wasmeier, Christina;
Tolmachova, Tanya;
El-Benna, Jamel;
Pham My-Chan Dang;
Pascolo, Steve;
Gougerot-Pocidalo, Maire-Anne;
Raposo, Graça;
Seabra, Miguel C.;
Amigorena, Sebastian

Publication type:

Article

Thousands of Rab GTPases for the Cell Biologist.

Published in:

PLoS Computational Biology, 2011, v. 7, n. 10, p. 1, doi. 10.1371/journal.pcbi.1002217

By:

Diekmann, Yoan;
Seixas, Elsa;
Gouw, Marc;
Tavares-Cadete, Filipe;
Seabra, Miguel C.;
Pereira-Leal, José B.

Publication type:

Article

Rapid Multilabel Detection of Geranylgeranylated Proteins by Using Bioorthogonal Ligation Chemistry.

Published in:

ChemBioChem, 2010, v. 11, n. 6, p. 771, doi. 10.1002/cbic.201000087

By:

Berry, Alexandra F. H.;
Heal, William P.;
Tarafder, Abul K.;
Tolmachova, Tanya;
Baron, Rudi A.;
Seabra, Miguel C.;
Tate, Edward W.

Publication type:

Article

Transfer of extracellular vesicle‐microRNA controls germinal center reaction and antibody production.

Published in:

EMBO Reports, 2020, v. 21, n. 4, p. 1, doi. 10.15252/embr.201948925

By:

Fernández‐Messina, Lola;
Rodríguez‐Galán, Ana;
de Yébenes, Virginia G;
Gutiérrez‐Vázquez, Cristina;
Tenreiro, Sandra;
Seabra, Miguel C;
Ramiro, Almudena R;
Sánchez‐Madrid, Francisco

Publication type:

Article

THE MELANOSOME: MEMBRANE DYNAMICS IN BLACK AND WHITE.

Published in:

Nature Reviews Molecular Cell Biology, 2001, v. 2, n. 10, p. 738, doi. 10.1038/35096009

By:

Marks, Michael S.;
Seabra, Miguel C.

Publication type:

Article

Correction: A Role for Na+,K+-ATPase α1 in Regulating Rab27a Localisation on Melanosomes.

Published in:

PLoS ONE, 2016, v. 11, n. 2, p. 1, doi. 10.1371/journal.pone.0148719

By:

Booth, Antonia E. G.;
Tarafder, Abul K.;
Hume, Alistair N.;
Recchi, Chiara;
Seabra, Miguel C.

Publication type:

Article

Effect of the Secretory Small GTPase Rab27B on Breast Cancer Growth, Invasion, and Metastasis.

Published in:

JNCI: Journal of the National Cancer Institute, 2010, v. 102, n. 12, p. 866, doi. 10.1093/jnci/djq153

By:

Hendrix, An;
Maynard, Dawn;
Pauwels, Patrick;
Braems, Geert;
Denys, Hannelore;
Broecke, Rudy Van den;
Lambert, Jo;
Belle, Simon Van;
Cocquyt, Veronique;
Gespach, Christian;
Bracke, Marc;
Seabra, Miguel C.;
Gahl, William A.;
De Wever, Olivier;
Westbroek, Wendy

Publication type:

Article

Reconstructed human pigmented skin/epidermis models achieve epidermal pigmentation through melanocore transfer.

Published in:

Pigment Cell & Melanoma Research, 2022, v. 35, n. 4, p. 425, doi. 10.1111/pcmr.13039

By:

Hall, Michael J.;
Lopes‐Ventura, Sara;
Neto, Matilde V.;
Charneca, João;
Zoio, Patricia;
Seabra, Miguel C.;
Oliva, Abel;
Barral, Duarte C.

Publication type:

Article

The exocyst is required for melanin exocytosis from melanocytes and transfer to keratinocytes.

Published in:

Pigment Cell & Melanoma Research, 2020, v. 33, n. 2, p. 366, doi. 10.1111/pcmr.12840

By:

Moreiras, Hugo;
Pereira, Francisco J. C.;
Neto, Matilde V.;
Bento‐Lopes, Liliana;
Festas, Tiago C.;
Seabra, Miguel C.;
Barral, Duarte C.

Publication type:

Article

Melanoma goes on a diet to get moving: toning down phagocytic Rab7 expression helps melanoma to metastasise.

Published in:

Pigment Cell & Melanoma Research, 2014, v. 27, n. 6, p. 1012, doi. 10.1111/pcmr.12310

By:

Hume, Alistair N.;
Seabra, Miguel C.

Publication type:

Article

Myrip uses distinct domains in the cellular activation of myosin VA and myosin VIIA in melanosome transport.

Published in:

Pigment Cell & Melanoma Research, 2009, v. 22, n. 4, p. 461, doi. 10.1111/j.1755-148X.2009.00567.x

By:

Ramalho, José S.;
Lopes, Vanda S.;
Tarafder, Abul K.;
Seabra, Miguel C.;
Hume, Alistair N.

Publication type:

Article

Novel functions for Rab GTPases in multiple aspects of tumour progression.

Published in:

Biochemical Society Transactions, 2012, v. 40, n. 6, p. 1398, doi. 10.1042/BST20120199

By:

Recchi, Chiara;
Seabra, Miguel C.

Publication type:

Article

Rab27a and melanosomes: a model to investigate the membrane targeting of Rabs.

Published in:

Biochemical Society Transactions, 2012, v. 40, n. 6, p. 1383, doi. 10.1042/BST20120200

By:

Booth, Antonia E. G.;
Seabra, Miguel C.;
Hume, Alistair N.

Publication type:

Article

A role for Rab27 in neutrophil chemotaxis and lung recruitment.

Published in:

BMC Cell Biology, 2014, v. 15, n. 1, p. 2, doi. 10.1186/s12860-014-0039-z

By:

Singh, Rajesh K.;
Furze, Rebecca C.;
Birrell, Mark A.;
Rankin, Sara M.;
Hume, Alistair N.;
Seabra, Miguel C.

Publication type:

Article

Rapid degradation of dominant-negative Rab27 proteins in vivo precludes their use in transgenic mouse models.

Published in:

BMC Cell Biology, 2002, v. 3, p. 1

By:

Ramalho, José S.;
Anders, Ross;
Jaissle, Gesine B.;
Seeliger, Mathias W.;
Huxley, Clare;
Seabra, Miguel C.

Publication type:

Article

Chromosomal mapping, gene structure and characterization of the human and murine RAB27B gene.

Published in:

BMC Genetics, 2001, v. 2, p. 1

By:

Ramalho, José S.;
Tolmachova, Tanya;
Hume, Alistair N.;
McGuigan, Amanda;
Gregory-Evans, Cheryl Y.;
Huxley, Clare;
Seabra, Miguel C.

Publication type:

Article

Rab38 and Rab32 control post-Golgi trafficking of melanogenic enzymes.

Published in:

Journal of Cell Biology, 2006, v. 175, n. 2, p. 271, doi. 10.1083/jcb.200606050

By:

Wasmeier, Christina;
Romao, Maryse;
Plowright, Lynn;
Bennett, Dorothy C.;
Raposo, Graça;
Seabra, Miguel C.

Publication type:

Article

Melanin's Journey from Melanocytes to Keratinocytes: Uncovering the Molecular Mechanisms of Melanin Transfer and Processing.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 14, p. 11289, doi. 10.3390/ijms241411289

By:

Bento-Lopes, Liliana;
Cabaço, Luís C.;
Charneca, João;
Neto, Matilde V.;
Seabra, Miguel C.;
Barral, Duarte C.

Publication type:

Article

Melanin Transfer in the Epidermis: The Pursuit of Skin Pigmentation Control Mechanisms.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 9, p. 4466, doi. 10.3390/ijms22094466

By:

Moreiras, Hugo;
Seabra, Miguel C.;
Barral, Duarte C.;
Ando, Hideya

Publication type:

Article

Rab GTPase regulation of bacteria and protozoa phagocytosis occurs through the modulation of phagocytic receptor surface expression.

Published in:

Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-31171-5

By:

Seixas, Elsa;
Escrevente, Cristina;
Seabra, Miguel C.;
Barral, Duarte C.

Publication type:

Article

Retinal Progression Biomarkers of Early and Intermediate Age-Related Macular Degeneration.

Published in:

Life (2075-1729), 2022, v. 12, n. 1, p. 36, doi. 10.3390/life12010036

By:

Flores, Rita;
Carneiro, Ângela;
Tenreiro, Sandra;
Seabra, Miguel C.

Publication type:

Article

Exosome-delivered microRNAs modulate the inflammatory response to endotoxin.

Published in:

Nature Communications, 2015, v. 6, n. 6, p. 7321, doi. 10.1038/ncomms8321

By:

Alexander, Margaret;
Hu, Ruozhen;
Runtsch, Marah C.;
Kagele, Dominique A.;
Mosbruger, Timothy L.;
Tolmachova, Tanya;
Seabra, Miguel C.;
Round, June L.;
Ward, Diane M.;
O'Connell, Ryan M.

Publication type:

Article

Clinical utility gene card for: Choroideremia.

Published in:

European Journal of Human Genetics, 2014, v. 22, n. 4, p. 00, doi. 10.1038/ejhg.2013.183

By:

Moosajee, Mariya;
Ramsden, Simon C;
Black, Graeme CM;
Seabra, Miguel C;
Webster, Andrew R

Publication type:

Article

Chronically shortened rod outer segments accompany photoreceptor cell death in Choroideremia.

Published in:

PLoS ONE, 2020, v. 15, n. 11, p. 1, doi. 10.1371/journal.pone.0242284

By:

Meschede, Ingrid P.;
Burgoyne, Thomas;
Tolmachova, Tanya;
Seabra, Miguel C.;
Futter, Clare E.

Publication type:

Article

Age-Related Macular Degeneration: Pathophysiology, Management, and Future Perspectives.

Published in:

Ophthalmologica, 2021, v. 244, n. 6, p. 495, doi. 10.1159/000517520

By:

Flores, Rita;
Carneiro, Ângela;
Vieira, Miguel;
Tenreiro, Sandra;
Seabra, Miguel C.

Publication type:

Article

Review Rab GTPases and Myosin Motors in Organelle Motility.

Published in:

Traffic, 2004, v. 5, n. 6, p. 393, doi. 10.1111/j.1398-9219.2004.00190.x

By:

Seabra, Miguel C.;
Coudrier, Evelyne

Publication type:

Article

The leaden Gene Product Is Required with Rab27a to Recruit Myosin Va to Melanosomes in Melanocytes.

Published in:

Traffic, 2002, v. 3, n. 3, p. 193, doi. 10.1034/j.1600-0854.2002.030305.x

By:

Hume, Alistair N.;
Collinson, Lucy M.;
Hopkins, Colin R.;
Strom, Molly;
Barral, Duarte C.;
Bossi, Giovanna;
Griffiths, Gillian M.;
Seabra, Miguel C.

Publication type:

Article

Photoreceptor phagosome processing defects and disturbed autophagy in retinal pigment epithelium of Cln3Δex1-6 mice modelling juvenile neuronal ceroid lipofuscinosis (Batten disease).

Published in:

Human Molecular Genetics, 2015, v. 24, n. 24, p. 7060, doi. 10.1093/hmg/ddv406

By:

Wavre-Shapton, Silène T.;
Calvi, Alessandra A.;
Turmaine, Mark;
Seabra, Miguel C.;
Cutler, Daniel F.;
Futter, Clare E.;
Mitchison, Hannah M.

Publication type:

Article

Defective cellular trafficking of missense NPR-B mutants is the major mechanism underlying acromesomelic dysplasia-type Maroteaux.

Published in:

Human Molecular Genetics, 2009, v. 18, n. 2, p. 267

By:

Hume, Alistair N.;
Buttgereit, Jens;
Al-Awadhi, Aydah M.;
Al-Suwaidi, Sarah S.;
John, Anne;
Bader, Michael;
Seabra, Miguel C.;
Al-Gazali, Lihadh;
Ali, Bassam R.

Publication type:

Article

Translational bypass of nonsense mutations in zebrafish rep1, pax2.1 and lamb1 highlights a viable therapeutic option for untreatable genetic eye disease.

Published in:

Human Molecular Genetics, 2008, v. 17, n. 24, p. 3987, doi. 10.1093/hmg/ddn302

By:

Moosajee, Mariya;
Gregory-Evans, Kevin;
Ellis, Charles D.;
Seabra, Miguel C.;
Gregory-Evans, Cheryl Y.

Publication type:

Article

A Role for Na+,K+-ATPase α1 in Regulating Rab27a Localisation on Melanosomes.

Published in:

PLoS ONE, 2014, v. 9, n. 7, p. 1, doi. 10.1371/journal.pone.0102851

By:

Booth, Antonia E. G.;
Tarafder, Abul K.;
Hume, Alistair N.;
Recchi, Chiara;
Seabra, Miguel C.

Publication type:

Article

Conditional Ablation of the Choroideremia Gene Causes Age-Related Changes in Mouse Retinal Pigment Epithelium.

Published in:

PLoS ONE, 2013, v. 8, n. 2, p. 1, doi. 10.1371/journal.pone.0057769

By:

Wavre-Shapton, Silène T.;
Tolmachova, Tanya;
da Silva, Mafalda Lopes;
Futter, Clare E.;
Seabra, Miguel C.

Publication type:

Article