Works by Sczakiel, Georg

Results: 40

Lipophilic 2′- O-Acetal Ester RNAs: Synthesis, Thermal Duplex Stability, Nuclease Resistance, Cellular Uptake, and siRNA Activity after Spontaneous Naked Delivery.

Published in:

ChemBioChem, 2016, v. 17, n. 21, p. 2054, doi. 10.1002/cbic.201600317

By:

Biscans, Annabelle;
Bertrand, Jean‐Rémi;
Dubois, Josephine;
Rüger, Jacqueline;
Vasseur, Jean‐Jacques;
Sczakiel, Georg;
Dupouy, Christelle;
Debart, Françoise

Publication type:

Article

Direct Synthesis of Partially Modified 2′- O-Pivaloyloxymethyl RNAs by a Base-Labile Protecting Group Strategy and their Potential for Prodrug-Based Gene-Silencing Applications.

Published in:

ChemBioChem, 2014, v. 15, n. 18, p. 2674, doi. 10.1002/cbic.201402382

By:

Biscans, Annabelle;
Bos, Maxence;
Martin, Anthony R.;
Ader, Nicholas;
Sczakiel, Georg;
Vasseur, Jean‐Jacques;
Dupouy, Christelle;
Debart, Françoise

Publication type:

Article

Spezifische Proteinerkennung durch Array-gebundene Hexanukleotide.

Published in:

Angewandte Chemie, 2011, v. 123, n. 5, p. 1084, doi. 10.1002/ange.201003462

By:

Mescalchin, Alessandra;
Wünsche, Winfried;
Sczakiel, Georg

Publication type:

Article

Inhibition of Ki-67 in a renal cell carcinoma severe combined immunodeficiency disease mouse model is associated with induction of apoptosis and tumour growth inhibition.

Published in:

BJU International, 2005, v. 95, n. 3, p. 415, doi. 10.1111/j.1464-410X.2005.05312.x

By:

Kausch, Ingo;
Jiang, Hai;
Ewerdwalbesloh, Nina;
Doehn, Christian;
Krüger, Stefan;
Sczakiel, Georg;
Jocham, Dieter

Publication type:

Article

Wie Gene abgelesen werden.

Published in:

Chemie in unserer Zeit, 2006, v. 40, n. 6, p. 362, doi. 10.1002/ciuz.200690074

By:

Restle, Tobias;
Sczakiel, Georg

Publication type:

Article

Editorial: Die Lebenswissenschaften durch die Brille der Chemie betrachtet: Erprobte Denkweisen auf neuartige Entwicklungen anwenden.

Published in:

Chemie in unserer Zeit, 2004, v. 38, n. 3, p. 155, doi. 10.1002/ciuz.200490040

By:

Sczakiel, Georg

Publication type:

Article

Mini-Chiuz.

Published in:

Chemie in unserer Zeit, 1993, v. 27, n. 1, p. 6, doi. 10.1002/ciuz.19930270102

By:

Wöhrle, Dieter;
Marti, E.;
Müller, A.;
Krahn, E.;
Kreutzer, Roland;
Kelinschmidt, Jürgen A.;
Sczakiel, Georg;
Jaenicke, L.;
Flöbl, Rainer;
Müller, Achim

Publication type:

Article

Functional binding of hexanucleotides to 3C protease of hepatitis A virus.

Published in:

Nucleic Acids Research, 2012, v. 40, n. 7, p. 3042, doi. 10.1093/nar/gkr1152

By:

Blaum, Bärbel S.;
Wünsche, Winfried;
Benie, Andrew J.;
Kusov, Yuri;
Peters, Hannelore;
Gauss-Müller, Verena;
Peters, Thomas;
Sczakiel, Georg

Publication type:

Article

Cell stress is related to re-localization of Argonaute 2 and to decreased RNA interference in human cells.

Published in:

Nucleic Acids Research, 2011, v. 39, n. 7, p. 2727, doi. 10.1093/nar/gkq1216

By:

Detzer, Anke;
Engel, Christina;
Wünsche, Winfried;
Sczakiel, Georg

Publication type:

Article

Specific binding of a hexanucleotide to HIV-1 reverse transcriptase: a novel class of bioactive molecules.

Published in:

Nucleic Acids Research, 2006, v. 34, n. 19, p. 5631, doi. 10.1093/nar/gkl533

By:

Mescalchin, Alessandra;
Wünsche, Winfried;
Laufer, Sandra D.;
Grohmann, Dina;
Restle, Tobias;
Sczakiel, Georg

Publication type:

Article

OBITUARY.

Published in:

Nucleic Acids Research, 2005, v. 33, n. 10, p. 3083, doi. 10.1093/nar/gki620

By:

Wagner, Gerhart;
Nellen, Wolfgang;
Berzal-Herranz, Alfredo;
Sczakiel, Georg

Publication type:

Article

Quantitative detection of siRNA and single-stranded oligonucleotides: relationship between uptake and biological activity of siRNA.

Published in:

Nucleic Acids Research, 2004, v. 32, n. 21, p. e170, doi. 10.1093/nar/gnh168

By:

Overhoff, Marita;
Wünsche, Winfried;
Sczakiel, Georg

Publication type:

Article

The activity of siRNA in mammalian cells is related to structural target accessibility: a comparison with antisense oligonucleotides.

Published in:

Nucleic Acids Research, 2003, v. 31, n. 15, p. 4417

By:

Kretschmer‐Kazemi Far, Rosel;
Sczakiel, Georg

Publication type:

Article

Endogenous expression of a high‐affinity pseudoknot RNA aptamer suppresses replication of HIV‐1.

Published in:

Nucleic Acids Research, 2002, v. 30, n. 18, p. 4001, doi. 10.1093/nar/gkf522

By:

Chaloin, Laurent;
Lehmann, Maik Jörg;
Sczakiel, Georg;
Restle, Tobias

Publication type:

Article

Oncoprotein 18 is necessary for malignant cell proliferation in bladder cancer cells and serves as a G3-specific non-invasive diagnostic marker candidate in urinary RNA.

Published in:

PLoS ONE, 2020, v. 15, n. 7, p. 1, doi. 10.1371/journal.pone.0229193

By:

Hanke, Merle;
Dubois, Josephine;
Kausch, Ingo;
Petkovic, Sonja;
Sczakiel, Georg

Publication type:

Article

Circular versus linear RNA topology: different modes of RNA–RNA interactions in vitro and in human cells.

Published in:

RNA Biology, 2021, v. 18, p. 674, doi. 10.1080/15476286.2021.1978214

By:

Petkovic, Sonja;
Graff, Sarah;
Feller, Nina;
Berghaus, Julia;
Ruppert, Vanessa-Patricia;
Dülfer, Jasmin;
Sczakiel, Georg

Publication type:

Article

Coronary Heart Disease-Associated Variation in <i>TCF21</i> Disrupts a miR-224 Binding Site and miRNA-Mediated Regulation.

Published in:

PLoS Genetics, 2014, v. 10, n. 3, p. 1, doi. 10.1371/journal.pgen.1004263

By:

Miller, Clint L.;
Haas, Ulrike;
Diaz, Roxanne;
Leeper, Nicholas J.;
Kundu, Ramendra K.;
Patlolla, Bhagat;
Assimes, Themistocles L.;
Kaiser, Frank J.;
Perisic, Ljubica;
Hedin, Ulf;
Maegdefessel, Lars;
Schunkert, Heribert;
Erdmann, Jeanette;
Quertermous, Thomas;
Sczakiel, Georg

Publication type:

Article

In vitro and in vivo action of antisense RNA.

Published in:

Molecular Biotechnology, 1996, v. 6, n. 1, p. 7, doi. 10.1007/BF02762319

By:

Nellen, Wolfgang;
Sczakiel, Georg

Publication type:

Article

Concepts to automate the theoretical design of effective antisense oligonucleotides.

Published in:

Bioinformatics, 2001, v. 17, n. 11, p. 1058, doi. 10.1093/bioinformatics/17.11.1058

By:

Kretschmer-Kazemi Far, Rosel;
Nedbal, Wolfgang;
Sczakiel, Georg

Publication type:

Article

Specific Recognition of Proteins by Array-Bound Hexanucleotides.

Published in:

Angewandte Chemie International Edition, 2011, v. 50, n. 5, p. 1052, doi. 10.1002/anie.201003462

By:

Mescalchin, Alessandra;
Wünsche, Winfried;
Sczakiel, Georg

Publication type:

Article

Antisense RNA-Mediated Inhibition of the Replication of the Human Immunodeficiency Virus Type 1.

Published in:

Annals of the New York Academy of Sciences, 1992, v. 660, n. 1, p. 268, doi. 10.1111/j.1749-6632.1992.tb21080.x

By:

SCZAKIEL, GEORG;
PAWLITA, MICHAEL;
RITTNER, KAROLA;
HOMANN, MATTHIAS

Publication type:

Article

Phosphorothioate-stimulated uptake of short interfering RNA by human cells.

Published in:

EMBO Reports, 2005, v. 6, n. 12, p. 1176, doi. 10.1038/sj.embor.7400535

By:

Overhoff, Marita;
Sczakiel, Georg

Publication type:

Article

'Chemie in unserer Zeit' in der Stadt der Wissenschaft 2012.

Published in:

Chemie in unserer Zeit, 2012, v. 46, n. 4, p. 199, doi. 10.1002/ciuz.201290041

By:

Sczakiel, Georg

Publication type:

Article

RNA accessibility prediction: a theoretical approach is consistent with experimental studies in cell extracts.

Published in:

Nucleic Acids Research, 2000, v. 28, n. 13, p. 2455, doi. 10.1093/nar/28.13.2455

By:

Scherr, Michaela;
Rossi, John J.;
Sczakiel, Georg;
Patzel, Volker

Publication type:

Article

In vitro selection supports the view of a kinetic control of antisense RNA-mediated inhibition of gene expression in mammalian cells.

Published in:

Nucleic Acids Research, 2000, v. 28, n. 13, p. 2462, doi. 10.1093/nar/28.13.2462

By:

Patzel, Volker;
Sczakiel, Georg

Publication type:

Article

Theoretical design of antisense genes with statistically increased efficacy.

Published in:

Nucleic Acids Research, 2000, v. 28, n. 13, p. 2597, doi. 10.1093/nar/28.13.2597

By:

Lehmann, Maik Jörg;
Patzel, Volker;
Sczakiel, Georg

Publication type:

Article

A theoretical approach to select effective antisense oligodeoxyribonucleotides at high statistical probability.

Published in:

Nucleic Acids Research, 1999, v. 27, n. 22, p. 4328, doi. 10.1093/nar/27.22.4328

By:

Patzel, Volker;
Steidl, Ulrich;
Kronenwett, Ralf;
Haas, Rainer;
Sczakiel, Georg

Publication type:

Article

Kinetic selection of HPV 16 E6 /E7‐directed antisense nucleic acids: anti‐proliferative effects on HPV 16‐transformed cells.

Published in:

Nucleic Acids Research, 1999, v. 27, n. 7, p. 1585, doi. 10.1093/nar/27.7.1585

By:

Venturini, Francesca;
Braspenning, Joris;
Homann, Matthias;
Gissmann, Lutz;
Sczakiel, Georg

Publication type:

Article

A spermidine-induced conformational change of long-armed hammerhead ribozymes: Ionic requirements for fast cleavage kinetics.

Published in:

Nucleic Acids Research, 1997, v. 25, n. 23, p. 4715, doi. 10.1093/nar/25.23.4715

By:

Hammann, Christian;
Hormes, Robert;
Sczakiel, Georg;
Tabler, Martin

Publication type:

Article

Dissociation of Long-Chain Duplex RNA Can Occur Via Strand Displacement in Vitro: Biological Implications.

Published in:

Nucleic Acids Research, 1996, v. 24, n. 22, p. 4395, doi. 10.1093/nar/24.22.4395

By:

Homann, Matthias;
Nedbal, Wolfgang;
Sczakiel, Georg

Publication type:

Article

Antisense treatment against Ki-67 mRNA inhibits proliferation and tumor growth in vitro and in vivo.

Published in:

International Journal of Cancer, 2003, v. 105, n. 5, p. 710, doi. 10.1002/ijc.11111

By:

Ingo Kausch;
Anja Lingnau;
Elmar Endl;
Kirsten Sellmann;
Irina Deinert;
Timothy L. Ratliff;
Dieter Jocham;
Georg Sczakiel;
Johannes Gerdes

Publication type:

Article

A hexanucleotide selected for increased cellular uptake in cis contains a highly active CpG-motif in human B cells and primary peripheral blood mononuclear cells.

Published in:

Immunology, 2007, v. 120, n. 2, p. 261, doi. 10.1111/j.1365-2567.2006.02497.x

By:

Mende, Miriam;
Hopert, Anne;
Wünsche, Winfried;
Overhoff, Marita;
Detzer, Anke;
Börngen, Kirsten;
Schlenke, Peter;
Kirchner, Holger;
Sczakiel, Georg

Publication type:

Article

Computational identification of biologically functional non-hairpin GC-helices in human Argonaute mRNA.

Published in:

BMC Bioinformatics, 2013, v. 14, n. 1, p. 1, doi. 10.1186/1471-2105-14-122

By:

Dornseifer, Simon;
Sczakiel, Georg

Publication type:

Article

Concentrations of Circulating RNA from Healthy Donors and Cancer Patients Estimated by Different Methods.

Published in:

Annals of the New York Academy of Sciences, 2006, v. 1075, n. 1, p. 328, doi. 10.1196/annals.1368.044

By:

RYKOVA, ELENA Y.;
WUNSCHE, WINFRIED;
BRIZGUNOVA, OLGA E.;
SKVORTSOVA, TATYANA E.;
TAMKOVICH, SVETLANA N.;
SENIN, ILIJA S.;
LAKTIONOV, PAVEL P.;
SCZAKIEL, GEORG;
VLASSOV, VALENTIN V.

Publication type:

Article

RNAi revised - target mRNA-dependent enhancement of gene silencing.

Published in:

Nucleic Acids Research, 2015, v. 43, n. 22, p. 10623, doi. 10.1093/nar/gkv1200

By:

Dornseifer, Simon;
Willkomm, Sarah;
Far, Rosel Kretschmer-Kazemi;
Liebschwager, Janine;
Beltsiou, Foteini;
Frank, Kirsten;
Laufer, Sandra D.;
Martinetz, Thomas;
Sczakiel, Georg;
Claussen, Jens Christian;
Restle, Tobias

Publication type:

Article

Sampling, Logistics, and Analytics of Urine for RT-qPCR-based Diagnostics.

Published in:

Cancers, 2021, v. 13, n. 17, p. 4381, doi. 10.3390/cancers13174381

By:

Kretschmer-Kazemi Far, Rosel;
Frank, Kirsten;
Sczakiel, Georg

Publication type:

Article

The Three-Dimensional Structure of Hammerhead Ribozymes.

Published in:

Angewandte Chemie International Edition, 1995, v. 34, n. 6, p. 643, doi. 10.1002/anie.199506431

By:

Sczakiel, Georg

Publication type:

Article

Activity and Stability of Hammerhead Ribozymes Containing 2′- C-Methyluridine: a New RNA Mimic.

Published in:

Chemistry & Biodiversity, 2005, v. 2, n. 2, p. 198, doi. 10.1002/cbdv.200590002

By:

Gallo, Mariana;
Kretschmer-Kazemi Far, Rosel;
Sczakiel, Georg;
Iribarren, Adolfo M.

Publication type:

Article

MicroRNA-mediated regulation of gene expression is affected by disease-associated SNPs within the 3'-UTR via altered RNA structure.

Published in:

RNA Biology, 2012, v. 9, n. 6, p. 924, doi. 10.4161/rna.20497

By:

Haas, Ulrike;
Sczakiel, Georg;
Laufer, Sandra D.

Publication type:

Article

The human TRAM1 locus expresses circular RNAs.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-01548-0

By:

Dubois, Josephine;
Sczakiel, Georg

Publication type:

Article