Works by Scrutton, Nigel S.

Results: 140

Coupled Motions Direct Electrons along Human Microsomal P450 Chains.

Published in:

PLoS Biology, 2011, v. 9, n. 12, p. 1, doi. 10.1371/journal.pbio.1001222

By:

Pudney, Christopher R.;
Khara, Basile;
Johannissen, Linus O.;
Scrutton, Nigel S.

Publication type:

Article

Protein Motions Are Coupled to the Reaction Chemistry in Coenzyme B12-Dependent Ethanolamine Ammonia Lyase.

Published in:

Angewandte Chemie, 2012, v. 124, n. 37, p. 9440, doi. 10.1002/ange.201202502

By:

Russell, Henry J.;
Jones, Alex R.;
Hay, Sam;
Greetham, Gregory M.;
Towrie, Michael;
Scrutton, Nigel S.

Publication type:

Article

Is There a Dynamic Protein Contribution to the Substrate Trigger in Coenzyme B12-Dependent Ethanolamine Ammonia Lyase?

Published in:

Angewandte Chemie, 2011, v. 123, n. 46, p. 11035, doi. 10.1002/ange.201105132

By:

Jones, Alex R.;
Hardman, Samantha J. O.;
Hay, Sam;
Scrutton, Nigel S.

Publication type:

Article

How Does Pressure Affect Barrier Compression and Isotope Effects in an Enzymatic Hydrogen Tunneling Reaction?

Published in:

Angewandte Chemie, 2011, v. 123, n. 9, p. 2177, doi. 10.1002/ange.201006668

By:

Johannissen, Linus O.;
Scrutton, Nigel S.;
Sutcliffe, Michael J.

Publication type:

Article

Chemoautotrophic production of gaseous hydrocarbons, bioplastics and osmolytes by a novel Halomonas species.

Published in:

Biotechnology for Biofuels & Bioproducts, 2023, v. 16, n. 1, p. 1, doi. 10.1186/s13068-023-02404-1

By:

Faulkner, Matthew;
Hoeven, Robin;
Kelly, Paul P.;
Sun, Yaqi;
Park, Helen;
Liu, Lu-Ning;
Toogood, Helen S.;
Scrutton, Nigel S.

Publication type:

Article

Photocobilins integrate B12 and bilin photochemistry for enzyme control.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-46995-1

By:

Zhang, Shaowei;
Jeffreys, Laura N.;
Poddar, Harshwardhan;
Yu, Yuqi;
Liu, Chuanyang;
Patel, Kaylee;
Johannissen, Linus O.;
Zhu, Lingyun;
Cliff, Matthew J.;
Yan, Cunyu;
Schirò, Giorgio;
Weik, Martin;
Sakuma, Michiyo;
Levy, Colin W.;
Leys, David;
Heyes, Derren J.;
Scrutton, Nigel S.

Publication type:

Article

Redox driven B12-ligand switch drives CarH photoresponse.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-40817-6

By:

Poddar, Harshwardhan;
Rios-Santacruz, Ronald;
Heyes, Derren J.;
Shanmugam, Muralidharan;
Brookfield, Adam;
Johannissen, Linus O.;
Levy, Colin W.;
Jeffreys, Laura N.;
Zhang, Shaowei;
Sakuma, Michiyo;
Colletier, Jacques-Philippe;
Hay, Sam;
Schirò, Giorgio;
Weik, Martin;
Scrutton, Nigel S.;
Leys, David

Publication type:

Article

Renewable and tuneable bio-LPG blends derived from amino acids.

Published in:

Biotechnology for Biofuels, 2020, v. 13, n. 1, p. 1, doi. 10.1186/s13068-020-01766-0

By:

Amer, Mohamed;
Hoeven, Robin;
Kelly, Paul;
Faulkner, Matthew;
Smith, Michael H.;
Toogood, Helen S.;
Scrutton, Nigel S.

Publication type:

Article

Active Intermediates in Copper Nitrite Reductase Reactions Probed by a Cryotrapping‐Electron Paramagnetic Resonance Approach.

Published in:

Angewandte Chemie International Edition, 2020, v. 59, n. 33, p. 13936, doi. 10.1002/anie.202005052

By:

Hedison, Tobias M.;
Shanmugam, Muralidharan;
Heyes, Derren J.;
Edge, Ruth;
Scrutton, Nigel S.

Publication type:

Article

Channelling and formation of 'active' formaldehyde in dimethylglycine oxidase.

Published in:

EMBO Journal, 2003, v. 22, n. 16, p. 4038, doi. 10.1093/emboj/cdg395

By:

Leys, David;
Basran, Jaswir;
Scrutton, Nigel S.

Publication type:

Article

Hierarchically Porous Silk/Activated-Carbon Composite Fibres for Adsorption and Repellence of Volatile Organic Compounds.

Published in:

Molecules, 2020, v. 25, n. 5, p. 1207, doi. 10.3390/molecules25051207

By:

Roberts, Aled D.;
Lee, Jet-Sing M.;
Magaz, Adrián;
Smith, Martin W.;
Dennis, Michael;
Scrutton, Nigel S.;
Blaker, Jonny J.;
Nakazawa, Yasumoto

Publication type:

Article

A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites.

Published in:

Communications Biology, 2019, v. 2, n. 1, p. N.PAG, doi. 10.1038/s42003-019-0520-5

By:

Zhang, Shaowei;
Sakuma, Michiyo;
Deora, Girdhar S.;
Levy, Colin W.;
Klausing, Alex;
Breda, Carlo;
Read, Kevin D.;
Edlin, Chris D.;
Ross, Benjamin P.;
Wright Muelas, Marina;
Day, Philip J.;
O'Hagan, Stephen;
Kell, Douglas B.;
Schwarcz, Robert;
Leys, David;
Heyes, Derren J.;
Giorgini, Flaviano;
Scrutton, Nigel S.

Publication type:

Article

Light-induced structural changes in a full-length cyanobacterial phytochrome probed by time-resolved X-ray scattering.

Published in:

Communications Biology, 2019, v. 2, n. 1, p. N.PAG, doi. 10.1038/s42003-018-0242-0

By:

Heyes, Derren J.;
Hardman, Samantha J. O.;
Pedersen, Martin N.;
Woodhouse, Joyce;
De La Mora, Eugenio;
Wulff, Michael;
Weik, Martin;
Cammarata, Marco;
Scrutton, Nigel S.;
Schirò, Giorgio

Publication type:

Article

Light-induced structural changes in a full-length cyanobacterial phytochrome probed by time-resolved X-ray scattering.

Published in:

Communications Biology, 2018, v. 1, n. 1, p. N.PAG, doi. 10.1038/s42003-018-0242-0

By:

Heyes, Derren J.;
Hardman, Samantha J. O.;
Pedersen, Martin N.;
Woodhouse, Joyce;
De La Mora, Eugenio;
Wulff, Michael;
Weik, Martin;
Cammarata, Marco;
Scrutton, Nigel S.;
Schirò, Giorgio

Publication type:

Article

The effect of terminal globular domains on the response of recombinant mini-spidroins to fiber spinning triggers.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-67703-1

By:

Finnigan, William;
Roberts, Aled D.;
Ligorio, Cosimo;
Scrutton, Nigel S.;
Breitling, Rainer;
Blaker, Jonny J.;
Takano, Eriko

Publication type:

Article

Engineering an Escherichia coli strain for enhanced production of flavonoids derived from pinocembrin.

Published in:

Microbial Cell Factories, 2024, v. 23, n. 1, p. 1, doi. 10.1186/s12934-024-02582-z

By:

Hanko, Erik K. R.;
Robinson, Christopher J.;
Bhanot, Sahara;
Jervis, Adrian J.;
Scrutton, Nigel S.

Publication type:

Article

SignatureFinder enables sequence mining to identify cobalamin‐dependent photoreceptor proteins.

Published in:

FEBS Journal, 2025, v. 292, n. 3, p. 635, doi. 10.1111/febs.17377

By:

Yu, Yuqi;
Jeffreys, Laura N.;
Poddar, Harshwardhan;
Hill, Adam;
Johannissen, Linus;
Dai, Fanzhuo;
Sakuma, Michiyo;
Leys, David;
Heyes, Derren J.;
Zhang, Shaowei;
Scrutton, Nigel S.

Publication type:

Article

Mechanistic implications of the ternary complex structural models for the photoenzyme protochlorophyllide oxidoreductase.

Published in:

FEBS Journal, 2024, v. 291, n. 7, p. 1404, doi. 10.1111/febs.17025

By:

Taylor, Aoife;
Zhang, Shaowei;
Johannissen, Linus O.;
Sakuma, Michiyo;
Phillips, Robert S.;
Green, Anthony P.;
Hay, Sam;
Heyes, Derren J.;
Scrutton, Nigel S.

Publication type:

Article

Unravelling the complexity of enzyme catalysis.

Published in:

FEBS Journal, 2023, v. 290, n. 9, p. 2204, doi. 10.1111/febs.16796

By:

Scrutton, Nigel S.

Publication type:

Article

A guide to time‐resolved structural analysis of light‐activated proteins.

Published in:

FEBS Journal, 2022, v. 289, n. 3, p. 576, doi. 10.1111/febs.15880

By:

Poddar, Harshwardhan;
Heyes, Derren J.;
Schirò, Giorgio;
Weik, Martin;
Leys, David;
Scrutton, Nigel S.

Publication type:

Article

Insights into the H2O2‐driven catalytic mechanism of fungal lytic polysaccharide monooxygenases.

Published in:

FEBS Journal, 2021, v. 288, n. 13, p. 4115, doi. 10.1111/febs.15704

By:

Hedison, Tobias M.;
Breslmayr, Erik;
Shanmugam, Muralidharan;
Karnpakdee, Kwankao;
Heyes, Derren J.;
Green, Anthony P.;
Ludwig, Roland;
Scrutton, Nigel S.;
Kracher, Daniel

Publication type:

Article

In conversation with Nigel Scrutton.

Published in:

FEBS Journal, 2021, v. 288, n. 6, p. 1728, doi. 10.1111/febs.15632

By:

Dhillon, Paraminder;
Scrutton, Nigel S.

Publication type:

Article

Dual role of the active site 'lid' regions of protochlorophyllide oxidoreductase in photocatalysis and plant development.

Published in:

FEBS Journal, 2021, v. 288, n. 1, p. 175, doi. 10.1111/febs.15542

By:

Zhang, Shaowei;
Godwin, Alan R. F.;
Taylor, Aoife;
Hardman, Samantha J. O.;
Jowitt, Thomas A.;
Johannissen, Linus O.;
Hay, Sam;
Baldock, Clair;
Heyes, Derren J.;
Scrutton, Nigel S.

Publication type:

Article

Structure of the Cannabis sativa olivetol‐producing enzyme reveals cyclization plasticity in type III polyketide synthases.

Published in:

FEBS Journal, 2020, v. 287, n. 8, p. 1511, doi. 10.1111/febs.15089

By:

Kearsey, Lewis J.;
Prandi, Nicole;
Karuppiah, Vijaykumar;
Yan, Cunyu;
Leys, David;
Toogood, Helen;
Takano, Eriko;
Scrutton, Nigel S.

Publication type:

Article

Selectivity through discriminatory induced fit enables switching of NAD(P)H coenzyme specificity in Old Yellow Enzyme ene‐reductases.

Published in:

FEBS Journal, 2019, v. 286, n. 16, p. 3117, doi. 10.1111/febs.14862

By:

Iorgu, Andreea I.;
Hedison, Tobias M.;
Hay, Sam;
Scrutton, Nigel S.

Publication type:

Article

Tripping the light fantastic in membrane redox biology: linking dynamic structures to function in ER electron transfer chains.

Published in:

FEBS Journal, 2019, v. 286, n. 11, p. 2004, doi. 10.1111/febs.14757

By:

Hedison, Tobias M.;
Scrutton, Nigel S.

Publication type:

Article

Liver microsomal lipid enhances the activity and redox coupling of colocalized cytochrome P450 reductase-cytochrome P450 3A4 in nanodiscs.

Published in:

FEBS Journal, 2017, v. 284, n. 14, p. 2302, doi. 10.1111/febs.14129

By:

Liu, Kang‐Cheng;
Hughes, John M. X.;
Hay, Sam;
Scrutton, Nigel S.

Publication type:

Article

Real-time analysis of conformational control in electron transfer reactions of human cytochrome P450 reductase with cytochrome c.

Published in:

FEBS Journal, 2015, v. 282, n. 22, p. 4357, doi. 10.1111/febs.13501

By:

Hedison, Tobias M.;
Hay, Sam;
Scrutton, Nigel S.

Publication type:

Article

Towards the free energy landscape for catalysis in mammalian nitric oxide synthases.

Published in:

FEBS Journal, 2015, v. 282, n. 16, p. 3016, doi. 10.1111/febs.13171

By:

Leferink, Nicole G. H.;
Hay, Sam;
Rigby, Stephen E. J.;
Scrutton, Nigel S.

Publication type:

Article

Does the pressure dependence of kinetic isotope effects report usefully on dynamics in enzyme H-transfer reactions?

Published in:

FEBS Journal, 2015, v. 282, n. 16, p. 3243, doi. 10.1111/febs.13193

By:

Hoeven, Robin;
Heyes, Derren J.;
Hay, Sam;
Scrutton, Nigel S.

Publication type:

Article

Special Issue: Flavins and Flavoproteins.

Published in:

FEBS Journal, 2015, v. 282, n. 16, p. 3001, doi. 10.1111/febs.13337

By:

Chaiyen, Pimchai;
Scrutton, Nigel S.

Publication type:

Article

Professor Richard Nelson Perham.

Published in:

FEBS Journal, 2015, v. 282, n. 8, p. 1349, doi. 10.1111/febs.13273

By:

Scrutton, Nigel S.

Publication type:

Article

Glutamate 338 is an electrostatic facilitator of C-Co bond breakage in a dynamic/electrostatic model of catalysis by ornithine aminomutase.

Published in:

FEBS Journal, 2015, v. 282, n. 7, p. 1242, doi. 10.1111/febs.13215

By:

Menon, Binuraj R. K.;
Menon, Navya;
Fisher, Karl;
Rigby, Stephen E. J.;
Leys, David;
Scrutton, Nigel S.

Publication type:

Article

Modulation of ligand-heme reactivity by binding pocket residues demonstrated in cytochrome c' over the femtosecond-second temporal range.

Published in:

FEBS Journal, 2013, v. 280, n. 23, p. 6070, doi. 10.1111/febs.12526

By:

Russell, Henry J.;
Hardman, Samantha J. O.;
Heyes, Derren J.;
Hough, Michael A.;
Greetham, Gregory M.;
Towrie, Michael;
Hay, Sam;
Scrutton, Nigel S.

Publication type:

Article

Dynamic, Electrostatic Model for the Generation and Control of High-Energy Radical Intermediates by a Coenzyme B12-Dependent Enzyme.

Published in:

ChemBioChem, 2013, v. 14, n. 13, p. 1529, doi. 10.1002/cbic.201300420

By:

Chen, Zhi‐Gang;
Ziętek, Monika A;
Russell, Henry J.;
Tait, Shirley;
Hay, Sam;
Jones, Alex R.;
Scrutton, Nigel S.

Publication type:

Article

Production of Propane and Other Short-Chain Alkanes by Structure-Based Engineering of Ligand Specificity in Aldehyde-Deformylating Oxygenase.

Published in:

ChemBioChem, 2013, v. 14, n. 10, p. 1204, doi. 10.1002/cbic.201300307

By:

Khara, Basile;
Menon, Navya;
Levy, Colin;
Mansell, David;
Das, Debasis;
Marsh, E. Neil G.;
Leys, David;
Scrutton, Nigel S.

Publication type:

Article

Crystal Structure of a Soluble Form of Human CD73 with Ecto-5′-Nucleotidase Activity.

Published in:

ChemBioChem, 2012, v. 13, n. 16, p. 2384, doi. 10.1002/cbic.201200426

By:

Heuts, Dominic P. H. M.;
Weissenborn, Martin J.;
Olkhov, Rouslan V.;
Shaw, Andrew M.;
Gummadova, Jennet;
Levy, Colin;
Scrutton, Nigel S.

Publication type:

Article

ELDOR Spectroscopy Reveals that Energy Landscapes in Human Methionine Synthase Reductase are Extensively Remodelled Following Ligand and Partner Protein Binding.

Published in:

ChemBioChem, 2011, v. 12, n. 6, p. 863, doi. 10.1002/cbic.201000630

By:

Rigby, Stephen E. J.;
Lou, Xiaodong;
Toogood, Helen S.;
Wolthers, Kirsten R.;
Scrutton, Nigel S.

Publication type:

Article

A Site-Saturated Mutagenesis Study of Pentaerythritol Tetranitrate Reductase Reveals that Residues 181 and 184 Influence Ligand Binding, Stereochemistry and Reactivity.

Published in:

ChemBioChem, 2011, v. 12, n. 5, p. 738, doi. 10.1002/cbic.201000662

By:

Toogood, Helen S.;
Fryszkowska, Anna;
Hulley, Martyn;
Sakuma, Michiyo;
Mansell, David;
Stephens, Gill M.;
Gardiner, John M.;
Scrutton, Nigel S.

Publication type:

Article

Focused Directed Evolution of Pentaerythritol Tetranitrate Reductase by Using Automated Anaerobic Kinetic Screening of Site-Saturated Libraries.

Published in:

ChemBioChem, 2010, v. 11, n. 17, p. 2433, doi. 10.1002/cbic.201000527

By:

Hulley, Martyn E.;
Toogood, Helen S.;
Fryszkowska, Anna;
Mansell, David;
Stephens, Gill M.;
Gardiner, John M.;
Scrutton, Nigel S.

Publication type:

Article

Inside Cover: Focused Directed Evolution of Pentaerythritol Tetranitrate Reductase by Using Automated Anaerobic Kinetic Screening of Site-Saturated Libraries (ChemBioChem 17/2010).

Published in:

ChemBioChem, 2010, v. 11, n. 17, p. 2326, doi. 10.1002/cbic.201090083

By:

Hulley, Martyn E.;
Toogood, Helen S.;
Fryszkowska, Anna;
Mansell, David;
Stephens, Gill M.;
Gardiner, John M.;
Scrutton, Nigel S.

Publication type:

Article

Tyrosyl Radical Formation and Propagation in Flavin Dependent Monoamine Oxidases.

Published in:

ChemBioChem, 2010, v. 11, n. 9, p. 1228, doi. 10.1002/cbic.201000184

By:

Dunn, Rachel V.;
Munro, Andrew W.;
Turner, Nicholas J.;
Rigby, Stephen E. J.;
Scrutton, Nigel S.

Publication type:

Article

Biocatalysis with Thermostable Enzymes: Structure and Properties of a Thermophilic 'ene'-Reductase related to Old Yellow Enzyme.

Published in:

ChemBioChem, 2010, v. 11, n. 2, p. 197, doi. 10.1002/cbic.200900570

By:

Adalbjörnsson, Björn V.;
Toogood, Helen S.;
Fryszkowska, Anna;
Pudney, Christopher R.;
Jowitt, Thomas A.;
Leys, David;
Scrutton, Nigel S.

Publication type:

Article

Are the Catalytic Properties of Enzymes from Piezophilic Organisms Pressure Adapted?

Published in:

ChemBioChem, 2009, v. 10, n. 14, p. 2348, doi. 10.1002/cbic.200900367

By:

Hay, Sam;
Evans, Rhiannon M.;
Levy, Colin;
Loveridge, E. Joel;
Wang, Xi;
Leys, David;
Allemann, Rudolf K.;
Scrutton, Nigel S.

Publication type:

Article

Parallel Pathways and Free-Energy Landscapes for Enzymatic Hydride Transfer Probed by Hydrostatic Pressure.

Published in:

ChemBioChem, 2009, v. 10, n. 8, p. 1379, doi. 10.1002/cbic.200900071

By:

Pudney, Christopher R.;
McGrory, Tom;
Lafite, Pierre;
Pang, Jiayun;
Hay, Sam;
Leys, David;
Sutcliffe, Michael J.;
Scrutton, Nigel S.

Publication type:

Article

Driving Force Analysis of Proton Tunnelling Across a Reactivity Series for an Enzyme-Substrate Complex.

Published in:

ChemBioChem, 2008, v. 9, n. 17, p. 2839, doi. 10.1002/cbic.200800408

By:

Hothi, Parvinder;
Hay, Sam;
Roujeinikova, Anna;
Sutcliffe, Michael J.;
Lee, Michael;
Leys, David;
Cullis, Paul M.;
Scrutton, Nigel S.

Publication type:

Article

Structural basis of kynurenine 3-monooxygenase inhibition.

Published in:

Nature, 2013, v. 496, n. 7445, p. 382, doi. 10.1038/nature12039

By:

Amaral, Marta;
Levy, Colin;
Heyes, Derren J.;
Lafite, Pierre;
Outeiro, Tiago F.;
Giorgini, Flaviano;
Leys, David;
Scrutton, Nigel S.

Publication type:

Article

Updated structure of Drosophila cryptochrome.

Published in:

Nature, 2013, v. 495, n. 7441, p. E3, doi. 10.1038/nature11995

By:

Levy, Colin;
Zoltowski, Brian D.;
Jones, Alex R.;
Vaidya, Anand T.;
Top, Deniz;
Widom, Joanne;
Young, Michael W.;
Scrutton, Nigel S.;
Crane, Brian R.;
Leys, David

Publication type:

Article

Alternative Hydride Sources for Ene-Reductases: Current Trends.

Published in:

ChemCatChem, 2014, v. 6, n. 4, p. 951, doi. 10.1002/cctc.201300911

By:

Toogood, Helen S.;
Knaus, Tanja;
Scrutton, Nigel S.

Publication type:

Article

Biocatalytic Reductions and Chemical Versatility of the Old Yellow Enzyme Family of Flavoprotein Oxidoreductases.

Published in:

ChemCatChem, 2010, v. 2, n. 8, p. 892, doi. 10.1002/cctc.201000094

By:

Toogood, Helen S.;
Gardiner, John M.;
Scrutton, Nigel S.

Publication type:

Article