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A pharmacokinetic study of radiprodil oral suspension in healthy adults comparing conventional venous blood sampling with two microsampling techniques.
Published in:
Pharmacology Research & Perspectives, 2019, v. 7, n. 1, p. 1, doi. 10.1002/prp2.459
By:
- Sciberras, David;
- Otoul, Christian;
- Lurquin, Françoise;
- Smeraglia, John;
- Lappert, Aurélia;
- De Bruyn, Steven;
- Jaap van Lier, Jan
Publication type:
Article
Elimination and Biochemical Responses to Intravenous Alendronate in Postmenopausal Osteoporosis.
Published in:
Journal of Bone & Mineral Research, 1997, v. 12, n. 10, p. 1700, doi. 10.1359/jbmr.1997.12.10.1700
By:
- Khan, Sohail A.;
- Kanis, John A.;
- Vasikaran, Samuel;
- Kline, W. F.;
- Matuszewski, B. K.;
- McCloskey, Eugene V.;
- Beneton, Monique N. C.;
- Gertz, Barry J.;
- Sciberras, David G.;
- Holland, S. D.;
- Orgee, Jane;
- Coombes, Gillian M.;
- Rogers, Suzanne R.;
- Porras, A. G.
Publication type:
Article
PHARMACOKINETICS AND FOOD INTERACTION OF MK-462 IN HEALTHY MALES.
Published in:
Biopharmaceutics & Drug Disposition, 1996, v. 17, n. 1, p. 17, doi. 10.1002/(SICI)1099-081X(199601)17:1<17::AID-BDD932>3.0.CO;2-F
By:
- Cheng, Haiyung;
- Polvino, William J.;
- Sciberras, David;
- Yogendran, L.;
- Cerchio, Kristine A.;
- Christie, Karen;
- Olah, Timothy V.;
- McLoughlin, Debra;
- James, Ian;
- Rogers, J. Douglas
Publication type:
Article
Clinical Bridging Studies and Modeling Approach for Implementation of a Patient Centric Sampling Technique in Padsevonil Clinical Development.
Published in:
AAPS Journal, 2024, v. 26, n. 1, p. 1, doi. 10.1208/s12248-023-00866-7
By:
- Kramer, Hester;
- Bicer, Ceyhun;
- Otoul, Christian;
- Rospo, Chiara;
- Macpherson, Merran;
- Watling, Mark;
- Bani, Massimo;
- Sciberras, David;
- Chanteux, Hugues
Publication type:
Article
Assessment of MK-467, a peripheral α2-adrenergic receptor antagonist, with intravenous clonidine.
Published in:
Clinical Pharmacology & Therapeutics, 1991, v. 50, n. 1, p. 71, doi. 10.1038/clpt.1991.105
By:
- Warren, John B;
- Dollery, Colin T;
- Sciberras, David;
- Goldberg, Michael R
Publication type:
Article
Validation of Parametric Methods for [11C]UCB-J PET Imaging Using Subcortical White Matter as Reference Tissue.
Published in:
2020
By:
- Mertens, Nathalie;
- Maguire, Ralph Paul;
- Serdons, Kim;
- Lacroix, Brigitte;
- Mercier, Joel;
- Sciberras, David;
- Van Laere, Koen;
- Koole, Michel
Publication type:
journal article
Human biodistribution and dosimetry of [11C]-UCB-J, a PET radiotracer for imaging synaptic density.
Published in:
EJNMMI Physics, 2021, v. 8, n. 1, p. 1, doi. 10.1186/s40658-021-00384-5
By:
- Cawthorne, Christopher;
- Maguire, Paul;
- Mercier, Joel;
- Sciberras, David;
- Serdons, Kim;
- Bormans, Guy;
- de Hoon, Jan;
- Van Laere, Koen;
- Koole, Michel
Publication type:
Article
Use of a physiologically based pharmacokinetic–pharmacodynamic model for initial dose prediction and escalation during a paediatric clinical trial.
Published in:
British Journal of Clinical Pharmacology, 2021, v. 87, n. 3, p. 1378, doi. 10.1111/bcp.14528
By:
- Johnson, Trevor N.;
- Abduljalil, Khaled;
- Nicolas, Jean‐Marie;
- Muglia, Pierandrea;
- Chanteux, Hugues;
- Nicolai, Johan;
- Gillent, Eric;
- Cornet, Miranda;
- Sciberras, David
Publication type:
Article
Safety, tolerability, pharmacokinetics, and efficacy of AMG 403, a human anti-nerve growth factor monoclonal antibody, in two phase I studies with healthy volunteers and knee osteoarthritis subjects.
Published in:
Arthritis Research & Therapy, 2015, v. 17, p. 1, doi. 10.1186/s13075-015-0797-9
By:
- Gow, Jason M.;
- Tsuji, Wayne H.;
- Williams, Gary J.;
- Mytych, Daniel;
- Sciberras, David;
- Searle, Shawn L.;
- Mant, Tim;
- Gibbs, John P.
Publication type:
Article
Safety, tolerability, pharmacokinetics, and efficacy of AMG 403, a human anti-nerve growth factor monoclonal antibody, in two phase I studies with healthy volunteers and knee osteoarthritis subjects.
Published in:
Arthritis Research & Therapy, 2015, v. 17, n. 1, p. 1, doi. 10.1186/s13075-015-0797-9
By:
- Gow, Jason M.;
- Tsuji, Wayne H.;
- Williams, Gary J.;
- Mytych, Daniel;
- Sciberras, David;
- Searle, Shawn L.;
- Mant, Tim;
- Gibbs, John P.
Publication type:
Article
Radiprodil, a NR2B negative allosteric modulator, from bench to bedside in infantile spasm syndrome.
Published in:
Annals of Clinical & Translational Neurology, 2020, v. 7, n. 3, p. 343, doi. 10.1002/acn3.50998
By:
- Auvin, Stéphane;
- Dozières‐Puyravel, Blandine;
- Avbersek, Andreja;
- Sciberras, David;
- Collier, Jo;
- Leclercq, Karine;
- Mares, Pavel;
- Kaminski, Rafal M.;
- Muglia, Pierandrea
Publication type:
Article
Repeatability of local forearm vasoconstriction to endothelin-1 measured by venous occlusion plethysmography.
Published in:
British Journal of Clinical Pharmacology, 2002, v. 54, n. 4, p. 386, doi. 10.1046/j.1365-2125.2002.01653.x
By:
- Strachan, Fiona E.;
- Newby, David E.;
- Sciberras, David G.;
- McCrea, Jacqueline B.;
- Goldberg, Michael R.;
- Webb, David J.
Publication type:
Article
Influence of β-adrenoceptor antagonists on the pharmacokinetics of rizatriptan, a 5-HT1B/1D agonist: differential effects of propranolol, nadolol and metoprolol.
Published in:
British Journal of Clinical Pharmacology, 2001, v. 52, n. 1, p. 69, doi. 10.1046/j.0306-5251.2001.01417.x
By:
- Goldberg, Michael R.;
- Sciberras, David;
- De Smet, Marina;
- Lowry, Richard;
- Tomasko, Lisa;
- Lee, Yih;
- Olah, Timothy V.;
- Zhao, Jamie;
- Vyas, Kamlesh P.;
- Halpin, Rita;
- Kari, Prasad H.;
- James, Ian
Publication type:
Article
Substance P-induced vasodilatation is mediated by the neurokinin type 1 receptor but does not contribute to basal vascular tone in man.
Published in:
British Journal of Clinical Pharmacology, 1999, v. 48, n. 3
By:
- Newby, David E.;
- Sciberras, David G.;
- Ferro, Charles J.;
- Gertz, Barry J.;
- Sommerville, David;
- Majumdar, Anup;
- Lowry, Richard C.;
- Webb, David J.
Publication type:
Article
Intra-arterial substance P mediated vasodilatation in the human forearm: pharmacology, reproducibility and tolerability.
Published in:
British Journal of Clinical Pharmacology, 1997, v. 43, n. 5, p. 493, doi. 10.1046/j.1365-2125.1997.00583.x
By:
- Newby, David E.;
- Sciberras, David G.;
- Mendel, Carl M.;
- Gertz, Barry J.;
- Boon, Nicholas A.;
- Webb, David J.
Publication type:
Article
Initial human experience with MK-462 (rizatriptan): a novel 5=HTID agonist.
Published in:
British Journal of Clinical Pharmacology, 1997, v. 43, n. 1, p. 49, doi. 10.1111/j.1365-2125.1997.tb00137.x
By:
- Sciberras, David G.;
- Polvino, William J.;
- Gertz, Barry J.;
- Cheng, Haiyung;
- Stepanavage, Michael;
- Wittreich, Johanna;
- Olah, Timothy;
- Edwards, Mark;
- Mant, Timothy
Publication type:
Article
Safety, Tolerability, and Pharmacokinetics of Escalating High Doses of Ivermectin in Healthy Adult Subjects.
Published in:
Journal of Clinical Pharmacology, 2002, v. 42, n. 10, p. 1122, doi. 10.1177/009127002237994
By:
- Guzzo, Cynthia A.;
- Furtek, Christine I.;
- Porras, Arturo G.;
- Chen, Cong;
- Tipping, Robert;
- Clineschmidt, Coleen M.;
- Sciberras, David G.;
- Hsieh, John Y-K.;
- Lasseter, Kenneth C.
Publication type:
Article
Quantifying SV2A density and drug occupancy in the human brain using [11C]UCB-J PET imaging and subcortical white matter as reference tissue.
Published in:
European Journal of Nuclear Medicine & Molecular Imaging, 2019, v. 46, n. 2, p. 396, doi. 10.1007/s00259-018-4119-8
By:
- Koole, Michel;
- van Aalst, June;
- Devrome, Martijn;
- Mertens, Nathalie;
- Serdons, Kim;
- Van Laere, Koen;
- Lacroix, Brigitte;
- Mercier, Joel;
- Sciberras, David;
- Maguire, Paul
Publication type:
Article
Antiparkinsonian effects of the "Radiprodil and Tozadenant" combination in MPTP-treated marmosets.
Published in:
PLoS ONE, 2017, v. 12, n. 8, p. 1, doi. 10.1371/journal.pone.0182887
By:
- Michel, Anne;
- Nicolas, Jean-Marie;
- Rose, Sarah;
- Jackson, Michael;
- Colman, Peter;
- Briône, Willy;
- Sciberras, David;
- Muglia, Pierandrea;
- Scheller, Dieter K.;
- Citron, Martin;
- Downey, Patrick
Publication type:
Article

Found: 19

A pharmacokinetic study of radiprodil oral suspension in healthy adults comparing conventional venous blood sampling with two microsampling techniques.

Elimination and Biochemical Responses to Intravenous Alendronate in Postmenopausal Osteoporosis.

PHARMACOKINETICS AND FOOD INTERACTION OF MK-462 IN HEALTHY MALES.

Clinical Bridging Studies and Modeling Approach for Implementation of a Patient Centric Sampling Technique in Padsevonil Clinical Development.

Assessment of MK-467, a peripheral α<sub>2</sub>-adrenergic receptor antagonist, with intravenous clonidine.

Validation of Parametric Methods for [<sup>11</sup>C]UCB-J PET Imaging Using Subcortical White Matter as Reference Tissue.

Human biodistribution and dosimetry of [11C]-UCB-J, a PET radiotracer for imaging synaptic density.

Use of a physiologically based pharmacokinetic–pharmacodynamic model for initial dose prediction and escalation during a paediatric clinical trial.

Safety, tolerability, pharmacokinetics, and efficacy of AMG 403, a human anti-nerve growth factor monoclonal antibody, in two phase I studies with healthy volunteers and knee osteoarthritis subjects.

Safety, tolerability, pharmacokinetics, and efficacy of AMG 403, a human anti-nerve growth factor monoclonal antibody, in two phase I studies with healthy volunteers and knee osteoarthritis subjects.

Radiprodil, a NR2B negative allosteric modulator, from bench to bedside in infantile spasm syndrome.

Repeatability of local forearm vasoconstriction to endothelin-1 measured by venous occlusion plethysmography.

Influence of β-adrenoceptor antagonists on the pharmacokinetics of rizatriptan, a 5-HT<sub>1B/1D</sub> agonist: differential effects of propranolol, nadolol and metoprolol.

Substance P-induced vasodilatation is mediated by the neurokinin type 1 receptor but does not contribute to basal vascular tone in man.

Intra-arterial substance P mediated vasodilatation in the human forearm: pharmacology, reproducibility and tolerability.

Initial human experience with MK-462 (rizatriptan): a novel 5=HT<sub>ID</sub> agonist.

Safety, Tolerability, and Pharmacokinetics of Escalating High Doses of Ivermectin in Healthy Adult Subjects.

Quantifying SV2A density and drug occupancy in the human brain using [<sup>11</sup>C]UCB-J PET imaging and subcortical white matter as reference tissue.

Antiparkinsonian effects of the "Radiprodil and Tozadenant" combination in MPTP-treated marmosets.