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Nonclinical cardiovascular safety of pitolisant: comparing International Conference on Harmonization S7B and Comprehensive in vitro Pro-arrhythmia Assay initiative studies.
- Published in:
- 2017
- By:
- Publication type:
- journal article
Pitolisant, a wake-promoting agent devoid of psychostimulant properties: Preclinical comparison with amphetamine, modafinil, and solriamfetol.
- Published in:
- Pharmacology Research & Perspectives, 2021, v. 9, n. 5, p. 1, doi. 10.1002/prp2.855
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- Publication type:
- Article
Molecular and Functional Diversity of Histamine Receptor Subtypes.
- Published in:
- Annals of the New York Academy of Sciences, 1995, v. 757, n. 1, p. 314, doi. 10.1111/j.1749-6632.1995.tb17489.x
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- Publication type:
- Article
Novel Dopamine Receptor Subtypes as Targets for Antipsychotic Drugs.
- Published in:
- Annals of the New York Academy of Sciences, 1995, v. 757, n. 1, p. 278, doi. 10.1111/j.1749-6632.1995.tb17486.x
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- Publication type:
- Article
Modulation of Histamine Synthesis and Release in Brain via Presynaptic Autoreceptors and Heteroreceptors.
- Published in:
- Annals of the New York Academy of Sciences, 1990, v. 604, n. 1, p. 40, doi. 10.1111/j.1749-6632.1990.tb31981.x
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- Publication type:
- Article
Stimulation of cerebral histamine H<sub>2</sub> receptors by clonidine.
- Published in:
- Nature, 1976, v. 262, n. 5566, p. 307, doi. 10.1038/262307a0
- By:
- Publication type:
- Article
Pitolisant for Daytime Sleepiness in Patients with Obstructive Sleep Apnea Who Refuse Continuous Positive Airway Pressure Treatment. A Randomized Trial.
- Published in:
- 2020
- By:
- Publication type:
- journal article
Pitolisant for Daytime Sleepiness in Obstructive Sleep Apnea Patients Refusing CPAP: A Randomized Trial.
- Published in:
- American Journal of Respiratory & Critical Care Medicine, 2020, v. 201, n. 9, p. E1, doi. 10.1164/rccm.201907-1284oc
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- Publication type:
- Article
Benzophenone Derivatives and Related Compounds as Potent Histamine H<sub>3</sub>-Receptor Antagonists and Potential PET/SPECT Ligands.
- Published in:
- Archiv der Pharmazie, 2001, v. 334, n. 2, p. 45, doi. 10.1002/1521-4184(200102)334:2<45::AID-ARDP45>3.0.CO;2-2
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- Publication type:
- Article
Synthesis of Potent Non-imidazole Histamine H<sub>3</sub>-Receptor Antagonists.
- Published in:
- Archiv der Pharmazie, 1998, v. 331, n. 12, p. 395, doi. 10.1002/(SICI)1521-4184(199812)331:12<395::AID-ARDP395>3.0.CO;2-7
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- Publication type:
- Article
Development of FUB 181, a Selective Histamine H<sub>3</sub>-Receptor Antagonist of High Oral in Vivo Potency with 4-(?gv-(Arylalkyloxy)alkyl)-1 H-imidazole Structure.
- Published in:
- Archiv der Pharmazie, 1998, v. 331, n. 6, p. 211, doi. 10.1002/(SICI)1521-4184(199806)331:6<211::AID-ARDP211>3.0.CO;2-P
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- Publication type:
- Article
Novel Histamine H<sub>3</sub>-Receptor Antagonists with Benzyl Ether Structure or Related Moieties: Synthesis and Structure-Activity Relationships.
- Published in:
- Archiv der Pharmazie, 1996, v. 329, n. 8/9, p. 379, doi. 10.1002/ardp.19963290802
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- Publication type:
- Article
New Potent Azomethine Prodrugs of the Histamine H<sub>3</sub>-Receptor Agonist ( R)-α-Methylhistamine Containing a Heteroarylphenyl Partial Structure.
- Published in:
- Archiv der Pharmazie, 1996, v. 329, n. 4, p. 209, doi. 10.1002/ardp.19963290407
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- Publication type:
- Article
Pyrazoles as Potential Histamine H<sub>3</sub>-Receptor Antagonists.
- Published in:
- Archiv der Pharmazie, 1995, v. 328, n. 5, p. 469, doi. 10.1002/ardp.19953280513
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- Publication type:
- Article
Azines and Diazines as Potential Histamine H<sub>3</sub>-Receptor Antagonists.
- Published in:
- Archiv der Pharmazie, 1995, v. 328, n. 5, p. 445, doi. 10.1002/ardp.19953280509
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- Publication type:
- Article
Cerebrospinal fluid histamine levels are decreased in patients with narcolepsy and excessive daytime sleepiness of other origin C. L. Bassetti et al. CSF histamine and sleepiness/narcolepsy.
- Published in:
- Journal of Sleep Research, 2010, v. 19, n. 4, p. 620, doi. 10.1111/j.1365-2869.2010.00819.x
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- Publication type:
- Article
Administration of oxathridine, a first‐in‐class histamine‐3 receptor partial agonist in healthy male volunteers: Central nervous system depression and pseudo‐hallucinations.
- Published in:
- British Journal of Clinical Pharmacology, 2024, v. 90, n. 1, p. 321, doi. 10.1111/bcp.15910
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- Publication type:
- Article
Bioavailability and cardiovascular effects of adrenaline administered by Anapen 500 μg auto‐injector in healthy volunteers.
- Published in:
- British Journal of Clinical Pharmacology, 2023, v. 89, n. 3, p. 1012, doi. 10.1111/bcp.15545
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- Publication type:
- Article
Clinical Impact of Pitolisant on Excessive Daytime Sleepiness and Cataplexy in Adults With Narcolepsy: An Analysis of Randomized Placebo-Controlled Trials.
- Published in:
- CNS Drugs, 2022, v. 36, n. 1, p. 61, doi. 10.1007/s40263-021-00886-x
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- Publication type:
- Article
Time to Onset of Response to Pitolisant for the Treatment of Excessive Daytime Sleepiness and Cataplexy in Patients With Narcolepsy: An Analysis of Randomized, Placebo-Controlled Trials.
- Published in:
- 2021
- By:
- Publication type:
- journal article
Effect of long-term therapy with fasidotril, a mixed inhibitor of neprilysin and angiotensin-converting enzyme (ACE), on survival of rats after myocardial infarction1.
- Published in:
- Cardiovascular Research, 1999, v. 41, n. 3, p. 544, doi. 10.1016/S0008-6363(98)00257-0
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- Publication type:
- Article
Assessment of the Role of 'Enkephalinase' in Cholecystokinin Inactivation.
- Published in:
- Annals of the New York Academy of Sciences, 1985, v. 448, n. 1, p. 685, doi. 10.1111/j.1749-6632.1985.tb29989.x
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- Publication type:
- Article
Sulfation and Desulfation of Cerebral Cholecystokinin.
- Published in:
- Annals of the New York Academy of Sciences, 1985, v. 448, n. 1, p. 110, doi. 10.1111/j.1749-6632.1985.tb29911.x
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- Publication type:
- Article
Edg-2 in myelin-forming cells: Isoforms, genomic mapping, and exclusion in Charcot-Marie-Tooth disease.
- Published in:
- Glia, 1999, v. 26, n. 2, p. 176, doi. 10.1002/(SICI)1098-1136(199904)26:2<176::AID-GLIA8>3.0.CO;2-K
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- Publication type:
- Article
BDNF controls dopamine D[sub 3] receptor expression and triggers behavioural sensitization.
- Published in:
- Nature, 2001, v. 411, n. 6833, p. 86, doi. 10.1038/35075076
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- Publication type:
- Article
High constitutive activity of native H[sub3] receptors regulates histamine neurons in brain.
- Published in:
- Nature, 2000, v. 408, n. 6814, p. 860, doi. 10.1038/35048583
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- Publication type:
- Article
Exploring occupancy of the histamine H<sub>3</sub> receptor by pitolisant in humans using PET.
- Published in:
- British Journal of Pharmacology, 2020, v. 177, n. 15, p. 3464, doi. 10.1111/bph.15067
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- Publication type:
- Article
Exploring occupancy of the histamine H<sub>3</sub> receptor by pitolisant in humans using PET.
- Published in:
- 2020
- By:
- Publication type:
- journal article
Ciproxifan, a histamine H<sub>3</sub> -receptor antagonist/inverse agonist, modulates the effects of methamphetamine on neuropeptide mRNA expression in rat striatum.
- Published in:
- European Journal of Neuroscience, 2003, v. 17, n. 2, p. 307, doi. 10.1046/j.1460-9568.2003.02422.x
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- Publication type:
- Article
Role of the dopamine D[sub 3] receptor in reactivity to cocaine-associated cues in mice.
- Published in:
- European Journal of Neuroscience, 2002, v. 15, n. 12, p. 2016, doi. 10.1046/j.1460-9568.2002.02049.x
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- Publication type:
- Article
Two splice variants of the hypoxia-inducible factor HIF-1α as potential dimerization partners of ARNT2 in neurons.
- Published in:
- European Journal of Neuroscience, 2000, v. 12, n. 10, p. 3701, doi. 10.1046/j.1460-9568.2000.00266.x
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- Publication type:
- Article
Involvement of the direct striatonigral pathway in levodopa-induced sensitization in 6-hydroxydopamine-lesioned rats.
- Published in:
- European Journal of Neuroscience, 2000, v. 12, n. 6, p. 427, doi. 10.1046/j.1460-9568.2000.00089.x
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- Publication type:
- Article
ARNT2, a transcription factor for brain neuron survival?
- Published in:
- European Journal of Neuroscience, 1999, v. 11, n. 5, p. 1545, doi. 10.1046/j.1460-9568.1999.00562.x
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- Publication type:
- Article
Coexpression of dopamine D<sub>1</sub> and D<sub>3</sub> receptors in islands of Calleja and shell of nucleus accumbens of the rat: opposite and synergistic functional interactions.
- Published in:
- European Journal of Neuroscience, 1998, v. 10, n. 5, p. 1676, doi. 10.1046/j.1460-9568.1998.00173.x
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- Publication type:
- Article
The histamine H3 receptor: from discovery to clinical trials with pitolisant.
- Published in:
- 2011
- By:
- Publication type:
- journal article
Responses of Anterior Pituitary Hormones and Hypothalamic Histamine to Blockade of Histamine Synthesis and to Selective Activation or Inactivation of Presynaptic Histamine H<sub>3</sub> Receptors in Stressed Rats.
- Published in:
- Neuroendocrinology, 1993, v. 57, n. 3, p. 532, doi. 10.1159/000126402
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- Publication type:
- Article
A Novel Potential Metallopeptidase Derived from the Enkephalinase Gene by Alternative Splicing.
- Published in:
- Journal of Neurochemistry, 1990, v. 55, n. 6, p. 2146, doi. 10.1111/j.1471-4159.1990.tb05810.x
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- Publication type:
- Article
Modulation of Histamine Release in the Rat Brain by K-Opioid Receptors.
- Published in:
- Journal of Neurochemistry, 1990, v. 55, n. 1, p. 47, doi. 10.1111/j.1471-4159.1990.tb08819.x
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- Publication type:
- Article
Modulation of Histamine Release and Synthesis in the Brain Mediated by α<sub>2</sub>-Adrenoceptors.
- Published in:
- Journal of Neurochemistry, 1989, v. 53, n. 2, p. 519, doi. 10.1111/j.1471-4159.1989.tb07364.x
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- Publication type:
- Article
Photoaffinity Labeling and Electrophoretic Identification of the H<sub>1</sub>-Receptor: Comparison of Several Brain Regions and Animal Species.
- Published in:
- Journal of Neurochemistry, 1989, v. 53, n. 2, p. 335, doi. 10.1111/j.1471-4159.1989.tb07339.x
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- Publication type:
- Article
Regulation of Histamine Release and Synthesis in the Brain by Muscarinic Receptors.
- Published in:
- Journal of Neurochemistry, 1989, v. 52, n. 1, p. 248, doi. 10.1111/j.1471-4159.1989.tb10924.x
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- Publication type:
- Article
H<sub>3</sub>-Receptors Control Histamine Release in Human Brain.
- Published in:
- Journal of Neurochemistry, 1988, v. 51, n. 1, p. 105, doi. 10.1111/j.1471-4159.1988.tb04841.x
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- Publication type:
- Article
Formation and Utilization of the Active Sulfate Donor [<sup>35</sup>S]3′-Phosphoadenosine 5′-Phosphosulfate in Brain Slices: Effects of Depolarizing Agents.
- Published in:
- Journal of Neurochemistry, 1987, v. 49, n. 5, p. 1443, doi. 10.1111/j.1471-4159.1987.tb01012.x
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- Publication type:
- Article
Properties and Localization of the Sulfate-Activating System in Rat Brain.
- Published in:
- Journal of Neurochemistry, 1987, v. 48, n. 4, p. 1171, doi. 10.1111/j.1471-4159.1987.tb05643.x
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- Publication type:
- Article
Histamine as a Neurotransmitter in Mammalian Brain: Neurochemical Evidence.
- Published in:
- Journal of Neurochemistry, 1980, v. 35, n. 1, p. 26, doi. 10.1111/j.1471-4159.1980.tb12485.x
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- Publication type:
- Article
Highly Potent Fluorescence-Tagged Nonimidazole Histamine H<sub>3</sub> Receptor Ligands.
- Published in:
- ChemMedChem, 2007, v. 2, n. 5, p. 708, doi. 10.1002/cmdc.200600270
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- Publication type:
- Article
N-methyl-d-aspartate receptor antagonists enhance histamine neuron activity in rodent brain.
- Published in:
- Journal of Neurochemistry, 2006, v. 98, n. 5, p. 1487, doi. 10.1111/j.1471-4159.2006.04002.x
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- Publication type:
- Article
Cloning and expression of the mouse histamine H<sub>3</sub> receptor: evidence for multiple isoforms.
- Published in:
- Journal of Neurochemistry, 2004, v. 90, n. 6, p. 1331, doi. 10.1111/j.1471-4159.2004.02606.x
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- Publication type:
- Article
Two Intracellular Signaling Pathways for the Dopamine D<sub>3</sub> Receptor: Opposite and Synergistic Interactions with Cyclic AMP.
- Published in:
- Journal of Neurochemistry, 1997, v. 68, n. 1, p. 1, doi. 10.1046/j.1471-4159.1997.68010001.x
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- Publication type:
- Article
Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 receptor agonist.
- Published in:
- Nature, 1999, v. 400, n. 6742, p. 371, doi. 10.1038/22560
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- Publication type:
- Article