Found: 25
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A combined physiologically‐based pharmacokinetic and quantitative systems pharmacology model for modeling amyloid aggregation in Alzheimer's disease.
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- CPT: Pharmacometrics & Systems Pharmacology, 2023, v. 12, n. 4, p. 444, doi. 10.1002/psp4.12912
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- Publication type:
- Article
Physiologically‐based pharmacokinetic modeling to predict drug interactions of lemborexant with CYP3A inhibitors.
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- CPT: Pharmacometrics & Systems Pharmacology, 2021, v. 10, n. 5, p. 455, doi. 10.1002/psp4.12606
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- Article
Perampanel and pregnancy.
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- Epilepsia (Series 4), 2021, v. 62, n. 3, p. 698, doi. 10.1111/epi.16821
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- Publication type:
- Article
Changes in perampanel levels during de‐induction: Simulations following carbamazepine discontinuation.
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- Acta Neurologica Scandinavica, 2020, v. 142, n. 2, p. 131, doi. 10.1111/ane.13286
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- Article
Quantitative Systems Pharmacology for Neuroscience Drug Discovery and Development: Current Status, Opportunities, and Challenges.
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- CPT: Pharmacometrics & Systems Pharmacology, 2020, v. 9, n. 1, p. 5, doi. 10.1002/psp4.12478
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- Article
Applications of Quantitative Systems Pharmacology in Model‐Informed Drug Discovery: Perspective on Impact and Opportunities.
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- CPT: Pharmacometrics & Systems Pharmacology, 2019, v. 8, n. 11, p. 777, doi. 10.1002/psp4.12463
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- Publication type:
- Article
Recommendations for the Design of Clinical Drug–Drug Interaction Studies With Itraconazole Using a Mechanistic Physiologically‐Based Pharmacokinetic Model.
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- CPT: Pharmacometrics & Systems Pharmacology, 2019, v. 8, n. 9, p. 685, doi. 10.1002/psp4.12449
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- Publication type:
- Article
P4‐657: POPULATION PHARMACOKINETIC/PHARMACODYNAMIC ANALYSES OF BAN2401 IN PATIENTS WITH EARLY ALZHEIMER'S DISEASE: CORRELATION OF BAN2401 EXPOSURE, PET STANDARD UPTAKE VALUE RATIO, AND COGNITIVE OUTCOMES.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P1582, doi. 10.1016/j.jalz.2019.09.023
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- Publication type:
- Article
Clinical Drug–Drug Interaction Potential of BFE1224, Prodrug of Antifungal Ravuconazole, Using Two Types of Cocktails in Healthy Subjects.
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- CTS: Clinical & Translational Science, 2018, v. 11, n. 5, p. 477, doi. 10.1111/cts.12557
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- Publication type:
- Article
P1‐055: E2027, A NOVEL PHOSPHODIESTERASE‐9 (PDE9) INHIBITOR IN DEVELOPMENT FOR TREATMENT OF DEMENTIA WITH LEWY BODIES (DLB), SHOWED NO CLINICALLY SIGNIFICANT DRUG INTERACTION WITH DILTIAZEM.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P289, doi. 10.1016/j.jalz.2018.06.057
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- Publication type:
- Article
O1‐12‐06: PHASE 1 MULTIPLE ASCENDING DOSE (MAD) STUDY OF PHOSPHODIESTERASE‐9 INHIBITOR E2027: CONFIRMATION OF TARGET ENGAGEMENT AND SELECTION OF PHASE 2 DOSE IN DEMENTIA WITH LEWY BODIES.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P251, doi. 10.1016/j.jalz.2018.06.2401
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- Publication type:
- Article
Physiologically Based Pharmacokinetic Model Qualification and Reporting Procedures for Regulatory Submissions: A Consortium Perspective.
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- Clinical Pharmacology & Therapeutics, 2018, v. 104, n. 1, p. 88, doi. 10.1002/cpt.1013
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- Publication type:
- Article
Pharmacokinetic/pharmacodynamic drug–drug interactions of avatrombopag when coadministered with dual or selective CYP2C9 and CYP3A interacting drugs.
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- British Journal of Clinical Pharmacology, 2018, v. 84, n. 5, p. 952, doi. 10.1111/bcp.13517
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- Publication type:
- Article
Preclinical QSP Modeling in the Pharmaceutical Industry: An IQ Consortium Survey Examining the Current Landscape.
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- CPT: Pharmacometrics & Systems Pharmacology, 2018, v. 7, n. 3, p. 135, doi. 10.1002/psp4.12282
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- Publication type:
- Article
Eribulin shows high concentration and long retention in xenograft tumor tissues.
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- 2017
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- Publication type:
- journal article
POPULATION PHARMACOKINETIC-PHARMACODYNAMIC (PK/PD) MODELING OF E2027, A SELECTIVE PHOSPHODIESTERASE-9 (PDE9) INHIBITOR, FOLLOWING SINGLE ASCENDING ORAL DOSES IN HEALTHY VOLUNTEERS.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P258, doi. 10.1016/j.jalz.2017.06.123
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- Publication type:
- Article
PHASE 1 INVESTIGATION INTO THE SAFETY, TOLERABILITY, PHARMACOKINETICS (PK) AND PHARMACODYNAMICS (PD) OF E2027, A SELECTIVE PHOSPHODIESTERASE-9 (PDE9) INHIBITOR.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P574, doi. 10.1016/j.jalz.2017.07.194
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- Publication type:
- Article
Preclinical Pharmacokinetic/Pharmacodynamic Modeling and Simulation in the Pharmaceutical Industry: An IQ Consortium Survey Examining the Current Landscape.
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- AAPS Journal, 2015, v. 17, n. 2, p. 462, doi. 10.1208/s12248-014-9716-2
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- Publication type:
- Article
Safety, tolerability, pharmacokinetics, and pharmacodynamics of the novel γ-secretase modulator, E2212, in healthy human subjects.
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- Journal of Clinical Pharmacology, 2014, v. 54, n. 5, p. 528, doi. 10.1002/jcph.249
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- Publication type:
- Article
Safety, tolerability, pharmacokinetics, and pharmacodynamics of the novel γ-secretase modulator, E2212, in healthy human subjects.
- Published in:
- 2014
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- Publication type:
- Journal Article
Safety, pharmacokinetics and pharmacodynamics of four-hour intravenous infusions of eritoran in healthy Japanese and Caucasian men.
- Published in:
- Innate Immunity, 2012, v. 18, n. 6, p. 793, doi. 10.1177/1753425912441845
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- Publication type:
- Article
Pharmacokinetic characterization of a natural product-inspired novel MEK1 inhibitor E6201 in preclinical species.
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- Cancer Chemotherapy & Pharmacology, 2012, v. 69, n. 1, p. 229, doi. 10.1007/s00280-011-1687-8
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- Publication type:
- Article
E2012, a novel gamma-secretase modulator, decreases plasma amyloid-beta (Aβ) levels in humans
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- 2010
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- Publication type:
- Abstract
Effect of Simulated Microgravity on the Disposition and Tissue Penetration of Ciprofloxacin in Healthy Volunteers.
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- Journal of Clinical Pharmacology, 2005, v. 45, n. 7, p. 822, doi. 10.1177/0091270005276620
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- Publication type:
- Article
Physiological, Pharmacokinetic, and Pharmacodynamic Changes in Space.
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- Journal of Clinical Pharmacology, 2004, v. 44, n. 8, p. 837
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- Publication type:
- Article