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Identification of a Novel Acid Sphingomyelinase Activity Associated with Recombinant Human Acid Ceramidase.
- Published in:
- Biomolecules (2218-273X), 2023, v. 13, n. 11, p. 1623, doi. 10.3390/biom13111623
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- Article
The cholesterol transporter NPC1 is essential for epigenetic regulation and maturation of oligodendrocyte lineage cells.
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- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-39733-6
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- Article
Modulation of Dietary Choline Uptake in a Mouse Model of Acid Sphingomyelinase Deficiency.
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- International Journal of Molecular Sciences, 2023, v. 24, n. 11, p. 9756, doi. 10.3390/ijms24119756
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- Article
Sphingomyelin 16:0 is a therapeutic target for neuronal death in acid sphingomyelinase deficiency.
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- Cell Death & Disease, 2023, v. 14, n. 4, p. 1, doi. 10.1038/s41419-023-05784-2
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- Article
The clinical spectrum of SMA‐PME and in vitro normalization of its cellular ceramide profile.
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- Annals of Clinical & Translational Neurology, 2022, v. 9, n. 12, p. 1941, doi. 10.1002/acn3.51687
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- Article
SiO<sub>2</sub> stimulates macrophage stress to induce the transformation of lung fibroblasts into myofibroblasts and its relationship with the sphingomyelin metabolic pathway.
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- Journal of Applied Toxicology, 2021, v. 41, n. 10, p. 1584, doi. 10.1002/jat.4148
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- Article
New paradigms for the treatment of lysosomal storage diseases: targeting the endocannabinoid system as a therapeutic strategy.
- Published in:
- 2021
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- Publication type:
- journal article
Inhibition of fatty acid amide hydrolase prevents pathology in neurovisceral acid sphingomyelinase deficiency by rescuing defective endocannabinoid signaling.
- Published in:
- EMBO Molecular Medicine, 2020, v. 12, n. 11, p. 1, doi. 10.15252/emmm.201911776
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- Article
Recombinant Acid Ceramidase Reduces Inflammation and Infection in Cystic Fibrosis.
- Published in:
- 2020
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- Publication type:
- journal article
N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer's disease.
- Published in:
- Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-16080-4
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- Publication type:
- Article
Safety Study of Sodium Pentosan Polysulfate for Adult Patients with Mucopolysaccharidosis Type II.
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- Diagnostics (2075-4418), 2019, v. 9, n. 4, p. 226, doi. 10.3390/diagnostics9040226
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- Article
Adeno-associated viral vector serotype 9–based gene therapy for Niemann-Pick disease type A.
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- Science Translational Medicine, 2019, v. 11, n. 506, p. 1, doi. 10.1126/scitranslmed.aat3738
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- Publication type:
- Article
Signalling Effects Induced by Acid Ceramidase in Human Epithelial Or Leukemic Cell Lines.
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- Cellular Physiology & Biochemistry (Cell Physiol Biochem Press GmbH & Co. KG), 2019, v. 52, n. 5, p. 1092, doi. 10.33594/000000074
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- Publication type:
- Article
Quantitative Systems Pharmacology Modeling of Acid Sphingomyelinase Deficiency and the Enzyme Replacement Therapy Olipudase Alfa Is an Innovative Tool for Linking Pathophysiology and Pharmacology.
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- CPT: Pharmacometrics & Systems Pharmacology, 2018, v. 7, n. 7, p. 442, doi. 10.1002/psp4.12304
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- Publication type:
- Article
Loss of acid ceramidase in myeloid cells suppresses intestinal neutrophil recruitment.
- Published in:
- FASEB Journal, 2018, v. 32, n. 5, p. 2339, doi. 10.1096/fj.201700585R
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- Publication type:
- Article
Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer’s Disease.
- Published in:
- Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-03674-2
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- Publication type:
- Article
Ceramide and Ischemia/Reperfusion Injury.
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- Journal of Lipids, 2018, p. 1, doi. 10.1155/2018/3646725
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- Publication type:
- Article
Using whole-exome sequencing to investigate the genetic bases of lysosomal storage diseases of unknown etiology.
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- Human Mutation, 2017, v. 38, n. 11, p. 1491, doi. 10.1002/humu.23291
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- Publication type:
- Article
Neuropeptide Y Induces Hematopoietic Stem/Progenitor Cell Mobilization by Regulating Matrix Metalloproteinase-9 Activity Through Y1 Receptor in Osteoblasts.
- Published in:
- Stem Cells, 2016, v. 34, n. 8, p. 2145, doi. 10.1002/stem.2383
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- Publication type:
- Article
Pentosan Polysulfate: Oral Versus Subcutaneous Injection in Mucopolysaccharidosis Type I Dogs.
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- PLoS ONE, 2016, v. 11, n. 4, p. 1, doi. 10.1371/journal.pone.0153136
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- Publication type:
- Article
Neuropeptide Y regulates the hematopoietic stem cell microenvironment and prevents nerve injury in the bone marrow.
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- EMBO Journal, 2015, v. 34, n. 12, p. 1648, doi. 10.15252/embj.201490174
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- Publication type:
- Article
The molecular medicine of acid ceramidase.
- Published in:
- Biological Chemistry, 2015, v. 396, n. 6/7, p. 759, doi. 10.1515/hsz-2014-0290
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- Publication type:
- Article
Pathological roles of the VEGF/SphK pathway in Niemann-Pick type C neurons.
- Published in:
- Nature Communications, 2014, v. 5, n. 11, p. 5514, doi. 10.1038/ncomms6514
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- Publication type:
- Article
Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa.
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- EMBO Molecular Medicine, 2014, v. 6, n. 9, p. 1205, doi. 10.15252/emmm.201404075
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- Publication type:
- Article
Dose Responsive Effects of Subcutaneous Pentosan Polysulfate Injection in Mucopolysaccharidosis Type VI Rats and Comparison to Oral Treatment.
- Published in:
- PLoS ONE, 2014, v. 9, n. 6, p. 1, doi. 10.1371/journal.pone.0100882
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- Publication type:
- Article
Pharmacological reversion of sphingomyelin-induced dendritic spine anomalies in a Niemann Pick disease type A mouse model.
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- EMBO Molecular Medicine, 2014, v. 6, n. 3, p. 398, doi. 10.1002/emmm.201302649
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- Publication type:
- Article
Systemic ceramide accumulation leads to severe and varied pathological consequences.
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- EMBO Molecular Medicine, 2013, v. 5, n. 6, p. 827, doi. 10.1002/emmm.201202301
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- Publication type:
- Article
Recombinant Human Acid Sphingomyelinase as an Adjuvant to Sorafenib Treatment of Experimental Liver Cancer
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- PLoS ONE, 2013, v. 8, n. 5, p. 1, doi. 10.1371/journal.pone.0065620
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- Publication type:
- Article
Structural, compositional, and biomechanical alterations of the lumbar spine in rats with mucopolysaccharidosis type VI (Maroteaux-Lamy syndrome).
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- Journal of Orthopaedic Research, 2013, v. 31, n. 4, p. 621, doi. 10.1002/jor.22281
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- Publication type:
- Article
Acid Ceramidase Maintains the Chondrogenic Phenotype of Expanded Primary Chondrocytes and Improves the Chondrogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells.
- Published in:
- PLoS ONE, 2013, v. 8, n. 4, p. 1, doi. 10.1371/journal.pone.0062715
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- Article
Pentosan Polysulfate: A Novel Therapy for the Mucopolysaccharidoses.
- Published in:
- PLoS ONE, 2013, v. 8, n. 1, p. 1, doi. 10.1371/journal.pone.0054459
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- Publication type:
- Article
Merits of Combination Cortical, Subcortical, and Cerebellar Injections for the Treatment of Niemann-Pick Disease Type A.
- Published in:
- Molecular Therapy, 2012, v. 20, n. 10, p. 1893, doi. 10.1038/mt.2012.118
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- Publication type:
- Article
Construction of Conditional Acid Ceramidase Knockout Mice and in vivo Effects on Oocyte Development and Fertility.
- Published in:
- Cellular Physiology & Biochemistry (Karger AG), 2012, v. 30, n. 3, p. 735, doi. 10.1159/000341453
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- Publication type:
- Article
Soluble CCL5 Derived from Bone Marrow-Derived Mesenchymal Stem Cells and Activated by Amyloid β Ameliorates Alzheimer's Disease in Mice by Recruiting Bone Marrow-Induced Microglia Immune Responses.
- Published in:
- Stem Cells, 2012, v. 30, n. 7, p. 1544, doi. 10.1002/stem.1125
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- Publication type:
- Article
Anti-TNF-Alpha Therapy Enhances the Effects of Enzyme Replacement Therapy in Rats with Mucopolysaccharidosis Type VI.
- Published in:
- PLoS ONE, 2011, v. 6, n. 8, p. 1, doi. 10.1371/journal.pone.0022447
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- Publication type:
- Article
Combined Effects of Hematopoietic Progenitor Cell Mobilization from Bone Marrow by Granulocyte Colony Stimulating Factor and AMD3100 and Chemotaxis into the Brain Using Stromal Cell-Derived Factor-1α in an Alzheimer's Disease Mouse Model.
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- Stem Cells, 2011, v. 29, n. 7, p. 1075, doi. 10.1002/stem.659
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- Publication type:
- Article
Brain pathology in Niemann Pick disease type A: insights from the acid sphingomyelinase knockout mice.
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- Journal of Neurochemistry, 2011, v. 116, n. 5, p. 779, doi. 10.1111/j.1471-4159.2010.07034.x
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- Publication type:
- Article
Acid Sphingomyelinase Deficiency Attenuates Bleomycin-Induced Lung Inflammation and Fibrosis in Mice.
- Published in:
- Cellular Physiology & Biochemistry (Karger AG), 2010, v. 26, n. 4/5, p. 749, doi. 10.1159/000322342
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- Publication type:
- Article
Identification and Characterization of Eight Novel SMPD1 Mutations Causing Types A and B Niemann-Pick Disease.
- Published in:
- Molecular Medicine, 2010, v. 16, n. 7/8, p. 316, doi. 10.2119/molmed.2010.00017
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- Publication type:
- Article
Acid sphingomyelinase, cell membranes and human disease: Lessons from Niemann–Pick disease
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- FEBS Letters, 2010, v. 584, n. 9, p. 1895, doi. 10.1016/j.febslet.2009.11.083
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- Publication type:
- Article
Improvement in Lipid and Protein Trafficking in Niemann-Pick C1 Cells by Correction of a Secondary Enzyme Defect.
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- Traffic, 2010, v. 11, n. 5, p. 601, doi. 10.1111/j.1600-0854.2010.01046.x
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- Publication type:
- Article
Acid ceramidase improves the quality of oocytes and embryos and the outcome of in vitro fertilization.
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- FASEB Journal, 2010, v. 24, n. 4, p. 1229, doi. 10.1096/fj.09-145508
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- Publication type:
- Article
Bone Marrow-Derived Mesenchymal Stem Cells Prevent the Loss of Niemann-Pick Type C Mouse Purkinje Neurons by Correcting Sphingolipid Metabolism and Increasing Sphingosine-1-phosphate.
- Published in:
- Stem Cells, 2010, v. 28, n. 4, p. 821, doi. 10.1002/stem.401
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- Publication type:
- Article
Intracerebral Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells Reduces Amyloid-Beta Deposition and Rescues Memory Deficits in Alzheimer's Disease Mice by Modulation of Immune Responses.
- Published in:
- Stem Cells, 2010, v. 28, n. 2, p. 329, doi. 10.1002/stem.277
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- Publication type:
- Article
Identification and characterization of SMPD1 mutations causing Niemann-Pick types A and B in Spanish patients.
- Published in:
- Human Mutation, 2009, v. 30, n. 7, p. 1117, doi. 10.1002/humu.21018
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- Publication type:
- Article
Acid sphingomyelinase activity triggers microparticle release from glial cells.
- Published in:
- 2009
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- Publication type:
- Erratum
Acid sphingomyelinase activity triggers microparticle release from glial cells.
- Published in:
- EMBO Journal, 2009, v. 28, n. 8, p. 1043, doi. 10.1038/emboj.2009.45
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- Publication type:
- Article
Alterations of myelin-specific proteins and sphingolipids characterize the brains of acid sphingomyelinase-deficient mice, an animal model of Niemann–Pick disease type A.
- Published in:
- Journal of Neurochemistry, 2009, v. 109, n. 1, p. 105, doi. 10.1111/j.1471-4159.2009.05947.x
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- Publication type:
- Article
Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium.
- Published in:
- Nature Medicine, 2008, v. 14, n. 11, p. 1247, doi. 10.1038/nm.1876
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- Publication type:
- Article
Lipid content of brain, brain membrane lipid domains, and neurons from acid sphingomyelinase deficient mice.
- Published in:
- Journal of Neurochemistry, 2008, v. 107, n. 2, p. 329, doi. 10.1111/j.1471-4159.2008.05591.x
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- Publication type:
- Article