Works by Schmitz, Werner

Results: 39

GDF-5 can act as a context-dependent BMP-2 antagonist.

Published in:

BMC Biology, 2015, v. 13, n. 1, p. 1, doi. 10.1186/s12915-015-0183-8

By:

Klammert, Uwe;
Mueller, Thomas D.;
Hellmann, Tina V.;
Wuerzler, Kristian K.;
Kotzsch, Alexander;
Schliermann, Anna;
Schmitz, Werner;
Kuebler, Alexander C.;
Sebald, Walter;
Nickel, Joachim

Publication type:

Article

The Molecular Basis of Catalysis by SDR Family Members Ketoacyl‐ACP Reductase FabG and Enoyl‐ACP Reductase FabI in Type‐II Fatty Acid Biosynthesis.

Published in:

Angewandte Chemie, 2023, v. 135, n. 46, p. 1, doi. 10.1002/ange.202313109

By:

Zhou, Jiashen;
Zhang, Lin;
Wang, Yiran;
Song, Wenyan;
Huang, Yuzhou;
Mu, Yajuan;
Schmitz, Werner;
Zhang, Shu‐Yu;
Lin, Houwen;
Chen, Hong‐Zhuan;
Ye, Fei;
Zhang, Liang

Publication type:

Article

A phosphoproteomic approach reveals that PKD3 controls PKA-mediated glucose and tyrosine metabolism.

Published in:

Life Science Alliance, 2021, v. 4, n. 8, p. 1, doi. 10.26508/lsa.202000863

By:

Loza-Valdes, Angel;
Mayer, Alexander E.;
Kassouf, Toufic;
Trujillo-Viera, Jonathan;
Schmitz, Werner;
Dziaczkowski, Filip;
Leitges, Michael;
Schlosser, Andreas;
Sumara, Grzegorz

Publication type:

Article

Crystallographic binding studies of rat peroxisomal multifunctional enzyme type 1 with 3‐ketodecanoyl‐CoA: capturing active and inactive states of its hydratase and dehydrogenase catalytic sites.

Published in:

Acta Crystallographica: Section D, Structural Biology, 2020, v. 76, n. 12, p. 1256, doi. 10.1107/S2059798320013819

By:

Sridhar, Shruthi;
Schmitz, Werner;
Hiltunen, J. Kalervo;
Venkatesan, Rajaram;
Bergmann, Ulrich;
Kiema, Tiila-Riikka;
Wierenga, Rikkert K.

Publication type:

Article

Neuroforensomics: metabolites as valuable biomarkers in cerebrospinal fluid of lethal traumatic brain injuries.

Published in:

Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-64312-0

By:

Bohnert, Simone;
Reinert, Christoph;
Trella, Stefanie;
Cattaneo, Andrea;
Preiß, Ulrich;
Bohnert, Michael;
Zwirner, Johann;
Büttner, Andreas;
Schmitz, Werner;
Ondruschka, Benjamin

Publication type:

Article

Low Energy Status under Methionine Restriction Is Essentially Independent of Proliferation or Cell Contact Inhibition.

Published in:

Cells (2073-4409), 2022, v. 11, n. 3, p. 551, doi. 10.3390/cells11030551

By:

Koderer, Corinna;
Schmitz, Werner;
Wünsch, Anna Chiara;
Balint, Julia;
El-Mesery, Mohamed;
Volland, Julian Manuel;
Hartmann, Stefan;
Linz, Christian;
Kübler, Alexander Christian;
Seher, Axel

Publication type:

Article

The isomerase and hydratase reaction mechanism of the crotonase active site of the multifunctional enzyme (type-1), as deduced from structures of complexes with 3 S-hydroxy-acyl- Co A.

Published in:

FEBS Journal, 2013, v. 280, n. 13, p. 3160, doi. 10.1111/febs.12150

By:

Kasaragod, Prasad;
Schmitz, Werner;
Hiltunen, Jukka K.;
Wierenga, Rik K.

Publication type:

Article

The sulfur atoms of the substrate CoA and the catalytic cysteine are required for a productive mode of substrate binding in bacterial biosynthetic thiolase, a thioester-dependent enzyme.

Published in:

FEBS Journal, 2008, v. 275, n. 24, p. 6136, doi. 10.1111/j.1742-4658.2008.06737.x

By:

Meriläinen, Gitte;
Schmitz, Werner;
Wierenga, Rik K.;
Kursula, Petri

Publication type:

Article

Mitochondrial 2,4-dienoyl-CoA Reductase Deficiency in Mice Results in Severe Hypoglycemia with Stress Intolerance and Unimpaired Ketogenesis.

Published in:

PLoS Genetics, 2009, v. 5, n. 7, p. 1, doi. 10.1371/journal.pgen.1000543

By:

Miinalainen, Ilkka J.;
Schmitz, Werner;
Huotari, Anne;
Autio, Kaija J.;
Soininen, Raija;
Van Themaat, Emiel Ver Loren;
Baes, Myriam;
Herzig, Karl-Heinz;
Conzelmann, Ernst;
Hiltunen, J. Kalervo

Publication type:

Article

Mass Spectrometric Metabolic Fingerprinting of 2-Deoxy-D-Glucose (2-DG)-Induced Inhibition of Glycolysis and Comparative Analysis of Methionine Restriction versus Glucose Restriction under Perfusion Culture in the Murine L929 Model System.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 16, p. 9220, doi. 10.3390/ijms23169220

By:

Volland, Julian Manuel;
Kaupp, Johannes;
Schmitz, Werner;
Wünsch, Anna Chiara;
Balint, Julia;
Möllmann, Marc;
El-Mesery, Mohamed;
Frackmann, Kyra;
Peter, Leslie;
Hartmann, Stefan;
Kübler, Alexander Christian;
Seher, Axel

Publication type:

Article

Cysteine Restriction in Murine L929 Fibroblasts as an Alternative Strategy to Methionine Restriction in Cancer Therapy.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 21, p. 11630, doi. 10.3390/ijms222111630

By:

Schmitz, Werner;
Ries, Elena;
Koderer, Corinna;
Völter, Maximilian Friedrich;
Wünsch, Anna Chiara;
El-Mesery, Mohamed;
Frackmann, Kyra;
Kübler, Alexander Christian;
Linz, Christian;
Seher, Axel

Publication type:

Article

Erratum to: Female carriers of X-chromosomal adrenoleukodystrophy: a major differential diagnosis in progressive myelopathy.

Published in:

2010

By:

Guettsches, Anne-Katrin;
Kuechler, Alma;
Gal, Andreas;
Schmitz, Werner;
Tegenthoff, Martin;
Vorgerd, Matthias

Publication type:

Correction Notice

Female carriers of X-chromosomal adrenoleukodystrophy: a major differential diagnosis in progressive myelopathy.

Published in:

2010

By:

Guettsches, Anne-Katrin;
Kuechler, Alma;
Gal, Andreas;
Schmitz, Werner;
Tegenthoff, Martin;
Vorgerd, Matthias

Publication type:

Letter

A mouse model for α-methylacyl-CoA racemase deficiency: adjustment of bile acid synthesis and intolerance to dietary methyl-branched lipids.

Published in:

Human Molecular Genetics, 2004, v. 13, n. 9, p. 955, doi. 10.1093/hmg/ddh107

By:

Savolainen, Kalle;
Kotti, Tiina J.;
Schmitz, Werner;
Savolainen, Teuvo I.;
Sormunen, Raija T.;
Ilves, Mika;
Vainio, Seppo J.;
Conzelmann, Ernst;
Hiltunen, J. Kalervo

Publication type:

Article

An engineered variant of MECR reductase reveals indispensability of long-chain acyl-ACPs for mitochondrial respiration.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-36358-7

By:

Tanvir Rahman, M.;
Kristian Koski, M.;
Panecka-Hofman, Joanna;
Schmitz, Werner;
Kastaniotis, Alexander J.;
Wade, Rebecca C.;
Wierenga, Rik K.;
Kalervo Hiltunen, J.;
Autio, Kaija J.

Publication type:

Article

Glycolytic flux control by drugging phosphoglycolate phosphatase.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-34228-2

By:

Jeanclos, Elisabeth;
Schlötzer, Jan;
Hadamek, Kerstin;
Yuan-Chen, Natalia;
Alwahsh, Mohammad;
Hollmann, Robert;
Fratz, Stefanie;
Yesilyurt-Gerhards, Dilan;
Frankenbach, Tina;
Engelmann, Daria;
Keller, Angelika;
Kaestner, Alexandra;
Schmitz, Werner;
Neuenschwander, Martin;
Hergenröder, Roland;
Sotriffer, Christoph;
von Kries, Jens Peter;
Schindelin, Hermann;
Gohla, Antje

Publication type:

Article

The Molecular Basis of Catalysis by SDR Family Members Ketoacyl‐ACP Reductase FabG and Enoyl‐ACP Reductase FabI in Type‐II Fatty Acid Biosynthesis.

Published in:

Angewandte Chemie International Edition, 2023, v. 62, n. 46, p. 1, doi. 10.1002/anie.202313109

By:

Zhou, Jiashen;
Zhang, Lin;
Wang, Yiran;
Song, Wenyan;
Huang, Yuzhou;
Mu, Yajuan;
Schmitz, Werner;
Zhang, Shu‐Yu;
Lin, Houwen;
Chen, Hong‐Zhuan;
Ye, Fei;
Zhang, Liang

Publication type:

Article

Protein kinase D1 deletion in adipocytes enhances energy dissipation and protects against adiposity.

Published in:

EMBO Journal, 2018, v. 37, n. 22, p. N.PAG, doi. 10.15252/embj.201899182

By:

Löffler, Mona C;
Mayer, Alexander E;
Trujillo Viera, Jonathan;
Loza Valdes, Angel;
El‐Merahbi, Rabih;
Ade, Carsten P;
Karwen, Till;
Schmitz, Werner;
Slotta, Anja;
Erk, Manuela;
Janaki‐Raman, Sudha;
Matesanz, Nuria;
Torres, Jorge L;
Marcos, Miguel;
Sabio, Guadalupe;
Eilers, Martin;
Schulze, Almut;
Sumara, Grzegorz

Publication type:

Article

Characterization of Hydrogen Storage Materials and Systems with Photons and Neutrons.

Published in:

Advanced Engineering Materials, 2011, v. 13, n. 8, p. 730, doi. 10.1002/adem.201000298

By:

Pranzas, P. Klaus;
Bösenberg, Ulrike;
Karimi, Fahim;
Münning, Martin;
Metz, Oliver;
Minella, Christian Bonatto;
Schmitz, Heinz-Werner;
Beckmann, Felix;
Vainio, Ulla;
Zajac, Dariusz;
Welter, Edmund;
Jensen, Torben R.;
Cerenius, Yngve;
Bormann, Rüdiger;
Klassen, Thomas;
Dornheim, Martin;
Schreyer, Andreas

Publication type:

Article

Cathepsin Inhibition Modulates Metabolism and Polarization of Tumor-Associated Macrophages.

Published in:

Cancers, 2020, v. 12, n. 9, p. 2579, doi. 10.3390/cancers12092579

By:

Oelschlaegel, Diana;
Weiss Sadan, Tommy;
Salpeter, Seth;
Krug, Sebastian;
Blum, Galia;
Schmitz, Werner;
Schulze, Almut;
Michl, Patrick

Publication type:

Article

Platelet‐derived lipids promote insulin secretion of pancreatic β cells.

Published in:

EMBO Molecular Medicine, 2023, v. 15, n. 9, p. 1, doi. 10.15252/emmm.202216858

By:

Karwen, Till;
Kolczynska‐Matysiak, Katarzyna;
Gross, Carina;
Löffler, Mona C;
Friedrich, Mike;
Loza‐Valdes, Angel;
Schmitz, Werner;
Wit, Magdalena;
Dziaczkowski, Filip;
Belykh, Andrei;
Trujillo‐Viera, Jonathan;
El‐Merahbi, Rabih;
Deppermann, Carsten;
Nawaz, Sameena;
Hastoy, Benoit;
Demczuk, Agnieszka;
Erk, Manuela;
Wieckowski, Mariusz R;
Rorsman, Patrik;
Heinze, Katrin G

Publication type:

Article

LRP8‐mediated selenocysteine uptake is a targetable vulnerability in MYCN‐amplified neuroblastoma.

Published in:

EMBO Molecular Medicine, 2023, v. 15, n. 8, p. 1, doi. 10.15252/emmm.202318014

By:

Alborzinia, Hamed;
Chen, Zhiyi;
Yildiz, Umut;
Freitas, Florencio Porto;
Vogel, Felix C E;
Varga, Julianna Patricia;
Batani, Jasmin;
Bartenhagen, Christoph;
Schmitz, Werner;
Büchel, Gabriele;
Michalke, Bernhard;
Zheng, Jashuo;
Meierjohann, Svenja;
Girardi, Enrico;
Espinet, Elisa;
Flórez, Andrés F;
dos Santos, Ancely Ferreira;
Aroua, Nesrine;
Cheytan, Tasneem;
Haenlin, Julie

Publication type:

Article

Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase.

Published in:

EMBO Molecular Medicine, 2014, v. 6, n. 12, p. 1525, doi. 10.15252/emmm.201403927

By:

Peter, Stefanie;
Bultinck, Jennyfer;
Myant, Kevin;
Jaenicke, Laura A;
Walz, Susanne;
Müller, Judith;
Gmachl, Michael;
Treu, Matthias;
Boehmelt, Guido;
Ade, Carsten P;
Schmitz, Werner;
Wiegering, Armin;
Otto, Christoph;
Popov, Nikita;
Sansom, Owen;
Kraut, Norbert;
Eilers, Martin

Publication type:

Article

Aziridide-Based Inhibitors of Cathepsin L: Synthesis, Inhibition Activity, and Docking Studies.

Published in:

ChemMedChem, 2006, v. 1, n. 10, p. 1126, doi. 10.1002/cmdc.200600106

By:

Vicik, Radim;
Busemann, Matthias;
Gelhaus, Christoph;
Stiefl, Nikolaus;
Scheiber, Josef;
Schmitz, Werner;
Schulz, Franziska;
Mladenovic, Milena;
Engels, Bernd;
Leippe, Matthias;
Baumann, Knut;
Schirmeister, Tanja

Publication type:

Article

Myelin basic protein and neurofilament H in postmortem cerebrospinal fluid as surrogate markers of fatal traumatic brain injury.

Published in:

International Journal of Legal Medicine, 2021, v. 135, n. 4, p. 1525, doi. 10.1007/s00414-021-02606-y

By:

Bohnert, Simone;
Wirth, Christoph;
Schmitz, Werner;
Trella, Stefanie;
Monoranu, Camelia-Maria;
Ondruschka, Benjamin;
Bohnert, Michael

Publication type:

Article

Metabolomics in postmortem cerebrospinal fluid diagnostics: a state-of-the-art method to interpret central nervous system–related pathological processes.

Published in:

International Journal of Legal Medicine, 2021, v. 135, n. 1, p. 183, doi. 10.1007/s00414-020-02462-2

By:

Bohnert, Simone;
Reinert, Christoph;
Trella, Stefanie;
Schmitz, Werner;
Ondruschka, Benjamin;
Bohnert, Michael

Publication type:

Article

Activation of the integrated stress response rewires cardiac metabolism in Barth syndrome.

Published in:

Basic Research in Cardiology, 2023, v. 118, n. 1, p. 1, doi. 10.1007/s00395-023-01017-x

By:

Kutschka, Ilona;
Bertero, Edoardo;
Wasmus, Christina;
Xiao, Ke;
Yang, Lifeng;
Chen, Xinyu;
Oshima, Yasuhiro;
Fischer, Marcus;
Erk, Manuela;
Arslan, Berkan;
Alhasan, Lin;
Grosser, Daria;
Ermer, Katharina J.;
Nickel, Alexander;
Kohlhaas, Michael;
Eberl, Hanna;
Rebs, Sabine;
Streckfuss-Bömeke, Katrin;
Schmitz, Werner;
Rehling, Peter

Publication type:

Article

Activation of the integrated stress response rewires cardiac metabolism in Barth syndrome.

Published in:

Basic Research in Cardiology, 2023, v. 118, n. 1, p. 1, doi. 10.1007/s00395-023-01017-x

By:

Kutschka, Ilona;
Bertero, Edoardo;
Wasmus, Christina;
Xiao, Ke;
Yang, Lifeng;
Chen, Xinyu;
Oshima, Yasuhiro;
Fischer, Marcus;
Erk, Manuela;
Arslan, Berkan;
Alhasan, Lin;
Grosser, Daria;
Ermer, Katharina J.;
Nickel, Alexander;
Kohlhaas, Michael;
Eberl, Hanna;
Rebs, Sabine;
Streckfuss-Bömeke, Katrin;
Schmitz, Werner;
Rehling, Peter

Publication type:

Article

Polyurethane-Based Synthetic Surfaces for Sports Facilities.

Published in:

Journal of Elastomers & Plastics, 1988, v. 20, n. 4, p. 311, doi. 10.1177/009524438802000404

By:

Schmitz, Werner

Publication type:

Article

Structural enzymology studies with the substrate 3S‐hydroxybutanoyl‐CoA: bifunctional MFE1 is a less efficient dehydrogenase than monofunctional HAD.

Published in:

FEBS Open Bio, 2024, v. 14, n. 4, p. 655, doi. 10.1002/2211-5463.13786

By:

Sridhar, Shruthi;
Kiema, Tiila‐Riikka;
Schmitz, Werner;
Widersten, Mikael;
Wierenga, Rik K.

Publication type:

Article

Structural enzymology comparisons of multifunctional enzyme, type-1 ( MFE1): the flexibility of its dehydrogenase part.

Published in:

FEBS Open Bio, 2017, v. 7, n. 12, p. 1830, doi. 10.1002/2211-5463.12337

By:

Kasaragod, Prasad;
Midekessa, Getnet B.;
Sridhar, Shruthi;
Schmitz, Werner;
Kiema, Tiila‐Riikka;
Hiltunen, Jukka K.;
Wierenga, Rik K.

Publication type:

Article

Integrated Metabolomics and Transcriptomics Analysis of Monolayer and Neurospheres from Established Glioblastoma Cell Lines.

Published in:

Cancers, 2021, v. 13, n. 6, p. 1327, doi. 10.3390/cancers13061327

By:

Peixoto, Joana;
Janaki-Raman, Sudha;
Schlicker, Lisa;
Schmitz, Werner;
Walz, Susanne;
Winkelkotte, Alina M.;
Herold-Mende, Christel;
Soares, Paula;
Schulze, Almut;
Lima, Jorge;
Pollok, Karen E.;
Nagrath, Deepak

Publication type:

Article

Complementary substrate specificity and distinct quaternary assembly of the Escherichia coli aerobic and anaerobic ß-oxidation trifunctional enzyme complexes.

Published in:

Biochemical Journal, 2019, v. 476, n. 13, p. 1975, doi. 10.1042/BCJ20190314

By:

Sah-Teli, Shiv K.;
Hynönen, Mikko J.;
Schmitz, Werner;
Geraets, James A.;
Seitsonen, Jani;
Pedersen, Jan Skov;
Butcher, Sarah J.;
Wierenga, Rik K.;
Venkatesan, Rajaram

Publication type:

Article

The peroxisomal zebrafish SCP2-thiolase (type-1) is a weak transient dimer as revealed by crystal structures and native mass spectrometry.

Published in:

Biochemical Journal, 2019, v. 476, n. 2, p. 307, doi. 10.1042/BCJ20180788

By:

Kiema, Tiila-Riikka;
Thapa, Chandan J.;
Mikko Laitaoja;
Schmitz, Werner;
Maksimainen, Mirko M.;
Toshiyuki Fukao;
Rouvinen, Juha;
Jänis, Janne;
Wierenga, Rik K.

Publication type:

Article

Peroxiredoxin 6 triggers melanoma cell growth by increasing arachidonic acid-dependent lipid signalling.

Published in:

Biochemical Journal, 2015, v. 471, n. 2, p. 267, doi. 10.1042/BJ20141204

By:

Schmitt, Alexandra;
Schmitz, Werner;
Hufnagel, Anita;
Schartl, Manfred;
Meierjohann, Svenja

Publication type:

Article

Role of AMACR (α-methylacyl-CoA racemase) and MFE-1 (peroxisomal multifunctional enzyme-1) in bile acid synthesis in mice.

Published in:

Biochemical Journal, 2014, v. 461, n. 1, p. 125, doi. 10.1042/BJ20130915

By:

AUTIO, Kaija J.;
SCHMITZ, Werner;
NAIR, Remya R.;
SELK ÄL Ä, Eija M.;
SORMUNEN, Raija T.;
MIINALAINEN, Ilkka J.;
CRICK, Peter J.;
Yuqin WANG;
GRIFFITHS, William J.;
REDDY, Janardan K.;
BAES, Myriam;
HILTUNEN, J. Kalervo

Publication type:

Article

c-Myc plays a key role in IFN-γ-induced persistence of Chlamydia trachomatis.

Published in:

eLife, 2022, p. 1, doi. 10.7554/eLife.76721

By:

Vollmuth, Nadine;
Schlicker, Lisa;
Yongxia Guo;
Hovhannisyan, Pargev;
Janaki-Raman, Sudha;
Kurmasheva, Naziia;
Schmitz, Werner;
Schulze, Almut;
Stelzner, Kathrin;
Rajeeve, Karthika;
Rudel, Thomas

Publication type:

Article

The kinase PKD3 provides negative feedback on cholesterol and triglyceride synthesis by suppressing insulin signaling.

Published in:

Science Signaling, 2019, v. 12, n. 593, p. 1, doi. 10.1126/scisignal.aav9150

By:

Mayer, Alexander E.;
Löffler, Mona C.;
Loza Valdés, Angel E.;
Schmitz, Werner;
El-Merahbi, Rabih;
Viera, Jonathan Trujillo;
Erk, Manuela;
Zhang, Thianzhou;
Braun, Ursula;
Heikenwalder, Mathias;
Leitges, Michael;
Schulze, Almut;
Sumara, Grzegorz

Publication type:

Article

Human Δ<sup>3</sup>,Δ<sup>2</sup>-enoyl-CoA isomerase, type 2: a structural enzymology study on the catalytic role of its ACBP domain and helix-10.

Published in:

FEBS Journal, 2015, v. 282, n. 4, p. 746, doi. 10.1111/febs.13179

By:

Onwukwe, Goodluck U.;
Kursula, Petri;
Koski, M. Kristian;
Schmitz, Werner;
Wierenga, Rik K.

Publication type:

Article