Works by Schmidt, Constanze

Results: 50

A perfusion-independent high-throughput method to isolate liver sinusoidal endothelial cells.

Published in:

Communications Biology, 2025, v. 8, n. 1, p. 1, doi. 10.1038/s42003-025-07458-5

By:

Babin-Ebell Gonçalves, Anna;
Mao, Yifang;
Baljkas, Tinja;
Wiedmann, Felix;
Eis, Larissa;
Pilz, Franziska;
Winkler, Manuel;
Kürschner-Zacharias, Sina W.;
Hoffarth, Marlene;
Funaya, Charlotta;
Shahidi, Réza;
Géraud, Cyrill;
Wu, Chi-Chung;
Schmidt, Constanze;
Goerdt, Sergij;
Reiners-Koch, Philipp-Sebastian;
Singhal, Mahak

Publication type:

Article

A porcine large animal model of radiofrequency ablation-induced left bundle branch block.

Published in:

Frontiers in Physiology, 2024, p. 1, doi. 10.3389/fphys.2024.1385277

By:

Wiedmann, Felix;
Jamros, Max;
Herlt, Valerie;
Paasche, Amelie;
Kraft, Manuel;
Beck, Moritz;
Prüser, Merten;
Erkal, Atilla;
Harder, Maren;
Zaradzki, Marcin;
Soethoff, Jasmin;
Karck, Matthias;
Frey, Norbert;
Schmidt, Constanze

Publication type:

Article

Therapeutic targeting of two-pore-domain potassium (K2P) channels in the cardiovascular system.

Published in:

Clinical Science, 2016, v. 130, n. 9, p. 643, doi. 10.1042/CS20150533

By:

Wiedmann, Felix;
Schmidt, Constanze;
Lugenbiel, Patrick;
Staudacher, Ingo;
Rahm, Ann-Kathrin;
Seyler, Claudia;
Schweizer, Patrick A.;
Katus, Hugo A.;
Thomas, Dierk

Publication type:

Article

Identification of the A293 (AVE1231) Binding Site in the Cardiac Two-Pore-Domain Potassium Channel TASK-1: a Common Low Affinity Antiarrhythmic Drug Binding Site.

Published in:

Cellular Physiology & Biochemistry (Cell Physiol Biochem Press GmbH & Co. KG), 2019, v. 52, n. 5, p. 1223, doi. 10.33594/000000083

By:

Wiedmann, Felix;
Kiper, Aytug K.;
Bedoya, Mauricio;
Ratte, Antonius;
Rinné, Susanne;
Kraft, Manuel;
Waibel, Maximilian;
Anad, Priya;
Wenzel, Wolfgang;
González, Wendy;
Katus, Hugo A.;
Decher, Niels;
Schmidt, Constanze

Publication type:

Article

Two-Pore-Domain Potassium (K 2P -) Channels: Cardiac Expression Patterns and Disease-Specific Remodelling Processes.

Published in:

Cells (2073-4409), 2021, v. 10, n. 11, p. 2914, doi. 10.3390/cells10112914

By:

Wiedmann, Felix;
Frey, Norbert;
Schmidt, Constanze

Publication type:

Article

Simultaneous Quantification and Pharmacokinetic Characterization of Doxapram and 2-Ketodoxapram in Porcine Plasma and Brain Tissue.

Published in:

Pharmaceutics, 2022, v. 14, n. 4, p. N.PAG, doi. 10.3390/pharmaceutics14040762

By:

Kraft, Manuel;
Foerster, Kathrin I.;
Wiedmann, Felix;
Sauter, Max;
Paasche, Amelie;
Blochberger, Pablo L.;
Yesilgöz, Baran;
L'hoste, Yannick;
Frey, Norbert;
Haefeli, Walter E.;
Burhenne, Jürgen;
Schmidt, Constanze

Publication type:

Article

Phosphodiesterase 8 governs cAMP/PKA-dependent reduction of L-type calcium current in human atrial fibrillation: a novel arrhythmogenic mechanism.

Published in:

European Heart Journal, 2023, v. 44, n. 27, p. 2483, doi. 10.1093/eurheartj/ehad086

By:

Pavlidou, Nefeli Grammatika;
Dobrev, Shokoufeh;
Beneke, Kira;
Reinhardt, Franziska;
Pecha, Simon;
Jacquet, Eric;
Abu-Taha, Issam H;
Schmidt, Constanze;
Voigt, Niels;
Kamler, Markus;
Schnabel, Renate B;
Baczkó, Istvan;
Garnier, Anne;
Reichenspurner, Hermann;
Nikolaev, Viacheslav O;
Dobrev, Dobromir;
Molina, Cristina E

Publication type:

Article

Pharmacologic TWIK-Related Acid-Sensitive K+ Channel (TASK-1) Potassium Channel Inhibitor A293 Facilitates Acute Cardioversion of Paroxysmal Atrial Fibrillation in a Porcine Large Animal Model.

Published in:

2020

By:

Wiedmann, Felix;
Beyersdorf, Christoph;
Xiaobo Zhou;
Büscher, Antonius;
Kraft, Manuel;
Nietfeld, Jendrik;
Teo Puig Walz;
Unger, Laura A.;
Loewe, Axel;
Schmack, Bastian;
Ruhparwar, Arjang;
Karck, Matthias;
Thomas, Dierk;
Borggrefe, Martin;
Seemann, Gunnar;
Katus, Hugo A.;
Schmidt, Constanze;
Zhou, Xiaobo;
Walz, Teo Puig

Publication type:

journal article

Hybrid grain production in wheat benefits from synchronized flowering and high female flower receptivity.

Published in:

Journal of Experimental Botany, 2025, v. 76, n. 2, p. 445, doi. 10.1093/jxb/erae430

By:

Schmidt, Constanze;
Hinterberger, Valentin;
Philipp, Norman;
Reif, Jochen C;
Schnurbusch, Thorsten

Publication type:

Article

Effects of oral valganciclovir prophylaxis for cytomegalovirus infection in heart transplant patients.

Published in:

Drug Design, Development & Therapy, 2012, v. 6, p. 289, doi. 10.2147/DDDT.S36578

By:

Doesch, Andreas O.;
Repp, Janika;
Hofmann, Nina;
Erbel, Christian;
Frankenstein, Lutz;
Gleissner, Christian A.;
Schmidt, Constanze;
Ruhparwar, Arjang;
Zugck, Christian;
Schnitzler, Paul;
Ehlermann, Philipp;
Dengler, Thomas J.;
Katus, Hugo A.

Publication type:

Article

Citizen Science in Germany as Research and Sustainability Education: Analysis of the Main Forms and Foci and Its Relation to the Sustainable Development Goals.

Published in:

Sustainability (2071-1050), 2020, v. 12, n. 15, p. 6044, doi. 10.3390/su12156044

By:

Schleicher, Katharina;
Schmidt, Constanze

Publication type:

Article

A Simple, Non-Invasive Score to Predict Paroxysmal Atrial Fibrillation.

Published in:

PLoS ONE, 2016, v. 11, n. 9, p. 1, doi. 10.1371/journal.pone.0163621

By:

Kallenberger, Stefan M.;
Schmid, Christian;
Wiedmann, Felix;
Mereles, Derliz;
Katus, Hugo A.;
Thomas, Dierk;
Schmidt, Constanze

Publication type:

Article

The pathology and treatment of cardiac arrhythmias: focus on atrial fibrillation.

Published in:

2011

By:

Schmidt, Constanze;
Kisselbach, Jana;
Schweizer, Patrick A.;
Katus, Hugo A.;
Thoma, Dierk;
Thomas, Dierk

Publication type:

journal article

Altered atrial cytosolic calcium handling contributes to the development of postoperative atrial fibrillation.

Published in:

Cardiovascular Research, 2021, v. 117, n. 7, p. 1790, doi. 10.1093/cvr/cvaa162

By:

Fakuade, Funsho E;
Steckmeister, Vanessa;
Seibertz, Fitzwilliam;
Gronwald, Judith;
Kestel, Stefanie;
Menzel, Julia;
Pronto, Julius Ryan D;
Taha, Karim;
Haghighi, Fereshteh;
Kensah, George;
Pearman, Charles M;
Wiedmann, Felix;
Teske, Arco J;
Schmidt, Constanze;
Dibb, Katharine M;
El-Essawi, Aschraf;
Danner, Bernhard C;
Baraki, Hassina;
Schwappach, Blanche;
Kutschka, Ingo

Publication type:

Article

ESC Congress 2020, the digital experience: a report from the ESC Scientists of Tomorrow.

Published in:

Cardiovascular Research, 2020, v. 116, n. 13, p. e190, doi. 10.1093/cvr/cvaa278

By:

Schmidt, Constanze;
Bollini, Sveva

Publication type:

Article

Ageing is associated with increased variability of cellular reprogramming and wound healing.

Published in:

Cardiovascular Research, 2020, v. 116, n. 13, p. e171, doi. 10.1093/cvr/cvaa294

By:

Schmidt, Constanze;
Kallenberger, Stefan M.

Publication type:

Article

Insights into cardiovascular research in Göttingen and Heidelberg: a report by the ESC Scientists of Tomorrow.

Published in:

Cardiovascular Research, 2020, v. 116, n. 12, p. e162, doi. 10.1093/cvr/cvaa165

By:

Schmidt, Constanze;
Voigt, Niels

Publication type:

Article

Genetic background of atrial fibrillation: influence of single-nucleotide polymorphisms.

Published in:

Cardiovascular Research, 2020, v. 116, n. 9, p. e106, doi. 10.1093/cvr/cvaa166

By:

Schmidt, Constanze;
Ravens, Ursula

Publication type:

Article

Scientists on the Spot: Moving forward from myocardial injury.

Published in:

Cardiovascular Research, 2020, v. 116, n. 2, p. e29, doi. 10.1093/cvr/cvz297

By:

Schmidt, Constanze;
Katus, Hugo A

Publication type:

Article

Forecasting the development of acute kidney injury using a recurrent neural network.

Published in:

Cardiovascular Research, 2019, v. 115, n. 14, p. e155, doi. 10.1093/cvr/cvz279

By:

Kallenberger, Stefan M;
Schmidt, Constanze

Publication type:

Article

new method to study membrane protein complexes by mass spectrometry.

Published in:

Cardiovascular Research, 2019, v. 115, n. 8, p. e69, doi. 10.1093/cvr/cvz113

By:

Schmidt, Constanze

Publication type:

Article

ESC Congress 2018 highlights in basic science: a report from the Scientists of Tomorrow.

Published in:

Cardiovascular Research, 2018, v. 114, n. 13, p. e103, doi. 10.1093/cvr/cvy234

By:

Schmidt, Constanze;
Voigt, Niels

Publication type:

Article

Single-cell transcriptomics in embryology: implications for cardiovascular science.

Published in:

Cardiovascular Research, 2018, v. 114, n. 12, p. e87, doi. 10.1093/cvr/cvy193

By:

Schmidt, Constanze

Publication type:

Article

Scientists on the Spot: Sequencing the human genome to influence patient healthcare.

Published in:

2018

By:

Schmidt, Constanze;
Hubbard, Tim

Publication type:

Interview

Anti-KCNQ1 K+ channel autoantibodies increase IKs current and are associated with QT interval shortening in dilated cardiomyopathy.

Published in:

Cardiovascular Research, 2013, v. 98, n. 3, p. 496, doi. 10.1093/cvr/cvt046

By:

Li, Jin;
Seyler, Claudia;
Wiedmann, Felix;
Schmidt, Constanze;
Schweizer, Patrick A.;
Becker, Rüdiger;
Katus, Hugo A.;
Thomas, Dierk

Publication type:

Article

Distress-Mediated Remodeling of Cardiac Connexin-43 in a Novel Cell Model for Arrhythmogenic Heart Diseases.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 17, p. 10174, doi. 10.3390/ijms231710174

By:

Wahl, Carl-Mattheis;
Schmidt, Constanze;
Hecker, Markus;
Ullrich, Nina D.

Publication type:

Article

N-Glycosylation of TREK-1/hK2P2.1 Two-Pore-Domain Potassium (K2P) Channels.

Published in:

International Journal of Molecular Sciences, 2019, v. 20, n. 20, p. 5193, doi. 10.3390/ijms20205193

By:

Wiedmann, Felix;
Schlund, Daniel;
Faustino, Francisco;
Kraft, Manuel;
Ratte, Antonius;
Thomas, Dierk;
Katus, Hugo A.;
Schmidt, Constanze

Publication type:

Article

Novel electrophysiological properties of dronedarone: inhibition of human cardiac two-pore-domain potassium (K) channels.

Published in:

Naunyn-Schmiedeberg's Archives of Pharmacology, 2012, v. 385, n. 10, p. 1003, doi. 10.1007/s00210-012-0780-9

By:

Schmidt, Constanze;
Wiedmann, Felix;
Schweizer, Patrick;
Becker, Rüdiger;
Katus, Hugo;
Thomas, Dierk

Publication type:

Article

Axial Tubule Junctions Activate Atrial Ca2+ Release Across Species.

Published in:

Frontiers in Psychology, 2018, p. N.PAG, doi. 10.3389/fphys.2018.01227

By:

Brandenburg, Sören;
Pawlowitz, Jan;
Fakuade, Funsho E.;
Kownatzki-Danger, Daniel;
Kohl, Tobias;
Mitronova, Gyuzel Y.;
Scardigli, Marina;
Neef, Jakob;
Schmidt, Constanze;
Wiedmann, Felix;
Pavone, Francesco S.;
Sacconi, Leonardo;
Kutschka, Ingo;
Sossalla, Samuel;
Moser, Tobias;
Voigt, Niels;
Lehnart, Stephan E.

Publication type:

Article

Current Drug Treatment Strategies for Atrial Fibrillation and TASK-1 Inhibition as an Emerging Novel Therapy Option.

Published in:

Frontiers in Pharmacology, 2021, v. 11, p. N.PAG, doi. 10.3389/fphar.2021.638445

By:

Kraft, Manuel;
Büscher, Antonius;
Wiedmann, Felix;
L'hoste, Yannick;
Haefeli, Walter E.;
Frey, Norbert;
Katus, Hugo A.;
Schmidt, Constanze

Publication type:

Article

SARS-CoV-2 ORF 3a-mediated currents are inhibited by antiarrhythmic drugs.

Published in:

EP: Europace, 2024, v. 26, n. 10, p. 1, doi. 10.1093/europace/euae252

By:

Wiedmann, Felix;
Boondej, Emika;
Stanifer, Megan;
Paasche, Amelie;
Kraft, Manuel;
Prüser, Merten;
Seeger, Timon;
Uhrig, Ulrike;
Boulant, Steeve;
Schmidt, Constanze

Publication type:

Article

Electrophysiological effects of non-vitamin K antagonist oral anticoagulants on atrial repolarizing potassium channels.

Published in:

2020

By:

Wiedmann, Felix;
Schlund, Daniel;
Kraft, Manuel;
Nietfeld, Jendrik;
Katus, Hugo A;
Schmidt, Constanze;
Thomas, Dierk

Publication type:

journal article

MicroRNAs Regulate TASK-1 and Are Linked to Myocardial Dilatation in Atrial Fibrillation.

Published in:

2022

By:

Wiedmann, Felix;
Kraft, Manuel;
Kallenberger, Stefan;
Büscher, Antonius;
Paasche, Amelie;
Blochberger, Pablo L.;
Seeger, Timon;
Jávorszky, Natasa;
Warnecke, Gregor;
Arif, Rawa;
Kremer, Jamila;
Karck, Matthias;
Frey, Norbert;
Schmidt, Constanze

Publication type:

journal article

The transcriptional landscape of atrial fibrillation: A systematic review and meta-analysis.

Published in:

PLoS ONE, 2025, v. 20, n. 5, p. 1, doi. 10.1371/journal.pone.0323534

By:

Gómez-Ochoa, Sergio Alejandro;
Möhn, Malte;
Malz, Michelle Victoria;
Ottenheijm, Roger;
Lanzer, Jan D.;
Wiedmann, Felix;
Kraft, Manuel;
Muka, Taulant;
Schmidt, Constanze;
Freichel, Marc;
Levinson, Rebecca T.

Publication type:

Article

Disease mechanism and novel drug therapies for atrial fibrillation.

Published in:

Medizinische Genetik, 2025, v. 37, n. 2, p. 147, doi. 10.1515/medgen-2025-2005

By:

Schmidt FESC, FEHRA, Constanze;
Wiedmann FESC, FEHRA, Felix

Publication type:

Article

Prospective multicentric validation of a novel prediction model for paroxysmal atrial fibrillation.

Published in:

Clinical Research in Cardiology, 2021, v. 110, n. 6, p. 868, doi. 10.1007/s00392-020-01773-z

By:

Schmidt, Constanze;
Benda, Sebastian;
Kraft, Patricia;
Wiedmann, Felix;
Pleger, Sven;
Büscher, Antonius;
Thomas, Dierk;
Wachter, Rolf;
Schmid, Christian;
Eils, Roland;
Katus, Hugo A.;
Kallenberger, Stefan M.

Publication type:

Article

Atrial fibrillation and heart failure-associated remodeling of two-pore-domain potassium (K2P) channels in murine disease models: focus on TASK-1.

Published in:

Basic Research in Cardiology, 2018, v. 113, n. 4, p. 1, doi. 10.1007/s00395-018-0687-9

By:

Wiedmann, Felix;
Schulte, Jan S.;
Gomes, Bruna;
Zafeiriou, Maria-Patapia;
Ratte, Antonius;
Rathjens, Franziska;
Fehrmann, Edda;
Scholz, Beatrix;
Voigt, Niels;
Müller, Frank Ulrich;
Thomas, Dierk;
Katus, Hugo A.;
Schmidt, Constanze

Publication type:

Article

Expression and function of Kv1.1 potassium channels in human atria from patients with atrial fibrillation.

Published in:

Basic Research in Cardiology, 2015, v. 110, n. 5, p. 1, doi. 10.1007/s00395-015-0505-6

By:

Glasscock, Edward;
Voigt, Niels;
McCauley, Mark D.;
Qiang Sun;
Na Li;
Chiang, David Y.;
Xiao-Bo Zhou;
Molina, Cristina E.;
Thomas, Dierk;
Schmidt, Constanze;
Skapura, Darlene G.;
Noebels, Jeffrey L.;
Dobrev, Dobromir;
Wehrens, Xander H. T.

Publication type:

Article

Treatment of a Paroxysmal Atrioventricular Block by Implantation of a Bipolar, Single-Chamber Cardiac Pacemaker in a Donkey.

Published in:

2023

By:

Heun, Frederik;
Niebuhr, Tobias;
Gutierrez Bautista, Alvaro;
Wiedmann, Felix;
Verhaar, Nicole;
Kästner, Sabine;
Feige, Karsten;
Schmidt, Constanze

Publication type:

Case Study

Functional characterization of zebrafish K18.1 (TRESK) two-pore-domain K channels.

Published in:

Naunyn-Schmiedeberg's Archives of Pharmacology, 2014, v. 387, n. 3, p. 291, doi. 10.1007/s00210-013-0945-1

By:

Rahm, Ann-Kathrin;
Wiedmann, Felix;
Gierten, Jakob;
Schmidt, Constanze;
Schweizer, Patrick;
Becker, Rüdiger;
Katus, Hugo;
Thomas, Dierk

Publication type:

Article

Case report of an S-ICD implantation for secondary prevention in a patient with complex congenital heart disease, dextrocardia, and situs solitus.

Published in:

European Heart Journal Case Reports, 2022, v. 6, n. 7, p. 1, doi. 10.1093/ehjcr/ytac253

By:

Wiedmann, Felix;
Simone, Raffaele De;
Rose, Peter;
Karck, Matthias;
Gorenflo, Matthias;
Frey, Norbert;
Schmidt, Constanze

Publication type:

Article

Comment on: 'Physiological and pathophysiological roles of the KCNK3 potassium channel in the pulmonary circulation and the heart' by Saint‐Martin Willer et al.

Published in:

Journal of Physiology, 2024, v. 602, n. 9, p. 2141, doi. 10.1113/JP286611

By:

Prüser, Merten;
Wiedmann, Felix;
Schmidt, Constanze

Publication type:

Article

Separating Fusion from Rivalry.

Published in:

PLoS ONE, 2014, v. 9, n. 7, p. 1, doi. 10.1371/journal.pone.0103037

By:

Kallenberger, Stefan M.;
Schmidt, Constanze;
Dechent, Peter;
Forster, Clemens;
von Steinbüchel, Nicole;
Wüstenberg, Torsten;
Strasburger, Hans

Publication type:

Article

Antiarrhythmic Properties of Ranolazine: Inhibition of Atrial Fibrillation Associated TASK-1 Potassium Channels.

Published in:

Frontiers in Pharmacology, 2019, v. 10, p. 1, doi. 10.3389/fphar.2019.01367

By:

Ratte, Antonius;
Wiedmann, Felix;
Kraft, Manuel;
Katus, Hugo A.;
Schmidt, Constanze

Publication type:

Article

Small Conductance Ca2 +-Activated K+ (SK) Channel mRNA Expression in Human Atrial and Ventricular Tissue: Comparison Between Donor, Atrial Fibrillation and Heart Failure Tissue.

Published in:

Frontiers in Physiology, 2021, v. 11, p. N.PAG, doi. 10.3389/fphys.2021.650964

By:

Darkow, Elisa;
Nguyen, Thong T.;
Stolina, Marina;
Kari, Fabian A.;
Schmidt, Constanze;
Wiedmann, Felix;
Baczkó, István;
Kohl, Peter;
Rajamani, Sridharan;
Ravens, Ursula;
Peyronnet, Rémi

Publication type:

Article

The Experimental TASK-1 Potassium Channel Inhibitor A293 Can Be Employed for Rhythm Control of Persistent Atrial Fibrillation in a Translational Large Animal Model.

Published in:

Frontiers in Physiology, 2021, v. 11, p. N.PAG, doi. 10.3389/fphys.2020.629421

By:

Wiedmann, Felix;
Beyersdorf, Christoph;
Zhou, Xiao-Bo;
Kraft, Manuel;
Foerster, Kathrin I.;
El-Battrawy, Ibrahim;
Lang, Siegfried;
Borggrefe, Martin;
Haefeli, Walter E.;
Frey, Norbert;
Schmidt, Constanze

Publication type:

Article

Inverse remodelling of K2P3.1 K+ channel expression and action potential duration in left ventricular dysfunction and atrial fibrillation: implications for patient-specific antiarrhythmic drug therapy.

Published in:

European Heart Journal, 2017, v. 38, n. 22, p. 1764, doi. 10.1093/eurheartj/ehw559

By:

Schmidt, Constanze;
Wiedmann, Felix;
Xiao-Bo Zhou;
Heijman, Jordi;
Voigt, Niels;
Ratte, Antonius;
Lang, Siegfried;
Kallenberger, Stefan M.;
Campana, Chiara;
Weymann, Alexander;
De Simone, Raffaele;
Szabo, Gabor;
Ruhparwar, Arjang;
Kallenbach, Klaus;
Karck, Matthias;
Ehrlich, Joachim R.;
Baczkó, István;
Borggrefe, Martin;
Ravens, Ursula;
Dobrev, Dobromir

Publication type:

Article

Precision medicine in the management of cardiac arrhythmias.

Published in:

Herz (0340-9937), 2025, v. 50, n. 2, p. 88, doi. 10.1007/s00059-025-05298-x

By:

Wiedmann, Felix;
Schmidt, Constanze

Publication type:

Article

Stress-Kinase Regulation of TASK-1 and TASK-3.

Published in:

Cellular Physiology & Biochemistry (Karger AG), 2017, v. 44, n. 3, p. 1024, doi. 10.1159/000485402

By:

Rinné, Susanne;
Kiper, Aytug K.;
Schmidt, Constanze;
Ortiz-Bonnin, Beatriz;
Zwiener, Simone;
Seebohm, Guiscard;
Decher, Niels

Publication type:

Article

Axial Tubule Junctions Activate Atrial Ca2+ Release Across Species.

Published in:

Frontiers in Physiology, 2018, p. N.PAG, doi. 10.3389/fphys.2018.01227

By:

Brandenburg, Sören;
Pawlowitz, Jan;
Fakuade, Funsho E.;
Kownatzki-Danger, Daniel;
Kohl, Tobias;
Mitronova, Gyuzel Y.;
Scardigli, Marina;
Neef, Jakob;
Schmidt, Constanze;
Wiedmann, Felix;
Pavone, Francesco S.;
Sacconi, Leonardo;
Kutschka, Ingo;
Sossalla, Samuel;
Moser, Tobias;
Voigt, Niels;
Lehnart, Stephan E.

Publication type:

Article