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RNAi-mediated rheostat for dynamic control of AAV-delivered transgenes.
Published in:
Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-37774-5
By:
- Subramanian, Megha;
- McIninch, James;
- Zlatev, Ivan;
- Schlegel, Mark K.;
- Kaittanis, Charalambos;
- Nguyen, Tuyen;
- Agarwal, Saket;
- Racie, Timothy;
- Alvarado, Martha Arbaiza;
- Wassarman, Kelly;
- Collins, Thomas S.;
- Chickering, Tyler;
- Brown, Christopher R.;
- Schmidt, Karyn;
- Castoreno, Adam B.;
- Shulga-Morskaya, Svetlana;
- Stamenova, Elena;
- Buckowing, Kira;
- Berman, Daniel;
- Barry, Joseph D.
Publication type:
Article
Reversal of siRNA-mediated gene silencing in vivo.
Published in:
Nature Biotechnology, 2018, v. 36, n. 6, p. 509, doi. 10.1038/nbt.4136
By:
- Zlatev, Ivan;
- Castoreno, Adam;
- Brown, Christopher R;
- Qin, June;
- Waldron, Scott;
- Schlegel, Mark K;
- Degaonkar, Rohan;
- Shulga-Morskaya, Svetlana;
- Xu, Huilei;
- Gupta, Swati;
- Matsuda, Shigeo;
- Akinc, Akin;
- Rajeev, Kallanthottathil G;
- Manoharan, Muthiah;
- Maier, Martin A;
- Jadhav, Vasant
Publication type:
Article
Inside Cover: Biological Evaluation of Multivalent Lewis X-MGL-1 Interactions (ChemBioChem 6/2014).
Published in:
ChemBioChem, 2014, v. 15, n. 6, p. 770, doi. 10.1002/cbic.201490017
By:
- Eriksson, Magdalena;
- Serna, Sonia;
- Maglinao, Maha;
- Schlegel, Mark K.;
- Seeberger, Peter H.;
- Reichardt, Niels‐Christian;
- Lepenies, Bernd
Publication type:
Article
Biological Evaluation of Multivalent Lewis X-MGL-1 Interactions.
Published in:
ChemBioChem, 2014, v. 15, n. 6, p. 844, doi. 10.1002/cbic.201300764
By:
- Eriksson, Magdalena;
- Serna, Sonia;
- Maglinao, Maha;
- Schlegel, Mark K.;
- Seeberger, Peter H.;
- Reichardt, Niels‐Christian;
- Lepenies, Bernd
Publication type:
Article
Defined Presentation of Carbohydrates on a Duplex DNA Scaffold.
Published in:
ChemBioChem, 2011, v. 12, n. 18, p. 2791, doi. 10.1002/cbic.201100511
By:
- Schlegel, Mark K.;
- Hütter, Julia;
- Eriksson, Magdalena;
- Lepenies, Bernd;
- Seeberger, Peter H.
Publication type:
Article
Synthesis and Characterization of Linker-Armed Fucose-Based Glycomimetics.
Published in:
European Journal of Organic Chemistry, 2013, v. 2013, n. 24, p. 5303, doi. 10.1002/ejoc.201300236
By:
- Doknic, Daniela;
- Abramo, Morena;
- Sutkeviciute, Ieva;
- Reinhardt, Anika;
- Guzzi, Cinzia;
- Schlegel, Mark K.;
- Potenza, Donatella;
- Nieto, Pedro M.;
- Fieschi, Franck;
- Seeberger, Peter H.;
- Bernardi, Anna
Publication type:
Article
From bench to bedside: Improving the clinical safety of GalNAc–siRNA conjugates using seed-pairing destabilization.
Published in:
Nucleic Acids Research, 2022, v. 50, n. 12, p. 6656, doi. 10.1093/nar/gkac539
By:
- Schlegel, Mark K;
- Janas, Maja M;
- Jiang, Yongfeng;
- Barry, Joseph D;
- Davis, Wendell;
- Agarwal, Saket;
- Berman, Daniel;
- Brown, Christopher R;
- Castoreno, Adam;
- LeBlanc, Sarah;
- Liebow, Abigail;
- Mayo, Tara;
- Milstein, Stuart;
- Nguyen, Tuyen;
- Shulga-Morskaya, Svetlana;
- Hyde, Sarah;
- Schofield, Sally;
- Szeto, John;
- Woods, Lauren Blair;
- Yilmaz, Vedat O
Publication type:
Article
Overcoming GNA/RNA base-pairing limitations using isonucleotides improves the pharmacodynamic activity of ESC+ GalNAc-siRNAs.
Published in:
Nucleic Acids Research, 2021, v. 49, n. 19, p. 10851, doi. 10.1093/nar/gkab916
By:
- Schlegel, Mark K;
- Matsuda, Shigeo;
- Brown, Christopher R;
- Harp, Joel M;
- Barry, Joseph D;
- Berman, Daniel;
- Castoreno, Adam;
- Schofield, Sally;
- Szeto, John;
- Manoharan, Muthiah;
- Charissé, Klaus;
- Egli, Martin;
- Maier, Martin A
Publication type:
Article
siRNAs containing 2′-fluorinated Northern-methanocarbacyclic (2′-F-NMC) nucleotides: in vitro and in vivo RNAi activity and inability of mitochondrial polymerases to incorporate 2′-F-NMC NTPs.
Published in:
Nucleic Acids Research, 2021, v. 49, n. 5, p. 2435, doi. 10.1093/nar/gkab050
By:
- Akabane-Nakata, Masaaki;
- Erande, Namrata D;
- Kumar, Pawan;
- Degaonkar, Rohan;
- Gilbert, Jason A;
- Qin, June;
- Mendez, Martha;
- Woods, Lauren Blair;
- Jiang, Yongfeng;
- Janas, Maja M;
- O'Flaherty, Derek K;
- Zlatev, Ivan;
- Schlegel, Mark K;
- Matsuda, Shigeo;
- Egli, Martin;
- Manoharan, Muthiah
Publication type:
Article
Investigating the pharmacodynamic durability of GalNAc–siRNA conjugates.
Published in:
Nucleic Acids Research, 2020, v. 48, n. 21, p. 11827, doi. 10.1093/nar/gkaa670
By:
- Brown, Christopher R;
- Gupta, Swati;
- Qin, June;
- Racie, Timothy;
- He, Guo;
- Lentini, Scott;
- Malone, Ryan;
- Yu, Mikyung;
- Matsuda, Shigeo;
- Shulga-Morskaya, Svetlana;
- Nair, Anil V;
- Theile, Christopher S;
- Schmidt, Karyn;
- Shahraz, Azar;
- Goel, Varun;
- Parmar, Rubina G;
- Zlatev, Ivan;
- Schlegel, Mark K;
- Nair, Jayaprakash K;
- Jayaraman, Muthusamy
Publication type:
Article
Synthesis, chirality-dependent conformational and biological properties of siRNAs containing 5′-(R)- and 5′-(S)-C-methyl-guanosine.
Published in:
Nucleic Acids Research, 2020, v. 48, n. 18, p. 10101, doi. 10.1093/nar/gkaa750
By:
- Mikami, Atsushi;
- Erande, Namrata;
- Matsuda, Shigeo;
- Kel'in, Alexander;
- Woods, Lauren Blair;
- Chickering, Tyler;
- Pallan, Pradeep S;
- Schlegel, Mark K;
- Zlatev, Ivan;
- Egli, Martin;
- Manoharan, Muthiah
Publication type:
Article
Chimeric siRNAs with chemically modified pentofuranose and hexopyranose nucleotides: altritol-nucleotide (ANA) containing GalNAc–siRNA conjugates: in vitro and in vivo RNAi activity and resistance to 5′-exonuclease.
Published in:
Nucleic Acids Research, 2020, v. 48, n. 8, p. 4028, doi. 10.1093/nar/gkaa125
By:
- Kumar, Pawan;
- Degaonkar, Rohan;
- Guenther, Dale C;
- Abramov, Mikhail;
- Schepers, Guy;
- Capobianco, Marie;
- Jiang, Yongfeng;
- Harp, Joel;
- Kaittanis, Charalambos;
- Janas, Maja M;
- Castoreno, Adam;
- Zlatev, Ivan;
- Schlegel, Mark K;
- Herdewijn, Piet;
- Egli, Martin;
- Manoharan, Muthiah
Publication type:
Article
Safety evaluation of 2′-deoxy-2′-fluoro nucleotides in GalNAc-siRNA conjugates.
Published in:
Nucleic Acids Research, 2019, v. 47, n. 7, p. 3306, doi. 10.1093/nar/gkz140
By:
- Janas, Maja M;
- Zlatev, Ivan;
- Liu, Ju;
- Jiang, Yongfeng;
- Barros, Scott A;
- Sutherland, Jessica E;
- Davis, Wendell P;
- Liu, Jingxuan;
- Brown, Christopher R;
- Liu, Xiumin;
- Schlegel, Mark K;
- Blair, Lauren;
- Zhang, Xuemei;
- Das, Biplab;
- Tran, Chris;
- Aluri, Krishna;
- Li, Jing;
- Agarwal, Saket;
- Indrakanti, Ramesh;
- Charisse, Klaus
Publication type:
Article
Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-02989-4
By:
- Janas, Maja M.;
- Schlegel, Mark K.;
- Harbison, Carole E.;
- Yilmaz, Vedat O.;
- Yongfeng Jiang;
- Parmar, Rubina;
- Zlatev, Ivan;
- Castoreno, Adam;
- Huilei Xu;
- Shulga-Morskaya, Svetlana;
- Rajeev, Kallanthottathil G.;
- Manoharan, Muthiah;
- Keirstead, Natalie D.;
- Maier, Martin A.;
- Jadhav, Vasant
Publication type:
Article
Structure and Stability of Ago2 MID‐Nucleotide Complexes: All‐in‐One (Drop) His<sub>6</sub>‐SUMO Tag Removal, Nucleotide Binding, and Crystal Growth.
Published in:
Current Protocols, 2024, v. 4, n. 6, p. 1, doi. 10.1002/cpz1.1088
By:
- Lei, Li;
- Harp, Joel M.;
- Chaput, John C.;
- Wassarman, Kelly;
- Schlegel, Mark K.;
- Manoharan, Muthiah;
- Egli, Martin
Publication type:
Article
Duplex Formation of the Simplified Nucleic Acid GNA.
Published in:
ChemBioChem, 2007, v. 8, n. 8, p. 927, doi. 10.1002/cbic.200600435
By:
- Schlegel, Mark K.;
- Peritz, Adam E.;
- Kittigowittana, Krisada;
- Zhang, Lilu;
- Meggers, Eric
Publication type:
Article
Insight into the High Duplex Stability of the Simplified Nucleic Acid GNA.
Published in:
Angewandte Chemie International Edition, 2009, v. 48, n. 5, p. 960, doi. 10.1002/anie.200803472
By:
- Schlegel, Mark K.;
- Xie, Xiulan;
- Zhang, Lilu;
- Meggers, Eric
Publication type:
Article

Found: 17