Works by Scheiflinger, Friedrich

Results: 24

Higher expression of fab antibody fragments in a CHO cell line at reduced temperature.

Published in:

Biotechnology & Bioengineering, 2003, v. 84, n. 4, p. 433, doi. 10.1002/bit.10793

By:

Simone M. Schatz;
Randolf J. Kerschbaumer;
Gabriele Gerstenbauer;
Martina Kral;
Friedrich Dorner;
Friedrich Scheiflinger

Publication type:

Article

Preclinical safety and efficacy of a new recombinant FIX drug product for treatment of hemophilia B.

Published in:

International Journal of Hematology, 2013, v. 98, n. 5, p. 525, doi. 10.1007/s12185-013-1448-z

By:

Dietrich, Barbara;
Schiviz, Alexandra;
Hoellriegl, Werner;
Horling, Frank;
Benamara, Karima;
Rottensteiner, Hanspeter;
Turecek, Peter L.;
Schwarz, Hans Peter;
Scheiflinger, Friedrich;
Muchitsch, Eva-Maria

Publication type:

Article

A patient with SLE-associated thrombotic microangiopathy and non-neutralizing antibodies against ADAMTS13.

Published in:

2010

By:

Knecht, Margrith E.;
Mayr, Michael;
Ferrari, Silvia;
Scheiflinger, Friedrich;
Trendelenburg, Marten

Publication type:

Case Study

Expression of recombinant human coagulation factors VII (rFVII) and IX (rFIX) in various cell types, glycosylation analysis, and pharmacokinetic comparison.

Published in:

2011

By:

Böhm, Ernst;
Dockal, Michael;
Graninger, Michael;
Hasslacher, Meinhard;
Kaliwoda, Martin;
Konetschny, Christian;
Mitterer, Artur;
Muchitsch, Eva-Maria;
Reiter, Manfred;
Scheiflinger, Friedrich

Publication type:

Abstract

Mutation of the surface-exposed amino acid Trp<sup>2313</sup> to Ala in the FVIII C2 domain results in defective secretion of the otherwise functional protein.

Published in:

British Journal of Haematology, 2004, v. 125, n. 5, p. 629, doi. 10.1111/j.1365-2141.2004.04959.x

By:

Schatz, Simone M.;
Zimmermann, Klaus;
Hasslacher, Meinhard;
Kerschbaumer, Randolf;
Dockal, Michael;
Gritsch, Herbert;
Turecek, Peter L.;
Schwarz, Hans P.;
Dorner, Friedrich;
Scheiflinger, Friedrich

Publication type:

Article

SHORT REPORT Evaluation of the haemostatic potential of factor VIII-heparin cofactor II hybrid proteins in a mouse model.

Published in:

British Journal of Haematology, 2003, v. 123, n. 4, p. 692, doi. 10.1046/j.1365-2141.2003.04674.x

By:

Schatz, Simone;
Turecek, Peter L.;
Fiedler, Christian;
Zimmermann, Klaus;
Gritsch, Herbert;
Voorberg, Jan;
Schwarz, Hans Peter;
Dorner, Friedrich;
Scheiflinger, Friedrich

Publication type:

Article

ADAMTS13 gene defects in two brothers with constitutional thrombotic thrombocytopenic purpura and normalization of von Willebrand factor-cleaving protease activity by recombinant human ADAMTS13.

Published in:

British Journal of Haematology, 2003, v. 120, n. 5, p. 821, doi. 10.1046/j.1365-2141.2003.04183.x

By:

Antoine, Gerhard;
Zimmermann, Klaus;
Plaimauer, Barbara;
Grillowitzer, Monika;
Studt, Jan-Dirk;
Lämmle, Bernhard;
Scheiflinger, Friedrich

Publication type:

Article

How Full-Length FVIII Benefits from Its Heterogeneity – Insights into the Role of the B-Domain.

Published in:

Pharmaceutical Research, 2019, v. 36, n. 5, p. N.PAG, doi. 10.1007/s11095-019-2599-2

By:

Anzengruber, Julia;
Feichtinger, Martin;
Bärnthaler, Philipp;
Haider, Norbert;
Ilas, Josenato;
Pruckner, Nina;
Benamara, Karima;
Scheiflinger, Friedrich;
Reipert, Birgit M.;
Malisauskas, Mantas

Publication type:

Article

The Mystery of Antibodies Against Polyethylene Glycol (PEG) - What do we Know?

Published in:

Pharmaceutical Research, 2016, v. 33, n. 9, p. 2239, doi. 10.1007/s11095-016-1961-x

By:

Lubich, Christian;
Allacher, Peter;
de la Rosa, Maurus;
Bauer, Alexander;
Prenninger, Thomas;
Horling, Frank;
Siekmann, Jürgen;
Oldenburg, Johannes;
Scheiflinger, Friedrich;
Reipert, Birgit

Publication type:

Article

A Flow-Cytometry-Based Approach to Facilitate Quantification, Size Estimation and Characterization of Sub-visible Particles in Protein Solutions.

Published in:

Pharmaceutical Research, 2015, v. 32, n. 9, p. 2863, doi. 10.1007/s11095-015-1669-3

By:

Lubich, Christian;
Malisauskas, Mantas;
Prenninger, Thomas;
Wurz, Thomas;
Matthiessen, Peter;
Turecek, Peter;
Scheiflinger, Friedrich;
Reipert, Birgit

Publication type:

Article

Development of a Transgenic Mouse Model with Immune Tolerance for Human Coagulation Factor VIIa.

Published in:

Pharmaceutical Research, 2013, v. 30, n. 11, p. 2855, doi. 10.1007/s11095-013-1115-3

By:

Lenk, Christine;
Unterthurner, Sabine;
Schuster, Maria;
Weiller, Markus;
Antoine, Gerhard;
Malisauskas, Mantas;
Scheiflinger, Friedrich;
Schwarz, Hans-Peter;
Rosa, Maurus;
Reipert, Birgit

Publication type:

Article

Genome editing for scalable production of alloantigen-free lentiviral vectors for in vivo gene therapy.

Published in:

EMBO Molecular Medicine, 2017, v. 9, n. 11, p. 1558, doi. 10.15252/emmm.201708148

By:

Milani, Michela;
Annoni, Andrea;
Bartolaccini, Sara;
Biffi, Mauro;
Russo, Fabio;
Di Tomaso, Tiziano;
Raimondi, Andrea;
Lengler, Johannes;
Holmes, Michael C;
Scheiflinger, Friedrich;
Lombardo, Angelo;
Cantore, Alessio;
Naldini, Luigi

Publication type:

Article

Immunochemical detection of prion protein on dipsticks prepared with crystalline bacterial cell-surface layers.

Published in:

Transfusion, 2003, v. 43, n. 12, p. 1677, doi. 10.1111/j.0041-1132.2003.00567.x

By:

Völkel, Dirk;
Zimmermann, Klaus;
Breitwieser, Andreas;
Pable, Sabrina;
Glatzel, Markus;
Scheiflinger, Friedrich;
Schwarz, Hans P.;
Sara, Margit;
Sleytr, Uwe B.;
Dorner, Friedrich

Publication type:

Article

Flow-induced elongation of von Willebrand factor precedes tension-dependent activation.

Published in:

Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-00230-2

By:

Hongxia Fu;
Yan Jiang;
Darren Yang;
Scheiflinger, Friedrich;
Wong, Wesley P.;
Springer, Timothy A.

Publication type:

Article

Poor responder to plasma exchange therapy in acquired thrombotic thrombocytopenic purpura is associated with ADAMTS13 inhibitor boosting: visualization of an ADAMTS13 inhibitor complex and its proteolytic clearance from plasma.

Published in:

2015

By:

Isonishi, Ayami;
Bennett, Charles L.;
Plaimauer, Barbara;
Scheiflinger, Friedrich;
Matsumoto, Masanori;
Fujimura, Yoshihiro

Publication type:

journal article

Optimization of an Antibody Light Chain Framework Enhances Expression, Biophysical Properties and Pharmacokinetics.

Published in:

Antibodies (2073-4468), 2019, v. 8, n. 3, p. 46, doi. 10.3390/antib8030046

By:

Douillard, Patrice;
Freissmuth, Michael;
Antoine, Gerhard;
Thiele, Michael;
Fleischanderl, Daniel;
Matthiessen, Peter;
Voelkel, Dirk;
Kerschbaumer, Randolf J.;
Scheiflinger, Friedrich;
Sabarth, Nicolas

Publication type:

Article

Structural analysis of the recombinant therapeutic product rFVIII and its PEGylated variants using 2-D DIGE.

Published in:

Electrophoresis, 2011, v. 32, n. 11, p. 1292, doi. 10.1002/elps.201000627

By:

Monetti, Christina;
Rottensteiner, Hanspeter;
Gritsch, Herbert;
Weber, Alfred;
Scheiflinger, Friedrich;
Turecek, Peter L.

Publication type:

Article

Structural analysis of the recombinant therapeutic product rFVIII and its PEGylated variants using 2-D DIGE.

Published in:

Proteomics - Clinical Applications, 2011, v. 5, n. 9/10, p. 573, doi. 10.1002/prca.201190095

By:

Monetti, Christina;
Rottensteiner, Hanspeter;
Gritsch, Herbert;
Weber, Alfred;
Scheiflinger, Friedrich;
Turecek, Peter L.

Publication type:

Article

Nonacog gamma, a novel recombinant factor IX with low factor IXa content for treatment and prophylaxis of bleeding episodes.

Published in:

Expert Review of Clinical Pharmacology, 2015, v. 8, n. 2, p. 163, doi. 10.1586/17512433.2015.1011126

By:

Turecek, Peter L;
Abbühl, Brigitt;
Tangada, Srilatha D;
Chapman, Miranda;
Gritsch, Herbert;
Rottensteiner, Hanspeter;
Schrenk, Gerald;
Mitterer, Artur;
Dietrich, Barbara;
Höllriegl, Werner;
Schiviz, Alexandra;
Horling, Frank;
Reipert, Birgit M;
Muchitsch, Eva-Maria;
Pavlova, Borislava G;
Scheiflinger, Friedrich

Publication type:

Article

Microchip capillary gel electrophoresis of multiply PEGylated high-molecular-mass glycoproteins.

Published in:

Biotechnology Journal, 2012, v. 7, n. 5, p. 635, doi. 10.1002/biot.201100407

By:

Seyfried, Birgit K.;
Marchetti-Deschmann, Martina;
Siekmann, Jürgen;
Bossard, Mary J.;
Scheiflinger, Friedrich;
Turecek, Peter L.;
Allmaier, Günter

Publication type:

Article

Ca concentration-dependent conformational change of FVIII B-domain observed by atomic force microscopy.

Published in:

Analytical & Bioanalytical Chemistry, 2015, v. 407, n. 20, p. 6051, doi. 10.1007/s00216-015-8778-z

By:

Bonazza, Klaus;
Rottensteiner, Hanspeter;
Schrenk, Gerald;
Fiedler, Christian;
Scheiflinger, Friedrich;
Allmaier, Günter;
Turecek, Peter;
Friedbacher, Gernot

Publication type:

Article

Thrombotic thrombocytopenic purpura in IgG4-related disease with severe deficiency of ADAMTS-13 activity and IgG4 autoantibody against ADAMTS-13.

Published in:

2011

By:

Saeki, Takako;
Ito, Tomoyuki;
Youkou, Akira;
Ishiguro, Hajime;
Sato, Naoko;
Yamazaki, Hajime;
Koike, Tadashi;
Kourakata, Hiroyo;
Ferrari, Silvia;
Scheiflinger, Friedrich;
Narita, Ichiei

Publication type:

journal article

Mining ancient proteins for next-generation drugs.

Published in:

Nature Biotechnology, 2017, v. 35, n. 1, p. 28, doi. 10.1038/nbt.3762

By:

Lazarus, Robert A;
Scheiflinger, Friedrich

Publication type:

Article

Differences in N-glycosylation of recombinant human coagulation factor VII derived from BHK, CHO, and HEK293 cells.

Published in:

BMC Biotechnology, 2015, v. 15, n. 1, p. 1, doi. 10.1186/s12896-015-0205-1

By:

Böhm, Ernst;
Seyfried, Birgit K.;
Dockal, Michael;
Graninger, Michael;
Hasslacher, Meinhard;
Neurath, Marianne;
Konetschny, Christian;
Matthiessen, Peter;
Mitterer, Artur;
Scheiflinger, Friedrich

Publication type:

Article