Works by Schaft, Niels

Results: 65

Rendering NK Cells Antigen-Specific for the Therapy of Solid Tumours.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 13, p. 6290, doi. 10.3390/ijms26136290

By:

Doeppner, Carina A.;
Binder, Amanda Katharina;
Bremm, Franziska;
Feuchter, Niklas;
Dörrie, Jan;
Schaft, Niels

Publication type:

Article

The future of affordable cancer immunotherapy.

Published in:

Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1248867

By:

Schaft, Niels;
Dörrie, Jan;
Schuler, Gerold;
Schuler-Thurner, Beatrice;
Sallam, Husam;
Klein, Shiri;
Eisenberg, Galit;
Frankenburg, Shoshana;
Lotem, Michal;
Khatib, Areej

Publication type:

Article

Human T cells loaded with superparamagnetic iron oxide nanoparticles retain antigen-specific TCR functionality.

Published in:

Frontiers in Immunology, 2023, p. 01, doi. 10.3389/fimmu.2023.1223695

By:

Pfister, Felix;
Dörrie, Jan;
Schaft, Niels;
Buchele, Vera;
Unterweger, Harald;
Carnell, Lucas R.;
Schreier, Patrick;
Stein, Rene;
Kubánková, Markéta;
Guck, Jochen;
Hackstein, Holger;
Alexiou, Christoph;
Janko, Christina

Publication type:

Article

RNA-transfection of γ/δ T cells with a chimeric antigen receptor or an α/β T-cell receptor: a safer alternative to genetically engineered α/β T cells for the immunotherapy of melanoma.

Published in:

2017

By:

Harrer, Dennis C.;
Simon, Bianca;
Shin-ichiro Fujii;
Kanako Shimizu;
Uslu, Ugur;
Schuler, Gerold;
Gerer, Kerstin F.;
Hoyer, Stefanie;
Dörrie, Jan;
Schaft, Niels;
Fujii, Shin-Ichiro;
Shimizu, Kanako

Publication type:

journal article

Transcriptional Targeting of Mature Dendritic Cells with Adenoviral Vectors via a Modular Promoter System for Antigen Expression and Functional Manipulation.

Published in:

2016

By:

Knippertz, Ilka;
Deinzer, Andrea;
Dörrie, Jan;
Schaft, Niels;
Nettelbeck, Dirk M.;
Steinkasserer, Alexander;
Dörrie, Jan

Publication type:

journal article

Electroporated Antigen-Encoding mRNA Is Not a Danger Signal to Human Mature Monocyte-Derived Dendritic Cells.

Published in:

2015

By:

Hoyer, Stefanie;
Gerer, Kerstin F.;
Pfeiffer, Isabell A.;
Prommersberger, Sabrina;
Höfflin, Sandra;
Jaitly, Tanushree;
Beltrame, Luca;
Cavalieri, Duccio;
Schuler, Gerold;
Vera, Julio;
Schaft, Niels;
Dörrie, Jan;
Höfflin, Sandra;
Dörrie, Jan

Publication type:

journal article

Electroporated Antigen-Encoding mRNA Is Not a Danger Signal to Human Mature Monocyte-Derived Dendritic Cells.

Published in:

Journal of Immunology Research, 2015, v. 2015, p. 1, doi. 10.1155/2015/952184

By:

Hoyer, Stefanie;
Gerer, Kerstin F.;
Pfeiffer, Isabell A.;
Prommersberger, Sabrina;
Höfflin, Sandra;
Jaitly, Tanushree;
Beltrame, Luca;
Cavalieri, Duccio;
Schuler, Gerold;
Vera, Julio;
Schaft, Niels;
Dörrie, Jan

Publication type:

Article

Chimeric Antigen Receptor (CAR) T Cells Releasing Soluble SLAMF6 Isoform 2 Gain Superior Anti-Cancer Cell Functionality in an Auto-Stimulatory Fashion.

Published in:

Cells (2073-4409), 2025, v. 14, n. 12, p. 901, doi. 10.3390/cells14120901

By:

Harrer, Dennis Christoph;
Schlierkamp-Voosen, Tim;
Barden, Markus;
Pan, Hong;
Xydia, Maria;
Herr, Wolfgang;
Dörrie, Jan;
Schaft, Niels;
Abken, Hinrich

Publication type:

Article

An altered gp100 peptide ligand with decreased binding by TCR and CD8α dissectsT cell cytotoxicity from production of cytokines and activation of NFAT.

Published in:

Frontiers in Immunology, 2013, v. 4, p. 1, doi. 10.3389/fimmu.2013.00270

By:

Schaft, Niels;
Coccoris, Miriam;
Drexhage, Joost;
Knoop, Christiaan;
De Vries, I. Jolanda M.;
Adema, Gosse J.;
Debets, Reno

Publication type:

Article

The Influence of Indisulam on Human Immune Effector Cells: Is a Combination with Immunotherapy Feasible?

Published in:

Pharmaceutics, 2025, v. 17, n. 3, p. 368, doi. 10.3390/pharmaceutics17030368

By:

Arnet, Lisa;
Emilius, Lisabeth;
Hamann, Annett;
Carmo-Fonseca, Maria;
Berking, Carola;
Dörrie, Jan;
Schaft, Niels

Publication type:

Article

Therapeutic Cancer Vaccination with Ex Vivo RNA-Transfected Dendritic Cells—An Update.

Published in:

Pharmaceutics, 2020, v. 12, n. 2, p. 92, doi. 10.3390/pharmaceutics12020092

By:

Dörrie, Jan;
Schaft, Niels;
Schuler, Gerold;
Schuler-Thurner, Beatrice

Publication type:

Article

Generation of an Oncolytic Herpes Simplex Virus 1 Expressing Human MelanA.

Published in:

Frontiers in Immunology, 2019, p. N.PAG, doi. 10.3389/fimmu.2019.00002

By:

Boscheinen, Jan B.;
Thomann, Sabrina;
Knipe, David M.;
DeLuca, Neal;
Schuler-Thurner, Beatrice;
Gross, Stefanie;
Dörrie, Jan;
Schaft, Niels;
Bach, Christian;
Rohrhofer, Anette;
Werner-Klein, Melanie;
Schmidt, Barbara;
Schuster, Philipp

Publication type:

Article

Concurrent interaction of DCs with CD4+ and CD8+ T cells improves secondary CTL expansion: It takes three to tango.

Published in:

European Journal of Immunology, 2014, v. 44, n. 12, p. 3543, doi. 10.1002/eji.201444477

By:

Hoyer, Stefanie;
Prommersberger, Sabrina;
Pfeiffer, Isabell A.;
Schuler‐Thurner, Beatrice;
Schuler, Gerold;
Dörrie, Jan;
Schaft, Niels

Publication type:

Article

Triggering of NF-κB in cytokine-matured human DCs generates superior DCs for T-cell priming in cancer immunotherapy.

Published in:

European Journal of Immunology, 2014, v. 44, n. 11, p. 3413, doi. 10.1002/eji.201344417

By:

Pfeiffer, Isabell A.;
Hoyer, Stefanie;
Gerer, Kerstin F.;
Voll, Reinhard E.;
Knippertz, Ilka;
Gückel, Eva;
Schuler, Gerold;
Schaft, Niels;
Dörrie, Jan

Publication type:

Article

Strong and sustained effector function of memory- versus naïve-derived T cells upon T-cell receptor RNA transfer: Implications for cellular therapy.

Published in:

European Journal of Immunology, 2012, v. 42, n. 12, p. 3442, doi. 10.1002/eji.201242666

By:

Thomas, Simone;
Klobuch, Sebastian;
Besold, Katrin;
Plachter, Bodo;
Dörrie, Jan;
Schaft, Niels;
Theobald, Matthias;
Herr, Wolfgang

Publication type:

Article

Non-Coding RNA in Tumor Cells and Tumor-Associated Myeloid Cells—Function and Therapeutic Potential.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 13, p. 7275, doi. 10.3390/ijms25137275

By:

Binder, Amanda Katharina;
Bremm, Franziska;
Dörrie, Jan;
Schaft, Niels

Publication type:

Article

Tumor Antigens beyond the Human Exome.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 9, p. 4673, doi. 10.3390/ijms25094673

By:

Emilius, Lisabeth;
Bremm, Franziska;
Binder, Amanda Katharina;
Schaft, Niels;
Dörrie, Jan

Publication type:

Article

CARs and Drugs: Pharmacological Ways of Boosting CAR-T-Cell Therapy.

Published in:

2023

By:

Harrer, Dennis Christoph;
Dörrie, Jan;
Schaft, Niels

Publication type:

Literature Review

Beyond Cancer: Regulation and Function of PD-L1 in Health and Immune-Related Diseases.

Published in:

2022

By:

Beenen, Amke C.;
Sauerer, Tatjana;
Schaft, Niels;
Dörrie, Jan

Publication type:

Literature Review

BRAF and MEK Inhibitors Affect Dendritic-Cell Maturation and T-Cell Stimulation.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 21, p. 11951, doi. 10.3390/ijms222111951

By:

Hoyer, Stefanie;
Eberlein, Valentina;
Schuler, Gerold;
Berking, Carola;
Heinzerling, Lucie;
Schaft, Niels;
Dörrie, Jan

Publication type:

Article

A Chimeric IL-15/IL-15Rα Molecule Expressed on NFκB-Activated Dendritic Cells Supports Their Capability to Activate Natural Killer Cells †.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 19, p. 10227, doi. 10.3390/ijms221910227

By:

Bosch, Naomi C.;
Martin, Lena-Marie;
Voskens, Caroline J.;
Berking, Carola;
Seliger, Barbara;
Schuler, Gerold;
Schaft, Niels;
Dörrie, Jan

Publication type:

Article

T-Cell Responses in Merkel Cell Carcinoma: Implications for Improved Immune Checkpoint Blockade and Other Therapeutic Options.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 16, p. 8679, doi. 10.3390/ijms22168679

By:

Gehrcken, Laura;
Sauerer, Tatjana;
Schaft, Niels;
Dörrie, Jan

Publication type:

Article

CARs: Beyond T Cells and T Cell-Derived Signaling Domains.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 10, p. 3525, doi. 10.3390/ijms21103525

By:

Sievers, Nico M.;
Dörrie, Jan;
Schaft, Niels

Publication type:

Article

CSPG4 as Target for CAR-T-Cell Therapy of Various Tumor Entities–Merits and Challenges.

Published in:

International Journal of Molecular Sciences, 2019, v. 20, n. 23, p. 5942, doi. 10.3390/ijms20235942

By:

Harrer, Dennis C.;
Dörrie, Jan;
Schaft, Niels

Publication type:

Article

CSPG4-Specific CAR T Cells for High-Risk Childhood B Cell Precursor Leukemia.

Published in:

International Journal of Molecular Sciences, 2019, v. 20, n. 11, p. 2764, doi. 10.3390/ijms20112764

By:

Harrer, Dennis C.;
Schuler, Gerold;
Dörrie, Jan;
Schaft, Niels

Publication type:

Article

BRAF and MEK Inhibitors Influence the Function of Reprogrammed T Cells: Consequences for Adoptive T-Cell Therapy.

Published in:

International Journal of Molecular Sciences, 2018, v. 19, n. 1, p. 289, doi. 10.3390/ijms19010289

By:

Dörrie, Jan;
Babalija, Lek;
Hoyer, Stefanie;
Gerer, Kerstin F.;
Schuler, Gerold;
Heinzerling, Lucie;
Schaft, Niels

Publication type:

Article

Proteomic Response of Human Umbilical Vein Endothelial Cells to Histamine Stimulation.

Published in:

Proteomics, 2017, v. 17, n. 21, p. n/a, doi. 10.1002/pmic.201700116

By:

Emirbayer, Pelin Esma;
Sinha, Ankit;
Ignatchenko, Vladimir;
Hoyer, Stefanie;
Dörrie, Jan;
Schaft, Niels;
Pischetsrieder, Monika;
Kislinger, Thomas

Publication type:

Article

Preclinical evaluation of NF-κB-triggered dendritic cells expressing the viral oncogenic driver of Merkel cell carcinoma for therapeutic vaccination.

Published in:

Therapeutic Advances in Medical Oncology, 2017, v. 9, n. 7, p. 451, doi. 10.1177/1758834017712630

By:

Gerer, Kerstin F.;
Erdmann, Michael;
Hadrup, Sine R.;
Lyngaa, Rikke;
Martin, Lena-Marie;
Voll, Reinhard E.;
Schuler-Thurner, Beatrice;
Schuler, Gerold;
Schaft, Niels;
Hoyer, Stefanie;
Dörrie, Jan

Publication type:

Article

The association between serum uric acid and the incidence of prediabetes and type 2 diabetes mellitus: The Rotterdam Study.

Published in:

PLoS ONE, 2017, v. 12, n. 6, p. 1, doi. 10.1371/journal.pone.0179482

By:

van der Schaft, Niels;
Brahimaj, Adela;
Wen, Ke-xin;
Franco, Oscar H.;
Dehghan, Abbas

Publication type:

Article

Generation of CD8 T cells expressing two additional T-cell receptors (TETARs) for personalised melanoma therapy.

Published in:

Cancer Biology & Therapy, 2015, v. 16, n. 9, p. 1323, doi. 10.1080/15384047.2015.1070981

By:

Höfflin, Sandra;
Prommersberger, Sabrina;
Uslu, Ugur;
Schuler, Gerold;
Schmidt, Christopher W;
Lennerz, Volker;
Dörrie, Jan;
Schaft, Niels

Publication type:

Article

Avelumab mediates antibody‐dependent cellular cytotoxicity against monocyte‐derived dendritic cells through natural killer cells.

Published in:

MedComm, 2025, v. 6, n. 3, p. 1, doi. 10.1002/mco2.70111

By:

Sauerer, Tatjana;
Bremm, Franziska;
Beenen, Amke C.;
Heger, Lukas;
Dudziak, Diana;
Bosch, Naomi C.;
Erdmann, Michael;
Berking, Carola;
Schaft, Niels;
Dörrie, Jan

Publication type:

Article

Loading of CAR‐T cells with magnetic nanoparticles for controlled targeting suppresses inflammatory cytokine release and switches tumor cell death mechanism.

Published in:

MedComm, 2025, v. 6, n. 1, p. 1, doi. 10.1002/mco2.70039

By:

Pfister, Felix;
Carnell, Lucas R.;
Löffler, Lisa;
Boosz, Philipp;
Schaft, Niels;
Dörrie, Jan;
Stein, René;
Lenz, Malte;
Spiecker, Erdmann;
Huber, Christian M.;
Haddadin, Sami;
Berking, Carola;
Alexiou, Christoph;
Janko, Christina

Publication type:

Article

The Landscape of CAR-T Cell Clinical Trials against Solid Tumors—A Comprehensive Overview.

Published in:

Cancers, 2020, v. 12, n. 9, p. 2567, doi. 10.3390/cancers12092567

By:

Schaft, Niels

Publication type:

Article

Clinical-Scale Production of CAR-T Cells for the Treatment of Melanoma Patients by mRNA Transfection of a CSPG4-Specific CAR under Full GMP Compliance.

Published in:

Cancers, 2019, v. 11, n. 8, p. 1198, doi. 10.3390/cancers11081198

By:

Wiesinger, Manuel;
März, Johannes;
Kummer, Mirko;
Schuler, Gerold;
Dörrie, Jan;
Schuler-Thurner, Beatrice;
Schaft, Niels

Publication type:

Article

Stability and activity of MCSP-specific chimeric antigen receptors (CARs) depend on the scFv antigen-binding domain and the protein backbone.

Published in:

Cancer Immunology, Immunotherapy, 2015, v. 64, n. 12, p. 1623, doi. 10.1007/s00262-015-1767-4

By:

Krug, Christian;
Birkholz, Katrin;
Paulus, Alexander;
Schwenkert, Michael;
Schmidt, Patrick;
Hoffmann, Nicole;
Hombach, Andreas;
Fey, Georg;
Abken, Hinrich;
Schuler, Gerold;
Schuler-Thurner, Beatrice;
Dörrie, Jan;
Schaft, Niels

Publication type:

Article

A GMP-compliant protocol to expand and transfect cancer patient T cells with mRNA encoding a tumor-specific chimeric antigen receptor.

Published in:

Cancer Immunology, Immunotherapy, 2014, v. 63, n. 10, p. 999, doi. 10.1007/s00262-014-1572-5

By:

Krug, Christian;
Wiesinger, Manuel;
Abken, Hinrich;
Schuler-Thurner, Beatrice;
Schuler, Gerold;
Dörrie, Jan;
Schaft, Niels

Publication type:

Article

CD8+ T-cell priming and boosting: more antigen-presenting DC, or more antigen per DC?

Published in:

Cancer Immunology, Immunotherapy, 2013, v. 62, n. 12, p. 1769, doi. 10.1007/s00262-013-1481-z

By:

Schaft, Niels;
Wellner, Verena;
Wohn, Christian;
Schuler, Gerold;
Dörrie, Jan

Publication type:

Article

Dendritic cell vaccination and other strategies to tip the balance of the immune system.

Published in:

Cancer Immunology, Immunotherapy, 2008, v. 57, n. 6, p. 913, doi. 10.1007/s00262-007-0443-8

By:

Schaft, Niels;
Birkholz, Katrin;
Hofmann, Christian;
Schmid, Martina;
Theiner, Gabi;
Dörrie, Jan

Publication type:

Article

Dendritic cell vaccination and other strategies to tip the balance of the immune system.

Published in:

2008

By:

Schaft, Niels;
Birkholz, Katrin;
Hofmann, Christian;
Schmid, Martina;
Theiner, Gabi;
Dörrie, Jan

Publication type:

Correction Notice

Introduction of functional chimeric E/L-selectin by RNA electroporation to target dendritic cells from blood to lymph nodes.

Published in:

Cancer Immunology, Immunotherapy, 2008, v. 57, n. 4, p. 467, doi. 10.1007/s00262-007-0385-1

By:

Dörrie, Jan;
Schaft, Niels;
Müller, Ina;
Wellner, Verena;
Schunder, Tanja;
Hänig, Jens;
Oostingh, Gertie J.;
Schön, Michael P.;
Robert, Caroline;
Kämpgen, Eckhart;
Schuler, Gerold

Publication type:

Article

Strategies for immune intervention; from bench to bedside.

Published in:

Cancer Immunology, Immunotherapy, 2007, v. 56, n. 10, p. 1677, doi. 10.1007/s00262-007-0311-6

By:

Dörrie, Jan;
Birkholz, Katrin;
Schaft, Niels

Publication type:

Article

A new way to generate cytolytic tumor-specific T cells: electroporation of RNA coding for a T cell receptor into T lymphocytes.

Published in:

Cancer Immunology, Immunotherapy, 2006, v. 55, n. 9, p. 1132, doi. 10.1007/s00262-005-0098-2

By:

Schaft, Niels;
Dörrie, Jan;
Müller, Ina;
Beck, Verena;
Baumann, Stefanie;
Schunder, Tanja;
Kämpgen, Eckhart;
Schuler, Gerold

Publication type:

Article

Strategies for immune intervention.

Published in:

Cancer Immunology, Immunotherapy, 2006, v. 55, n. 5, p. 612, doi. 10.1007/s00262-005-0113-7

By:

Schaft, Niels;
Dörrie, Jan

Publication type:

Article

Autophagic degradation of lamins facilitates the nuclear egress of herpes simplex virus type 1.

Published in:

Journal of Cell Biology, 2019, v. 218, n. 2, p. 508, doi. 10.1083/jcb.201801151

By:

Turan, Aykut;
Grosche, Linda;
Krawczyk, Adalbert;
Mühl-Zürbes, Petra;
Drassner, Christina;
Düthorn, Alexandra;
Kummer, Mirko;
Hasenberg, Mike;
Voortmann, Sylvia;
Jastrow, Holger;
Dörrie, Jan;
Schaft, Niels;
Kraner, Max;
Döhner, Katinka;
Sodeik, Beate;
Steinkasserer, Alexander;
Heilingloh, Christiane Silke

Publication type:

Article

T cell re-targeting to EBV antigens following TCR gene transfer: CD28-containing receptors mediate enhanced antigen-specific IFNγ production.

Published in:

International Immunology, 2006, v. 18, n. 4, p. 591, doi. 10.1093/intimm/dxh401

By:

Niels Schaft;
Birgit Lankiewicz;
Joost Drexhage;
Cor Berrevoets;
Denis J. Moss;
Victor Levitsky;
Marc Bonneville;
Steven P. Lee;
Andrew J. McMichael;
Jan-Willem Gratama;
Reinier L. H. Bolhuis;
Ralph Willemsen;
Reno Debets

Publication type:

Article

Network- and systems-based re-engineering of dendritic cells with non-coding RNAs for cancer immunotherapy.

Published in:

Theranostics, 2021, v. 11, n. 3, p. 1412, doi. 10.7150/thno.53092

By:

Xin Lai;
Dreyer, Florian S.;
Cantone, Martina;
Eberhardt, Martin;
Gerer, Kerstin F.;
Jaitly, Tanushree;
Uebe, Steffen;
Lischer, Christopher;
Ekici, Arif;
Wittmann, Jürgen;
Jäck, Hans-Martin;
Schaft, Niels;
Dörrie, Jan;
Vera, Julio

Publication type:

Article

Total Dietary Antioxidant Capacity and Longitudinal Trajectories of Body Composition.

Published in:

Antioxidants, 2020, v. 9, n. 8, p. 728, doi. 10.3390/antiox9080728

By:

van der Schaft, Niels;
Trajanoska, Katerina;
Rivadeneira, Fernando;
Ikram, M. Arfan;
Schoufour, Josje D.;
Voortman, Trudy

Publication type:

Article

Design, implementation and initial findings of COVID-19 research in the Rotterdam Study: leveraging existing infrastructure for population-based investigations on an emerging disease.

Published in:

European Journal of Epidemiology, 2021, v. 36, n. 6, p. 649, doi. 10.1007/s10654-021-00789-7

By:

Licher, Silvan;
Terzikhan, Natalie;
Splinter, Marije J.;
Velek, Premysl;
van Rooij, Frank J. A.;
Heemst, Jolande Verkroost-van;
Haarman, Annechien E. G.;
Thee, Eric F.;
Geurts, Sven;
Mens, Michelle M. J.;
van der Schaft, Niels;
de Feijter, Maud;
Pardo, Luba M.;
Kieboom, Brenda C. T.;
Ikram, M. Arfan

Publication type:

Article

Total dietary antioxidant capacity and risk of type 2 diabetes.

Published in:

2020

By:

van der Schaft, Niels;
Voortman, Trudy

Publication type:

Letter

Dietary protein intake and all-cause and cause-specific mortality: results from the Rotterdam Study and a meta-analysis of prospective cohort studies.

Published in:

European Journal of Epidemiology, 2020, v. 35, n. 5, p. 411, doi. 10.1007/s10654-020-00607-6

By:

Chen, Zhangling;
Glisic, Marija;
Song, Mingyang;
Aliahmad, Hamid A.;
Zhang, Xiaofang;
Moumdjian, Alice C.;
Gonzalez-Jaramillo, Valentina;
van der Schaft, Niels;
Bramer, Wichor M.;
Ikram, Mohammad Arfan;
Voortman, Trudy

Publication type:

Article