Works by Schaer, Dominik J

Results: 32

Characterization of high molecular weight multimeric states of human haptoglobin and hemoglobin‐based oxygen carriers by high‐mass MALDI MS.

Published in:

Journal of Separation Science, 2009, v. 32, n. 8, p. 1224, doi. 10.1002/jssc.200800625

By:

Pimenova, Tatiana;
Pereira, Claudia P.;
Schaer, Dominik J.;
Zenobi, Renato

Publication type:

Article

C1-inhibitor to prevent intracerebral hemorrhage-related secondary brain injury.

Published in:

Fluids & Barriers of the CNS, 2024, v. 21, n. 1, p. 1, doi. 10.1186/s12987-024-00594-w

By:

Akeret, Kevin;
Thomson, Bart R.;
Ghosh, Subhajit;
Nolte, Marc;
Fischer, Urs;
Humar, Rok;
Regli, Luca;
Schaer, Dominik J.;
Hugelshofer, Michael;
Buzzi, Raphael M.

Publication type:

Article

model to visualize the fate of iron after intracranial hemorrhage using isotopic tracers and elemental bioimaging.

Published in:

Metallomics, 2022, v. 14, n. 8, p. 1, doi. 10.1093/mtomcs/mfac057

By:

Bücker, Patrick;
Buzzi, Raphael M;
Akeret, Kevin;
Mosberger, Leila;
Richter, Henning;
Sperling, Michael;
Hugelshofer, Michael;
Schaer, Dominik J;
Karst, Uwe

Publication type:

Article

Hemophagocytic macrophages constitute a major compartment of heme oxygenase expression in sepsis.

Published in:

European Journal of Haematology, 2006, v. 77, n. 5, p. 432, doi. 10.1111/j.1600-0609.2006.00730.x

By:

Schaer, Dominik J.;
Schaer, Christian A.;
Schoedon, Gabriele;
Imhof, Alexander;
Kurrer, Michael O.

Publication type:

Article

Soluble hemoglobin–haptoglobin scavenger receptor CD163 as a lineage-specific marker in the reactive hemophagocytic syndrome.

Published in:

European Journal of Haematology, 2005, v. 74, n. 1, p. 6, doi. 10.1111/j.1600-0609.2004.00318.x

By:

Schaer, Dominik J.;
Schleiffenbaum, Boris;
Kurrer, Michael;
Imhof, Alexander;
Bächli, Esther;
Fehr, Jörg;
Moller, Holger J.;
Moestrup, Soren K.;
Schaffner, Andreas

Publication type:

Article

Retinal microangiopathy and rapidly fatal cerebral edema in a patient with adult-onset Still's disease and concurrent macrophage activation syndrome.

Published in:

American Journal of Hematology, 2008, v. 83, n. 5, p. 424, doi. 10.1002/ajh.21084

By:

Gianella, Sara;
Schaer, Dominik J.;
Schwarz, Urs;
Kurrer, Michael;
Heppner, Frank L.;
Fehr, Jörg;
Seebach, Jörg D.

Publication type:

Article

Haptoglobin preserves vascular nitric oxide signaling during hemolysis.

Published in:

American Journal of Respiratory & Critical Care Medicine, 2016, v. 193, n. 10, p. E1, doi. 10.1164/rccm.201510-2058oc

By:

Schaer, Christian A.;
Deuel, Jeremy W.;
Schildknecht, Daniela;
Mahmoudi, Leila;
Garcia-Rubio, Ines;
Owczarek, Catherine;
Schauer, Stefan;
Kissner, Reinhard;
Banerjee, Uddyalok;
Palmer, Andre F.;
Spahn, Donat R.;
Irwin, David C.;
Vallelian, Florence;
Buehler, Paul W.;
Schaer, Dominik J.

Publication type:

Article

Haptoglobin Preserves Vascular Nitric Oxide Signaling during Hemolysis.

Published in:

2016

By:

Schaer, Christian A.;
Deuel, Jeremy W.;
Schildknecht, Daniela;
Mahmoudi, Leila;
Garcia-Rubio, Ines;
Owczarek, Catherine;
Schauer, Stefan;
Kissner, Reinhard;
Banerjee, Uddyalok;
Palmer, Andre F.;
Spahn, Donat R.;
Irwin, David C.;
Vallelian, Florence;
Buehler, Paul W.;
Schaer, Dominik J.

Publication type:

journal article

Cerebrospinal fluid hemoglobin drives subarachnoid hemorrhage-related secondary brain injury.

Published in:

Journal of Cerebral Blood Flow & Metabolism, 2021, v. 41, n. 11, p. 3000, doi. 10.1177/0271678X211020629

By:

Akeret, Kevin;
Buzzi, Raphael M;
Schaer, Christian A;
Thomson, Bart R;
Vallelian, Florence;
Wang, Sophie;
Willms, Jan;
Sebök, Martina;
Held, Ulrike;
Deuel, Jeremy W;
Humar, Rok;
Regli, Luca;
Keller, Emanuela;
Hugelshofer, Michael;
Schaer, Dominik J

Publication type:

Article

Phenotype-specific recombinant haptoglobin polymers co-expressed with C1r-like protein as optimized hemoglobin-binding therapeutics.

Published in:

BMC Biotechnology, 2018, v. 18, p. 1, doi. 10.1186/s12896-018-0424-3

By:

Schaer, Christian A.;
Owczarek, Catherine;
Deuel, Jeremy W.;
Schauer, Stefan;
Baek, Jin Hyen;
Yalamanoglu, Ayla;
Hardy, Matthew P.;
Scotney, Pierre D.;
Schmidt, Peter M.;
Pelzing, Matthias;
Soupourmas, Peter;
Buehler, Paul W.;
Schaer, Dominik J.

Publication type:

Article

Hemolysis transforms liver macrophages into antiinflammatory erythrophagocytes.

Published in:

2020

By:

Pfefferlé, Marc;
Ingoglia, Giada;
Schaer, Christian A.;
Ayla Yalamanoglu;
Buzzi, Raphael;
Dubach, Irina L.;
Ge Tan;
López-Cano, Emilio Y.;
Schulthess, Nadja;
Hansen, Kerstin;
Humar, Rok;
Schaer, Dominik J.;
Vallelian, Florence;
Yalamanoglu, Ayla;
Tan, Ge

Publication type:

journal article

Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy.

Published in:

Journal of Clinical Investigation, 2012, v. 122, n. 4, p. 1444, doi. 10.1172/JCI59770

By:

Baek, Jin Hyen;
D'Agnillo, Felice;
Vallelian, Florence;
Pereira, Claudia P.;
Williams, Matthew C.;
Yiping Jia;
Schaer, Dominik J.;
Buehler, Paul W.

Publication type:

Article

Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs.

Published in:

2009

By:

Boretti, Felicitas S.;
Buehler, Paul W.;
d'Agnillo, Felice;
Kluge, Katharina;
Glaus, Tony;
Butt, Omer I.;
Yiping Jia;
Goede, Jeroen;
Pereira, Claudia P.;
Maggiorini, Marco;
Schoedon, Gabriele;
Alayash, Abdu I.;
Schaer, Dominik J.;
Jia, Yiping

Publication type:

journal article

Revisiting the putative role of heme as a trigger of inflammation.

Published in:

Pharmacology Research & Perspectives, 2018, v. 6, n. 2, p. 1, doi. 10.1002/prp2.392

By:

Vallelian, Florence;
Schaer, Christian A.;
Deuel, Jeremy W.;
Ingoglia, Giada;
Humar, Rok;
Buehler, Paul W.;
Schaer, Dominik J.

Publication type:

Article

Induction of the CD163-dependent haemoglobin uptake by macrophages as a novel anti-inflammatory action of glucocorticoids.

Published in:

British Journal of Haematology, 2002, v. 119, n. 1, p. 219, doi. 10.1046/j.1365-2141.2002.03790.x

By:

Schaer, Dominik J.;
Boretti, Felicitas S.;
Schoedon, Gabriele;
Schaffner, Andreas

Publication type:

Article

Determining the Optimal Normalization Factor of Different Target Arteries for ex vivo Vascular Function Experiments: A New Standardized Procedure.

Published in:

Journal of Vascular Research, 2020, v. 57, n. 2, p. 106, doi. 10.1159/000505729

By:

Hugelshofer, Michael;
Deuel, Jeremy W.;
Buzzi, Raphael M.;
Humar, Rok;
Schaer, Dominik J.;
Schaer, Christian A.

Publication type:

Article

Human Plasma and Recombinant Hemopexins: Heme Binding Revisited.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 3, p. 1199, doi. 10.3390/ijms22031199

By:

Karnaukhova, Elena;
Owczarek, Catherine;
Schmidt, Peter;
Schaer, Dominik J.;
Buehler, Paul W.

Publication type:

Article

The HeMoVal study protocol: a prospective international multicenter cohort study to validate cerebrospinal fluid hemoglobin as a monitoring biomarker for aneurysmal subarachnoid hemorrhage related secondary brain injury.

Published in:

BMC Neurology, 2022, v. 22, n. 1, p. 1, doi. 10.1186/s12883-022-02789-w

By:

Akeret, Kevin;
Buzzi, Raphael M.;
Saxenhofer, Moritz;
Bieri, Kathrin;
Chiavi, Deborah;
Thomson, Bart R.;
Grüttner-Durmaz, Manuela;
Schwendinger, Nina;
Humar, Rok;
Regli, Luca;
van Doormaal, Tristan P. C.;
Held, Ulrike;
Keller, Emanuela;
Hugelshofer, Michael;
Schaer, Dominik J.;
HeMoVal Research Group;
Zuercher, Adrian;
Grob, Alexandra;
Abdulazim, Amr;
Grüter, Basil

Publication type:

Article

Profound dysregulation of T cell homeostasis and function in patients with severe COVID‐19.

Published in:

Allergy, 2021, v. 76, n. 9, p. 2866, doi. 10.1111/all.14866

By:

Adamo, Sarah;
Chevrier, Stéphane;
Cervia, Carlo;
Zurbuchen, Yves;
Raeber, Miro E.;
Yang, Liliane;
Sivapatham, Sujana;
Jacobs, Andrea;
Baechli, Esther;
Rudiger, Alain;
Stüssi‐Helbling, Melina;
Huber, Lars C.;
Schaer, Dominik J.;
Bodenmiller, Bernd;
Boyman, Onur;
Nilsson, Jakob

Publication type:

Article

Haptoglobin, hemopexin, and related defense pathways-basic science, clinical perspectives, and drug development.

Published in:

Frontiers in Physiology, 2014, v. 5, p. 1, doi. 10.3389/fphys.2014.00415

By:

Schaer, Dominik J.;
Vinchi, Francesca;
Ingoglia, Giada;
Tolosano, Emanuela;
Buehler, Paul W.

Publication type:

Article

Modeling hemoglobin and hemoglobin:haptoglobin complex clearance in a non-rodent species-pharmacokinetic and therapeutic implications.

Published in:

Frontiers in Physiology, 2014, v. 5, p. 1, doi. 10.3389/fphys.2014.00385

By:

Boretti, Felicitas S.;
Baek, Jin Hyen;
Palmer, Andre F.;
Schaer, Dominik J.;
Buehler, Paul W.

Publication type:

Article

MyD88-TLR4-dependent choroid plexus activation precedes perilesional inflammation and secondary brain edema in a mouse model of intracerebral hemorrhage.

Published in:

Journal of Neuroinflammation, 2022, v. 19, n. 1, p. 1, doi. 10.1186/s12974-022-02641-5

By:

Akeret, Kevin;
Buzzi, Raphael M.;
Thomson, Bart R.;
Schwendinger, Nina;
Klohs, Jan;
Schulthess-Lutz, Nadja;
Baselgia, Livio;
Hansen, Kerstin;
Regli, Luca;
Vallelian, Florence;
Hugelshofer, Michael;
Schaer, Dominik J.

Publication type:

Article

Down Selection of Polymerized Bovine Hemoglobins for Use as Oxygen Releasing Therapeutics in a Guinea Pig Model.

Published in:

Toxicological Sciences, 2012, v. 127, n. 2, p. 567, doi. 10.1093/toxsci/kfs109

By:

Baek, Jin Hyen;
Zhou, Yipin;
Harris, David R.;
Schaer, Dominik J.;
Palmer, Andre F.;
Buehler, Paul W.

Publication type:

Article

Acute Hemolysis and Heme Suppress Anti-CD40 Antibody-Induced Necro-Inflammatory Liver Disease.

Published in:

Frontiers in Immunology, 2021, v. 12, p. N.PAG, doi. 10.3389/fimmu.2021.680855

By:

Pfefferlé, Marc;
Ingoglia, Giada;
Schaer, Christian A.;
Hansen, Kerstin;
Schulthess, Nadja;
Humar, Rok;
Schaer, Dominik J.;
Vallelian, Florence

Publication type:

Article

Agonistic Anti-CD40 Antibody Triggers an Acute Liver Crisis With Systemic Inflammation in Humanized Sickle Cell Disease Mice.

Published in:

Frontiers in Immunology, 2021, v. 11, p. N.PAG, doi. 10.3389/fimmu.2021.627944

By:

Yalamanoglu, Ayla;
Dubach, Irina L.;
Schulthess, Nadja;
Ingoglia, Giada;
Swindle, Delaney C.;
Humar, Rok;
Schaer, Dominik J.;
Buehler, Paul W.;
Irwin, David C.;
Vallelian, Florence

Publication type:

Article

Expression of CD163 on human histiocytic cells is different in tuberculosis-induced and schistosomiasis-induced granulomas.

Published in:

Histopathology, 2012, v. 60, n. 3, p. 511, doi. 10.1111/j.1365-2559.2011.04059.x

By:

Strebel, Bruno M;
Lepper, Philipp M;
Schaer, Dominik J;
Sendensky, Alexander H;
Kurrer, Michael O

Publication type:

Article

Extracellular Hb Enhances Cardiac Toxicity in Endotoxemic Guinea Pigs: Protective Role of Haptoglobin.

Published in:

Toxins, 2014, v. 6, n. 4, p. 1244, doi. 10.3390/toxins6041244

By:

Jin Hyen Baek;
Xiaoyuan Zhang;
Williams, Matthew C.;
Buehler, Paul W.;
Schaer, Dominik J.;
D'Agnillo, Felice

Publication type:

Article

Transcriptome Analysis Revealed Unique Genes as Targets for the Anti-inflammatory Action of Activated Protein C in Human Macrophages.

Published in:

PLoS ONE, 2010, v. 5, n. 10, p. 1, doi. 10.1371/journal.pone.0015352

By:

Pereira, Claudia P.;
Bachli, Esther B.;
Schaer, Dominik J.;
Schoedon, Gabriele

Publication type:

Article

Molecular cloning and characterization of the mouse CD163 homologue, a highly glucocorticoid-inducible member of the scavenger receptor cysteine-rich family.

Published in:

Immunogenetics, 2001, v. 53, n. 2, p. 170, doi. 10.1007/s002510100304

By:

Schaer, Dominik J.;
Boretti, Felicitas S.;
Hongegger, Annemarie;
Poehler, Doris;
Linnscheid, Philippe;
Staege, Hannah;
Müller, Christoph;
Schoedon, Gabriele;
Schaffner, Andreas

Publication type:

Article

Haptoglobin treatment prevents cell-free hemoglobin exacerbated mortality in experimental rat sepsis.

Published in:

2021

By:

Schaer, Christian A.;
Jeger, Victor;
Gentinetta, Thomas;
Spahn, Donat R.;
Vallelian, Florence;
Rudiger, Alain;
Schaer, Dominik J.

Publication type:

Letter

Chloroquine Interference with Hemoglobin Endocytic Trafficking Suppresses Adaptive Heme and Iron Homeostasis in Macrophages: The Paradox of an Antimalarial Agent.

Published in:

Oxidative Medicine & Cellular Longevity, 2013, v. 2013, p. 1, doi. 10.1155/2013/870472

By:

Schaer, Christian A.;
Laczko, Endre;
Schoedon, Gabriele;
Schaer, Dominik J.;
Vallelian, Florence

Publication type:

Article

Effect of a nurse-led integrated care intervention on quality of life and rehospitalisation in patients with severe exacerbation of COPD—a pilot study.

Published in:

Chronic Respiratory Disease, 2024, v. 21, p. 1, doi. 10.1177/14799731241291067

By:

Schmid-Mohler, Gabriela;
Hübsch, Christine;
Braun, Julia;
Steurer-Stey, Claudia;
Aregger, Celine;
Schaer, Dominik J.;
Clarenbach, Christian

Publication type:

Article