Works by Schürer, Stephan

Results: 40

Neighborhood Disadvantage is Associated with Worse Pathologic Response in Pancreatic Cancer.

Published in:

2025

By:

Martos, Mary P.;
Lee, Ming S.;
Merchant, Nipun B.;
Kobetz, Erin;
Hester, Caitlin A.;
Stathias, Vasileios;
Maithel, Shishir K.;
Schürer, Stephan;
Datta, Jashodeep

Publication type:

Letter

Small Molecule-Mediated Activation of the Integrin CD11b/CD18 Reduces Inflammatory Disease.

Published in:

Science Signaling, 2011, v. 4, n. 189, p. 1, doi. 10.1126/scisignal.2001811

By:

Maiguel, Dony;
Faridi, Mohd Hafeez;
Wei, Changli;
Kuwano, Yoshihiro;
Balla, Keir M.;
Hernandez, Dayami;
Barth, Constantinos J.;
Lugo, Geanncarlo;
Donnelly, Mary;
Nayer, Ali;
Moita, Luis F.;
Schürer, Stephan;
Traver, David;
Ruiz, Phillip;
Vazquez-Padron, Roberto I.;
Ley, Klaus;
Reiser, Jochen;
Gupta, Vineet

Publication type:

Article

Automation, live-cell imaging, and endpoint cell viability for prostate cancer drug screens.

Published in:

PLoS ONE, 2023, v. 18, n. 10, p. 1, doi. 10.1371/journal.pone.0287126

By:

Lyles, Rolando D. Z.;
Martinez, Maria J.;
Sherman, Benjamin;
Schürer, Stephan;
Burnstein, Kerry L.

Publication type:

Article

Predictors of Clinical Outcome After Early Veno-Arterial Extracorporeal Membrane Oxygenation in Cardiogenic Shock Complicating ST-Elevation Myocardial Infarction.

Published in:

Journal of Invasive Cardiology, 2021, v. 33, n. 5, p. E329, doi. 10.25270/jic/20.00542

By:

Szczanowicz, Lukasz;
Majunke, Nicolas;
de Waha-Thiele, Suzanne;
Tietz, Franziska;
Schürer, Stephan;
Kirsch, Katharina;
Desch, Steffen;
Thiele, Holger;
Sandri, Marcus

Publication type:

Article

Improving the Utility of the Tox21 Dataset by Deep Metadata Annotations and Constructing Reusable Benchmarked Chemical Reference Signatures.

Published in:

Molecules, 2019, v. 24, n. 8, p. 1604, doi. 10.3390/molecules24081604

By:

Cooper, Daniel J.;
Schürer, Stephan

Publication type:

Article

Antidiabetic actions of a non-agonist PPAR? ligand blocking Cdk5-mediated phosphorylation.

Published in:

Nature, 2011, v. 477, n. 7365, p. 477, doi. 10.1038/nature10383

By:

Jang Hyun Choi;
Banks, Alexander S.;
Kamenecka, Theodore M.;
Busby, Scott A.;
Chalmers, Michael J.;
Kumar, Naresh;
Kuruvilla, Dana S.;
Youseung Shin;
Yuanjun He;
Bruning, John B.;
Marciano, David P.;
Cameron, Michael D.;
Laznik, Dina;
Jurczak, Michael J.;
Schürer, Stephan C.;
Vidović, Dušica;
Shulman, Gerald I.;
Spiegelman, Bruce M.;
Griffin, Patrick R.

Publication type:

Article

Suppression of T<sub>H</sub>17 differentiation and autoimmunity by a synthetic ROR ligand.

Published in:

Nature, 2011, v. 472, n. 7344, p. 491, doi. 10.1038/nature10075

By:

Solt, Laura A.;
Kumar, Naresh;
Nuhant, Philippe;
Yongjun Wang;
Lauer, Janelle L.;
Jin Liu;
Istrate, Monica A.;
Kamenecka, Theodore M.;
Roush, William R.;
Vidović, Dušica;
Schürer, Stephan C.;
Jihong Xu;
Wagoner, Gail;
Drew, Paul D.;
Griffin, Patrick R.;
Burris, Thomas P.

Publication type:

Article

Polypharmacology or Promiscuity? Structural Interactions of Resveratrol With Its Bandwagon of Targets.

Published in:

Frontiers in Pharmacology, 2018, p. N.PAG, doi. 10.3389/fphar.2018.01201

By:

Saqib, Uzma;
Kelley, Tanya T.;
Panguluri, Siva K.;
Liu, Dongfang;
Savai, Rajkumar;
Baig, Mirza S.;
Schürer, Stephan C.

Publication type:

Article

Large-scale integration of small molecule-induced genome-wide transcriptional responses, Kinome-wide binding affinities and cell-growth inhibition profiles reveal global trends characterizing systems-level drug action.

Published in:

Frontiers in Genetics, 2014, v. 5, p. 1, doi. 10.3389/fgene.2014.00342

By:

Vidović, Dušica;
Koleti, Amar;
Schürer, Stephan C.

Publication type:

Article

Multiscale mapping of transcriptomic signatures for cardiotoxic drugs.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-52145-4

By:

Hansen, Jens;
Xiong, Yuguang;
Siddiq, Mustafa M.;
Dhanan, Priyanka;
Hu, Bin;
Shewale, Bhavana;
Yadaw, Arjun S.;
Jayaraman, Gomathi;
Tolentino, Rosa E.;
Chen, Yibang;
Martinez, Pedro;
Beaumont, Kristin G.;
Sebra, Robert;
Vidovic, Dusica;
Schürer, Stephan C.;
Goldfarb, Joseph;
Gallo, James M.;
Birtwistle, Marc R.;
Sobie, Eric A.;
Azeloglu, Evren U.

Publication type:

Article

Tyrosine phosphorylation of CARM1 promotes its enzymatic activity and alters its target specificity.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-47689-4

By:

Itonaga, Hidehiro;
Mookhtiar, Adnan K.;
Greenblatt, Sarah M.;
Liu, Fan;
Martinez, Concepcion;
Bilbao, Daniel;
Rains, Masai;
Hamard, Pierre-Jacques;
Sun, Jun;
Umeano, Afoma C.;
Duffort, Stephanie;
Chen, Chuan;
Man, Na;
Mas, Gloria;
Tottone, Luca;
Totiger, Tulasigeri;
Bradley, Terrence;
Taylor, Justin;
Schürer, Stephan;
Nimer, Stephen D.

Publication type:

Article

OSCI: standardized stem cell ontology representation and use cases for stem cell investigation.

Published in:

BMC Bioinformatics, 2019, v. 20, n. 1, p. 237, doi. 10.1186/s12859-019-2723-7

By:

He, Yongqun;
Duncan, William D.;
Cooper, Daniel J.;
Hansen, Jens;
Iyengar, Ravi;
Ong, Edison;
Walker, Kendal;
Tibi, Omar;
Smith, Sam;
Serra, Lucas M.;
Zheng, Jie;
Sarntivijai, Sirarat;
Schürer, Stephan;
O'Shea, K. Sue;
Diehl, Alexander D.

Publication type:

Article

Ontological representation, integration, and analysis of LINCS cell line cells and their cellular responses.

Published in:

BMC Bioinformatics, 2017, v. 18, p. 1, doi. 10.1186/s12859-017-1981-5

By:

Ong, Edison;
Jiangan Xie;
Zhaohui Ni;
Qingping Liu;
Sarntivijai, Sirarat;
Yu Lin;
Cooper, Daniel;
Terryn, Raymond;
Stathias, Vasileios;
Chung, Caty;
Schürer, Stephan;
Yongqun He

Publication type:

Article

Drug and disease signature integration identifies synergistic combinations in glioblastoma.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-07659-z

By:

Stathias, Vasileios;
Jermakowicz, Anna M.;
Maloof, Marie E.;
Forlin, Michele;
Walters, Winston;
Suter, Robert K.;
Durante, Michael A.;
Williams, Sion L.;
Harbour, J. William;
Volmar, Claude-Henry;
Lyons, Nicholas J.;
Wahlestedt, Claes;
Graham, Regina M.;
Ivan, Michael E.;
Komotar, Ricardo J.;
Sarkaria, Jann N.;
Subramanian, Aravind;
Golub, Todd R.;
Schürer, Stephan C.;
Ayad, Nagi G.

Publication type:

Article

Novel Curcumin Inspired Bis-Chalcone Promotes Endoplasmic Reticulum Stress and Glioblastoma Neurosphere Cell Death.

Published in:

Cancers, 2019, v. 11, n. 3, p. 357, doi. 10.3390/cancers11030357

By:

Sansalone, Lorenzo;
Veliz, Eduardo A.;
Myrthil, Nadia G.;
Stathias, Vasileios;
Walters, Winston;
Torrens, Ingrid I.;
Schürer, Stephan C.;
Vanni, Steven;
Leblanc, Roger M.;
Graham, Regina M.

Publication type:

Article

A Combined Ligand- and Structure-Based Virtual Screening Protocol Identifies Submicromolar PPARγ Partial Agonists.

Published in:

ChemMedChem, 2011, v. 6, n. 1, p. 94, doi. 10.1002/cmdc.201000428

By:

Vidović, Dušica;
Busby, Scott A.;
Griffin, Patrick R.;
Schürer, Stephan C.

Publication type:

Article

Use of machine learning to identify novel, behaviorally active antagonists of the insect odorant receptor co-receptor (Orco) subunit.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41598-019-40640-4

By:

Kepchia, Devin;
Xu, Pingxi;
Terryn, Raymond;
Castro, Ana;
Schürer, Stephan C.;
Leal, Walter S.;
Luetje, Charles W.

Publication type:

Article

Far away from the lamppost.

Published in:

PLoS Biology, 2018, v. 16, n. 12, p. 1, doi. 10.1371/journal.pbio.3000067

By:

Oprea, Tudor I.;
Jan, Lily;
Johnson, Gary L.;
Roth, Bryan L.;
Ma’ayan, Avi;
Schürer, Stephan;
Shoichet, Brian K.;
Sklar, Larry A.;
McManus, Michael T.

Publication type:

Article

GPCR ontology: development and application of a G protein-coupled receptor pharmacology knowledge framework.

Published in:

Bioinformatics, 2013, v. 29, n. 24, p. 3211, doi. 10.1093/bioinformatics/btt565

By:

Przydzial, Magdalena J.;
Bhhatarai, Barun;
Koleti, Amar;
Vempati, Uma;
Schürer, Stephan C.

Publication type:

Article

Kinome-Wide Virtual Screening by Multi-Task Deep Learning.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 5, p. 2538, doi. 10.3390/ijms25052538

By:

Hu, Jiaming;
Allen, Bryce K.;
Stathias, Vasileios;
Ayad, Nagi G.;
Schürer, Stephan C.

Publication type:

Article

BioAssay Ontology (BAO): a semantic description of bioassays and high-throughput screening results.

Published in:

BMC Bioinformatics, 2011, v. 12, n. 1, p. 257, doi. 10.1186/1471-2105-12-257

By:

Visser, Ubbo;
Abeyruwan, Saminda;
Vempati, Uma;
Smith, Robin P.;
Lemmon, Vance;
Schürer, Stephan C.

Publication type:

Article

TIN-X: target importance and novelty explorer.

Published in:

Bioinformatics, 2017, v. 33, n. 16, p. 2601, doi. 10.1093/bioinformatics/btx200

By:

Cannon, Daniel C.;
Yang, Jeremy J.;
Mathias, Stephen L.;
Ursu, Oleg;
Mani, Subramani;
Waller, Anna;
Schürer, Stephan C.;
Jensen, Lars Juhl;
Sklar, Larry A.;
Bologa, Cristian G.;
Oprea, Tudor I.

Publication type:

Article

Pharos 2023: an integrated resource for the understudied human proteome.

Published in:

Nucleic Acids Research, 2023, v. 51, n. D1, p. D1405, doi. 10.1093/nar/gkac1033

By:

Kelleher, Keith J;
Sheils, Timothy K;
Mathias, Stephen L;
Yang, Jeremy J;
Metzger, Vincent T;
Siramshetty, Vishal B;
Nguyen, Dac-Trung;
Jensen, Lars Juhl;
Vidović, Dušica;
Schürer, Stephan C;
Holmes, Jayme;
Sharma, Karlie R;
Pillai, Ajay;
Bologa, Cristian G;
Edwards, Jeremy S;
Mathé, Ewy A;
Oprea, Tudor I

Publication type:

Article

SigCom LINCS: data and metadata search engine for a million gene expression signatures.

Published in:

Nucleic Acids Research, 2022, v. 50, n. W1, p. W697, doi. 10.1093/nar/gkac328

By:

Evangelista, John Erol;
Clarke, Daniel J B;
Xie, Zhuorui;
Lachmann, Alexander;
Jeon, Minji;
Chen, Kerwin;
Jagodnik, Kathleen M;
Jenkins, Sherry L;
Kuleshov, Maxim V;
Wojciechowicz, Megan L;
Schürer, Stephan C;
Medvedovic, Mario;
Ma'ayan, Avi

Publication type:

Article

piNET: a versatile web platform for downstream analysis and visualization of proteomics data.

Published in:

Nucleic Acids Research, 2020, v. 48, n. W1, p. W85, doi. 10.1093/nar/gkaa436

By:

Shamsaei, Behrouz;
Chojnacki, Szymon;
Pilarczyk, Marcin;
Najafabadi, Mehdi;
Niu, Wen;
Chen, Chuming;
Ross, Karen;
Matlock, Andrea;
Muhlich, Jeremy;
Chutipongtanate, Somchai;
Zheng, Jie;
Turner, John;
Vidović, Dušica;
Jaffe, Jake;
MacCoss, Michael;
Wu, Cathy;
Pillai, Ajay;
Ma'ayan, Avi;
Schürer, Stephan;
Kouril, Michal

Publication type:

Article

LINCS Data Portal 2.0: next generation access point for perturbation-response signatures.

Published in:

Nucleic Acids Research, 2020, v. 48, n. D1, p. D431, doi. 10.1093/nar/gkz1023

By:

Stathias, Vasileios;
Turner, John;
Koleti, Amar;
Vidovic, Dusica;
Cooper, Daniel;
Fazel-Najafabadi, Mehdi;
Pilarczyk, Marcin;
Terryn, Raymond;
Chung, Caty;
Umeano, Afoma;
Clarke, Daniel J B;
Lachmann, Alexander;
Evangelista, John Erol;
Ma'ayan, Avi;
Medvedovic, Mario;
Schürer, Stephan C

Publication type:

Article

DrugCentral 2018: an update.

Published in:

Nucleic Acids Research, 2019, v. 47, n. D1, p. D963, doi. 10.1093/nar/gky963

By:

Ursu, Oleg;
Holmes, Jayme;
Bologa, Cristian G;
Yang, Jeremy J;
Mathias, Stephen L;
Stathias, Vasileios;
Nguyen, Dac-Trung;
Schürer, Stephan;
Oprea, Tudor

Publication type:

Article

Pharos: Collating protein information to shed light on the druggable genome.

Published in:

Nucleic Acids Research, 2017, v. 45, n. D1, p. D995, doi. 10.1093/nar/gkw1072

By:

Dac-Trung Nguyen;
Mathias, Stephen;
Bologa, Cristian;
Brunak, Soren;
Fernandez, Nicolas;
Gaulton, Anna;
Hersey, Anne;
Holmes, Jayme;
Jensen, Lars Juhl;
Karlsson, Anneli;
Guixia Liu;
Ma'ayan, Avi;
Mandava, Geetha;
Mani, Subramani;
Mehta, Saurabh;
Overington, John;
Patel, Juhee;
Rouillard, Andrew D.;
Schürer, Stephan;
Sheils, Timothy

Publication type:

Article

Expanding a Wastewater-Based Surveillance Methodology for DNA Isolation from a Workflow Optimized for SARS-CoV-2 RNA Quantification.

Published in:

Journal of Biomolecular Techniques, 2023, v. 34, n. 4, p. 1, doi. 10.7171/3fc1f5fe.dfa8d906

By:

Babler, Kristina M.;
Sharkey, Mark E.;
Amirali, Ayaaz;
Boone, Melinda M.;
Comerford, Samuel;
Currall, Benjamin B.;
Grills, George S.;
Laine, Jennifer;
Mason, Christopher E.;
Reding, Brian;
Schürer, Stephan;
Stevenson, Mario;
Vidović, Dušica;
Williams, Sion L.;
Solo-Gabriele, Helena M.

Publication type:

Article

Distinct functional and conformational states of the human lymphoid tyrosine phosphatase catalytic domain can be targeted by choice of the inhibitor chemotype.

Published in:

Journal of Computer-Aided Molecular Design, 2011, v. 25, n. 9, p. 873, doi. 10.1007/s10822-011-9469-2

By:

Vidović, Dušica;
Xie, Yuli;
Rinderspacher, Alison;
Deng, Shi-Xian;
Landry, Donald;
Chung, Caty;
Smith, Deborah;
Tautz, Lutz;
Schürer, Stephan

Publication type:

Article

Utilizing high throughput screening data for predictive toxicology models: protocols and application to MLSCN assays.

Published in:

Journal of Computer-Aided Molecular Design, 2008, v. 22, n. 6/7, p. 367, doi. 10.1007/s10822-008-9192-9

By:

Guha, Rajarshi;
Schürer, Stephan C.

Publication type:

Article

Large-Scale Computational Screening Identifies First in Class Multitarget Inhibitor of EGFR Kinase and BRD4.

Published in:

Scientific Reports, 2015, p. 16924, doi. 10.1038/srep16924

By:

Allen, Bryce K.;
Mehta, Saurabh;
Ember, Stewart W. J.;
Schonbrunn, Ernst;
Ayad, Nagi;
Schürer, Stephan C.

Publication type:

Article

Formalization, Annotation and Analysis of Diverse Drug and Probe Screening Assay Datasets Using the BioAssay Ontology (BAO).

Published in:

PLoS ONE, 2012, v. 7, n. 11, p. 1, doi. 10.1371/journal.pone.0049198

By:

Vempati, Uma D.;
Przydzial, Magdalena J.;
Chung, Caty;
Abeyruwan, Saminda;
Mir, Ahsan;
Sakurai, Kunie;
Visser, Ubbo;
Lemmon, Vance P.;
Schürer, Stephan C.

Publication type:

Article

Synthesis and Application of a Permanently Immobilized Olefin-Metathesis Catalyst.

Published in:

Angewandte Chemie International Edition, 2000, v. 39, n. 21, p. 3898, doi. 10.1002/1521-3773(20001103)39:21<3898::AID-ANIE3898>3.0.CO;2-X

By:

Schürer, Stephan C.;
Gessler, Simon;
Buschmann, Nicole;
Blechert, Siegfried

Publication type:

Article

TIN-X version 3: update with expanded dataset and modernized architecture for enhanced illumination of understudied targets.

Published in:

PeerJ, 2024, p. 1, doi. 10.7717/peerj.17470

By:

Metzger, Vincent T.;
Cannon, Daniel C.;
Yang, Jeremy J.;
Mathias, Stephen L.;
Bologa, Cristian G.;
Waller, Anna;
Schürer, Stephan C.;
Vidović, Dušica;
Kelleher, Keith J.;
Sheils, Timothy K.;
Jensen, Lars Juhl;
Lambert, Christophe G.;
Oprea, Tudor I.;
Edwards, Jeremy S.

Publication type:

Article

Divergent allosteric control of the IRE1? endoribonuclease using kinase inhibitors.

Published in:

Nature Chemical Biology, 2012, v. 8, n. 12, p. 982, doi. 10.1038/nchembio.1094

By:

Wang, Likun;
Perera, B Gayani K;
Hari, Sanjay B;
Bhhatarai, Barun;
Backes, Bradley J;
Seeliger, Markus A;
Schürer, Stephan C;
Oakes, Scott A;
Papa, Feroz R;
Maly, Dustin J

Publication type:

Article

Correction: AI-Assisted chemical probe discovery for the understudied Calcium-Calmodulin Dependent Kinase, PNCK.

Published in:

2023

By:

Essegian, Derek J.;
Chavez, Valery;
Khurshid, Rabia;
Merchan, Jaime R.;
Schürer, Stephan C.

Publication type:

Correction Notice

AI-Assisted chemical probe discovery for the understudied Calcium-Calmodulin Dependent Kinase, PNCK.

Published in:

PLoS Computational Biology, 2023, v. 19, n. 5, p. 1, doi. 10.1371/journal.pcbi.1010263

By:

Essegian, Derek J.;
Chavez, Valery;
Khurshid, Rabia;
Merchan, Jaime R.;
Schürer, Stephan C.

Publication type:

Article

Proteomic cellular signatures of kinase inhibitor-induced cardiotoxicity.

Published in:

Scientific Data, 2022, v. 9, n. 1, p. 1, doi. 10.1038/s41597-021-01114-3

By:

Xiong, Yuguang;
Liu, Tong;
Chen, Tong;
Hansen, Jens;
Hu, Bin;
Chen, Yibang;
Jayaraman, Gomathi;
Schürer, Stephan;
Vidovic, Dusica;
Goldfarb, Joseph;
Sobie, Eric A.;
Birtwistle, Marc R.;
Iyengar, Ravi;
Li, Hong;
Azeloglu, Evren U.

Publication type:

Article

GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation.

Published in:

Cell Cycle, 2015, v. 14, n. 3, p. 417, doi. 10.4161/15384101.2014.974439

By:

Penas, Clara;
Mishra, Jitendra K;
Wood, Spencer D;
Schürer, Stephan C;
Roush, William R;
Ayad, Nagi G

Publication type:

Article