Works by Scammells, Peter

Results: 43

Solution NMR characterization of apical membrane antigen 1 and small molecule interactions as a basis for designing new antimalarials.
Published in:
Journal of Molecular Recognition, 2016, v. 29, n. 6, p. 281, doi. 10.1002/jmr.2529
By:
- Krishnarjuna, Bankala;
- Lim, San Sui;
- Devine, Shane M.;
- Debono, Cael O.;
- Lam, Raymond;
- Chandrashekaran, Indu R.;
- Jaipuria, Garima;
- Yagi, Hiromasa;
- Atreya, Hanudatta S.;
- Scanlon, Martin J.;
- MacRaild, Christopher A.;
- Scammells, Peter J.;
- Norton, Raymond S.
Publication type:
Article
Design, Synthesis, and Biological Evaluation of Tetra-Substituted Thiophenes as Inhibitors of p38α MAPK.
Published in:
ChemistryOpen, 2015, v. 4, n. 1, p. 56, doi. 10.1002/open.201402076
By:
- Vinh, Natalie B.;
- Devine, Shane M.;
- Munoz, Lenka;
- Ryan, Renae M.;
- Wang, Bing H.;
- Krum, Henry;
- Chalmers, David K.;
- Simpson, Jamie S.;
- Scammells, Peter J.
Publication type:
Article
Total Synthesis of (−)-Episilvestrol and (−)-Silvestrol.
Published in:
Angewandte Chemie International Edition, 2007, v. 46, n. 41, p. 7835, doi. 10.1002/anie.200702700
By:
- El Sous, Mariana;
- Khoo, Mui Ling;
- Holloway, Georgina;
- Owen, David;
- Scammells, Peter J.;
- Rizzacasa, Mark A.
Publication type:
Article
NMR case study of ropinirole: concentration-dependent effects of nonexchangeable proton resonances.
Published in:
2014
By:
- Jörg, Manuela;
- Headey, Stephen;
- Scammells, Peter J.;
- Capuano, Ben
Publication type:
Other
Genetic and chemical validation of Plasmodium falciparum aminopeptidase PfA-M17 as a drug target in the hemoglobin digestion pathway.
Published in:
eLife, 2022, p. 1, doi. 10.7554/eLife.80813
By:
- Edgar, Rebecca C. S.;
- Siddiqui, Ghizal;
- Hjerrild, Katheryn;
- Malcolm, Tess R.;
- Vinh, Natalie B.;
- Webb, Chaille T.;
- Holmes, Clare;
- MacRaild, Christopher A.;
- Chernih, Hope C.;
- Suen, Willy W.;
- Counihan, Natalie A.;
- Creek, Darren J.;
- Scammells, Peter J.;
- McGowan, Sheena;
- de Koning-Ward, Tania F.
Publication type:
Article
Nitrogen-Containing Ionic Liquids: Biodegradation Studies and Utility in Base-Mediated Reactions.
Published in:
Australian Journal of Chemistry, 2015, v. 68, n. 6, p. 849, doi. 10.1071/CH14499
By:
- Ford, Leigh;
- Ylijoki, Kai E. O.;
- Garcia, M. Teresa;
- Singer, Robert D.;
- Scammells, Peter J.
Publication type:
Article
Effect of a novel partial adenosine A1 receptor agonist VCP102 in reducing ischemic damage in the mouse heart.
Published in:
Drug Development Research, 2007, v. 68, n. 8, p. 529, doi. 10.1002/ddr.20220
By:
- Butcher, Anna;
- Gregg, Alison;
- Scammells, Peter J.;
- Rose' Meyer, Roselyn B.
Publication type:
Article
Structure and substrate fingerprint of aminopeptidase P from Plasmodium falciparum.
Published in:
Biochemical Journal, 2016, v. 473, n. 19, p. 3189, doi. 10.1042/BCJ20160550
By:
- Drinkwater, Nyssa;
- Sivaraman, Komagal Kannan;
- Bamert, Rebecca S.;
- Rut, Wioletta;
- Mohamed, Khadija;
- Vinh, Natalie B.;
- Scammells, Peter J.;
- Drag, Marcin;
- McGowan, Sheena
Publication type:
Article
The role of kinetic context in apparent biased agonism at GPCRs.
Published in:
Nature Communications, 2016, v. 7, n. 2, p. 10842, doi. 10.1038/ncomms10842
By:
- Klein Herenbrink, Carmen;
- Sykes, David A.;
- Donthamsetti, Prashant;
- Canals, Meritxell;
- Coudrat, Thomas;
- Shonberg, Jeremy;
- Scammells, Peter J.;
- Capuano, Ben;
- Sexton, Patrick M.;
- Charlton, Steven J.;
- Javitch, Jonathan A.;
- Christopoulos, Arthur;
- Lane, J. Robert
Publication type:
Article
Screening the Medicines for Malaria Venture "Malaria Box" against the Plasmodium falciparum Aminopeptidases, M1, M17 and M18.
Published in:
PLoS ONE, 2015, v. 10, n. 2, p. 1, doi. 10.1371/journal.pone.0115859
By:
- Paiardini, Alessandro;
- Bamert, Rebecca S.;
- Kannan-Sivaraman, Komagal;
- Drinkwater, Nyssa;
- Mistry, Shailesh N.;
- Scammells, Peter J.;
- McGowan, Sheena
Publication type:
Article
Zwitterionic Modification of Ultrasmall Iron Oxide Nanoparticles for Reduced Protein Corona Formation.
Published in:
ChemPlusChem, 2017, v. 82, n. 4, p. 638, doi. 10.1002/cplu.201700052
By:
- Pombo‐García, Karina;
- Rühl, Carmen L.;
- Lam, Raymond;
- Barreto, José A.;
- Ang, Ching‐Seng;
- Scammells, Peter J.;
- Comba, Peter;
- Spiccia†, Leone;
- Graham, Bim;
- Joshi, Tanmaya;
- Stephan, Holger
Publication type:
Article
Chemoproteomics validates selective targeting of Plasmodium M1 alanyl aminopeptidase as an antimalarial strategy.
Published in:
eLife, 2024, p. 1, doi. 10.7554/eLife.92990
By:
- Giannangelo, Carlo;
- Challis, Matthew P.;
- Siddiqui, Ghizal;
- Edgar, Rebecca;
- Malcolm, Tess R.;
- Webb, Chaille T.;
- Drinkwater, Nyssa;
- Vinh, Natalie;
- Macraild, Christopher;
- Counihan, Natalie;
- Duffy, Sandra;
- Wittlin, Sergio;
- Devine, Shane M.;
- Avery, Vicky M.;
- De Koning-Ward, Tania;
- Scammells, Peter;
- McGowan, Sheena;
- Creek, Darren J.
Publication type:
Article
1,3‐Benzodioxole‐Modified Noscapine Analogues: Synthesis, Antiproliferative Activity, and Tubulin‐Bound Structure.
Published in:
ChemMedChem, 2021, v. 16, n. 18, p. 2882, doi. 10.1002/cmdc.202100363
By:
- Yong, Cassandra;
- Devine, Shane M.;
- Abel, Anne‐Catherine;
- Tomlins, Stefan D.;
- Muthiah, Divya;
- Gao, Xuexin;
- Callaghan, Richard;
- Steinmetz, Michel O.;
- Prota, Andrea E.;
- Capuano, Ben;
- Scammells, Peter J.
Publication type:
Article
Development of Novel 4‐Arylpyridin‐2‐one and 6‐Arylpyrimidin‐4‐one Positive Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor.
Published in:
ChemMedChem, 2021, v. 16, n. 1, p. 216, doi. 10.1002/cmdc.202000540
By:
- Jörg, Manuela;
- Khajehali, Elham;
- Westhuizen, Emma T.;
- C. Choy, K. H.;
- Shackleford, David M.;
- Tobin, Andrew B.;
- Sexton, Patrick M.;
- Valant, Celine;
- Capuano, Ben;
- Christopoulos, Arthur;
- Scammells, Peter J.
Publication type:
Article
A Structure−Activity Relationship Study of Novel Hydroxamic Acid Inhibitors around the S1 Subsite of Human Aminopeptidase N.
Published in:
ChemMedChem, 2021, v. 16, n. 1, p. 234, doi. 10.1002/cmdc.202000527
By:
- Lee, Jisook;
- Drinkwater, Nyssa;
- McGowan, Sheena;
- Scammells, Peter
Publication type:
Article
Front Cover: A Novel Class of N‐Sulfonyl and N‐Sulfamoyl Noscapine Derivatives that Promote Mitotic Arrest in Cancer Cells (ChemMedChem 23/2019).
Published in:
ChemMedChem, 2019, v. 14, n. 23, p. 1950, doi. 10.1002/cmdc.201900651
By:
- Yong, Cassandra;
- Devine, Shane M.;
- Gao, Xuexin;
- Yan, Angelina;
- Callaghan, Richard;
- Capuano, Ben;
- Scammells, Peter J.
Publication type:
Article
A Novel Class of N‐Sulfonyl and N‐Sulfamoyl Noscapine Derivatives that Promote Mitotic Arrest in Cancer Cells.
Published in:
ChemMedChem, 2019, v. 14, n. 23, p. 1968, doi. 10.1002/cmdc.201900477
By:
- Yong, Cassandra;
- Devine, Shane M.;
- Gao, Xuexin;
- Yan, Angelina;
- Callaghan, Richard;
- Capuano, Ben;
- Scammells, Peter J.
Publication type:
Article
Identification of the Binding Site of Apical Membrane Antigen 1 (AMA1) Inhibitors Using a Paramagnetic Probe.
Published in:
ChemMedChem, 2019, v. 14, n. 5, p. 603, doi. 10.1002/cmdc.201800802
By:
- Akter, Mansura;
- Drinkwater, Nyssa;
- Devine, Shane M.;
- Drew, Simon C.;
- Krishnarjuna, Bankala;
- Debono, Cael O.;
- Wang, Geqing;
- Scanlon, Martin J.;
- Scammells, Peter J.;
- McGowan, Sheena;
- MacRaild, Christopher A.;
- Norton, Raymond S.
Publication type:
Article
Guidelines for the Synthesis of Small-Molecule Irreversible Probes Targeting G Protein-Coupled Receptors.
Published in:
ChemMedChem, 2016, v. 11, n. 14, p. 1488, doi. 10.1002/cmdc.201600066
By:
- Jörg, Manuela;
- Scammells, Peter J.
Publication type:
Article
The Synthesis and Biological Evaluation of Multifunctionalised Derivatives of Noscapine as Cytotoxic Agents.
Published in:
ChemMedChem, 2014, v. 9, n. 2, p. 399, doi. 10.1002/cmdc.201300395
By:
- DeBono, Aaron J.;
- Mistry, Sarah J.;
- Xie, Jinhan;
- Muthiah, Divya;
- Phillips, Jackson;
- Ventura, Sabatino;
- Callaghan, Richard;
- Pouton, Colin W.;
- Capuano, Ben;
- Scammells, Peter J.
Publication type:
Article
Effect of Linker Length and Composition on Heterobivalent Ligand-Mediated Receptor Cross-Talk between the A1 Adenosine and β2 Adrenergic Receptors.
Published in:
ChemMedChem, 2013, v. 8, n. 12, p. 2036, doi. 10.1002/cmdc.201300286
By:
- Barlow, Nicholas;
- Baker, Stephen P.;
- Scammells, Peter J.
Publication type:
Article
Synthesis and Biological Evaluation of N-Substituted Noscapine Analogues.
Published in:
ChemMedChem, 2012, v. 7, n. 12, p. 2122, doi. 10.1002/cmdc.201200365
By:
- DeBono, Aaron J.;
- Xie, Jin Han;
- Ventura, Sabatino;
- Pouton, Colin W.;
- Capuano, Ben;
- Scammells, Peter J.
Publication type:
Article
Synthesis and Biological Evaluation of Adenosines with Heterobicyclic and Polycyclic N6-Substituents as Adenosine A1 Receptor Agonists.
Published in:
ChemMedChem, 2012, v. 7, n. 7, p. 1191, doi. 10.1002/cmdc.201200208
By:
- Gosling, Joshua I.;
- Baker, Stephen P.;
- Haynes, John M.;
- Kassiou, Michael;
- Pouton, Colin W.;
- Warfe, Lyndon;
- White, Paul J.;
- Scammells, Peter J.
Publication type:
Article
Design Strategies for Bivalent Ligands Targeting GPCRs.
Published in:
ChemMedChem, 2011, v. 6, n. 6, p. 963, doi. 10.1002/cmdc.201100101
By:
- Shonberg, Jeremy;
- Scammells, Peter J.;
- Capuano, Ben
Publication type:
Article
Synthesis of Thieno-Fused Heterocycles through Reiterative Iodocyclization.
Published in:
Advanced Synthesis & Catalysis, 2014, v. 356, n. 9, p. 1974, doi. 10.1002/adsc.201400072
By:
- Aurelio, Luigi;
- Volpe, Rohan;
- Halim, Rosliana;
- Scammells, Peter J.;
- Flynn, Bernard L.
Publication type:
Article
Enantioenriched Positive Allosteric Modulators Display Distinct Pharmacology at the Dopamine D 1 Receptor.
Published in:
Molecules, 2021, v. 26, n. 13, p. 3799, doi. 10.3390/molecules26133799
By:
- Fyfe, Tim J.;
- Scammells, Peter J.;
- Lane, J. Robert;
- Capuano, Ben
Publication type:
Article
Ionic Liquid Forms of the Antimalarial Lumefantrine in Combination with LFCS Type IIIB Lipid-Based Formulations Preferentially Increase Lipid Solubility, In Vitro Solubilization Behavior and In Vivo Exposure.
Published in:
Pharmaceutics, 2020, v. 12, n. 1, p. 17, doi. 10.3390/pharmaceutics12010017
By:
- Tay, Erin;
- Nguyen, Tri-Hung;
- Ford, Leigh;
- Williams, Hywel D.;
- Benameur, Hassan;
- Scammells, Peter J.;
- Porter, Christopher J. H.
Publication type:
Article
An Allosteric Modulator of the Adenosine A1 Receptor Improves Cardiac Function Following Ischaemia in Murine Isolated Hearts.
Published in:
Pharmaceuticals (14248247), 2013, v. 6, n. 4, p. 546, doi. 10.3390/ph6040546
By:
- Butcher, Anna;
- Scammells, Peter J.;
- White, Paul J.;
- Devine, Shane M.;
- Rose'Meyer, Roselyn B.
Publication type:
Article
VCP746, a novel A1 adenosine receptor biased agonist, reduces hypertrophy in a rat neonatal cardiac myocyte model.
Published in:
Clinical & Experimental Pharmacology & Physiology, 2016, v. 43, n. 10, p. 976, doi. 10.1111/1440-1681.12616
By:
- Chuo, Chung H;
- Devine, Shane M;
- Scammells, Peter J;
- Krum, Henry;
- Christopoulos, Arthur;
- May, Lauren T;
- White, Paul J;
- Wang, Bing H
Publication type:
Article
The effect of two selective A1 -receptor agonists and the bitopic ligand VCP746 on heart rate and regional vascular conductance in conscious rats.
Published in:
2020
By:
- Cooper, Samantha L.;
- March, Julie;
- Sabbatini, Andrea R.;
- Hill, Stephen J.;
- Jörg, Manuela;
- Scammells, Peter J.;
- Woolard, Jeanette
Publication type:
journal article
Probe dependence of allosteric enhancers on the binding affinity of adenosine A1 -receptor agonists at rat and human A1 -receptors measured using NanoBRET.
Published in:
2019
By:
- Cooper, Samantha L.;
- Soave, Mark;
- Jörg, Manuela;
- Scammells, Peter J.;
- Woolard, Jeanette;
- Hill, Stephen J.
Publication type:
journal article
Cryptic pocket formation underlies allosteric modulator selectivity at muscarinic GPCRs.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-11062-7
By:
- Hollingsworth, Scott A.;
- Kelly, Brendan;
- Valant, Celine;
- Michaelis, Jordan Arthur;
- Mastromihalis, Olivia;
- Thompson, Geoff;
- Venkatakrishnan, A. J.;
- Hertig, Samuel;
- Scammells, Peter J.;
- Sexton, Patrick M.;
- Felder, Christian C.;
- Christopoulos, Arthur;
- Dror, Ron O.
Publication type:
Article
Development of Inhibitors of Plasmodium falciparum Apical Membrane Antigen 1 Based on Fragment Screening.
Published in:
Australian Journal of Chemistry, 2013, v. 66, n. 12, p. 1530, doi. 10.1071/CH13266
By:
- Lim, San Sui;
- Debono, Cael O.;
- MacRaild, Christopher A.;
- Chandrashekaran, Indu R.;
- Dolezal, Olan;
- Anders, Robin F.;
- Simpson, Jamie S.;
- Scanlon, Martin J.;
- Devine, Shane M.;
- Scammells, Peter J.;
- Norton, Raymond S.
Publication type:
Article
A Multi-Step Continuous Flow Process for the N-Demethylation of Alkaloids.
Published in:
Australian Journal of Chemistry, 2013, v. 66, n. 2, p. 17, doi. 10.1071/CH12463
By:
- Nakano, Yuji;
- Savage, G. Paul;
- Saubern, Simon;
- Scammells, Peter J.;
- Polyzos, Anastasios
Publication type:
Article
Efficient Iron-Catalyzed N-Demethylation of Tertiary Amine-N-oxides under Oxidative Conditions.
Published in:
Australian Journal of Chemistry, 2011, v. 64, n. 11, p. 21, doi. 10.1071/CH11320
By:
- Kok, Gaik B.;
- Scammells, Peter J.
Publication type:
Article
Driving antimalarial design through understanding of target mechanism.
Published in:
Biochemical Society Transactions, 2020, v. 48, n. 5, p. 2067, doi. 10.1042/BST20200224
By:
- Calic, Petar P. S.;
- Mansouri, Mahta;
- Scammells, Peter J.;
- McGowan, Sheena
Publication type:
Article
Virtual screening using a conformationally flexible target protein: models for ligand binding to p38α MAPK.
Published in:
Journal of Computer-Aided Molecular Design, 2012, v. 26, n. 4, p. 409, doi. 10.1007/s10822-012-9569-7
By:
- Vinh, Natalie;
- Simpson, Jamie;
- Scammells, Peter;
- Chalmers, David
Publication type:
Article
Biased Agonism at G Protein-Coupled Receptors: The Promise and the Challenges-A Medicinal Chemistry Perspective.
Published in:
Medicinal Research Reviews, 2014, v. 34, n. 6, p. 1286, doi. 10.1002/med.21318
By:
- Shonberg, Jeremy;
- Lopez, Laura;
- Scammells, Peter J.;
- Christopoulos, Arthur;
- Capuano, Ben;
- Lane, J. Robert
Publication type:
Article
Biocompatible Cationic Lipoamino Acids as Counterions for Oral Administration of API-Ionic Liquids.
Published in:
Pharmaceutical Research, 2022, v. 39, n. 10, p. 2405, doi. 10.1007/s11095-022-03305-y
By:
- Lai, Anthony;
- Leong, Nathania;
- Zheng, Dan;
- Ford, Leigh;
- Nguyen, Tri-Hung;
- Williams, Hywel D.;
- Benameur, Hassan;
- Scammells, Peter J.;
- Porter, Christopher J. H.
Publication type:
Article
Lipophilic Salts and Lipid-Based Formulations: Enhancing the Oral Delivery of Octreotide.
Published in:
Pharmaceutical Research, 2021, v. 38, n. 6, p. 1125, doi. 10.1007/s11095-021-03063-3
By:
- Li, Peng;
- Ford, Leigh;
- Haque, Shadabul;
- McInerney, Mitchell P.;
- Williams, Hywel D.;
- Scammells, Peter J.;
- Thompson, Philip E.;
- Jannin, Vincent;
- Porter, Christopher J. H.;
- Benameur, Hassan;
- Pouton, Colin W.
Publication type:
Article
Synthesis and Utility of 2-Halo- O.
Published in:
European Journal of Organic Chemistry, 2011, v. 2011, n. 6, p. 1092, doi. 10.1002/ejoc.201001395
By:
- Devine, Shane M.;
- Scammells, Peter J.
Publication type:
Article
Grignard Reactions in Pyridinium and Phosphonium Ionic Liquids.
Published in:
European Journal of Organic Chemistry, 2011, v. 2011, n. 5, p. 942, doi. 10.1002/ejoc.201001468
By:
- Ford, Leigh;
- Atefi, Farzad;
- Singer, Robert D.;
- Scammells, Peter J.
Publication type:
Article
A new mechanism of allostery in a G protein-coupled receptor dimer.
Published in:
Nature Chemical Biology, 2014, v. 10, n. 9, p. 745, doi. 10.1038/nchembio.1593
By:
- Lane, J Robert;
- Donthamsetti, Prashant;
- Shonberg, Jeremy;
- Draper-Joyce, Christopher J;
- Dentry, Samuel;
- Michino, Mayako;
- Shi, Lei;
- López, Laura;
- Scammells, Peter J;
- Capuano, Ben;
- Sexton, Patrick M;
- Javitch, Jonathan A;
- Christopoulos, Arthur
Publication type:
Article