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Issues and progress with protein kinase inhibitors for cancer treatment.
Published in:
Nature Reviews Drug Discovery, 2003, v. 2, n. 4, p. 296, doi. 10.1038/nrd1066
By:
- Dancey, Janet;
- Sausville, Edward A.
Publication type:
Article
Growth Inhibition With Reversible Cell Cycle Arrest of Carcinoma Cells by Flavone L86-8275.
Published in:
JNCI: Journal of the National Cancer Institute, 1992, v. 84, n. 22, p. 1736
By:
- Kaur, Gurmeet;
- Stetler-Stevenson, Maryalice;
- Sebers, Sandra;
- Worland, Peter;
- Sedlacek, Harald;
- Myers, Charles;
- Czech, Jörg;
- Naik, Ramachandra;
- Sausville, Edward
Publication type:
Article
BOOK REVIEWS.
Published in:
JNCI: Journal of the National Cancer Institute, 1990, v. 82, n. 10, p. 875
By:
- SAUSVILLE, EDWARD A.
Publication type:
Article
BOOK REVIEWS.
Published in:
JNCI: Journal of the National Cancer Institute, 1990, v. 82, n. 10, p. 874
By:
- SAUSVILLE, EDWARD A.
Publication type:
Article
Hydroxylated Dimeric Naphthoquinones Increase the Generation of Reactive Oxygen Species, Induce Apoptosis of Acute Myeloid Leukemia Cells and Are Not Substrates of the Multidrug Resistance Proteins ABCB1 and ABCG2.
Published in:
Pharmaceuticals (14248247), 2016, v. 9, n. 1, p. 4, doi. 10.3390/ph9010004
By:
- Lapidus, Rena G.;
- Carter-Cooper, Brandon A.;
- Sadowska, Mariola;
- Eun Yong Choi;
- Wonodi, Omasiri;
- Muvarak, Nidal;
- Natarajan, Karthika;
- Pidugu, Lakshmi S.;
- Jaiswal, Anil;
- Toth, Eric A.;
- Rassool, Feyruz V.;
- Etemadi, Arash;
- Sausville, Edward A.;
- Baer, Maria R.;
- Emadi, Ashkan
Publication type:
Article
A direct interaction between NQO1 and a chemotherapeutic dimeric naphthoquinone.
Published in:
BMC Structural Biology, 2016, v. 16, p. 1, doi. 10.1186/s12900-016-0052-x
By:
- Mukhi Pidugu, Lakshmi Swarna;
- Mbimba, J. C. Emmanuel;
- Ahmad, Muqeet;
- Pozharski, Edwin;
- Sausville, Edward A.;
- Emadi, Ashkan;
- Toth, Eric A.
Publication type:
Article
T-cell lymphoma, tropical spastic paraparesis, and malignant fibrous histiocytoma in a patient with human T-cell lymphotropic virus, type 1.
Published in:
1989
By:
- Lee, James W.;
- Fox, Edward P.;
- Rodgers-Johnson, Pamela;
- Gibbs Jr., Clarence J.;
- DeFreitas, Elaine;
- Manns, Angela;
- Blattner, William;
- Cotelingam, James;
- Piccardo, Pedro;
- Mora, Carlos;
- Safar, Jiri;
- Liberski, Pawel;
- Sausville, Edward;
- Trepel, Jane;
- Kramer, Barnett S.;
- Lee, J W;
- Fox, E P;
- Rodgers-Johnson, P;
- Gibbs, C J Jr;
- DeFreitas, E
Publication type:
journal article
Histopathologic staging at initial diagnosis of mycosis fungoides and the Sézary syndrome. Definition of three distinctive prognostic groups.
Published in:
1988
By:
- Sausville, Edward A.;
- Eddy, Joyce L.;
- Makuch, Robert W.;
- Fischmann, A. B.;
- Schechter, Geraldine P.;
- Mathews, Mary;
- Glatstein, Eli;
- Ihde, Daniel C.;
- Kaye, Frederic;
- Veach, Stephen R.;
- Phelps, Ruby;
- O'Connor, Terry;
- Trepel, Jane B.;
- Cotelingam, James D.;
- Gazder, Adi F.;
- Minna, John D.;
- Bunn Jr., Paul A.;
- Sausville, E A;
- Eddy, J L;
- Makuch, R W
Publication type:
journal article
Aurora kinases dawn as cancer drug targets.
Published in:
Nature Medicine, 2004, v. 10, n. 3, p. 234, doi. 10.1038/nm0304-234
By:
- Sausville, Edward A.
Publication type:
Article
Peripheral blood blast rate of clearance is an independent predictor of clinical response and outcomes in acute myeloid leukaemia.
Published in:
British Journal of Haematology, 2020, v. 188, n. 6, p. 881, doi. 10.1111/bjh.16261
By:
- Holtzman, Noa G.;
- El Chaer, Firas;
- Baer, Maria R.;
- Ali, Omer;
- Patel, Ameet;
- Duong, Vu H.;
- Sausville, Edward A.;
- Singh, Zeba N.;
- Koka, Rima;
- Zou, Ying S.;
- Etemadi, Arash;
- Emadi, Ashkan
Publication type:
Article
A gene expression database for the molecular pharmacology of cancer.
Published in:
Nature Genetics, 2000, v. 24, n. 3, p. 236, doi. 10.1038/73439
By:
- Scherf, Uwe;
- Ross, Douglas T.;
- Waltham, Mark;
- Smith, Lawrence H.;
- Lee, Jae K.;
- Tanabe, Lorraine;
- Kohn, Kurt W.;
- Reinhold, William C.;
- Myers, Timothy G.;
- Andrews, Darren T.;
- Scudiero, Dominic A.;
- Eisen, Michael B.;
- Sausville, Edward A.;
- Pommier, Yves;
- Botstein, David;
- Brown, Patrick O.;
- Weinstein, John N.
Publication type:
Article
Optimizing pegylated asparaginase use: An institutional guideline for dosing, monitoring, and management.
Published in:
Journal of Oncology Pharmacy Practice, 2020, v. 26, n. 1, p. 74, doi. 10.1177/1078155219838316
By:
- Bade, Najeebah A;
- Lu, Crystal;
- Patzke, Ciera L;
- Baer, Maria R;
- Duong, Vu H;
- Law, Jennie Y;
- Lee, Seung T;
- Sausville, Edward A;
- Zimrin, Ann B;
- Duffy, Alison P;
- Lawson, Justin;
- Emadi, Ashkan
Publication type:
Article
Identification of small molecule inhibitors of anthrax lethal factor.
Published in:
Nature Structural & Molecular Biology, 2004, v. 11, n. 1, p. 67, doi. 10.1038/nsmb711
By:
- Panchal, Rekha G.;
- Hermone, Ann R.;
- Tam Luong Nguyen;
- Tiang Yian Wong, Ann R.;
- Schwarzenbacher, Robert;
- Schmidt, James;
- Lane, Douglas;
- McGrath, Connor;
- Turk, Benjamin E.;
- Burnett, James;
- Aman, M. Javad;
- Little, Stephen;
- Sausville, Edward A.;
- Zaharevitz, Daniel W.;
- Cantley, Lewis C.;
- Liddington, Robert C.;
- Gussio, Rick;
- Bavari, Sina
Publication type:
Article
Phase 1 trial of navitoclax and sorafenib in patients with relapsed or refractory solid tumors with hepatocellular carcinoma expansion cohort.
Published in:
Investigational New Drugs, 2024, v. 42, n. 1, p. 127, doi. 10.1007/s10637-024-01420-8
By:
- Emiloju, Oluwadunni E.;
- Yin, Jun;
- Koubek, Emily;
- Reid, Joel M.;
- Borad, Mitesh J.;
- Lou, Yanyan;
- Seetharam, Mahesh;
- Edelman, Martin J.;
- Sausville, Edward A.;
- Jiang, Yixing;
- Kaseb, Ahmed O.;
- Posey, James A.;
- Davis, Sarah L.;
- Gores, Gregory J.;
- Roberts, Lewis R.;
- Takebe, Naoko;
- Schwartz, Gary K.;
- Hendrickson, Andrea E. Wahner;
- Kaufmann, Scott H.;
- Adjei, Alex A.
Publication type:
Article
First-in-human phase 1 study of filanesib (ARRY-520), a kinesin spindle protein inhibitor, in patients with advanced solid tumors.
Published in:
Investigational New Drugs, 2015, v. 33, n. 2, p. 440, doi. 10.1007/s10637-015-0211-0
By:
- LoRusso, Patricia;
- Goncalves, Priscila;
- Casetta, Lindsay;
- Carter, Judith;
- Litwiler, Kevin;
- Roseberry, Dale;
- Rush, Selena;
- Schreiber, Jennifer;
- Simmons, Heidi;
- Ptaszynski, Mieke;
- Sausville, Edward
Publication type:
Article
Surgical resection for recurrent retroperitoneal leiomyosarcoma and liposarcoma.
Published in:
World Journal of Surgical Oncology, 2018, v. 16, n. 1, p. N.PAG, doi. 10.1186/s12957-018-1505-4
By:
- Nathenson, Michael J;
- Barysauskas, Constance M;
- Nathenson, Robert A;
- Regine, William F;
- Hanna, Nader;
- Sausville, Edward
Publication type:
Article
Preclinical Modeling of Combination Treatments: Fantasy or Requirement?
Published in:
Annals of the New York Academy of Sciences, 2005, v. 1059, n. 1, p. 61, doi. 10.1196/annals.1339.024
By:
- DECKER, SHANNON;
- SAUSVILLE, EDWARD A.
Publication type:
Article
Inhibition of CDKs as a Therapeutic Modality.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 910, n. 1, p. 207, doi. 10.1111/j.1749-6632.2000.tb06710.x
By:
- SAUSVILLE, EDWARD A.;
- JOHNSON, JILL;
- ALLEY, MICHAEL;
- ZAHAREVITZ, DANIEL;
- SENDEROWICZ, ADRIAN M.
Publication type:
Article
Strategy and planning for chemopreventive drug development: Clinical development plans.
Published in:
Journal of Cellular Biochemistry, 1994, v. 56, p. 55, doi. 10.1002/jcb.240560906
By:
- Kelloff, Gary J.;
- Crowell, James A.;
- Boone, Charles W.;
- Steele, Vernon E.;
- Lubet, Ronald A.;
- Greenwald, Peter;
- Alberts, David S.;
- Covey, Joseph M.;
- Doody, Linda A.;
- Knapp, Gene G.;
- Nayfield, Susan;
- Parkinson, David R.;
- Prasad, V. K.;
- Prorok, Phillip C.;
- Sausville, Edward A.;
- Sigman, Caroline C.
Publication type:
Article
L-myc, a new myc-related gene amplified and expressed in human small cell lung cancer.
Published in:
Nature, 1985, v. 318, n. 6041, p. 69, doi. 10.1038/318069a0
By:
- Nau, Marion M.;
- Brooks, Burke J.;
- Battey, James;
- Sausville, Edward;
- Gazdar, Adi F.;
- Kirsch, Ilan R.;
- McBride, O. Wesley;
- Bertness, Virginia;
- Hollis, Gregory F.;
- Minna, John D.
Publication type:
Article
Respecting Cancer Drug Transportability: A Basis for Successful Lead Selection.
Published in:
2006
By:
- Sausville, Edward A.
Publication type:
Editorial
Versipelostatin: Unfolding an Unsweetened Death.
Published in:
JNCI: Journal of the National Cancer Institute, 2004, v. 96, n. 17, p. 1266, doi. 10.1093/jnci/djh276
By:
- Sausville, Edward A.
Publication type:
Article
Dragons 'Round the Fleece Again.
Published in:
2000
By:
- Sausville, Edward A.
Publication type:
Editorial
Preclinical and clinical development of cyclin-dependent kinase modulators.
Published in:
2000
By:
- Senderowicz, Adrian M.;
- Sausville, Edward A.;
- Senderowicz, A M;
- Sausville, E A
Publication type:
journal article
A Bcr/Abl kinase antagonist for chronic myelogenous leukemia: a promising path for progress emerges.
Published in:
1999
By:
- Sausville, Edward A.;
- Sausville, E A
Publication type:
commentary
Geldanamycins exquisitely inhibit HGF/SF-mediated tumor cell invasion.
Published in:
Oncogene, 2005, v. 24, n. 23, p. 3697, doi. 10.1038/sj.onc.1208499
By:
- Xie, Qian;
- Gao, Chong-Feng;
- Shinomiya, Nariyoshi;
- Sausville, Edward;
- Hay, Rick;
- Gustafson, Margaret;
- Shen, Yuehai;
- Wenkert, David;
- Woude, George F. Vande
Publication type:
Article
The broad-range cyclin-dependent kinase inhibitor UCN-01 induces apoptosis in colon carcinoma cells through transcriptional suppression of the Bcl-x<sub>L</sub> protein.
Published in:
Oncogene, 2005, v. 24, n. 1, p. 148, doi. 10.1038/sj.onc.1207842
By:
- Bhonde, Mandar R.;
- Hanski, Marie-Luise;
- Magrini, Roberta;
- Moorthy, Dhatchana;
- Müller, Antje;
- Sausville, Edward A.;
- Kohno, Kimitoshi;
- Wiegand, Peter;
- Daniel, Peter T.;
- Zeitz, Martin;
- Hanski, Christoph
Publication type:
Article
Induction of apoptosis in human leukemia cells by the tyrosine kinase inhibitor adaphostin proceeds through a RAF-1/MEK/ERK- and AKT-dependent process.
Published in:
Oncogene, 2004, v. 23, n. 7, p. 1364, doi. 10.1038/sj.onc.1207248
By:
- Chunrong Yu, Khalid;
- Rahmani, Mohamed;
- Almenara, Jorge;
- Dent, Paul;
- Grant, Steven;
- Sausville, Edward A.
Publication type:
Article
Antitumor activity of suramin in hormone-refractory prostate cancer controlling for hydrocortisone treatment and flutamide withdrawal as potentially confounding variables.
Published in:
1995
By:
- Dawson, Nancy A.;
- Cooper, Michael R.;
- Figg, William D.;
- Headlee, Donna J.;
- Thibault, Alain;
- Bergan, Raymond C.;
- Steinberg, Seth M.;
- Sausville, Edward A.;
- Myers, Charles E.;
- Sartor, Oliver;
- Dawson, N A;
- Cooper, M R;
- Figg, W D;
- Headlee, D J;
- Thibault, A;
- Bergan, R C;
- Steinberg, S M;
- Sausville, E A;
- Myers, C E;
- Sartor, O
Publication type:
journal article
Lymphomatoid papulosis associated with Ki-1-positive anaplastic large cell lymphoma. A report of two cases and a review of the literature.
Published in:
1994
By:
- McCarty, Matthew J.;
- Vukelja, Svetislava J.;
- Sausville, Edward A.;
- Perry, James J.;
- James, William D.;
- Jaffe, Elaine S.;
- Weiss, Raymond B.;
- McCarty, M J;
- Vukelja, S J;
- Sausville, E A;
- Perry, J J;
- James, W D;
- Jaffe, E S;
- Weiss, R B
Publication type:
journal article
Prognostic implications of a bone marrow histopathologic classification system in mycosis fungoides and the Sézary syndrome.
Published in:
1993
By:
- Graham, Scott J.;
- Sharpe, Robert W.;
- Steinberg, Seth M.;
- Cotelingam, James D.;
- Sausville, Edward A.;
- Foss, Francine M.;
- Graham, S J;
- Sharpe, R W;
- Steinberg, S M;
- Cotelingam, J D;
- Sausville, E A;
- Foss, F M
Publication type:
journal article
Prolactin-producing pituitary carcinoma with pulmonary metastases.
Published in:
1991
By:
- Atienza, Daniel M.;
- Vigersky, Robert J.;
- Lack, Ernest E.;
- Carriaga, Marisa;
- Rusnock, Eileen J.;
- Tsou, Edward;
- Cerrone, Federico;
- Kattah, Jorge G.;
- Sausville, Edward A.;
- Atienza, D M;
- Vigersky, R J;
- Lack, E E;
- Carriaga, M;
- Rusnock, E J;
- Tsou, E;
- Cerrone, F;
- Kattah, J G;
- Sausville, E A
Publication type:
journal article
A protein expression database for the molecular pharmacology of cancer.
Published in:
Electrophoresis, 1997, v. 18, n. 3/4, p. 647, doi. 10.1002/elps.1150180351
By:
- Myers, Timothy G.;
- Anderson, N. Leigh;
- Waltham, Mark;
- Li, Guang;
- Buolamwini, John K.;
- Scudiero, Dominic A.;
- Paull, Kenneth D.;
- Sausville, Edward A.;
- Weinstein, John N.
Publication type:
Article
Phase 1 dose-escalation, pharmacokinetic, and cerebrospinal fluid distribution study of TAK-285, an investigational inhibitor of EGFR and HER2.
Published in:
Investigational New Drugs, 2014, v. 32, n. 1, p. 160, doi. 10.1007/s10637-013-9988-x
By:
- LoRusso, Patricia;
- Venkatakrishnan, Karthik;
- Chiorean, E.;
- Noe, Dennis;
- Wu, Jing-Tao;
- Sankoh, Serap;
- Corvez, Maria;
- Sausville, Edward
Publication type:
Article
Phase I study of UCN-01 and perifosine in patients with relapsed and refractory acute leukemias and high-risk myelodysplastic syndrome.
Published in:
Investigational New Drugs, 2013, v. 31, n. 5, p. 1217, doi. 10.1007/s10637-013-9937-8
By:
- Gojo, Ivana;
- Perl, Alexander;
- Luger, Selina;
- Baer, Maria;
- Norsworthy, Kelly;
- Bauer, Kenneth;
- Tidwell, Michael;
- Fleckinger, Stephanie;
- Carroll, Martin;
- Sausville, Edward
Publication type:
Article
Factors affecting the pharmacokinetic profile of MS-275, a novel histone deacetylase inhibitor, in patients with cancer.
Published in:
Investigational New Drugs, 2006, v. 24, n. 5, p. 367, doi. 10.1007/s10637-005-5707-6
By:
- Milin Acharya;
- Judith Karp;
- Edward Sausville;
- Kyunghwa Hwang;
- Qin Ryan;
- Ivana Gojo;
- Jűrgen Venitz;
- William Figg;
- Alex Sparreboom
Publication type:
Article
A high-performance liquid chromatography method using ultraviolet detection for the quantitation of flavopiridol from human plasma.
Published in:
Biomedical Chromatography, 2002, v. 16, n. 6, p. 379, doi. 10.1002/bmc.166
By:
- Zhai, Suoping;
- Sausville, Edward;
- Figg, William D.
Publication type:
Article
A high-performance liquid chromatography method using ultraviolet and fluorescence detection for the quantitation of UCN-01, 7-hydroxystaurosporine, from human plasma and saliva.
Published in:
Biomedical Chromatography, 2000, v. 14, n. 5, p. 338, doi. 10.1002/1099-0801(200008)14:5<338::AID-BMC993>3.0.CO;2-6
By:
- Bauer, Kenneth S.;
- Lush, Richard M.;
- Rudek, Michelle A.;
- Shih, Carolyn;
- Sausville, Edward;
- Figg, William D.
Publication type:
Article
A Phase II Trial of Gallium Nitrate in Patients with Androgen-Metastatic Prostate Cancer.
Published in:
Urologia Internationalis, 1999, v. 63, n. 2, p. 120, doi. 10.1159/000030430
By:
- Senderowicz, Adrian M.;
- Reid, Robert;
- Headlee, Donna;
- Abornathy, Troy;
- Horti, József;
- Lush, Richard M.;
- Reed, Eddie;
- Figg, William D.;
- Sausville, Edward A.
Publication type:
Article
Reviews and notes: Oncology.
Published in:
1995
By:
- Sausville, Edward E.
Publication type:
Book Review
Schistocytes, Echinocytes, Iron Deficiency Anemia, and Thrombocytopenia -- Hematologic Manifestations of Splenic Angiosarcoma.
Published in:
2013
By:
- Rosenblatt, Paula;
- Koka, Rima;
- Qing Chen;
- Papadimitriou, John C.;
- Sausville, Edward A.;
- Emadi, Ashkan
Publication type:
Journal Article
Schistocytes, Echinocytes, Iron Deficiency Anemia, and Thrombocytopenia -- Hematologic Manifestations of Splenic Angiosarcoma.
Published in:
Archives of Iranian Medicine (AIM), 2013, v. 16, n. 10, p. 602
By:
- Rosenblatt, Paula;
- Koka, Rima;
- Qing Chen;
- Papadimitriou, John C.;
- Sausville, Edward A.;
- Emadi, Ashkan
Publication type:
Article
Asparaginase Erwinia chrysanthemi effectively depletes plasma glutamine in adult patients with relapsed/refractory acute myeloid leukemia.
Published in:
2018
By:
- Emadi, Ashkan;
- Law, Jennie Y.;
- Strovel, Erin T.;
- Lapidus, Rena G.;
- Jeng, Linda J. B.;
- Lee, Myounghee;
- Blitzer, Miriam G.;
- Carter-Cooper, Brandon A.;
- Sewell, Danielle;
- Van Der Merwe, Isabella;
- Philip, Sunita;
- Imran, Mohammad;
- Yu, Stephen L.;
- Li, Hongxia;
- Amrein, Philip C.;
- Duong, Vu H.;
- Sausville, Edward A.;
- Baer, Maria R.;
- Fathi, Amir T.;
- Singh, Zeba
Publication type:
journal article
Looking for answers: the current status of neoadjuvant treatment in localized soft tissue sarcomas.
Published in:
2016
By:
- Nathenson, Michael;
- Sausville, Edward;
- Nathenson, Michael J
Publication type:
journal article
Cytotoxic drugs: past, present and future.
Published in:
2016
By:
- Newell, Herbie;
- Sausville, Edward
Publication type:
journal article
Autophagy modulation: a target for cancer treatment development.
Published in:
Cancer Chemotherapy & Pharmacology, 2015, v. 75, n. 3, p. 439, doi. 10.1007/s00280-014-2637-z
By:
- Duffy, Alison;
- Le, Jackson;
- Sausville, Edward;
- Emadi, Ashkan
Publication type:
Article
A phase I and pharmacokinetic study of oral perifosine with different loading schedules in patients with refractory neoplasms.
Published in:
Cancer Chemotherapy & Pharmacology, 2014, v. 74, n. 5, p. 955, doi. 10.1007/s00280-014-2569-7
By:
- Figg, William;
- Monga, Manish;
- Headlee, Donna;
- Shah, Avni;
- Chau, Cindy;
- Peer, Cody;
- Messman, Richard;
- Elsayed, Yusri;
- Murgo, Anthony;
- Melillo, Giovanni;
- Ryan, Qin;
- Kalnitskiy, Mikhail;
- Senderowicz, Adrian;
- Hollingshead, Melinda;
- Arbuck, Susan;
- Sausville, Edward
Publication type:
Article
Asparaginase in the treatment of non-ALL hematologic malignancies.
Published in:
Cancer Chemotherapy & Pharmacology, 2014, v. 73, n. 5, p. 875, doi. 10.1007/s00280-014-2402-3
By:
- Emadi, Ashkan;
- Zokaee, Hania;
- Sausville, Edward
Publication type:
Article
Phase I dose-escalation study of AZD7762, a checkpoint kinase inhibitor, in combination with gemcitabine in US patients with advanced solid tumors.
Published in:
Cancer Chemotherapy & Pharmacology, 2014, v. 73, n. 3, p. 539, doi. 10.1007/s00280-014-2380-5
By:
- Sausville, Edward;
- LoRusso, Patricia;
- Carducci, Michael;
- Carter, Judith;
- Quinn, Mary;
- Malburg, Lisa;
- Azad, Nilofer;
- Cosgrove, David;
- Knight, Richard;
- Barker, Peter;
- Zabludoff, Sonya;
- Agbo, Felix;
- Oakes, Patricia;
- Senderowicz, Adrian
Publication type:
Article
A phase I/II study of carfilzomib 2-10-min infusion in patients with advanced solid tumors.
Published in:
Cancer Chemotherapy & Pharmacology, 2013, v. 72, n. 4, p. 861, doi. 10.1007/s00280-013-2267-x
By:
- Papadopoulos, Kyriakos;
- Burris, Howard;
- Gordon, Michael;
- Lee, Peter;
- Sausville, Edward;
- Rosen, Peter;
- Patnaik, Amita;
- Cutler, Richard;
- Wang, Zhengping;
- Lee, Susan;
- Jones, Suzanne;
- Infante, Jeffery
Publication type:
Article

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