Works by Satała, Grzegorz

Results: 34

In the search for a lead structure among series of potent and selective hydantoin 5- HT7R agents: The drug-likeness in vitro study.

Published in:

Chemical Biology & Drug Design, 2017, v. 90, n. 6, p. 1295, doi. 10.1111/cbdd.13106

By:

Latacz, Gniewomir;
Lubelska, Annamaria;
Jastrzębska‐Więsek, Magdalena;
Partyka, Anna;
Sobiło, Andrzej;
Olejarz, Agnieszka;
Kucwaj‐Brysz, Katarzyna;
Satała, Grzegorz;
Bojarski, Andrzej J.;
Wesołowska, Anna;
Kieć‐Kononowicz, Katarzyna;
Handzlik, Jadwiga

Publication type:

Article

Solid-Supported Synthesis and 5- HT7/5- HT1A Receptor Affinity of Arylpiperazinylbutyl Derivatives of 4,5-dihydro-1,2,4-triazine-6-(1 H)-one.

Published in:

Chemical Biology & Drug Design, 2015, v. 86, n. 4, p. 697, doi. 10.1111/cbdd.12539

By:

Grychowska, Katarzyna;
Masurier, Nicolas;
Verdié, Pascal;
Satała, Grzegorz;
Bojarski, Andrzej J.;
Martinez, Jean;
Pawłowski, Maciej;
Subra, Gilles;
Zajdel, Paweł

Publication type:

Article

Synthesis and Evaluation of Antidepressant-like Activity of Some 4-Substituted 1-(2-methoxyphenyl) Piperazine Derivatives.

Published in:

Chemical Biology & Drug Design, 2015, v. 85, n. 3, p. 326, doi. 10.1111/cbdd.12394

By:

Waszkielewicz, Anna M.;
Pytka, Karolina;
Rapacz, Anna;
Wełna, Elżbieta;
Jarzyna, Monika;
Satała, Grzegorz;
Bojarski, Andrzej;
Sapa, Jacek;
Żmudzki, Paweł;
Filipek, Barbara;
Marona, Henryk

Publication type:

Article

Structural determinants influencing halogen bonding: a case study on azinesulfonamide analogs of aripiprazole as 5-HT1A, 5-HT7, and D2 receptor ligands.

Published in:

Chemistry Central Journal, 2018, v. 12, n. 1, p. 1, doi. 10.1186/s13065-018-0422-5

By:

Marciniec, Krzysztof;
Kurczab, Rafał;
Książek, Maria;
Bębenek, Ewa;
Chrobak, Elwira;
Satała, Grzegorz;
Bojarski, Andrzej J.;
Kusz, Joachim;
Zajdel, Paweł

Publication type:

Article

Amisulpride as a potential disease‐modifying drug in the treatment of tauopathies.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 12, p. 5482, doi. 10.1002/alz.13090

By:

Jahreis, Kathrin;
Brüge, Alina;
Borsdorf, Saskia;
Müller, Franziska E.;
Sun, Weilun;
Jia, Shaobo;
Kang, Dong Min;
Boesen, Nicolette;
Shin, Seulgi;
Lim, Sungsu;
Koroleva, Anastasia;
Satała, Grzegorz;
Bojarski, Andrzej J.;
Rakuša, Elena;
Fink, Anne;
Doblhammer‐Reiter, Gabriele;
Kim, Yun Kyung;
Dityatev, Alexander;
Ponimaskin, Evgeni;
Labus, Josephine

Publication type:

Article

Erratum: Synthesis of Some Aminophosphonates Bearing N-(Fluorophenyl)-piperazynyl Moiety and Their Activity toward Serotonin Receptors.

Published in:

Heteroatom Chemistry, 2016, v. 27, n. 2, p. 135, doi. 10.1002/hc.21312

By:

Lewkowski, Jarosław;
Jóźwiak, Andrzej;
Tokarz, Paweł;
Zagórski, Piotr M.;
Hamera, Róża;
Cal, Dariusz;
Satała, Grzegorz;
Bojarski, Andrzej J.

Publication type:

Article

Synthesis of Some Aminophosphonates Bearing N-(Fluorophenyl)-piperazynyl Moiety and Their Activity toward Serotonin Receptors.

Published in:

Heteroatom Chemistry, 2015, v. 26, n. 4, p. 290, doi. 10.1002/hc.21259

By:

Lewkowski, Jarosław;
Jóźwiak, Andrzej;
Tokarz, Paweł;
Zagórski, Piotr M.;
Hamera, Róża;
Cal, Dariusz;
Satała, Grzegorz;
Bojarski, Andrzej J.

Publication type:

Article

Arylpiperazinylalkyl derivatives of 8-amino-1,3-dimethylpurine-2,6-dione as novel multitarget 5-HT/D receptor agents with potential antipsychotic activity.

Published in:

Journal of Enzyme Inhibition & Medicinal Chemistry, 2016, v. 31, n. 6, p. 1048, doi. 10.3109/14756366.2015.1088844

By:

Chłoń-Rzepa, Grażyna;
Bucki, Adam;
Kołaczkowski, Marcin;
Partyka, Anna;
Jastrzębska-Więsek, Magdalena;
Satała, Grzegorz;
Bojarski, Andrzej J.;
Kalinowska-Tłuścik, Justyna;
Kazek, Grzegorz;
Mordyl, Barbara;
Głuch-Lutwin, Monika;
Wesołowska, Anna

Publication type:

Article

Xanthine–Dopamine Hybrid Molecules as Multitarget Drugs with Potential for the Treatment of Neurodegenerative Diseases.

Published in:

Biomolecules (2218-273X), 2023, v. 13, n. 7, p. 1079, doi. 10.3390/biom13071079

By:

Załuski, Michał;
Karcz, Tadeusz;
Drabczyńska, Anna;
Vielmuth, Christin;
Olejarz-Maciej, Agnieszka;
Głuch-Lutwin, Monika;
Mordyl, Barbara;
Siwek, Agata;
Satała, Grzegorz;
Müller, Christa E.;
Kieć-Kononowicz, Katarzyna

Publication type:

Article

1-(Arylsulfonyl-isoindol-2-yl)piperazines as 5-HT 6 R Antagonists: Mechanochemical Synthesis, In Vitro Pharmacological Properties and Glioprotective Activity.

Published in:

Biomolecules (2218-273X), 2023, v. 13, n. 1, p. 12, doi. 10.3390/biom13010012

By:

Canale, Vittorio;
Trybała, Wojciech;
Chaumont-Dubel, Séverine;
Koczurkiewicz-Adamczyk, Paulina;
Satała, Grzegorz;
Bento, Ophélie;
Blicharz-Futera, Klaudia;
Bantreil, Xavier;
Pękala, Elżbieta;
Bojarski, Andrzej J.;
Lamaty, Frédéric;
Marin, Philippe;
Zajdel, Paweł

Publication type:

Article

The Novel Pimavanserin Derivative ST-2300 with Histamine H 3 Receptor Affinity Shows Reduced 5-HT 2A Binding, but Maintains Antidepressant- and Anxiolytic-like Properties in Mice.

Published in:

Biomolecules (2218-273X), 2022, v. 12, n. 5, p. 683, doi. 10.3390/biom12050683

By:

Venkatachalam, Karthikkumar;
Zhong, Sicheng;
Dubiel, Mariam;
Satała, Grzegorz;
Sadek, Bassem;
Stark, Holger

Publication type:

Article

Exploring protein hotspots by optimized fragment pharmacophores.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-23443-y

By:

Bajusz, Dávid;
Wade, Warren S.;
Satała, Grzegorz;
Bojarski, Andrzej J.;
Ilaš, Janez;
Ebner, Jessica;
Grebien, Florian;
Papp, Henrietta;
Jakab, Ferenc;
Douangamath, Alice;
Fearon, Daren;
von Delft, Frank;
Schuller, Marion;
Ahel, Ivan;
Wakefield, Amanda;
Vajda, Sándor;
Gerencsér, János;
Pallai, Péter;
Keserű, György M.

Publication type:

Article

Allosteric Inhibition of Serotonin 5-HT7 Receptors by Zinc Ions.

Published in:

Molecular Neurobiology, 2018, v. 55, n. 4, p. 2897, doi. 10.1007/s12035-017-0536-0

By:

Satała, Grzegorz;
Duszyńska, Beata;
Lenda, Tomasz;
Nowak, Gabriel;
Bojarski, Andrzej J.

Publication type:

Article

Concentration-Dependent Dual Mode of Zn Action at Serotonin 5-HT1A Receptors: In Vitro and In Vivo Studies.

Published in:

Molecular Neurobiology, 2016, v. 53, n. 10, p. 6869, doi. 10.1007/s12035-015-9586-3

By:

Satała, Grzegorz;
Duszyńska, Beata;
Stachowicz, Katarzyna;
Rafalo, Anna;
Pochwat, Bartlomiej;
Luckhart, Christine;
Albert, Paul;
Daigle, Mireille;
Tanaka, Kenji;
Hen, René;
Lenda, Tomasz;
Nowak, Gabriel;
Bojarski, Andrzej;
Szewczyk, Bernadeta

Publication type:

Article

The Effect of Carboxamide/Sulfonamide Replacement in Arylpiperazinylalkyl Derivatives on Activity to Serotonin and Dopamine Receptors.

Published in:

Archiv der Pharmazie, 2017, v. 350, n. 10, p. n/a, doi. 10.1002/ardp.201700090

By:

Kowalski, Piotr;
Śliwa, Paweł;
Satała, Grzegorz;
Kurczab, Rafał;
Bartos, Ilona;
Zuchowicz, Karol

Publication type:

Article

Structure-5-HT/D2 Receptor Affinity Relationship in a New Group of 1-Arylpiperazynylalkyl Derivatives of 8-Dialkylamino-3,7-dimethyl-1 H-purine-2,6(3 H,7 H)-dione.

Published in:

Archiv der Pharmazie, 2016, v. 349, n. 10, p. 774, doi. 10.1002/ardp.201600162

By:

Żmudzki, Paweł;
Satała, Grzegorz;
Chłoń ‐ Rzepa, Grażyna;
Bojarski, Andrzej J.;
Kazek, Grzegorz;
Siwek, Agata;
Gryboś, Anna;
Głuch ‐ Lutwin, Monika;
Wesołowska, Anna;
Pawłowski, Maciej

Publication type:

Article

New Arylpiperazinylalkyl Derivatives of 8-Alkoxy-purine-2,6-dione and Dihydro[1,3]oxazolo[2,3- f]purinedione Targeting the Serotonin 5-HT1A/5-HT2A/5-HT7 and Dopamine D2 Receptors.

Published in:

Archiv der Pharmazie, 2015, v. 348, n. 4, p. 242, doi. 10.1002/ardp.201500015

By:

Chłoń ‐ Rzepa, Grażyna;
Zagórska, Agnieszka;
Bucki, Adam;
Kołaczkowski, Marcin;
Pawłowski, Maciej;
Satała, Grzegorz;
Bojarski, Andrzej J.;
Partyka, Anna;
Wesołowska, Anna;
Pękala, Elżbieta;
Słoczyńska, Karolina

Publication type:

Article

Quinolinesulfonamides of Aryloxy-/Arylthio-ethyl Piperidines: Influence of an Arylether Fragment on 5-HT1A/5-HT7 Receptor Selectivity.

Published in:

Archiv der Pharmazie, 2013, v. 346, n. 3, p. 180, doi. 10.1002/ardp.201200322

By:

Grychowska, Katarzyna;
Marciniec, Krzysztof;
Canale, Vittorio;
Szymiec, Michał;
Glanowski, Grzegorz;
Satała, Grzegorz;
Maślankiewicz, Andrzej;
Pawłowski, Maciej;
Bojarski, Andrzej J.;
Zajdel, Paweł

Publication type:

Article

New Triazine Derivatives as Serotonin 5-HT 6 Receptor Ligands.

Published in:

Molecules, 2023, v. 28, n. 3, p. 1108, doi. 10.3390/molecules28031108

By:

Łażewska, Dorota;
Więcek, Małgorzata;
Satała, Grzegorz;
Chałupnik, Paulina;
Żesławska, Ewa;
Honkisz-Orzechowska, Ewelina;
Tarasek, Monika;
Latacz, Gniewomir;
Nitek, Wojciech;
Szymańska, Ewa;
Handzlik, Jadwiga

Publication type:

Article

Impact of the Substitution Pattern at the Basic Center and Geometry of the Amine Fragment on 5-HT 6 and D 3 R Affinity in the 1 H -Pyrrolo[3,2- c ]quinoline Series.

Published in:

Molecules, 2023, v. 28, n. 3, p. 1096, doi. 10.3390/molecules28031096

By:

Grychowska, Katarzyna;
Pietruś, Wojciech;
Kulawik, Ludmiła;
Bento, Ophélie;
Satała, Grzegorz;
Bantreil, Xavier;
Lamaty, Frédéric;
Bojarski, Andrzej J.;
Gołębiowska, Joanna;
Nikiforuk, Agnieszka;
Marin, Philippe;
Chaumont-Dubel, Séverine;
Kurczab, Rafał;
Zajdel, Paweł

Publication type:

Article

New, Eco-Friendly Method for Synthesis of 3-Chlorophenyl and 1,1′-Biphenyl Piperazinylhexyl Trazodone Analogues with Dual 5-HT 1A /5-HT 7 Affinity and Its Antidepressant-like Activity.

Published in:

Molecules, 2022, v. 27, n. 21, p. 7270, doi. 10.3390/molecules27217270

By:

Zaręba, Przemysław;
Partyka, Anna;
Latacz, Gniewomir;
Satała, Grzegorz;
Zajdel, Paweł;
Jaśkowska, Jolanta

Publication type:

Article

The Structural Determinants for α 1 -Adrenergic/Serotonin Receptors Activity among Phenylpiperazine-Hydantoin Derivatives.

Published in:

Molecules, 2021, v. 26, n. 22, p. 7025, doi. 10.3390/molecules26227025

By:

Kucwaj-Brysz, Katarzyna;
Dela, Anna;
Podlewska, Sabina;
Bednarski, Marek;
Siwek, Agata;
Satała, Grzegorz;
Czarnota, Kinga;
Handzlik, Jadwiga;
Kieć-Kononowicz, Katarzyna

Publication type:

Article

N -Skatyltryptamines—Dual 5-HT 6 R/D 2 R Ligands with Antipsychotic and Procognitive Potential.

Published in:

Molecules, 2021, v. 26, n. 15, p. 4605, doi. 10.3390/molecules26154605

By:

Hogendorf, Agata;
Hogendorf, Adam S.;
Kurczab, Rafał;
Satała, Grzegorz;
Szewczyk, Bernadeta;
Cieślik, Paulina;
Latacz, Gniewomir;
Handzlik, Jadwiga;
Lenda, Tomasz;
Kaczorowska, Katarzyna;
Staroń, Jakub;
Bugno, Ryszard;
Duszyńska, Beata;
Bojarski, Andrzej J.

Publication type:

Article

Design, Sustainable Synthesis and Biological Evaluation of a Novel Dual α2A/5-HT7 Receptor Antagonist with Antidepressant-Like Properties.

Published in:

Molecules, 2021, v. 26, n. 13, p. 3828, doi. 10.3390/molecules26133828

By:

Canale, Vittorio;
Kotańska, Magdalena;
Dziubina, Anna;
Stefaniak, Matylda;
Siwek, Agata;
Starowicz, Gabriela;
Marciniec, Krzysztof;
Kasza, Patryk;
Satała, Grzegorz;
Duszyńska, Beata;
Bantreil, Xavier;
Lamaty, Frédéric;
Bednarski, Marek;
Sapa, Jacek;
Zajdel, Paweł

Publication type:

Article

Microwave-Assisted Synthesis of Trazodone and Its Derivatives as New 5-HT1A Ligands: Binding and Docking Studies.

Published in:

Molecules, 2019, v. 24, n. 8, p. 1609, doi. 10.3390/molecules24081609

By:

Jaśkowska, Jolanta;
Zaręba, Przemysław;
Śliwa, Paweł;
Pindelska, Edyta;
Satała, Grzegorz;
Majka, Zbigniew;
Zhang, Wei

Publication type:

Article

Computer-Aided Studies for Novel Arylhydantoin 1,3,5-Triazine Derivatives as 5-HT6 Serotonin Receptor Ligands with Antidepressive-Like, Anxiolytic and Antiobesity Action In Vivo.

Published in:

Molecules, 2018, v. 23, n. 10, p. 2529, doi. 10.3390/molecules23102529

By:

Kurczab, Rafał;
Ali, Wesam;
Łażewska, Dorota;
Kotańska, Magdalena;
Jastrzębska-Więsek, Magdalena;
Satała, Grzegorz;
Więcek, Małgorzata;
Lubelska, Annamaria;
Latacz, Gniewomir;
Partyka, Anna;
Starek, Małgorzata;
Dąbrowska, Monika;
Wesołowska, Anna;
Jacob, Claus;
Kieć-Kononowicz, Katarzyna;
Handzlik, Jadwiga

Publication type:

Article

N-(4-Arylpiperazinoalkyl)acetamide derivatives of 1,3- and 3,7-dimethyl-1 H-purine-2,6(3 H,7 H)-diones and their 5-HT6, 5-HT7, and D2 receptors affinity.

Published in:

Heterocyclic Communications, 2015, v. 21, n. 1, p. 13, doi. 10.1515/hc-2014-0200

By:

Żmudzki, Paweł;
Satała, Grzegorz;
Chłoń-Rzepa, Grażyna;
Bojarski, Andrzej J.;
Popik, Piotr;
Zajdel, Paweł

Publication type:

Article

Design and Synthesis of Potential Multi-Target Antidepressants: Exploration of 1-(4-(7-Azaindole)-3,6-dihydropyridin-1-yl)alkyl-3-(1 H -indol-3-yl)pyrrolidine-2,5-dione Derivatives with Affinity for the Serotonin Transporter.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 20, p. 11276, doi. 10.3390/ijms252011276

By:

Wróbel, Martyna Z.;
Chodkowski, Andrzej;
Siwek, Agata;
Satała, Grzegorz;
Bojarski, Andrzej J.;
Dawidowski, Maciej

Publication type:

Article

Design, Synthesis and Biological Evaluation of Novel 1,3,5-Triazines: Effect of Aromatic Ring Decoration on Affinity to 5-HT 7 Receptor.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 21, p. 13308, doi. 10.3390/ijms232113308

By:

Kułaga, Damian;
Drabczyk, Anna Karolina;
Satała, Grzegorz;
Latacz, Gniewomir;
Boguszewska-Czubara, Anna;
Plażuk, Damian;
Jaśkowska, Jolanta

Publication type:

Article

The Phenoxyalkyltriazine Antagonists for 5-HT 6 Receptor with Promising Procognitive and Pharmacokinetic Properties In Vivo in Search for a Novel Therapeutic Approach to Dementia Diseases.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 19, p. 10773, doi. 10.3390/ijms221910773

By:

Sudoł, Sylwia;
Cios, Agnieszka;
Jastrzębska-Więsek, Magdalena;
Honkisz-Orzechowska, Ewelina;
Mordyl, Barbara;
Wilczyńska-Zawal, Natalia;
Satała, Grzegorz;
Kucwaj-Brysz, Katarzyna;
Partyka, Anna;
Latacz, Gniewomir;
Olejarz-Maciej, Agnieszka;
Wesołowska, Anna;
Handzlik, Jadwiga

Publication type:

Article

Antidepressants Differentially Regulate Intracellular Signaling from α1-Adrenergic Receptor Subtypes In Vitro.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 9, p. 4817, doi. 10.3390/ijms22094817

By:

Chmielarz, Piotr;
Kuśmierczyk, Justyna;
Rafa-Zabłocka, Katarzyna;
Chorązka, Katarzyna;
Kowalska, Marta;
Satała, Grzegorz;
Nalepa, Irena;
Pisani, Antonio

Publication type:

Article

The 1,3,5-Triazine Derivatives as Innovative Chemical Family of 5-HT6 Serotonin Receptor Agents with Therapeutic Perspectives for Cognitive Impairment.

Published in:

International Journal of Molecular Sciences, 2019, v. 20, n. 14, p. 3420, doi. 10.3390/ijms20143420

By:

Latacz, Gniewomir;
Lubelska, Annamaria;
Jastrzębska-Więsek, Magdalena;
Partyka, Anna;
Marć, Małgorzata Anna;
Satała, Grzegorz;
Wilczyńska, Daria;
Kotańska, Magdalena;
Więcek, Małgorzata;
Kamińska, Katarzyna;
Wesołowska, Anna;
Kieć-Kononowicz, Katarzyna;
Handzlik, Jadwiga

Publication type:

Article

Synthesis and Structure-Activity Relationship Analysis of 5-HT7 Receptor Antagonists: Piperazin-1-yl Substituted Unfused Heterobiaryls.

Published in:

Molecules, 2016, v. 21, n. 4, p. 433, doi. 10.3390/molecules21040433

By:

Strekowski, Lucjan;
Saçzewski, Jarosław;
Raux, Elizabeth A.;
Fernando, Nilmi T.;
Klenc, Jeff;
Paranjpe, Shirish;
Raszkiewicz, Aldona;
Blake, Ava L.;
Ehalt, Adam J.;
Barnes, Samuel;
Baranowski, Timothy C.;
Sullivan, Shannon M.;
Satała, Grzegorz;
Bojarski, Andrzej J.

Publication type:

Article

Solid-Phase Synthesis of Arylpiperazine Derivatives and Implementation of the Distributed Drug Discovery (D3) Project in the Search for CNS Agents.

Published in:

Molecules, 2011, v. 16, n. 5, p. 4104, doi. 10.3390/molecules16054104

By:

Zajdel, Paweł;
Król, Joanna;
Grychowska, Katarzyna;
Pawłowski, Maciej;
Subra, Gilles;
Nomezine, Gaël;
Martinez, Jean;
Satała, Grzegorz;
Bojarski, Andrzej J.;
Ziniu Zhou;
O'Donnell, Martin J.;
Scott, William L.

Publication type:

Article

Works by Satała, Grzegorz

In the search for a lead structure among series of potent and selective hydantoin 5- HT<sub>7</sub>R agents: The drug-likeness in vitro study.

Solid-Supported Synthesis and 5- HT<sub>7</sub>/5- HT<sub>1A</sub> Receptor Affinity of Arylpiperazinylbutyl Derivatives of 4,5-dihydro-1,2,4-triazine-6-(1 H)-one.

Synthesis and Evaluation of Antidepressant-like Activity of Some 4-Substituted 1-(2-methoxyphenyl) Piperazine Derivatives.

Structural determinants influencing halogen bonding: a case study on azinesulfonamide analogs of aripiprazole as 5-HT<sub>1A</sub>, 5-HT<sub>7</sub>, and D<sub>2</sub> receptor ligands.

Amisulpride as a potential disease‐modifying drug in the treatment of tauopathies.

Erratum: Synthesis of Some Aminophosphonates Bearing N-(Fluorophenyl)-piperazynyl Moiety and Their Activity toward Serotonin Receptors.

Synthesis of Some Aminophosphonates Bearing N-(Fluorophenyl)-piperazynyl Moiety and Their Activity toward Serotonin Receptors.

Arylpiperazinylalkyl derivatives of 8-amino-1,3-dimethylpurine-2,6-dione as novel multitarget 5-HT/D receptor agents with potential antipsychotic activity.

Xanthine–Dopamine Hybrid Molecules as Multitarget Drugs with Potential for the Treatment of Neurodegenerative Diseases.

1-(Arylsulfonyl-isoindol-2-yl)piperazines as 5-HT 6 R Antagonists: Mechanochemical Synthesis, In Vitro Pharmacological Properties and Glioprotective Activity.

The Novel Pimavanserin Derivative ST-2300 with Histamine H 3 Receptor Affinity Shows Reduced 5-HT 2A Binding, but Maintains Antidepressant- and Anxiolytic-like Properties in Mice.

Exploring protein hotspots by optimized fragment pharmacophores.

Allosteric Inhibition of Serotonin 5-HT<sub>7</sub> Receptors by Zinc Ions.

Concentration-Dependent Dual Mode of Zn Action at Serotonin 5-HT1A Receptors: In Vitro and In Vivo Studies.

The Effect of Carboxamide/Sulfonamide Replacement in Arylpiperazinylalkyl Derivatives on Activity to Serotonin and Dopamine Receptors.

Structure-5-HT/D<sub>2</sub> Receptor Affinity Relationship in a New Group of 1-Arylpiperazynylalkyl Derivatives of 8-Dialkylamino-3,7-dimethyl-1 H-purine-2,6(3 H,7 H)-dione.

New Arylpiperazinylalkyl Derivatives of 8-Alkoxy-purine-2,6-dione and Dihydro[1,3]oxazolo[2,3- f]purinedione Targeting the Serotonin 5-HT<sub>1A</sub>/5-HT<sub>2A</sub>/5-HT<sub>7</sub> and Dopamine D<sub>2</sub> Receptors.

Quinolinesulfonamides of Aryloxy-/Arylthio-ethyl Piperidines: Influence of an Arylether Fragment on 5-HT<sub>1A</sub>/5-HT<sub>7</sub> Receptor Selectivity.

New Triazine Derivatives as Serotonin 5-HT 6 Receptor Ligands.

Impact of the Substitution Pattern at the Basic Center and Geometry of the Amine Fragment on 5-HT 6 and D 3 R Affinity in the 1 H -Pyrrolo[3,2- c ]quinoline Series.

New, Eco-Friendly Method for Synthesis of 3-Chlorophenyl and 1,1′-Biphenyl Piperazinylhexyl Trazodone Analogues with Dual 5-HT 1A /5-HT 7 Affinity and Its Antidepressant-like Activity.

The Structural Determinants for α 1 -Adrenergic/Serotonin Receptors Activity among Phenylpiperazine-Hydantoin Derivatives.

N -Skatyltryptamines—Dual 5-HT 6 R/D 2 R Ligands with Antipsychotic and Procognitive Potential.

Design, Sustainable Synthesis and Biological Evaluation of a Novel Dual α2A/5-HT7 Receptor Antagonist with Antidepressant-Like Properties.

Microwave-Assisted Synthesis of Trazodone and Its Derivatives as New 5-HT1A Ligands: Binding and Docking Studies.

Computer-Aided Studies for Novel Arylhydantoin 1,3,5-Triazine Derivatives as 5-HT6 Serotonin Receptor Ligands with Antidepressive-Like, Anxiolytic and Antiobesity Action In Vivo.

N-(4-Arylpiperazinoalkyl)acetamide derivatives of 1,3- and 3,7-dimethyl-1 H-purine-2,6(3 H,7 H)-diones and their 5-HT<sub>6</sub>, 5-HT<sub>7</sub>, and D<sub>2</sub> receptors affinity.

Design and Synthesis of Potential Multi-Target Antidepressants: Exploration of 1-(4-(7-Azaindole)-3,6-dihydropyridin-1-yl)alkyl-3-(1 H -indol-3-yl)pyrrolidine-2,5-dione Derivatives with Affinity for the Serotonin Transporter.

Design, Synthesis and Biological Evaluation of Novel 1,3,5-Triazines: Effect of Aromatic Ring Decoration on Affinity to 5-HT 7 Receptor.

The Phenoxyalkyltriazine Antagonists for 5-HT 6 Receptor with Promising Procognitive and Pharmacokinetic Properties In Vivo in Search for a Novel Therapeutic Approach to Dementia Diseases.

Antidepressants Differentially Regulate Intracellular Signaling from α1-Adrenergic Receptor Subtypes In Vitro.

The 1,3,5-Triazine Derivatives as Innovative Chemical Family of 5-HT6 Serotonin Receptor Agents with Therapeutic Perspectives for Cognitive Impairment.

Synthesis and Structure-Activity Relationship Analysis of 5-HT7 Receptor Antagonists: Piperazin-1-yl Substituted Unfused Heterobiaryls.

Solid-Phase Synthesis of Arylpiperazine Derivatives and Implementation of the Distributed Drug Discovery (D3) Project in the Search for CNS Agents.