Works by Sarantopoulos, John

Results: 39

Dose-escalating and pharmacological study of bortezomib in adult cancer patients with impaired renal function: a National Cancer Institute Organ Dysfunction Working Group Study.

Published in:

Cancer Chemotherapy & Pharmacology, 2011, v. 68, n. 6, p. 1439, doi. 10.1007/s00280-011-1637-5

By:

Leal, Ticiana;
Remick, Scot;
Takimoto, Chris;
Ramanathan, Ramesh;
Davies, Angela;
Egorin, Merrill;
Hamilton, Anne;
LoRusso, Patricia;
Shibata, Stephen;
Lenz, Heinz-Josef;
Mier, James;
Sarantopoulos, John;
Mani, Sridhar;
Wright, John;
Ivy, S.;
Neuwirth, Rachel;
Moltke, Lisa;
Venkatakrishnan, Karthik;
Mulkerin, Daniel

Publication type:

Article

Tesetaxel, a new oral taxane, in combination with capecitabine: a phase I, dose-escalation study in patients with advanced solid tumors.

Published in:

Cancer Chemotherapy & Pharmacology, 2011, v. 68, n. 6, p. 1565, doi. 10.1007/s00280-011-1639-3

By:

Saif, Muhammad;
Sarantopoulos, John;
Patnaik, Amita;
Tolcher, Anthony;
Takimoto, Chris;
Beeram, Murali

Publication type:

Article

A phase I study of MN-029 (denibulin), a novel vascular-disrupting agent, in patients with advanced solid tumors.

Published in:

Cancer Chemotherapy & Pharmacology, 2011, v. 68, n. 4, p. 959, doi. 10.1007/s00280-011-1565-4

By:

Ricart, Alejandro;
Ashton, Edward;
Cooney, Matthew;
Sarantopoulos, John;
Brell, Joanna;
Feldman, Maria;
Ruby, Kale;
Matsuda, Kazuko;
Munsey, Mark;
Medina, Gerardo;
Zambito, Angela;
Tolcher, Anthony;
Remick, Scot

Publication type:

Article

Phase I study of paclitaxel poliglumex administered weekly for patients with advanced solid malignancies.

Published in:

Cancer Chemotherapy & Pharmacology, 2009, v. 64, n. 2, p. 287, doi. 10.1007/s00280-008-0869-5

By:

Mita, Monica;
Mita, Alain;
Sarantopoulos, John;
Takimoto, Chris H.;
Rowinsky, Eric K.;
Romero, Ofelia;
Angiuli, Patrizia;
Allievi, Cecilia;
Eisenfeld, Amy;
Verschraegen, Claire F.

Publication type:

Article

Phase I study of cetuximab, erlotinib, and bevacizumab in patients with advanced solid tumors.

Published in:

Cancer Chemotherapy & Pharmacology, 2009, v. 63, n. 6, p. 1065, doi. 10.1007/s00280-008-0811-x

By:

Chia-Chi Lin;
Calvo, Emiliano;
Papadopoulos, Kyriakos P.;
Patnaik, Amita;
Sarantopoulos, John;
Mita, Alain C.;
Preston, Glenn G.;
Mita, Monica M.;
Rodon, Jordi;
Mays, Theresa;
I.-Tien Yeh;
O'Rourke, Pat;
Takimoto, Chris H.;
Dancey, Janet E.;
Chen, Helen;
Tolcher, Anthony W.

Publication type:

Article

Modulation of autophagy: a Phase II study of vorinostat plus hydroxychloroquine versus regorafenib in chemotherapy-refractory metastatic colorectal cancer (mCRC).

Published in:

2022

By:

Arora, Sukeshi Patel;
Tenner, Laura;
Sarantopoulos, John;
Morris, Jay;
Liu, Qianqian;
Mendez, Jenny A.;
Curiel, Tyler;
Michalek, Joel;
Mahalingam, Devalingam

Publication type:

journal article

Phase 1 safety, pharmacokinetic and pharmacodynamic study of the cyclin-dependent kinase inhibitor dinaciclib administered every three weeks in patients with advanced malignancies.

Published in:

2017

By:

Mita, Monica M;
Mita, Alain C;
Moseley, Jennifer L;
Poon, Jennifer;
Small, Karen A;
Jou, Ying-Ming;
Kirschmeier, Paul;
Zhang, Da;
Zhu, Yali;
Statkevich, Paul;
Sankhala, Kamelesh K;
Sarantopoulos, John;
Cleary, James M;
Chirieac, Lucian R;
Rodig, Scott J;
Bannerji, Rajat;
Shapiro, Geoffrey I

Publication type:

journal article

Phase II trial of single-agent foretinib (GSK1363089) in patients with recurrent or metastatic squamous cell carcinoma of the head and neck.

Published in:

Investigational New Drugs, 2013, v. 31, n. 2, p. 417, doi. 10.1007/s10637-012-9861-3

By:

Seiwert, Tanguy;
Sarantopoulos, John;
Kallender, Howard;
McCallum, Stewart;
Keer, Harold;
Blumenschein, George

Publication type:

Article

Phase 1 study of M2698, a p70S6K/AKT dual inhibitor, in patients with advanced cancer.

Published in:

Journal of Hematology & Oncology, 2021, v. 14, n. 1, p. 1, doi. 10.1186/s13045-021-01132-z

By:

Tsimberidou, Apostolia-Maria;
Shaw, Jamie V.;
Juric, Dejan;
Verschraegen, Claire;
Weise, Amy M.;
Sarantopoulos, John;
Lopes, Gilberto;
Nemunaitis, John;
Mita, Monica;
Park, Haeseong;
Ellers-Lenz, Barbara;
Tian, Hui;
Xiong, Wenyuan;
Kaleta, Remigiusz;
Kurzrock, Razelle

Publication type:

Article

Pharmacokinetics of the Investigational Aurora A Kinase Inhibitor Alisertib in Adult Patients With Advanced Solid Tumors or Relapsed/Refractory Lymphoma With Varying Degrees of Hepatic Dysfunction.

Published in:

Journal of Clinical Pharmacology, 2019, v. 59, n. 9, p. 1204, doi. 10.1002/jcph.1416

By:

Zhou, Xiaofei;
Lockhart, A. Craig;
Fu, Siqing;
Nemunaitis, John;
Sarantopoulos, John;
Muehler, Andreas;
Rangachari, Lakshmi;
Bargfrede, Michael;
Venkatakrishnan, Karthik

Publication type:

Article

A Phase II, Multicenter, Single-Arm Study of Mipsagargin (G-202) as a Second-Line Therapy Following Sorafenib for Adult Patients with Progressive Advanced Hepatocellular Carcinoma.

Published in:

Cancers, 2019, v. 11, n. 6, p. 833, doi. 10.3390/cancers11060833

By:

Mahalingam, Devalingam;
Peguero, Julio;
Cen, Putao;
Arora, Sukeshi P.;
Sarantopoulos, John;
Rowe, Julie;
Allgood, Victoria;
Tubb, Benjamin;
Campos, Luis

Publication type:

Article

Open-label, multicenter, phase 1 study of alisertib (MLN8237), an aurora A kinase inhibitor, with docetaxel in patients with solid tumors.

Published in:

2016

By:

Graff, Julie N.;
Higano, Celestia S.;
Hahn, Noah M.;
Taylor, Matthew H.;
Zhang, Bin;
Zhou, Xiaofei;
Venkatakrishnan, Karthik;
Leonard, E. Jane;
Sarantopoulos, John

Publication type:

journal article

Evaluation of hepatic impairment on pharmacokinetics and safety of crizotinib in patients with advanced cancer.

Published in:

2018

By:

El-Khoueiry, Anthony B;
Sarantopoulos, John;
O'Bryant, Cindy L;
Ciombor, Kristen K;
Xu, Huiping;
O'Gorman, Melissa;
Chakrabarti, Jayeta;
Usari, Tiziana;
El-Rayes, Bassel F

Publication type:

journal article

A phase II study of REOLYSIN<sup>®</sup> (pelareorep) in combination with carboplatin and paclitaxel for patients with advanced malignant melanoma.

Published in:

2017

By:

Mahalingam, Devalingam;
Fountzilas, Christos;
Moseley, Jennifer;
Noronha, Nicole;
Tran, Hue;
Chakrabarty, Romit;
Selvaggi, Giovanni;
Coffey, Matthew;
Thompson, Brad;
Sarantopoulos, John

Publication type:

journal article

Safety and pharmacokinetics of cabazitaxel in patients with hepatic impairment: a phase I dose-escalation study.

Published in:

2017

By:

Sarantopoulos, John;
Mita, Alain;
He, Aiwu;
Wade, James;
Hsueh, Chung-Tsen;
Morris, John;
Lockhart, A.;
Quinn, David;
Hwang, Jimmy;
Mier, James;
Zhang, Wenping;
Wack, Claudine;
Yin, Jian;
Clot, Pierre-François;
Rixe, Olivier;
Mita, Alain C;
Wade, James L;
Morris, John C;
Lockhart, A Craig;
Quinn, David I

Publication type:

journal article

Randomized phase 1 crossover study assessing the bioequivalence of capsule and tablet formulations of dovitinib (TKI258) in patients with advanced solid tumors.

Published in:

2016

By:

Sarantopoulos, John;
Goel, Sanjay;
Chung, Vincent;
Munster, Pamela;
Pant, Shubham;
Patel, Manish;
Infante, Jeffrey;
Tawbi, Hussein;
Becerra, Carlos;
Bruce, Justine;
Kabbinavar, Fairooz;
Lockhart, A.;
Tan, Eugene;
Yang, Shu;
Carlson, Gary;
Scott, Jeffrey;
Sharma, Sunil;
Patel, Manish R;
Lockhart, A Craig;
Scott, Jeffrey W

Publication type:

journal article

Phase 1 study evaluating the safety and pharmacokinetics of pralatrexate in relapsed/refractory advanced solid tumors and lymphoma patients with mild, moderate, and severe renal impairment.

Published in:

2016

By:

Kelly, Kevin R.;
Gabrail, Nashat;
Weitman, Steven;
Sarantopoulos, John;
Olszanski, Anthony;
Edenfield, William;
Venitz, Jurgen;
Reddy, Guru;
Yang, Allen;
Hasal, Steven;
Lockhart, A.;
Olszanski, Anthony J;
Hasal, Steven J;
Lockhart, A Craig

Publication type:

journal article

Pharmacokinetics of eribulin mesylate in cancer patients with normal and impaired renal function.

Published in:

2015

By:

Tan, Antoinette;
Sarantopoulos, John;
Lee, Lucy;
Reyderman, Larisa;
He, Yi;
Olivo, Martin;
Goel, Sanjay;
Tan, Antoinette R

Publication type:

journal article

Phase I study of cabazitaxel plus cisplatin in patients with advanced solid tumors: study to evaluate the impact of cytochrome P450 3A inhibitors (aprepitant, ketoconazole) or inducers (rifampin) on the pharmacokinetics of cabazitaxel.

Published in:

Cancer Chemotherapy & Pharmacology, 2014, v. 74, n. 6, p. 1113, doi. 10.1007/s00280-014-2572-z

By:

Sarantopoulos, John;
Mita, Alain;
Wade, James;
Morris, John;
Rixe, Olivier;
Mita, Monica;
Dedieu, Jean-François;
Wack, Claudine;
Kassalow, Laurent;
Craig Lockhart, A.

Publication type:

Article

Phase I study of intravenously administered ATI-1123, a liposomal docetaxel formulation in patients with advanced solid tumors.

Published in:

Cancer Chemotherapy & Pharmacology, 2014, v. 74, n. 6, p. 1241, doi. 10.1007/s00280-014-2602-x

By:

Mahalingam, Devalingam;
Nemunaitis, John;
Malik, Laeeq;
Sarantopoulos, John;
Weitman, Steven;
Sankhala, Kamalesh;
Hart, Jessica;
Kousba, Ahmed;
Gallegos, Nicole;
Anderson, Gavin;
Charles, John;
Rogers, Jon;
Senzer, Neil;
Mita, Alain

Publication type:

Article

Predicting success in regulatory approval from Phase I results.

Published in:

Cancer Chemotherapy & Pharmacology, 2014, v. 74, n. 5, p. 1099, doi. 10.1007/s00280-014-2596-4

By:

Malik, Laeeq;
Mejia, Alex;
Parsons, Helen;
Ehler, Benjamin;
Mahalingam, Devalingam;
Brenner, Andrew;
Sarantopoulos, John;
Weitman, Steven

Publication type:

Article

Phase II study evaluating the efficacy, safety, and pharmacodynamic correlative study of dual antiangiogenic inhibition using bevacizumab in combination with sorafenib in patients with advanced malignant melanoma.

Published in:

Cancer Chemotherapy & Pharmacology, 2014, v. 74, n. 1, p. 77, doi. 10.1007/s00280-014-2479-8

By:

Mahalingam, Devalingam;
Malik, Laeeq;
Beeram, Muralidhar;
Rodon, Jordi;
Sankhala, Kamalesh;
Mita, Alain;
Benjamin, Daniel;
Ketchum, Norma;
Michalek, Joel;
Tolcher, Anthony;
Wright, John;
Sarantopoulos, John

Publication type:

Article

Novel LHRH-receptor-targeted cytolytic peptide, EP-100: first-in-human phase I study in patients with advanced LHRH-receptor-expressing solid tumors.

Published in:

Cancer Chemotherapy & Pharmacology, 2014, v. 73, n. 5, p. 931, doi. 10.1007/s00280-014-2424-x

By:

Curtis, Kelly;
Sarantopoulos, John;
Northfelt, Donald;
Weiss, Glen;
Barnhart, Kerry;
Whisnant, John;
Leuschner, Carola;
Alila, Hector;
Borad, Mitesh;
Ramanathan, Ramesh

Publication type:

Article

Pharmacokinetic study of omacetaxine mepesuccinate administered subcutaneously to patients with advanced solid and hematologic tumors.

Published in:

Cancer Chemotherapy & Pharmacology, 2013, v. 71, n. 1, p. 35, doi. 10.1007/s00280-012-1963-2

By:

Nemunaitis, John;
Mita, Alain;
Stephenson, Joe;
Mita, Monica;
Sarantopoulos, John;
Padmanabhan-Iyer, Swami;
Nanda, Nisha;
Gleich, Lyon;
Benichou, Annie-Claude;
Craig, Adam

Publication type:

Article

The effect of sonidegib (LDE225) on the pharmacokinetics of bupropion and warfarin in patients with advanced solid tumours.

Published in:

British Journal of Clinical Pharmacology, 2021, v. 87, n. 3, p. 1291, doi. 10.1111/bcp.14508

By:

Pooler, Darcy B.;
Ness, Dylan B.;
Sarantopoulos, John;
Squittieri, Nicholas;
Ravichandran, Shoba;
Britten, Carolyn D.;
Amaravadi, Ravi K.;
Vaishampayan, Ulka;
LoRusso, Patricia;
Shapiro, Geoffrey I.;
Olszanski, Anthony J.;
Perez, Raymond;
Gutierrez, Martin;
O'Rourke, Mark Allen;
Chung, Vincent;
Lee, James J.;
Lewis, Lionel D.

Publication type:

Article

Phase I study of imalumab (BAX69), a fully human recombinant antioxidized macrophage migration inhibitory factor antibody in advanced solid tumours.

Published in:

British Journal of Clinical Pharmacology, 2020, v. 86, n. 9, p. 1836, doi. 10.1111/bcp.14289

By:

Mahalingam, Devalingam;
Patel, Manish R.;
Sachdev, Jasgit C.;
Hart, Lowell L.;
Halama, Niels;
Ramanathan, Ramesh K.;
Sarantopoulos, John;
Völkel, Dirk;
Youssef, Ashraf;
Jong, Floris A.;
Tsimberidou, Apostolia Maria

Publication type:

Article

Evaluation of the effect of dabrafenib and metabolites on QTc interval in patients with <italic>BRAF</italic> V600–mutant tumours.

Published in:

British Journal of Clinical Pharmacology, 2018, v. 84, n. 4, p. 764, doi. 10.1111/bcp.13488

By:

Nebot, Noelia;
Arkenau, Hendrik‐Tobias;
Infante, Jeffrey R.;
Chandler, Jason C.;
Weickhardt, Andrew;
Lickliter, Jason D.;
Sarantopoulos, John;
Gordon, Michael S.;
Mak, Gabriel;
St‐Pierre, Annie;
Tang, Lihua;
Mookerjee, Bijoyesh;
Carson, Stanley W.;
Hayes, Siobhan;
Grossmann, Kenneth F.

Publication type:

Article

Nuclear cholesterol content and nucleoside triphosphatase activity are altered in the JCR:LA- cp corpulent rat.

Published in:

Journal of Cellular Biochemistry, 1996, v. 63, n. 3, p. 349, doi. 10.1002/(SICI)1097-4644(19961201)63:3<349::AID-JCB10>3.0.CO;2-C

By:

Czubryt, Michael P.;
Russell, James C.;
Sarantopoulos, John;
Pierce, Grant N.

Publication type:

Article

Pharmacokinetics of carfilzomib in patients with advanced malignancies and varying degrees of hepatic impairment: an open-label, single-arm, phase 1 study.

Published in:

Experimental Hematology & Oncology, 2017, v. 6, p. 1, doi. 10.1186/s40164-017-0086-1

By:

Brown, Jennifer;
Plummer, Ruth;
Bauer, Todd M.;
Anthony, Stephen;
Sarantopoulos, John;
De Vos, Filip;
White, Mike;
Schupp, Marco;
Ying Ou;
Vaishampayan, Ulka

Publication type:

Article

Academic Cancer Center Phase I Program Development.

Published in:

Oncologist, 2017, v. 22, n. 4, p. 369, doi. 10.1634/theoncologist.2016-0409

By:

Frankel, Arthur E.;
Flaherty, Keith T.;
Weiner, George J.;
Chen, Robert;
Azad, Nilofer S.;
Pishvaian, Michael J.;
Thompson, John A.;
Taylor, Matthew H.;
Mahadevan, Daruka;
Lockhart, A. Craig;
Vaishampayan, Ulka N.;
Berlin, Jordan D.;
Smith, David C.;
Sarantopoulos, John;
Riese, Matthew;
Saleh, Mansoor N.;
Ahn, Chul;
Frenkel, Eugene P.

Publication type:

Article

Phase Ib Study of the Histone Deacetylase 6 Inhibitor Citarinostat in Combination With Paclitaxel in Patients With Advanced Solid Tumors.

Published in:

Frontiers in Oncology, 2022, v. 11, p. 1, doi. 10.3389/fonc.2021.786120

By:

Gordon, Michael S.;
Shapiro, Geoffrey I.;
Sarantopoulos, John;
Juric, Dejan;
Lu, Brian;
Zarotiadou, Angeliki;
Connarn, Jamie N.;
Le Bruchec, Yvan;
Dumitru, Calin Dan;
Harvey, R. Donald

Publication type:

Article

Combined autophagy and HDAC inhibition.

Published in:

Autophagy, 2014, v. 10, n. 8, p. 1403, doi. 10.4161/auto.29231

By:

Mahalingam, Devalingam;
Mita, Monica;
Sarantopoulos, John;
Wood, Leslie;
Amaravadi, Ravi K.;
Davis, Lisa E.;
Mita, Alain C.;
Curiel, Tyler J.;
Espitia, Claudia M.;
Nawrocki, Steffan T.;
Giles, Francis J.;
Carew, Jennifer S.

Publication type:

Article

RANK Ligand: Effects of Inhibition.

Published in:

Current Oncology Reports, 2010, v. 12, n. 2, p. 80, doi. 10.1007/s11912-010-0088-1

By:

George, Saby;
Brenner, Andrew;
Sarantopoulos, John;
Bukowski, Ronald

Publication type:

Article

Effects of rifampin, itraconazole and esomeprazole on the pharmacokinetics of alisertib, an investigational aurora a kinase inhibitor in patients with advanced malignancies.

Published in:

Investigational New Drugs, 2018, v. 36, n. 2, p. 248, doi. 10.1007/s10637-017-0499-z

By:

Xiaofei Zhou;
Pant, Shubham;
Nemunaitis, John;
Lockhart, A. Craig;
Falchook, Gerald;
Bauer, Todd M.;
Patel, Manish;
Sarantopoulos, John;
Bargfrede, Michael;
Muehler, Andreas;
Rangachari, Lakshmi;
Bin Zhang;
Venkatakrishnan, Karthik

Publication type:

Article

Effect of alisertib, an investigational aurora a kinase inhibitor on the QTc interval in patients with advanced malignancies.

Published in:

Investigational New Drugs, 2018, v. 36, n. 2, p. 240, doi. 10.1007/s10637-017-0498-0

By:

Xiaofei Zhou;
Nemunaitis, John;
Pant, Shubham;
Bauer, Todd M.;
Patel, Manish;
Sarantopoulos, John;
Lockhart, A. Craig;
Goodman, Daniel;
Huebner, Dirk;
Mould, Diane R.;
Venkatakrishnan, Karthik

Publication type:

Article

Risks and benefits of phase I liver dysfunction studies: should patients with severe liver dysfunction be included in these trials?

Published in:

Investigational New Drugs, 2017, v. 35, n. 3, p. 386, doi. 10.1007/s10637-017-0425-4

By:

Fountzilas, Christos;
Stuart, Selena;
Hernandez, Brian;
Bowhay-Carnes, Elizabeth;
Michalek, Joel;
Sarantopoulos, John;
Karnad, Anand;
Patel, Sukeshi;
Weitman, Steven;
Mahalingam, Devalingam

Publication type:

Article

Phase I dose-escalation study of cabazitaxel administered in combination with cisplatin in patients with advanced solid tumors.

Published in:

Investigational New Drugs, 2014, v. 32, n. 6, p. 1236, doi. 10.1007/s10637-014-0145-y

By:

Lockhart, A.;
Sundaram, Shankar;
Sarantopoulos, John;
Mita, Monica;
Wang-Gillam, Andrea;
Moseley, Jennifer;
Barber, Stephanie;
Lane, Alex;
Wack, Claudine;
Kassalow, Laurent;
Dedieu, Jean-François;
Mita, Alain

Publication type:

Article

Effect of Food on the Pharmacokinetics of the Investigational Aurora A Kinase Inhibitor Alisertib (MLN8237) in Patients with Advanced Solid Tumors.

Published in:

Drugs in R&D, 2016, v. 16, n. 1, p. 45, doi. 10.1007/s40268-015-0114-8

By:

Falchook, Gerald;
Zhou, Xiaofei;
Venkatakrishnan, Karthik;
Kurzrock, Razelle;
Mahalingam, Devalingam;
Goldman, Jonathan;
Jung, JungAh;
Ullmann, Claudio;
Milch, Catherine;
Rosen, Lee;
Sarantopoulos, John

Publication type:

Article

Phase 1 Study of Monotherapy with KHK2866, an Anti-Heparin-Binding Epidermal Growth Factor-Like Growth Factor Monoclonal Antibody, in Patients with Advanced Cancer.

Published in:

2016

By:

Sarantopoulos, John;
Mita, Monica;
Birrer, Michael;
Cranmer, Lee;
Campos, Luis;
Zhang, Xiaoping;
Bristow, Penelope;
Kaito, Hidekuni;
Strout, Vincent;
Camacho, Luis;
Mita, Monica M;
Birrer, Michael J;
Cranmer, Lee D;
Campos, Luis T;
Camacho, Luis H

Publication type:

journal article