Works by Saragovi, H. Uri

Results: 34

Bladder p75 NTR -Mediated Anti-Inflammatory Response via the TLR4/TRAF6/NF-κB Axis.

Published in:

Life (2075-1729), 2025, v. 15, n. 6, p. 957, doi. 10.3390/life15060957

By:

Covarrubias, Claudia;
Mossa, Abubakr H.;
Yan, Laura R.;
Desormeau, Benjamin;
Cammisotto, Philippe G.;
Saragovi, H. Uri;
Campeau, Lysanne

Publication type:

Article

Loss of nucleus basalis neurons containing trkA immunoreactivity in individuals with mild cognitive impairment and early Alzheimer's disease.

Published in:

Journal of Comparative Neurology, 2000, v. 427, n. 1, p. 19, doi. 10.1002/1096-9861(20001106)427:1<19::AID-CNE2>3.0.CO;2-A

By:

Mufson, Elliott J.;
Ma, Shuang Y.;
Cochran, Elizabeth J.;
Bennett, David A.;
Beckett, Laural A.;
Jaffar, Syed;
Saragovi, H. Uri;
Kordower, Jeffrey H.

Publication type:

Article

p75NTR and Its Ligand ProNGF Activate Paracrine Mechanisms Etiological to the Vascular, Inflammatory, and Neurodegenerative Pathologies of Diabetic Retinopathy.

Published in:

Journal of Neuroscience, 2016, v. 36, n. 34, p. 8826, doi. 10.1523/JNEUROSCI.4278-15.2016

By:

Barcelona, Pablo F.;
Sitaras, Nicholas;
Galan, Alba;
Esquiva, Gema;
Jmaeff, Sean;
Jian, Yifan;
Sarunic, Marinko V.;
Cuenca, Nicolas;
Sapieha, Przemyslaw;
Saragovi, H. Uri

Publication type:

Article

BDNF, NT-3 and Trk receptor agonist monoclonal antibodies promote neuron survival, neurite extension, and synapse restoration in rat cochlea ex vivo models relevant for hidden hearing loss.

Published in:

PLoS ONE, 2019, v. 14, n. 10, p. 1, doi. 10.1371/journal.pone.0224022

By:

Szobota, Stephanie;
Mathur, Pranav D.;
Siegel, Sairey;
Black, KristenAnn;
Saragovi, H. Uri;
Foster, Alan C.

Publication type:

Article

Long-Lasting Rescue of Age-Associated Deficits in Cognition and the CNS Cholinergic Phenotype by a Partial Agonist Peptidomimetic Ligand of TrkA.

Published in:

Journal of Neuroscience, 2004, v. 24, n. 37, p. 8009, doi. 10.1523/JNEUROSCI.1508-04.2004

By:

Bruno, Martin A.;
Clarke, Paul B.;
Seltzer, Alicia;
Quirion, Rémi;
Burgess, Kevin;
Cuello, A. Claudio;
Saragovi, H. Uri

Publication type:

Article

HER2-Mediated Internalization of a Targeted Prodrug Cytotoxic Conjugate Is Dependent on the Valency of the Targeting Ligand.

Published in:

DNA & Cell Biology, 2005, v. 24, n. 6, p. 350, doi. 10.1089/dna.2005.24.351

By:

Guillemard, Veronique;
Nedev, Hinyu N.;
Berezov, Alan;
Murali, Ramachandran;
Saragovi, H. Uri

Publication type:

Article

A G[sub 1] Cell Cycle Arrest Induced by Ligands of the Reovirus Type 3 Receptor Is Secondary to Inactivation of p21ras and Mitogen-Activated Protein Kinase.

Published in:

DNA & Cell Biology, 1999, v. 18, n. 10, p. 763, doi. 10.1089/104454999314908

By:

Saragovi, H. Uri;
Rebai, Najet;
Guglielmo, Gianni M. Di;
MaCleod, Robert;
Sheng, Jinsong;
Rubin, Donald H.;
Greene, Mark I.

Publication type:

Article

A Cell Cycle Regulating Receptor Is Localized on Cell Surface and in Nuclei of Mitotically and Meiotically Dividing Cells.

Published in:

DNA & Cell Biology, 1998, v. 17, n. 3, p. 239, doi. 10.1089/dna.1998.17.239

By:

ROUX, EMMANUELLE;
ROBAIRE, BERNARD;
SARAGOVI, H. URI

Publication type:

Article

Differential roles of Trk and p75 neurotrophin receptors in tumorigenesis and chemoresistance ex vivo and in vivo.

Published in:

Cancer Chemotherapy & Pharmacology, 2010, v. 65, n. 6, p. 1047, doi. 10.1007/s00280-009-1110-x

By:

Bassili, Muriel;
Birman, Elena;
Schor, Nina F.;
Saragovi, H. Uri

Publication type:

Article

The Paradoxical Signals of Two TrkC Receptor Isoforms Supports a Rationale for Novel Therapeutic Strategies in ALS.

Published in:

PLoS ONE, 2016, v. 11, n. 10, p. 1, doi. 10.1371/journal.pone.0162307

By:

Brahimi, Fouad;
Maira, Mario;
Barcelona, Pablo F.;
Galan, Alba;
Aboulkassim, Tahar;
Teske, Katrina;
Rogers, Mary-Louise;
Bertram, Lisa;
Wang, Jing;
Yousefi, Masoud;
Rush, Robert;
Fabian, Marc;
Cashman, Neil;
Saragovi, H. Uri

Publication type:

Article

A kinase-deficient TrkC receptor isoform activates Arf6-Rac1 signaling through the scaffold protein tamalin.

Published in:

Journal of Cell Biology, 2006, v. 173, n. 2, p. 291, doi. 10.1083/jcb.200512013

By:

Esteban, Pedro F.;
Becker, Jodi;
Dorsey, Susan G.;
Caprari, Paola;
Palko, Mary Ellen;
Coppola, Vincenzo;
Tessarollo, Lino;
Hye-Young Yoon;
Randazzo, Paul A.;
Saragovi, H. Uri

Publication type:

Article

A p65/p95 Neural Surface Receptor is Expressed at the S-G2 Phase of the Cell Cycle and Defines Distinct Populations.

Published in:

European Journal of Neuroscience, 1996, v. 8, n. 2, p. 273, doi. 10.1111/j.1460-9568.1996.tb01211.x

By:

Rebai, Najet;
Almazan, Guillermina;
Wei, Ling;
Greene, Mark I.;
Uri Saragovi, H.

Publication type:

Article

Reduction of cortical TrkA but not p75NTR protein in early‐stage Alzheimer's disease.

Published in:

Annals of Neurology, 2004, v. 56, n. 4, p. 520, doi. 10.1002/ana.20233

By:

Scott E. Counts;
Muhammad Nadeem;
Joanne Wuu;
Stephen D. Ginsberg;
H. Uri Saragovi;
Elliott J. Mufson

Publication type:

Article

Signaling pathways mediating a selective induction of nitric oxide synthase II by tumor necrosis factor alpha in nerve growth factor-responsive cells.

Published in:

Journal of Neuroinflammation, 2005, v. 2, p. 19, doi. 10.1186/1742-2094-2-19

By:

Thomas, Michael S.;
WenRu Zhang;
Jordan, Paivi M.;
Saragovi, H. Uri;
Taglialatela, Giulio

Publication type:

Article

The intracellular domain of p75NTR as a determinant of cellular reducing potential and response to oxidant stress.

Published in:

Aging Cell, 2005, v. 4, n. 4, p. 187, doi. 10.1111/j.1474-9726.2005.00160.x

By:

Tyurina, Yulia Y.;
Nylander, Karen D.;
Mirnics, Zeljka Korade;
Portugal, Carmel;
Yan, Chaohua;
Zaccaro, Clara;
Saragovi, H. Uri;
Kagan, Valerian E.;
Schor, Nina F.

Publication type:

Article

A Pro-Nerve Growth Factor (proNGF) and NGF Binding Protein, α2-Macroglobulin, Differentially Regulates p75 and TrkA Receptors and Is Relevant to Neurodegeneration Ex Vivo and In Vivo.

Published in:

Molecular & Cellular Biology, 2015, v. 35, n. 19, p. 3396, doi. 10.1128/MCB.00544-15

By:

Barcelona, Pablo F.;
Saragovi, H. Uri

Publication type:

Article

Antagonism of proNGF or its receptor p75NTR reverses remodelling and improves bladder function in a mouse model of diabetic voiding dysfunction.

Published in:

Diabetologia, 2020, v. 63, n. 9, p. 1932, doi. 10.1007/s00125-020-05222-4

By:

Mossa, Abubakr H.;
Galan, Alba;
Cammisotto, Philippe G.;
Velasquez Flores, Monica;
Shamout, Samer;
Barcelona, Pablo;
Saragovi, H. Uri;
Campeau, Lysanne

Publication type:

Article

Pharmacological interrogation of TrkA-mediated mechanisms in hippocampal-dependent memory consolidation.

Published in:

PLoS ONE, 2019, v. 14, n. 6, p. 1, doi. 10.1371/journal.pone.0218036

By:

Josephy-Hernandez, Sylvia;
Pirvulescu, Iulia;
Maira, Mario;
Aboulkassim, Tahar;
Wong, Tak Pan;
McKinney, R. Anne;
Saragovi, H. Uri

Publication type:

Article

The route of administration influences the therapeutic index of an anti-proNGF neutralizing mAb for experimental treatment of Diabetic Retinopathy.

Published in:

PLoS ONE, 2018, v. 13, n. 6, p. 1, doi. 10.1371/journal.pone.0199079

By:

Barcelona, Pablo F.;
Galan, Alba;
Nedev, Hinyu;
Jian, Yifan;
Sarunic, Marinko V.;
Saragovi, H. Uri

Publication type:

Article

Aiming for the Sweet Spot: Glyco-Immune Checkpoints and γδ T Cells in Targeted Immunotherapy.

Published in:

Frontiers in Immunology, 2020, v. 11, p. N.PAG, doi. 10.3389/fimmu.2020.564499

By:

Bartish, Margarita;
del Rincón, Sonia V.;
Rudd, Christopher E.;
Saragovi, H. Uri

Publication type:

Article

Differential cross-regulation of TrkA and TrkC tyrosine kinase receptors with p75.

Published in:

Oncogene, 2003, v. 22, n. 36, p. 5677, doi. 10.1038/sj.onc.1206864

By:

Ivanisevic, Ljubica;
Banerjee, Kris;
Saragovi, H Uri

Publication type:

Article

Ultrasound delivery of a TrkA agonist confers neuroprotection to Alzheimer-associated pathologies.

Published in:

2022

By:

Xhima, Kristiana;
Markham-Coultes, Kelly;
Kofoed, Rikke Hahn;
Saragovi, H Uri;
Hynynen, Kullervo;
Aubert, Isabelle;
Hahn Kofoed, Rikke

Publication type:

journal article

Progression of age-associated cognitive impairment correlates with quantitative and qualitative loss of TrkA receptor protein in nucleus basalis and cortex.

Published in:

Journal of Neurochemistry, 2005, v. 95, n. 5, p. 1472, doi. 10.1111/j.1471-4159.2005.03479.x

By:

Saragovi, H. Uri

Publication type:

Article

An agonistic mAb directed to the TrkC receptor juxtamembrane region defines a trophic hot spot and interactions with p75 coreceptors.

Published in:

Developmental Neurobiology (19328451), 2010, v. 70, n. 3, p. 150, doi. 10.1002/dneu.20776

By:

Guillemard, Veronique;
Ivanisevic, Ljubica;
Garcia, Alba Galan;
Scholten, Vicki;
Lazo, Oscar M.;
Bronfman, Francisca C.;
Saragovi, H. Uri

Publication type:

Article

Neurotrophic rationale in glaucoma: A TrkA agonist, but not NGF or a p75 antagonist, protects retinal ganglion cells in vivo.

Published in:

Developmental Neurobiology (19328451), 2007, v. 67, n. 11, p. 1547, doi. 10.1002/dneu.20565

By:

Shi, ZhiHua;
Birman, Elena;
Saragovi, H. Uri

Publication type:

Article

Neurotrophic rationale in glaucoma: A TrkA agonist, but not NGF or a p75 antagonist, protects retinal ganglion cells in vivo.

Published in:

Developmental Neurobiology (19328451), 2007, v. 67, n. 7, p. 884, doi. 10.1002/dneu.20360

By:

Shi, ZhiHua;
Birman, Elena;
Saragovi, H. Uri

Publication type:

Article

Ligands Binding to Cell Surface Ganglioside GD2 Cause Src-Dependent Activation of N-Methyl-D-Aspartate Receptor Signaling and Changes in Cellular Morphology.

Published in:

PLoS ONE, 2015, v. 10, n. 8, p. 1, doi. 10.1371/journal.pone.0134255

By:

Tong, Wenyong;
Maira, Mario;
Gagnon, Martin;
Saragovi, H. Uri

Publication type:

Article

Neuronal Injury External to the Retina Rapidly Activates Retinal Glia, Followed by Elevation of Markers for Cell Cycle Re-Entry and Death in Retinal Ganglion Cells.

Published in:

PLoS ONE, 2014, v. 9, n. 7, p. 1, doi. 10.1371/journal.pone.0101349

By:

Galan, Alba;
Dergham, Pauline;
Escoll, Pedro;
de-la-Hera, Antonio;
D'Onofrio, Philippe M.;
Magharious, Mark M.;
Koeberle, Paulo D.;
Frade, José María;
Saragovi, H. Uri

Publication type:

Article

Combinatorial Assembly of Small Molecules into Bivalent Antagonists of TrkC or TrkA Receptors.

Published in:

PLoS ONE, 2014, v. 9, n. 3, p. 1, doi. 10.1371/journal.pone.0089617

By:

Brahimi, Fouad;
Ko, Eunhwa;
Malakhov, Andrey;
Burgess, Kevin;
Saragovi, H. Uri

Publication type:

Article

Raft-Dependent Endocytosis of Autocrine Motility Factor/Phosphoglucose Isomerase: A Potential Drug Delivery Route for Tumor Cells.

Published in:

PLoS ONE, 2008, v. 3, n. 10, p. 1, doi. 10.1371/journal.pone.0003597

By:

Kojic, Liliana D.;
Wiseman, Sam M.;
Ghaidi, Fariba;
Joshi, Bharat;
Nedev, Hinyu;
Saragovi, H. Uri;
Nabi, Ivan R.

Publication type:

Article

GD2 and GD3 gangliosides as diagnostic biomarkers for all stages and subtypes of epithelial ovarian cancer.

Published in:

Frontiers in Oncology, 2023, p. 1, doi. 10.3389/fonc.2023.1134763

By:

Galan, Alba;
Papaluca, Arturo;
Nejatie, Ali;
Matanes, Emad;
Brahimi, Fouad;
Wenyong Tong;
Hachim, Ibrahim Yaseen;
Yasmeen, Amber;
Carmona, Euridice;
Klein, Kathleen Oros;
Billes, Sonja;
Dawod, Ahmed E.;
Gawande, Prasad;
Jeter, Anna Milik;
Mes-Masson, Anne-Marie;
Greenwood, Celia M. T.;
Gotlieb, Walter H.;
Saragovi, H. Uri

Publication type:

Article

Prodrug chemotherapeutics bypass p-glycoprotein resistance and kill tumors in vivo with high efficacy and target-dependent selectivity.

Published in:

Oncogene, 2004, v. 23, n. 20, p. 3613, doi. 10.1038/sj.onc.1207463

By:

Guillemard, Veronique;
Saragovi, H. Uri

Publication type:

Article

In retinitis pigmentosa TrkC.T1-dependent vectorial Erk activity upregulates glial TNF-α, causing selective neuronal death.

Published in:

Cell Death & Disease, 2017, v. 8, n. 12, p. 1, doi. 10.1038/s41419-017-0074-8

By:

Galán, Alba;
Jmaeff, Sean;
Barcelona, Pablo F.;
Brahimi, Fouad;
Sarunic, Marinko V.;
Saragovi, H. Uri

Publication type:

Article

A Receptor That Subserves Reovirus Binding Can Inhibit Lymphocyte Proliferation Triggered by Mitogenic Signals.

Published in:

DNA & Cell Biology, 1995, v. 14, n. 8, p. 653, doi. 10.1089/dna.1995.14.653

By:

SARAGOVI, H. URI;
BHANDOOLA, AVINASH;
LEMERCIER, MAUD M.;
AKBAR, G.K. MOHAMMAD;
GREENE, MARK I.

Publication type:

Article

Works by Saragovi, H. Uri

Bladder p75 NTR -Mediated Anti-Inflammatory Response via the TLR4/TRAF6/NF-κB Axis.

Loss of nucleus basalis neurons containing trkA immunoreactivity in individuals with mild cognitive impairment and early Alzheimer's disease.

p75<sup>NTR</sup> and Its Ligand ProNGF Activate Paracrine Mechanisms Etiological to the Vascular, Inflammatory, and Neurodegenerative Pathologies of Diabetic Retinopathy.

BDNF, NT-3 and Trk receptor agonist monoclonal antibodies promote neuron survival, neurite extension, and synapse restoration in rat cochlea ex vivo models relevant for hidden hearing loss.

Long-Lasting Rescue of Age-Associated Deficits in Cognition and the CNS Cholinergic Phenotype by a Partial Agonist Peptidomimetic Ligand of TrkA.

HER2-Mediated Internalization of a Targeted Prodrug Cytotoxic Conjugate Is Dependent on the Valency of the Targeting Ligand.

A G[sub 1] Cell Cycle Arrest Induced by Ligands of the Reovirus Type 3 Receptor Is Secondary to Inactivation of p21ras and Mitogen-Activated Protein Kinase.

A Cell Cycle Regulating Receptor Is Localized on Cell Surface and in Nuclei of Mitotically and Meiotically Dividing Cells.

Differential roles of Trk and p75 neurotrophin receptors in tumorigenesis and chemoresistance ex vivo and in vivo.

The Paradoxical Signals of Two TrkC Receptor Isoforms Supports a Rationale for Novel Therapeutic Strategies in ALS.

A kinase-deficient TrkC receptor isoform activates Arf6-Rac1 signaling through the scaffold protein tamalin.

A p65/p95 Neural Surface Receptor is Expressed at the S-G<sub>2</sub> Phase of the Cell Cycle and Defines Distinct Populations.

Reduction of cortical TrkA but not p75NTR protein in early‐stage Alzheimer's disease.

Signaling pathways mediating a selective induction of nitric oxide synthase II by tumor necrosis factor alpha in nerve growth factor-responsive cells.

The intracellular domain of p75NTR as a determinant of cellular reducing potential and response to oxidant stress.

A Pro-Nerve Growth Factor (proNGF) and NGF Binding Protein, α<sub>2</sub>-Macroglobulin, Differentially Regulates p75 and TrkA Receptors and Is Relevant to Neurodegeneration Ex Vivo and In Vivo.

Antagonism of proNGF or its receptor p75NTR reverses remodelling and improves bladder function in a mouse model of diabetic voiding dysfunction.

Pharmacological interrogation of TrkA-mediated mechanisms in hippocampal-dependent memory consolidation.

The route of administration influences the therapeutic index of an anti-proNGF neutralizing mAb for experimental treatment of Diabetic Retinopathy.

Aiming for the Sweet Spot: Glyco-Immune Checkpoints and γδ T Cells in Targeted Immunotherapy.

Differential cross-regulation of TrkA and TrkC tyrosine kinase receptors with p75.

Ultrasound delivery of a TrkA agonist confers neuroprotection to Alzheimer-associated pathologies.

Progression of age-associated cognitive impairment correlates with quantitative and qualitative loss of TrkA receptor protein in nucleus basalis and cortex.

An agonistic mAb directed to the TrkC receptor juxtamembrane region defines a trophic hot spot and interactions with p75 coreceptors.

Neurotrophic rationale in glaucoma: A TrkA agonist, but not NGF or a p75 antagonist, protects retinal ganglion cells in vivo.

Neurotrophic rationale in glaucoma: A TrkA agonist, but not NGF or a p75 antagonist, protects retinal ganglion cells in vivo.

Ligands Binding to Cell Surface Ganglioside GD2 Cause Src-Dependent Activation of N-Methyl-D-Aspartate Receptor Signaling and Changes in Cellular Morphology.

Neuronal Injury External to the Retina Rapidly Activates Retinal Glia, Followed by Elevation of Markers for Cell Cycle Re-Entry and Death in Retinal Ganglion Cells.

Combinatorial Assembly of Small Molecules into Bivalent Antagonists of TrkC or TrkA Receptors.

Raft-Dependent Endocytosis of Autocrine Motility Factor/Phosphoglucose Isomerase: A Potential Drug Delivery Route for Tumor Cells.

GD2 and GD3 gangliosides as diagnostic biomarkers for all stages and subtypes of epithelial ovarian cancer.

Prodrug chemotherapeutics bypass p-glycoprotein resistance and kill tumors in vivo with high efficacy and target-dependent selectivity.

In retinitis pigmentosa TrkC.T1-dependent vectorial Erk activity upregulates glial TNF-α, causing selective neuronal death.

A Receptor That Subserves Reovirus Binding Can Inhibit Lymphocyte Proliferation Triggered by Mitogenic Signals.