Works matching AU Sansom, Owen

Results: 133

Melanoma Cells Break Down LPA to Establish Local Gradients That Drive Chemotactic Dispersal.

Published in:

PLoS Biology, 2014, v. 12, n. 10, p. 1, doi. 10.1371/journal.pbio.1001966

By:

Muinonen-Martin, Andrew J.;
Susanto, Olivia;
Zhang, Qifeng;
Smethurst, Elizabeth;
Faller, William J.;
Veltman, Douwe M.;
Kalna, Gabriela;
Lindsay, Colin;
Bennett, Dorothy C.;
Sansom, Owen J.;
Herd, Robert;
Jones, Robert;
Machesky, Laura M.;
Wakelam, Michael J. O.;
Knecht, David A.;
Insall, Robert H.

Publication type:

Article

Enterocyte-like differentiation defines metabolic gene signatures of CMS3 colorectal cancers and provides therapeutic vulnerability.

Published in:

Nature Communications, 2025, v. 16, p. 1, doi. 10.1038/s41467-024-55574-3

By:

Torang, Arezo;
Kirov, Aleksandar B.;
Lammers, Veerle;
Cameron, Kate;
Wouters, Valérie M.;
Jackstadt, Rene F.;
Lannagan, Tamsin R. M.;
de Jong, Joan H.;
Koster, Jan;
Sansom, Owen;
Medema, Jan Paul

Publication type:

Article

SHANK3 depletion leads to ERK signalling overdose and cell death in KRAS-mutant cancers.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-52326-1

By:

Lilja, Johanna;
Kaivola, Jasmin;
Conway, James R. W.;
Vuorio, Joni;
Parkkola, Hanna;
Roivas, Pekka;
Dibus, Michal;
Chastney, Megan R.;
Varila, Taru;
Jacquemet, Guillaume;
Peuhu, Emilia;
Wang, Emily;
Pentikäinen, Ulla;
Martinez D. Posada, Itziar;
Hamidi, Hellyeh;
Najumudeen, Arafath K.;
Sansom, Owen J.;
Barsukov, Igor L.;
Abankwa, Daniel;
Vattulainen, Ilpo

Publication type:

Article

Rac1 in the driver's seat for melanoma.

Published in:

Pigment Cell & Melanoma Research, 2012, v. 25, n. 6, p. 762, doi. 10.1111/pcmr.12004

By:

Machesky, Laura M.;
Sansom, Owen J.

Publication type:

Article

Loss of TGF-β signaling drives cSCC from skin stem cells – More evidence.

Published in:

Cell Cycle, 2017, v. 16, n. 5, p. 386, doi. 10.1080/15384101.2016.1259892

By:

Rose, Aidan M.;
Sansom, Owen J.;
Inman, Gareth J.

Publication type:

Article

Rac1 drives intestinal stem cell proliferation and regeneration.

Published in:

Cell Cycle, 2013, v. 12, n. 18, p. 2973, doi. 10.4161/cc.26031

By:

Myant, Kevin B.;
Scopelliti, Alessandro;
Haque, Sara;
Vidal, Marcos;
Sansom, Owen J.;
Cordero, Julia B.

Publication type:

Article

MYC-y mice: From tumour initiation to therapeutic targeting of endogenous MYC

Published in:

Molecular Oncology, 2013, v. 7, n. 2, p. 248, doi. 10.1016/j.molonc.2013.02.015

By:

Morton, Jennifer P.;
Sansom, Owen J.

Publication type:

Article

Report of the 113th Annual Meeting of the Association of Physicians of Great Britain and Ireland.

Published in:

QJM: An International Journal of Medicine, 2019, v. 112, n. 9, p. 733, doi. 10.1093/qjmed/hcz176

By:

Dominiczak, Dame Anna;
Samani, Nilesh;
Sudlow, Cathie;
Sansom, Owen;
Davies, Dame Sally

Publication type:

Article

Crypt stem cells as the cells-of-origin of intestinal cancer.

Published in:

Nature, 2009, v. 457, n. 7229, p. 608, doi. 10.1038/nature07602

By:

Barker, Nick;
Ridgway, Rachel A.;
van Es, Johan H.;
van de Wetering, Marc;
Begthel, Harry;
van den Born, Maaike;
Danenberg, Esther;
Clarke, Alan R.;
Sansom, Owen J.;
Clevers, Hans

Publication type:

Article

Myc deletion rescues Apc deficiency in the small intestine.

Published in:

Nature, 2007, v. 446, n. 7136, p. 676, doi. 10.1038/nature05674

By:

Sansom, Owen J.;
Meniel, Valerie S.;
Muncan, Vanesa;
Phesse, Toby J.;
Wilkins, Julie A.;
Reed, Karen R.;
Vass, J. Keith;
Athineos, Dimitris;
Clevers, Hans;
Clarke, Alan R.

Publication type:

Article

RNA helicase EIF4A1-mediated translation is essential for the GC response.

Published in:

Life Science Alliance, 2024, v. 7, n. 2, p. 1, doi. 10.26508/lsa.202302301

By:

Screen, Michael;
Matheson, Louise S.;
Howden, Andrew J. M.;
Strathdee, Douglas;
Willis, Anne E.;
Bushell, Martin;
Sansom, Owen;
Turner, Martin

Publication type:

Article

CRISPR activation screen in mice identifies novel membrane proteins enhancing pulmonary metastatic colonisation.

Published in:

Communications Biology, 2021, v. 4, n. 1, p. 1, doi. 10.1038/s42003-021-01912-w

By:

van der Weyden, Louise;
Harle, Victoria;
Turner, Gemma;
Offord, Victoria;
Iyer, Vivek;
Droop, Alastair;
Swiatkowska, Agnieszka;
Rabbie, Roy;
Campbell, Andrew D.;
Sansom, Owen J.;
Pardo, Mercedes;
Choudhary, Jyoti S.;
Ferreira, Ingrid;
Tullett, Mark;
Arends, Mark J.;
Speak, Anneliese O.;
Adams, David J.

Publication type:

Article

Suppression of tumor-associated neutrophils by lorlatinib attenuates pancreatic cancer growth and improves treatment with immune checkpoint blockade.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-23731-7

By:

Nielsen, Sebastian R.;
Strøbech, Jan E.;
Horton, Edward R.;
Jackstadt, Rene;
Laitala, Anu;
Bravo, Marina C.;
Maltese, Giorgia;
Jensen, Adina R. D.;
Reuten, Raphael;
Rafaeva, Maria;
Karim, Saadia A.;
Hwang, Chang-Il;
Arnes, Luis;
Tuveson, David A.;
Sansom, Owen J.;
Morton, Jennifer P.;
Erler, Janine T.

Publication type:

Article

The in vivo function of the p53 target gene TIGAR.

Published in:

2012

By:

Cheung, Eric C.;
Athineos, Dimitris;
Ridgway, Rachel;
Blyth, Karen;
Strathdee, Douglas;
Sansom, Owen;
Vousden, Karen H.

Publication type:

Abstract

Correction: Lkb1 Deficiency Alters Goblet and Paneth Cell Differentiation in the Small Intestine.

Published in:

PLoS ONE, 2019, v. 14, n. 9, p. 1, doi. 10.1371/journal.pone.0223041

By:

Shorning, Boris Y.;
Zabkiewicz, Joanna;
McCarthy, Afshan;
Pearson, Helen B.;
Winton, Douglas J.;
Sansom, Owen J.;
Ashworth, Alan;
Clarke, Alan R.

Publication type:

Article

Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation.

Published in:

Nature Genetics, 2008, v. 40, n. 12, p. 1436, doi. 10.1038/ng.256

By:

Marsh, Victoria;
Winton, Douglas J.;
Williams, Geraint T.;
Dubois, Nicole;
.Trumpp, Andreas;
Sansom, Owen J.;
Clarke, Alan R.

Publication type:

Article

Deficiency of Mbd2 suppresses intestinal tumorigenesis.

Published in:

Nature Genetics, 2003, v. 34, n. 2, p. 145, doi. 10.1038/ng1155

By:

Sansom, Owen J;
Berger, Jennifer;
Bishop, Stefan M;
Hendrich, Brian;
Bird, Adrian;
Clarke, Alan R

Publication type:

Article

Advanced intravital subcellular imaging reveals vital three-dimensional signalling events driving cancer cell behaviour and drug responses in live tissue.

Published in:

FEBS Journal, 2013, v. 280, n. 21, p. 5177, doi. 10.1111/febs.12348

By:

Nobis, Max;
Carragher, Neil O.;
McGhee, Ewan J.;
Morton, Jennifer P.;
Sansom, Owen J.;
Anderson, Kurt I.;
Timpson, Paul

Publication type:

Article

Genetic Dissection of Differential Signaling Threshold Requirements for the Wnt/β-Catenin Pathway In Vivo.

Published in:

PLoS Genetics, 2010, v. 6, n. 1, p. 1, doi. 10.1371/journal.pgen.1000816

By:

Buchert, Michael;
Athineos, Dimitris;
Abud, Helen E.;
Burke, Zoe D.;
Faux, Maree C.;
Samuel, Michael S.;
Jarnicki, Andrew G.;
Winbanks, Catherine E.;
Newton, Ian P.;
Meniel, Valerie S.;
Suzuki, Hiromu;
Stacker, Steven A.;
Näthke, Inke S.;
Tosh, David;
Huelsken, Joerg;
Clarke, Alan R.;
Heath, Joan K.;
Sansom, Owen J.;
Ernst, Matthias

Publication type:

Article

RelA regulates CXCL1/CXCR2-dependent oncogene-induced senescence in murine Kras-driven pancreatic carcinogenesis.

Published in:

2016

By:

Lesina, Marina;
Wörmann, Sonja Maria;
Morton, Jennifer;
Diakopoulos, Kalliope Nina;
Korneeva, Olga;
Wimmer, Margit;
Einwächter, Henrik;
Sperveslage, Jan;
Demir, Ihsan Ekin;
Kehl, Timo;
Saur, Dieter;
Sipos, Bence;
Heikenwälder, Mathias;
Steiner, Jörg Manfred;
Wang, Timothy Cragin;
Sansom, Owen J.;
Schmid, Roland Michael;
Algül, Hana

Publication type:

journal article

WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited.

Published in:

Journal of Clinical Investigation, 2015, v. 125, n. 3, p. 1269, doi. 10.1172/JCI76452

By:

Boulter, Luke;
Guest, Rachel V.;
Kendall, Timothy J.;
Wilson, David H.;
Wojtacha, Davina;
Robson, Andrew J.;
Ridgway, Rachel A.;
Samuel, Kay;
Van Rooijen, Nico;
Barry, Simon T.;
Wigmore, Stephen J.;
Sansom, Owen J.;
Forbes, Stuart J.

Publication type:

Article

Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis.

Published in:

2014

By:

Arjonen, Antti;
Kaukonen, Riina;
Mattila, Elina;
Rouhi, Pegah;
Högnäs, Gunilla;
Sihto, Harri;
Miller, Bryan W;
Morton, Jennifer P;
Bucher, Elmar;
Taimen, Pekka;
Virtakoivu, Reetta;
Cao, Yihai;
Sansom, Owen J;
Joensuu, Heikki;
Ivaska, Johanna

Publication type:

journal article

Mutant p53--associated myosin-X upregulation promotes breast cancer invasion and metastasis.

Published in:

Journal of Clinical Investigation, 2014, v. 124, n. 3, p. 1069, doi. 10.1172/JCI67280

By:

Arjonen, Antti;
Kaukonen, Riina;
Mattila, Elina;
Rouhi, Pegah;
Högnäs, Gunilla;
Harri Sihto;
Miller, Bryan W.;
Morton, Jennifer P.;
Bucher, Elmar;
Taimen, Pekka;
Virtakoivu, Reetta;
Yihai Cao;
Sansom, Owen J.;
Joensuu, Heikki;
Ivaska, Johanna

Publication type:

Article

Sprouty2, PTEN, and PP2A interact to regulate prostate cancer progression.

Published in:

Journal of Clinical Investigation, 2013, v. 123, n. 3, p. 1157, doi. 10.1172/JCI63672

By:

Patel, Rachana;
Meiling Gao;
Ahmad, Imran;
Fleming, Janis;
Singh, Lukram B.;
Rai, Taranjit Singh;
McKie, Arthur B.;
Seywright, Morag;
Barnetson, Robert J.;
Edwards, Joanne;
Sansom, Owen J.;
Leung, Hing Y.

Publication type:

Article

Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis.

Published in:

Journal of Clinical Investigation, 2012, v. 122, n. 9, p. 3127, doi. 10.1172/JCI61067

By:

Jamieson, Thomas;
Clarke, Mairi;
Steele, Colin W.;
Samuel, Michael S.;
Neumann, Jens;
Jung, Andreas;
Huels, David;
Olson, Michael F.;
Das, Sudipto;
Nibbs, Robert J. B.;
Sansom, Owen J.

Publication type:

Article

Accounting for intensity variation in image analysis of large‐scale multiplexed clinical trial datasets.

Published in:

Journal of Pathology: Clinical Research, 2023, v. 9, n. 6, p. 449, doi. 10.1002/cjp2.342

By:

Frei, Anja L;
McGuigan, Anthony;
Sinha, Ritik RAK;
Glaire, Mark A;
Jabbar, Faiz;
Gneo, Luciana;
Tomasevic, Tijana;
Harkin, Andrea;
Iveson, Tim J;
Saunders, Mark;
Oein, Karin;
Maka, Noori;
Pezella, Francesco;
Campo, Leticia;
Hay, Jennifer;
Edwards, Joanne;
Sansom, Owen J;
Kelly, Caroline;
Tomlinson, Ian;
Kildal, Wanja

Publication type:

Article

Histological phenotypic subtypes predict recurrence risk and response to adjuvant chemotherapy in patients with stage III colorectal cancer.

Published in:

Journal of Pathology: Clinical Research, 2020, v. 6, n. 4, p. 283, doi. 10.1002/cjp2.171

By:

Roseweir, Antonia K;
Park, James H;
Hoorn, Sanne ten;
Powell, Arfon GMT;
Aherne, Susan;
Roxburgh, Campbell SD;
McMillan, Donald C;
Horgan, Paul G;
Ryan, Elizabeth;
Sheahan, Kieran;
Vermeulen, Louis;
Paul, James;
Harkin, Andrea;
Graham, Janet;
Sansom, Owen;
Church, David N;
Tomlinson, Ian;
Saunders, Mark;
Iveson, Tim J;
Edwards, Joanne

Publication type:

Article

Efficient Wnt mediated intestinal hyperproliferation requires the cyclin D2-CDK4/6 complex.

Published in:

Cell Division, 2011, v. 6, n. 1, p. 1, doi. 10.1186/1747-1028-6-3

By:

Myant, Kevin;
Sansom, Owen

Publication type:

Article

A Rac1-Independent Role for P-Rex1 in Melanoblasts.

Published in:

Journal of Investigative Dermatology, 2015, v. 135, n. 1, p. 314, doi. 10.1038/jid.2014.323

By:

Lindsay, Colin R;
Li, Ang;
Faller, William;
Ozanne, Brad;
Welch, Heidi;
Machesky, Laura M;
Sansom, Owen J

Publication type:

Article

Activated Mutant NRasQ61K Drives Aberrant Melanocyte Signaling, Survival, and Invasiveness via a Rac1-Dependent Mechanism.

Published in:

Journal of Investigative Dermatology, 2012, v. 132, n. 11, p. 2610, doi. 10.1038/jid.2012.186

By:

Li, Ang;
Ma, Yafeng;
Jin, Meng;
Mason, Susan;
Mort, Richard L;
Blyth, Karen;
Larue, Lionel;
Sansom, Owen J;
Machesky, Laura M

Publication type:

Article

Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis.

Published in:

Journal of Cell Biology, 2007, v. 176, n. 2, p. 183, doi. 10.1083/jcb.200610099

By:

Dikovskaya, Dina;
Schiffmann, David;
Newton, Ian P.;
Oakley, Abigail;
Kroboth, Karin;
Sansom, Owen;
Jamieson, Thomas J.;
Meniel, Valerie;
Clarke, Alan;
Näthke, Inke S.

Publication type:

Article

Rpl24Bst mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K.

Published in:

eLife, 2021, p. 1, doi. 10.7554/eLife.69729

By:

Knight, John R. P.;
Vlahov, Nikola;
Gay, David M.;
Ridgway, Rachel A.;
Faller, William James;
Proud, Christopher;
Mallucci, Giovanna R.;
von der Haar, Tobias;
Smales, Christopher Mark;
Willis, Anne E.;
Sansom, Owen J.

Publication type:

Article

RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis.

Published in:

eLife, 2021, p. 1, doi. 10.7554/eLife.63807

By:

Nászai, Máté;
Bellec, Karen;
Yachuan Yu;
Román-Fernández, Alvaro;
Sandilands, Emma;
Johansson, Joel;
Campbell, Andrew D.;
Norman, Jim C.;
Sansom, Owen J.;
Bryant, David M.;
Cordero, Julia B.

Publication type:

Article

Phenotypic plasticity underlies local invasion and distant metastasis in colon cancer.

Published in:

eLife, 2021, p. 1, doi. 10.7554/eLife.61461

By:

Sacchetti, Andrea;
Teeuwssen, Miriam;
Verhagen, Mathijs;
Joosten, Rosalie;
Tong Xu;
Stabile, Roberto;
van der Steen, Berdine;
Watson, Martin M.;
Gusinac, Alem;
Won Kyu Kim;
Ubink, Inge;
Van de Werken, Harmen JG;
Fumagalli, Arianna;
Paauwe, Madelon;
Van Rheenen, Jacco;
Sansom, Owen J.;
Kranenburg, Onno;
Fodde, Riccardo

Publication type:

Article

Aspirin reprogrammes colorectal cancer cell metabolism and sensitises to glutaminase inhibition.

Published in:

Cancer & Metabolism, 2023, v. 11, n. 1, p. 1, doi. 10.1186/s40170-023-00318-y

By:

Holt, Amy K.;
Najumudeen, Arafath K.;
Collard, Tracey J.;
Li, Hao;
Millett, Laura M.;
Hoskin, Ashley J.;
Legge, Danny N.;
Mortensson, Eleanor M. H.;
Flanagan, Dustin J.;
Jones, Nicholas;
Kollareddy, Madhu;
Timms, Penny;
Hitchings, Matthew D.;
Cronin, James;
Sansom, Owen J.;
Williams, Ann C.;
Vincent, Emma E.

Publication type:

Article

Co-inhibition of TGF-β and PD-L1 pathways in a metastatic colorectal cancer mouse model triggers interferon responses, innate cells and T cells, alongside metabolic changes and tumor resistance.

Published in:

OncoImmunology, 2024, v. 13, n. 1, p. 1, doi. 10.1080/2162402X.2024.2330194

By:

Nair, Reshmi;
Lannagan, Tamsin R. M.;
Jackstadt, Rene;
Andrusaite, Anna;
Cole, John;
Boyne, Caitlin;
Nibbs, Robert J. B.;
Sansom, Owen J.;
Milling, Simon

Publication type:

Article

Traject3d allows label-free identification of distinct co-occurring phenotypes within 3D culture by live imaging.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-32958-x

By:

Freckmann, Eva C.;
Sandilands, Emma;
Cumming, Erin;
Neilson, Matthew;
Román-Fernández, Alvaro;
Nikolatou, Konstantina;
Nacke, Marisa;
Lannagan, Tamsin R. M.;
Hedley, Ann;
Strachan, David;
Salji, Mark;
Morton, Jennifer P.;
McGarry, Lynn;
Leung, Hing Y.;
Sansom, Owen J.;
Miller, Crispin J.;
Bryant, David M.

Publication type:

Article

An EphB-Abl signaling pathway is associated with intestinal tumor initiation and growth.

Published in:

Science Translational Medicine, 2015, v. 7, n. 281, p. 1, doi. 10.1126/scitranslmed.3010567

By:

Kundu, Parag;
Genander, Maria;
Strååt, Klas;
Classon, Johanna;
Ridgway, Rachel A.;
Ee Hong Tan;
Björk, Jan;
Martling, Anna;
van Es, Johan;
Sansom, Owen J.;
Clevers, Hans;
Pettersson, Sven;
Frisén, Jonas

Publication type:

Article

Morphological and molecular preservation through universal preparation of fresh-frozen tissue samples for multimodal imaging workflows.

Published in:

Nature Protocols, 2024, v. 19, n. 9, p. 2685, doi. 10.1038/s41596-024-00987-z

By:

Dannhorn, Andreas;
Kazanc, Emine;
Flint, Lucy;
Guo, Fei;
Carter, Alfie;
Hall, Andrew R.;
Jones, Stewart A.;
Poulogiannis, George;
Barry, Simon T.;
Sansom, Owen J.;
Bunch, Josephine;
Takats, Zoltan;
Goodwin, Richard J. A.

Publication type:

Article

Accepting from the best donor; analysis of long-lifetime donor fluorescent protein pairings to optimise dynamic FLIM-based FRET experiments.

Published in:

PLoS ONE, 2018, v. 13, n. 1, p. 1, doi. 10.1371/journal.pone.0183585

By:

Martin, Kirsty J.;
McGhee, Ewan J.;
Schwarz, Juliana P.;
Drysdale, Martin;
Brachmann, Saskia M.;
Stucke, Volker;
Sansom, Owen J.;
Anderson, Kurt I.

Publication type:

Article

An efficient and robust MRI-guided radiotherapy planning approach for targeting abdominal organs and tumours in the mouse.

Published in:

PLoS ONE, 2017, v. 12, n. 4, p. 1, doi. 10.1371/journal.pone.0176693

By:

Kersemans, Veerle;
Beech, John S.;
Gilchrist, Stuart;
Kinchesh, Paul;
Allen, Philip D.;
Thompson, James;
Gomes, Ana L.;
D’Costa, Zenobia;
Bird, Luke;
Tullis, Iain D. C.;
Newman, Robert G.;
Corroyer-Dulmont, Aurelien;
Falzone, Nadia;
Azad, Abul;
Vallis, Katherine A.;
Sansom, Owen J.;
Muschel, Ruth J.;
Vojnovic, Borivoj;
Hill, Mark A.;
Fokas, Emmanouil

Publication type:

Article

Wnt and Src signals converge on YAP‐TEAD to drive intestinal regeneration.

Published in:

EMBO Journal, 2021, v. 40, n. 13, p. 1, doi. 10.15252/embj.2020105770

By:

Guillermin, Oriane;
Angelis, Nikolaos;
Sidor, Clara M;
Ridgway, Rachel;
Baulies, Anna;
Kucharska, Anna;
Antas, Pedro;
Rose, Melissa R;
Cordero, Julia;
Sansom, Owen;
Li, Vivian S W;
Thompson, Barry J

Publication type:

Article

The Wae to repair: prostaglandin E2 (PGE2) triggers intestinal wound repair.

Published in:

EMBO Journal, 2017, v. 36, n. 1, p. 3, doi. 10.15252/embj.201695973

By:

Jackstadt, Rene;
Sansom, Owen James

Publication type:

Article

c-Src drives intestinal regeneration and transformation.

Published in:

EMBO Journal, 2014, v. 33, n. 13, p. 1474, doi. 10.1002/embj.201387454

By:

Cordero, Julia B;
Ridgway, Rachel A;
Valeri, Nicola;
Nixon, Colin;
Frame, Margaret C;
Muller, William J;
Vidal, Marcos;
Sansom, Owen J

Publication type:

Article

mTORC1 activity is essential for erythropoiesis and B cell lineage commitment.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-53141-1

By:

Malik, Natasha;
Dunn, Karen M.;
Cassels, Jennifer;
Hay, Jodie;
Estell, Christopher;
Sansom, Owen J.;
Michie, Alison M.

Publication type:

Article

Subversion of Niche-Signalling Pathways in Colorectal Cancer: What Makes and Breaks the Intestinal Stem Cell.

Published in:

Cancers, 2021, v. 13, n. 5, p. 1000, doi. 10.3390/cancers13051000

By:

Sphyris, Nathalie;
Hodder, Michael C.;
Sansom, Owen J.;
Allegrucci, Cinzia;
Ordóñez-Morán, Paloma

Publication type:

Article

Cancer cell adaptation to hypoxia involves a HIF‐GPRC5A‐YAP axis.

Published in:

EMBO Molecular Medicine, 2018, v. 10, n. 11, p. N.PAG, doi. 10.15252/emmm.201708699

By:

Greenhough, Alexander;
Bagley, Clare;
Heesom, Kate J;
Gurevich, David B;
Gay, David;
Bond, Mark;
Collard, Tracey J;
Paraskeva, Chris;
Martin, Paul;
Sansom, Owen J;
Malik, Karim;
Williams, Ann C

Publication type:

Article

Sprouty2 loss‐induced IL6 drives castration‐resistant prostate cancer through scavenger receptor B1.

Published in:

EMBO Molecular Medicine, 2018, v. 10, n. 4, p. 1, doi. 10.15252/emmm.201708347

By:

Patel, Rachana;
Fleming, Janis;
Mui, Ernest;
Loveridge, Carolyn;
Repiscak, Peter;
Blomme, Arnaud;
Harle, Victoria;
Salji, Mark;
Ahmad, Imran;
Teo, Katy;
Hamdy, Freddie C.;
Hedley, Ann;
van den Broek, Niels;
Mackay, Gillian;
Edwards, Joanne;
Sansom, Owen J.;
Leung, Hing Y.

Publication type:

Article

PD-L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy.

Published in:

EMBO Molecular Medicine, 2017, v. 9, n. 2, p. 167, doi. 10.15252/emmm.201606674

By:

Azad, Abul;
Yin Lim, Su;
D'Costa, Zenobia;
Jones, Keaton;
Diana, Angela;
Sansom, Owen J;
Kruger, Philipp;
Liu, Stanley;
McKenna, W Gillies;
Dushek, Omer;
Muschel, Ruth J;
Fokas, Emmanouil

Publication type:

Article

HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation.

Published in:

EMBO Molecular Medicine, 2017, v. 9, n. 2, p. 181, doi. 10.15252/emmm.201606684

By:

Myant, Kevin B;
Cammareri, Patrizia;
Hodder, Michael C;
Wills, Jimi;
Von Kriegsheim, Alex;
Győrffy, Balázs;
Rashid, Mamun;
Polo, Simona;
Maspero, Elena;
Vaughan, Lynsey;
Gurung, Basanta;
Barry, Evan;
Malliri, Angeliki;
Camargo, Fernando;
Adams, David J;
Iavarone, Antonio;
Lasorella, Anna;
Sansom, Owen J

Publication type:

Article