Works by Sang Geon Kim

Results: 81

Gα13 ablation reprograms myofibers to oxidative phenotype and enhances whole-body metabolism.

Published in:

2017

By:

Ja Hyun Koo;
Tae Hyun Kim;
Shi-Young Park;
Min Sung Joo;
Chang Yeob Han;
Cheol Soo Choi;
Sang Geon Kim;
Koo, Ja Hyun;
Kim, Tae Hyun;
Park, Shi-Young;
Joo, Min Sung;
Han, Chang Yeob;
Choi, Cheol Soo;
Kim, Sang Geon

Publication type:

journal article

DA-125, a novel anthracycline derivative showing high-affinity DNA binding and topoisomerase II inhibitory activities, exerts cytotoxicity via c-Jun N-terminal kinase pathway.

Published in:

Cancer Chemotherapy & Pharmacology, 2001, v. 47, n. 6, p. 511, doi. 10.1007/s002800100276

By:

Sang Geon Kim;
Mina Sung;
Keon Wook Kang;
Soon Hoe Kim;
Moon Ho Son;
Won Bae Kim

Publication type:

Article

Oltipraz therapy in patients with liver fibrosis or cirrhosis: a randomized, double-blind, placebo-controlled phase II trial.

Published in:

Journal of Pharmacy & Pharmacology, 2011, v. 63, n. 5, p. 627, doi. 10.1111/j.2042-7158.2011.01259.x

By:

Kim, Sang Geon;
Kim, Young Mi;
Choi, Jong Young;
Han, Joon-Yeol;
Jang, Jeong Won;
Cho, Se-Hyun;
Um, Soon Ho;
Chon, Chae Yoon;
Lee, Dong Hoo;
Jang, Ja-June;
Yu, Eunsil;
Lee, Young Sok

Publication type:

Article

Pharmacokinetic interaction between oltipraz and dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylene dioxybiphenyl-2,2'-dicarboxylate (DDB) after single intravenous and oral administration to rats.

Published in:

Journal of Pharmacy & Pharmacology, 2003, v. 55, n. 9, p. 1241

By:

Soo Kyung Bae;
Eun Jung Kim;
Suk Jae Chung;
Sang Geon Kim;
Myung Gull Lee

Publication type:

Article

Effects of acute renal failure induced by uranyl nitrate on the pharmacokinetics of intravenous theophylline in rats: the role of CYP2E1 induction in 1,3-dimethyluric acid formation.

Published in:

Journal of Pharmacy & Pharmacology, 2002, v. 54, n. 12, p. 1687, doi. 10.1211/002235702333

By:

Yu, Su Yeon;
Chung, Hye Chin;
Kim, Eun Jung;
Kim, So Hee;
Lee, Inchull;
Kim, Sang Geon;
Lee, Myung Gull

Publication type:

Article

Gα12 and endoplasmic reticulum stress-mediated pyroptosis in a single cycle of dextran sulfate-induced mouse colitis.

Published in:

Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-56685-z

By:

Tak, Jihoon;
An, Quanxi;
Lee, Sang Gil;
Lee, Chang Hoon;
Kim, Sang Geon

Publication type:

Article

AMPK-Dependent Metabolic Regulation by PPAR Agonists.

Published in:

PPAR Research, 2010, p. 1, doi. 10.1155/2010/549101

By:

Woo Hyung Lee;
Sang Geon Kim

Publication type:

Article

Efficacy and tolerability of diphenyl-dimethyl-dicarboxylate plus garlic oil in patients with chronic hepatitis.

Published in:

International Journal of Clinical Pharmacology & Therapeutics, 2012, v. 50, n. 11, p. 778, doi. 10.5414/CP201746

By:

Min Ho Lee;
Young Mi Kim;
Sang Geon Kim

Publication type:

Article

Transactivation of Genes Encoding for Phase II Enzymes and Phase III Transporters by Phytochemical Antioxidants.

Published in:

Molecules, 2010, v. 15, n. 9, p. 6332, doi. 10.3390/molecules15096332

By:

Yoon Mee Yang;
Kyoung Noh;
Chang Yeob Han;
Sang Geon Kim

Publication type:

Article

Hypoxia-inducible factor-1α inhibition by a pyrrolopyrazine metabolite of oltipraz as a consequence of microRNAs 199a-5p and 20a induction.

Published in:

Carcinogenesis, 2012, v. 33, n. 3, p. 661, doi. 10.1093/carcin/bgr320

By:

Kang, Seul Gi;
Lee, Woo Hyung;
Lee, Young Hun;
Lee, Yong Sup;
Kim, Sang Geon

Publication type:

Article

Gα12/13 inhibition enhances the anticancer effect of bortezomib through PSMB5 downregulation.

Published in:

Carcinogenesis, 2010, v. 31, n. 7, p. 1230, doi. 10.1093/carcin/bgq097

By:

Yoon Mee Yang;
Lee, Sanghwan;
Chang Won Nam;
Ji Hee Ha;
Jayaraman, Muralidharan;
Dhanasekaran, Danny N.;
Chang Ho Lee;
Mi-Kyoung Kwak;
Sang Geon Kim

Publication type:

Article

Gα12 regulates osteoclastogenesis by modulating NFATc1 expression.

Published in:

Journal of Cellular & Molecular Medicine, 2018, v. 22, n. 2, p. 849, doi. 10.1111/jcmm.13370

By:

Song, Min‐Kyoung;
Park, Cheolkyu;
Lee, Yong Deok;
Kim, Haemin;
Kim, Min Kyung;
Kwon, Jun‐Oh;
Koo, Ja Hyun;
Joo, Min Sung;
Kim, Sang Geon;
Kim, Hong‐Hee

Publication type:

Article

Differential induction of hepatic microsomal epoxide hydrolase by alkyl sulphides and alkyl ethers in rat.

Published in:

Xenobiotica, 1997, v. 27, n. 8, p. 759, doi. 10.1080/004982597240145

By:

Cho, Joo Youn;
Kim, Sang Geon

Publication type:

Article

Effects of garlic oil on rat hepatic P4502E1 expression

Published in:

Xenobiotica, 1995, v. 25, n. 10, p. 1021

By:

Kim, Sang Geon;
Kim, Nak Doo;
Kwak, Mi Kyong

Publication type:

Article

1-benzylimidazole induces rat hepatic microsomal epoxide hydrolase with the elevation of its mRNA levels

Published in:

Xenobiotica, 1995, v. 25, n. 8, p. 791

By:

Nam, Seon Young;
Choo, Joo Youn;
Kim, Sang Geon

Publication type:

Article

Piperine effects on the expression of 4502E1, P4502B and P4501A in rat

Published in:

Xenobiotica, 1994, v. 24, n. 12, p. 1195

By:

Kim, Sang Geon;
Kang, Min Hee;
Won, Sun Me;
Park, Sang Shin;
Kim, Nak Doo;
Novak, R. F.

Publication type:

Article

Role of Gα12/Gα13 as novel switches for the activity of Nrf2.

Published in:

FASEB Journal, 2007, v. 21, n. 6, p. A1181, doi. 10.1096/fasebj.21.6.a1181-b

By:

Won Dong Kim;
Min Kyung Cho;
Chang Ho Lee;
Sang Geon Kim

Publication type:

Article

Gα12 specifically regulates COX-2 induction by sphingosine 1-phosphate.

Published in:

FASEB Journal, 2007, v. 21, n. 6, p. A978, doi. 10.1096/fasebj.21.6.a978-d

By:

Sung Hwan Ki;
Min Jung Choi;
Chang Ho Lee;
Sang Geon Kim

Publication type:

Article

Role of Gα12 family members in mdm4-mediated p53 expression.

Published in:

FASEB Journal, 2007, v. 21, n. 5, p. A431, doi. 10.1096/fasebj.21.5.a431-b

By:

Sang Geon Kim;
Mi-Sung Kim;
Sang Min Lee;
Won Dong Kim;
Moon, Aree;
Chang Ho Lee

Publication type:

Article

A role of activating transcription factor (ATF)2 in transcriptional activation of matrix metalloproteinase (MMP)-2 in human breast epithelial cells.

Published in:

FASEB Journal, 2007, v. 21, n. 5, p. A388, doi. 10.1096/fasebj.21.5.a388

By:

Hyun Song;
Sung Hwan Ki;
Sang Geon Kim;
Aree Moon

Publication type:

Article

Oltipraz regenerates cirrhotic liver through CCAAT/enhancer binding protein‐mediated stellate cell inactivation.

Published in:

FASEB Journal, 2002, v. 16, n. 14, p. 1988, doi. 10.1096/fj.02-0406fje

By:

Wook Kang, Keon;
Gyoon Kim, Yoon;
Kyong Cho, Min;
Kyung Bae, Soo;
Won Kim, Choon;
Gull Lee, Myung;
Geon Kim, Sang

Publication type:

Article

Expression of microsomal epoxide hydrolase is elevated in Alzheimer's hippocampus and induced by exogenous β-amyloid and trimethyl-tin.

Published in:

European Journal of Neuroscience, 2006, v. 23, n. 8, p. 2027, doi. 10.1111/j.1460-9568.2006.04724.x

By:

Liu, Mei;
Sun, Anyang;
Shin, Eun‐Joo;
Liu, Xianxi;
Kim, Sang‐Geon;
Runyons, Cecil R.;
Markesbery, William;
Kim, Hyoung‐Chun;
Bing, Guoying

Publication type:

Article

Sex-biased differences in the correlation between epithelial-to-mesenchymal transition-associated genes in cancer cell lines.

Published in:

Oncology Letters, 2019, v. 18, n. 6, p. 6852, doi. 10.3892/ol.2019.11016

By:

Kim, Sun Young;
Lee, Seungeun;
Lee, Eunhye;
Lim, Hyesol;
Shin, Ji Yoon;
Jung, Joohee;
Kim, Sang Geon;
Moon, Aree

Publication type:

Article

ERα inhibits mesenchymal and amoeboidal movement of liver cancer cell via Gα12.

Published in:

International Journal of Cancer, 2022, v. 150, n. 10, p. 1690, doi. 10.1002/ijc.33929

By:

Yun, Jessica;
Kim, Yun Seok;
Heo, Mi Jeong;
Kim, Min Joo;
Moon, Aree;
Kim, Sang Geon

Publication type:

Article

UBC12‐mediated SREBP‐1 neddylation worsens metastatic tumor prognosis.

Published in:

International Journal of Cancer, 2020, v. 147, n. 9, p. 2550, doi. 10.1002/ijc.33113

By:

Heo, Mi Jeong;
Kang, Sung Hyun;
Kim, Yun Seok;
Lee, Jung Min;
Yu, Jinha;
Kim, Hong‐Rae;
Lim, Hyesol;
Kim, Kyoung Mee;
Jung, Joohee;
Jeong, Lak Shin;
Moon, Aree;
Kim, Sang Geon

Publication type:

Article

Regulation of thymus-dependent and thymus-independent production of immunoglobulin G subclasses by Galpha12 and Galpha13.

Published in:

Journal of Molecular Signaling, 2008, v. 3, p. 1, doi. 10.1186/1750-2187-3-12

By:

Song Jin Lee;
Woo Hyung Lee;
Chang Ho Lee;
Sang Geon Kim

Publication type:

Article

AMPK Facilitates Nuclear Accumulation of Nrf2 by Phosphorylating at Serine 550.

Published in:

Molecular & Cellular Biology, 2016, v. 36, n. 14, p. 1931, doi. 10.1128/MCB.00118-16

By:

Min Sung Joo;
Won Dong Kim;
Ki Young Lee;
Ji Hyun Kim;
Ja Hyun Koo;
Sang Geon Kim

Publication type:

Article

Essential role of phosphatidylinositol 3-kinase-dependent CCAAT/enhancer binding protein beta activation in the induction of glutathione S-transferase by oltipraz.

Published in:

2003

By:

Kang, Keon Wook;
Cho, Il Je;
Lee, Chang Ho;
Kim, Sang Geon

Publication type:

journal article

Essential Role of Phosphatidylinositol 3-Kinase-Dependent CCAAT/Enhancer Binding Protein Β Activation in the Induction of Glutathione S-Transferase by Oltipraz.

Published in:

JNCI: Journal of the National Cancer Institute, 2003, v. 95, n. 1, p. 53, doi. 10.1093/jnci/95.1.53

By:

Keon Wook Kang;
Il Je Cho;
Chang Ho Lee;
Sang Geon Kim

Publication type:

Article

Ginsenoside Rg3 inhibits phenylephrine-induced vascular contraction through induction of nitric oxide synthase.

Published in:

British Journal of Pharmacology, 2003, v. 140, n. 4, p. 661, doi. 10.1038/sj.bjp.0705490

By:

Nak Doo Kim;
Eun Mi Kim;
Keon Wook Kang;
Min Kyung Cho;
So Yeon Choi;
Sang Geon Kim

Publication type:

Article

Inhibition of lipopolysaccaride-inducible nitric oxide synthase, TNF-α and COX-2 expression by sauchinone effects on I-κBα phosphorylation, C/EBP and AP-1 activation.

Published in:

British Journal of Pharmacology, 2003, v. 139, n. 1, p. 11, doi. 10.1038/sj.bjp.0705231

By:

Ae Kyung Lee;
Sang Hyun Sung;
Young Choong Kim;
Sang Geon Kim

Publication type:

Article

Overproduction of inter-α-trypsin inhibitor heavy chain 1 after loss of Gα13 in liver exacerbates systemic insulin resistance in mice.

Published in:

Science Translational Medicine, 2019, v. 11, n. 513, p. 1, doi. 10.1126/scitranslmed.aan4735

By:

Kim, Tae Hyun;
Koo, Ja Hyun;
Heo, Mi Jeong;
Han, Chang Yeob;
Kim, Yong-In;
Park, Shi-Young;
Cho, Il Je;
Lee, Chang Ho;
Choi, Cheol Soo;
Lee, Jung Weon;
Kim, Won;
Cho, Je-Yoel;
Kim, Sang Geon

Publication type:

Article

Plk2-mediated phosphorylation and translocalization of Nrf2 activates anti-inflammation through p53/Plk2/p21cip1 signaling in acute kidney injury.

Published in:

Cell Biology & Toxicology, 2023, v. 39, n. 4, p. 1509, doi. 10.1007/s10565-022-09741-1

By:

Kim, Da-Eun;
Byeon, Hye Eun;
Kim, Dae-Hoon;
Kim, Sang Geon;
Yim, Hyungshin

Publication type:

Article

Roles of X-box binding protein 1 in liver pathogenesis.

Published in:

Clinical & Molecular Hepatology, 2025, v. 31, n. 1, p. 1, doi. 10.3350/cmh.2024.0441

By:

Jihoon Tak;
Yun Seok Kim;
Sang Geon Kim

Publication type:

Article

Endoplasmic reticulum stress and autophagy dysregulation in alcoholic and non-alcoholic liver diseases.

Published in:

Clinical & Molecular Hepatology, 2020, v. 26, n. 4, p. 715, doi. 10.3350/cmh.2020.0173

By:

Yun Seok Kim;
Sang Geon Kim

Publication type:

Article

Dual regulation of NEMO by Nrf2 and miR-125a inhibits ferroptosis and protects liver from endoplasmic reticulum stress-induced injury.

Published in:

Theranostics, 2024, v. 14, n. 5, p. 1841, doi. 10.7150/thno.89703

By:

Jihoon Tak;
Min Sung Joo;
Yun Seok Kim;
Hyun Woo Park;
Chang Hoon Lee;
Gil-Chun Park;
Shin Hwang;
Sang Geon Kim

Publication type:

Article

Gα12 overexpression in hepatocytes by ER stress exacerbates acute liver injury via ROCK1-mediated miR-15a and ALOX12 dysregulation.

Published in:

Theranostics, 2022, v. 12, n. 4, p. 1570, doi. 10.7150/thno.67722

By:

Jihoon Tak;
Yun Seok Kim;
Tae Hyun Kim;
Gil-Chun Park;
Shin Hwang;
Sang Geon Kim

Publication type:

Article

Intestinal Inflammation and Regeneration–Interdigitating Processes Controlled by Dietary Lipids in Inflammatory Bowel Disease.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 2, p. 1311, doi. 10.3390/ijms25021311

By:

Kwon, Soon Jae;
Khan, Muhammad Sohaib;
Kim, Sang Geon

Publication type:

Article

Dysregulated Liver Metabolism and Polycystic Ovarian Syndrome.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 8, p. 7454, doi. 10.3390/ijms24087454

By:

Khan, Muhammad Sohaib;
Kim, Hee-Sun;
Kim, Ranhee;
Yoon, Sang Ho;
Kim, Sang Geon

Publication type:

Article

Knockout of Purinergic P2Y 6 Receptor Fails to Improve Liver Injury and Inflammation in Non-Alcoholic Steatohepatitis.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 4, p. 3800, doi. 10.3390/ijms24043800

By:

Nishiyama, Kazuhiro;
Ariyoshi, Kohei;
Nishimura, Akiyuki;
Kato, Yuri;
Mi, Xinya;
Kurose, Hitoshi;
Kim, Sang Geon;
Nishida, Motohiro

Publication type:

Article

Hypergravity Load Modulates Acetaminophen Nephrotoxicity via Endoplasmic Reticulum Stress in Association with Hepatic microRNA-122 Expression.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 9, p. 4901, doi. 10.3390/ijms22094901

By:

Wu, Hong-Min;
Lee, Sang-Gil;
Oh, Choong-Sik;
Kim, Sang-Geon;
Grimm, Daniela

Publication type:

Article

Expression of Cytochrome P-450s and Glutathione S-Transferases in the Rat Liver during Water Deprivation: Effects of Glucose Supplementation.

Published in:

Journal of Applied Toxicology, 2001, v. 21, n. 2, p. 123, doi. 10.1002/jat.734

By:

Sang Geon Kim;
Eun Jung Kim;
Yoon Gyoon Kim;
Myung Gull Lee

Publication type:

Article

Mitigation of carbon tetrachloride-induced hepatic injury by methylene blue, a repurposed drug, is mediated by dual inhibition of GSK3β downstream of PKA.

Published in:

2014

By:

Wu, Hong Min;
Lee, Chan Gyu;
Hwang, Se Jin;
Kim, Sang Geon

Publication type:

journal article

Mitigation of carbon tetrachloride-induced hepatic injury by methylene blue, a repurposed drug, is mediated by dual inhibition of GSK3β downstream of PKA.

Published in:

British Journal of Pharmacology, 2014, v. 171, n. 11, p. 2790, doi. 10.1111/bph.12637

By:

Wu, Hong Min;
Lee, Chan Gyu;
Hwang, Se Jin;
Kim, Sang Geon

Publication type:

Article

An active metabolite of oltipraz (M2) increases mitochondrial fuel oxidation and inhibits lipogenesis in the liver by dually activating AMPK.

Published in:

2013

By:

Kim, Tae Hyun;
Eom, Jeong Sik;
Lee, Chan Gyu;
Yang, Yoon Mee;
Lee, Yong Sup;
Kim, Sang Geon

Publication type:

journal article

An active metabolite of oltipraz ( M2) increases mitochondrial fuel oxidation and inhibits lipogenesis in the liver by dually activating AMPK.

Published in:

British Journal of Pharmacology, 2013, v. 168, n. 7, p. 1647, doi. 10.1111/bph.12057

By:

Kim, Tae Hyun;
Eom, Jeong Sik;
Lee, Chan Gyu;
Yang, Yoon Mee;
Lee, Yong Sup;
Kim, Sang Geon

Publication type:

Article

Nrf2-mediated liver protection by sauchinone, an antioxidant lignan, from acetaminophen toxicity through the PKCδ-GSK3β pathway.

Published in:

2011

By:

Kay, Hee Yeon;
Kim, Young Woo;
Ryu, Da Hye;
Sung, Sang Hyun;
Hwang, Se Jin;
Kim, Sang Geon

Publication type:

journal article

Hepcidin inhibits Smad3 phosphorylation in hepatic stellate cells by impeding ferroportin-mediated regulation of Akt.

Published in:

Nature Communications, 2016, v. 7, n. 12, p. 13817, doi. 10.1038/ncomms13817

By:

Han, Chang Yeob;
Koo, Ja Hyun;
Kim, Sung Hoon;
Gardenghi, Sara;
Rivella, Stefano;
Strnad, Pavel;
Hwang, Se Jin;
Kim, Sang Geon

Publication type:

Article

Metformin Prevents an Adaptive Increase in GSH and Induces Apoptosis Under the Conditions of GSH Deficiency in H4IIE Cells.

Published in:

Journal of Toxicology & Environmental Health: Part A, 2007, v. 70, n. 15/16, p. 1371, doi. 10.1080/15287390701434430

By:

Eun Ju Bae;
Min Joo Cho;
Sang Geon Kim

Publication type:

Article

DEPRENYL, A THERAPEUTIC AGENT FOR PARKINSON’S DISEASE, INHIBITS ARSENIC TOXICITY POTENTIATED BY GSH DEPLETION VIA INHIBITION OF JNK ACTIVATION.

Published in:

Journal of Toxicology & Environmental Health: Part A, 2004, v. 67, n. 23/24, p. 2013, doi. 10.1080/15287390490514732

By:

Sang Geon Kim;
Chang Ho Lee;
Jeong Weon Park

Publication type:

Article