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Batch-to-batch variability of two human designer cell lines - AGE1. HN and AGE1. HN. AAT - carried out by different laboratories under defined culture conditions using a mathematical model.
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- Engineering in Life Sciences, 2013, v. 13, n. 6, p. 580, doi. 10.1002/elsc.201200111
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- Article
Evaluation of criteria for bioreactor comparison and operation standardization for mammalian cell culture Evaluation of criteria for bioreactor comparison and operation standardization for mammalian cell culture.
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- Engineering in Life Sciences, 2012, v. 12, n. 5, p. 518, doi. 10.1002/elsc.201100163
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- Article
Quantitative characterization of metabolism and metabolic shifts during growth of the new human cell line AGE1.HN using time resolved metabolic flux analysis.
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- Bioprocess & Biosystems Engineering, 2011, v. 34, n. 5, p. 533, doi. 10.1007/s00449-010-0502-y
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- Article
Process intensification strategies toward cell culture‐based high‐yield production of a fusogenic oncolytic virus.
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- Biotechnology & Bioengineering, 2023, v. 120, n. 9, p. 2639, doi. 10.1002/bit.28353
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- Article
A dynamic model linking cell growth to intracellular metabolism and extracellular by‐product accumulation.
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- Biotechnology & Bioengineering, 2020, v. 117, n. 5, p. 1533, doi. 10.1002/bit.27288
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- Article
High titer MVA and influenza A virus production using a hybrid fed-batch/perfusion strategy with an ATF system.
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- Applied Microbiology & Biotechnology, 2019, v. 103, n. 7, p. 3025, doi. 10.1007/s00253-019-09694-2
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- Article
Quercetin treatment changes fluxes in the primary metabolism and increases culture longevity and recombinant α-antitrypsin production in human AGE1.HN cells.
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- Applied Microbiology & Biotechnology, 2012, v. 94, n. 1, p. 57, doi. 10.1007/s00253-011-3811-4
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- Article
Primary metabolism in the new human cell line AGE1.HN at various substrate levels: increased metabolic efficiency and α-antitrypsin production at reduced pyruvate load.
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- Applied Microbiology & Biotechnology, 2012, v. 93, n. 4, p. 1637, doi. 10.1007/s00253-011-3526-6
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- Article
N-glycosylation and biological activity of recombinant human alpha1-antitrypsin expressed in a novel human neuronal cell line.
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- Biotechnology & Bioengineering, 2011, v. 108, n. 9, p. 2118, doi. 10.1002/bit.23158
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- Article
Production of non-fucosylated antibodies by co-expression of heterologous GDP-6-deoxy-d-lyxo-4-hexulose reductase.
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- Glycobiology, 2010, v. 20, n. 12, p. 1607, doi. 10.1093/glycob/cwq109
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- Article
Computationally designed Spike antigens induce neutralising responses against the breadth of SARS-COV-2 variants.
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- NPJ Vaccines, 2024, v. 9, n. 1, p. 1, doi. 10.1038/s41541-024-00950-9
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- Article
Live attenuated influenza viruses produced in a suspension process with avian AGE1.CR.pIX cells.
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- BMC Biotechnology, 2012, v. 12, n. 1, p. 79, doi. 10.1186/1472-6750-12-79
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- Article
Cell-line screening and process development for a fusogenic oncolytic virus in small-scale suspension cultures.
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- Applied Microbiology & Biotechnology, 2022, v. 106, n. 13-16, p. 4945, doi. 10.1007/s00253-022-12027-5
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- Article
Parallel Multifactorial Process Optimization and Intensification for High-Yield Production of Live YF17D-Vectored Zika Vaccine.
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- Vaccines, 2024, v. 12, n. 7, p. 755, doi. 10.3390/vaccines12070755
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- Article
Continuous influenza virus production in a tubular bioreactor system provides stable titers and avoids the "von Magnus effect".
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- PLoS ONE, 2019, v. 14, n. 11, p. 1, doi. 10.1371/journal.pone.0224317
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- Article
Seamless Coupling of Chemical Glycan Release and Labeling for an Accelerated Protein N -Glycan Sample Preparation Workflow.
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- Bioengineering (Basel), 2023, v. 10, n. 6, p. 651, doi. 10.3390/bioengineering10060651
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Forced Degradation Testing as Complementary Tool for Biosimilarity Assessment.
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- Bioengineering (Basel), 2019, v. 6, n. 3, p. 1, doi. 10.3390/bioengineering6030062
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- Article
A Deleted Deletion Site in a New Vector Strain and Exceptional Genomic Stability of Plaque-Purified Modified Vaccinia Ankara (MVA).
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- Virologica Sinica (16740769), 2020, v. 35, n. 2, p. 212, doi. 10.1007/s12250-019-00176-3
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- Article
Establishment of Fruit Bat Cells (Rousettus aegyptiacus) as a Model System for the Investigation of Filoviral Infection.
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- PLoS Neglected Tropical Diseases, 2010, v. 4, n. 8, p. 1, doi. 10.1371/journal.pntd.0000802
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- Article
Establishment of Fruit Bat Cells (Rousettus aegyptiacus) as a Model System for the Investigation of Filoviral Infection.
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- PLoS Neglected Tropical Diseases, 2010, v. 4, n. 8, p. 1, doi. 10.1371/journal.pntd.0000802
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- Article
Matrix and Backstage: Cellular Substrates for Viral Vaccines.
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- Viruses (1999-4915), 2014, v. 6, n. 4, p. 1672, doi. 10.3390/v6041672
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A Genotype of Modified Vaccinia Ankara (MVA) that Facilitates Replication in Suspension Cultures in Chemically Defined Medium.
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- Viruses (1999-4915), 2013, v. 5, n. 1, p. 321, doi. 10.3390/v5010321
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- Article
Authentication of the R06E Fruit Bat Cell Line.
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- Viruses (1999-4915), 2012, v. 4, n. 5, p. 889, doi. 10.3390/v4050889
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- Article
Evaluation of HBV Promoters for Use in Hepatic Gene Therapy.
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- Biological Chemistry, 1996, v. 377, n. 3, p. 187
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Hepatocyte-Specific Binding of L/S-HBV Particles Expressed in Insect Cells.
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- Biological Chemistry, 1995, v. 376, n. 3, p. 173
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Transgene expression knockdown in recombinant Modified Vaccinia virus Ankara vectors improves genetic stability and sustained transgene maintenance across multiple passages.
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- Frontiers in Immunology, 2024, p. 1, doi. 10.3389/fimmu.2024.1338492
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- Article
Development of an efficient veterinary rabies vaccine production process in the avian suspension cell line AGE1.CR.pIX.
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- BMC Biotechnology, 2022, v. 22, n. 1, p. 1, doi. 10.1186/s12896-022-00747-5
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- Article
Multi-level glyco-engineering techniques to generate IgG with defined Fc-glycans.
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- Scientific Reports, 2016, p. 36964, doi. 10.1038/srep36964
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- Article
Cre-mediated somatic site-specific recombination in mice.
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- Nucleic Acids Research, 1997, v. 25, n. 9, p. 1766, doi. 10.1093/nar/25.9.1766
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- Article
Cre-mediated somatic site-specific recombination in mice.
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- Nucleic Acids Research, 1997, v. 25, n. 2, p. 1766, doi. 10.1093/nar/25.9.1766
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- Article
Combination Therapy for the Treatment of Shingles with an Immunostimulatory Vaccine Virus and Acyclovir.
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- Pharmaceuticals (14248247), 2023, v. 16, n. 2, p. 226, doi. 10.3390/ph16020226
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- Article
CHO starter cell lines for manufacturing of proteins with pre-defined glycoprofiles.
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- BMC Proceedings, 2013, p. 1, doi. 10.1186/1753-6561-7-S6-P96
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A robust RMCE system based on a CHO-DG44 platform enables efficient evaluation of complex biological drug candidates.
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- BMC Proceedings, 2013, p. 1, doi. 10.1186/1753-6561-7-S6-P66
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- Article
Evaluation of process parameters in shake flasks for mammalian cell culture.
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- BMC Proceedings, 2013, p. 1, doi. 10.1186/1753-6561-7-S6-P17
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- Article
An integrated synchronization approach for studying cell-cycle dependent processes of mammalian cells under physiological conditions.
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- BMC Proceedings, 2013, p. 1, doi. 10.1186/1753-6561-7-S6-P16
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Model-based design of the first steps of a seed train for cell culture processes.
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- BMC Proceedings, 2013, p. 1, doi. 10.1186/1753-6561-7-S6-P11
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- Article
A novel genotype of MVA that efficiently replicates in single cell suspensions.
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- BMC Proceedings, 2013, p. 1, doi. 10.1186/1753-6561-7-S6-O1
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- Article
Characterisation of cultivation of the human cell line AGE1.HN.AAT.
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- 2011
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- Abstract
Analysis of the mitochondrial subproteome of the human cell line AGE1.HN - a contribution to a systems biology approach.
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- 2011
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- Abstract
Producer vs. parental cell - metabolic changes and burden upon α<sub>1</sub>-antitrypsin production in AGE1.HN.
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- 2011
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- Abstract
Pysical methods for synchronization of a human production cell line.
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- 2011
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- Abstract
Criteria for bioreactor comparison and operation standardisation during process development for mammalian cell culture.
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- 2011
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- Abstract
DoE of fed-batch processes - model-based design and experimental evaluation.
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- 2011
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- Abstract
Toolbox approach for fast generation of stable CHO production cell lines from different hosts.
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- 2011
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Increasing antibody yield and modulating final product quality using the FreedomTM CHO-STM production platform.
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- 2011
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Highly efficient, chemically defined and fully scalable biphasic production of vaccine viruses.
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- 2011
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- Abstract
Biosynthetic pathway deflection - a new cell line engineering approach.
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- 2011
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- Abstract