Works by Samuel J. Danishefsky

Results: 123

Der gewundene Pfad zum Erythropoietin entlang der Grenze von Chemie und Biologie.

Published in:

Angewandte Chemie, 2013, v. 125, n. 30, p. 7798, doi. 10.1002/ange.201301666

By:

Wilson, Rebecca M.;
Dong, Suwei;
Wang, Ping;
Danishefsky, Samuel J.

Publication type:

Article

Chemistry as an Expanding Resource in Protein Science: Fully Synthetic and Fully Active Human Parathyroid Hormone-Related Protein (1 -141).

Published in:

Angewandte Chemie, 2012, v. 124, n. 49, p. 12429, doi. 10.1002/ange.201207603

By:

Li, Jianfeng;
Dong, Suwei;
Townsend, Steven D.;
Dean, Thomas;
Gardella, Thomas J.;
Danishefsky, Samuel J.

Publication type:

Article

Titelbild: At Last: Erythropoietin as a Single Glycoform (Angew. Chem. 46/2012).

Published in:

Angewandte Chemie, 2012, v. 124, n. 46, p. 11555, doi. 10.1002/ange.201208087

By:

Wang, Ping;
Dong, Suwei;
Brailsford, John A.;
Iyer, Karthik;
Townsend, Steven D.;
Zhang, Qiang;
Hendrickson, Ronald C.;
Shieh, JaeHung;
Moore, Malcolm A. S.;
Danishefsky, Samuel J.

Publication type:

Article

An Advance in the Chemical Synthesis of Homogeneous N-Linked Glycopolypeptides by Convergent Aspartylation.

Published in:

Angewandte Chemie, 2012, v. 124, n. 46, p. 11739, doi. 10.1002/ange.201205038

By:

Wang, Ping;
Aussedat, Baptiste;
Vohra, Yusufbhai;
Danishefsky, Samuel J.

Publication type:

Article

At Last: Erythropoietin as a Single Glycoform.

Published in:

Angewandte Chemie, 2012, v. 124, n. 46, p. 11744, doi. 10.1002/ange.201206090

By:

Wang, Ping;
Dong, Suwei;
Brailsford, John A.;
Iyer, Karthik;
Townsend, Steven D.;
Zhang, Qiang;
Hendrickson, Ronald C.;
Shieh, JaeHung;
Moore, Malcolm A. S.;
Danishefsky, Samuel J.

Publication type:

Article

Eine faszinierende Reise in die Geschichte: Isonitrile als Ausgangsverbindungen für komplexe Amide.

Published in:

Angewandte Chemie, 2012, v. 124, n. 12, p. 2888, doi. 10.1002/ange.201106628

By:

Wilson, Rebecca M.;
Stockdill, Jennifer L.;
Wu, Xiangyang;
Li, Xuechen;
Vadola, Paul A.;
Park, Peter K.;
Wang, Ping;
Danishefsky, Samuel J.

Publication type:

Article

Probing the Frontiers of Glycoprotein Synthesis: The Fully Elaborated β-Subunit of the Human Follicle-Stimulating Hormone.

Published in:

Angewandte Chemie, 2012, v. 124, n. 4, p. 999, doi. 10.1002/ange.201107482

By:

Nagorny, Pavel;
Sane, Neeraj;
Fasching, Bernhard;
Aussedat, Baptiste;
Danishefsky, Samuel J.

Publication type:

Article

Experimental Diels-Alder Reactivities of Cycloalkenones and Cyclic Dienes Explained through Transition-State Distortion Energies.

Published in:

Angewandte Chemie, 2011, v. 123, n. 44, p. 10550, doi. 10.1002/ange.201103998

By:

Paton, Robert S.;
Kim, Seonah;
Ross, Audrey G.;
Danishefsky, Samuel J.;
Houk, K. N.

Publication type:

Article

Insights into the Finer Issues of Native Chemical Ligation: An Approach to Cascade Ligations.

Published in:

Angewandte Chemie, 2010, v. 122, n. 49, p. 9690, doi. 10.1002/ange.201005513

By:

Tan, Zhongping;
Shang, Shiying;
Danishefsky, Samuel J.

Publication type:

Article

Zum Wirkungsbereich der chemischen Synthese: Aufbau einer Minipipeline in einem akademischen Labor.

Published in:

Angewandte Chemie, 2010, v. 122, n. 35, p. 6168, doi. 10.1002/ange.201000775

By:

Wilson, Rebecca M.;
Danishefsky, Samuel J.

Publication type:

Article

Titelbild: Zum Wirkungsbereich der chemischen Synthese: Aufbau einer Minipipeline in einem akademischen Labor (Angew. Chem. 35/2010).

Published in:

Angewandte Chemie, 2010, v. 122, n. 35, p. 6139, doi. 10.1002/ange.201004265

By:

Wilson, Rebecca M.;
Danishefsky, Samuel J.

Publication type:

Article

Building Complex Glycopeptides: Development of a Cysteine-Free Native Chemical Ligation ProtocolThis work was supported by the National Institutes of Health (Grant CA28824 to S.J.D., and CA62948 to J.D.W.) and by New York State Department of Health, New York State Breast Cancer Research and Education Fund (to B.W.).

Published in:

Angewandte Chemie, 2006, v. 118, n. 25, p. 4222, doi. 10.1002/ange.200600538

By:

Bin Wu;
Jiehao Chen;
J. David Warren;
Gong Chen;
Zihao Hua;
Samuel J. Danishefsky

Publication type:

Article

Titelbild: Der Weg zu Fludelon: ein Tumortherapeutikum mit außergewöhnlichen Eigenschaften (Angew. Chem. 19/2005).

Published in:

Angewandte Chemie, 2005, v. 117, n. 19, p. 2877, doi. 10.1002/ange.200590063

By:

Alexey Rivkin;
Ting-Chao Chou;
Samuel J. Danishefsky

Publication type:

Article

Der Weg zu Fludelon: ein Tumortherapeutikum mit außergewöhnlichen Eigenschaften.

Published in:

Angewandte Chemie, 2005, v. 117, n. 19, p. 2898, doi. 10.1002/ange.200461751

By:

Alexey Rivkin;
Ting-Chao Chou;
Samuel J. Danishefsky

Publication type:

Article

Toward fully synthetic, homogeneous glycoproteins: Advances in chemical ligation.

Published in:

Biopolymers, 2010, v. 94, n. 4, p. 373, doi. 10.1002/bip.21374

By:

Yuan, Yu;
Chen, Jin;
Wan, Qian;
Wilson, Rebecca M.;
Danishefsky, Samuel J.

Publication type:

Article

Potent reversal of multidrug resistance by ningalins and its use in drug combinations against human colon carcinoma xenograft in nude mice.

Published in:

Cancer Chemotherapy & Pharmacology, 2005, v. 56, n. 4, p. 379, doi. 10.1007/s00280-005-1019-y

By:

Ting-Chao Chou;
Yongbiao Guan;
Soenen, Danielle R.;
Danishefsky, Samuel J.;
Boger, Dale L.

Publication type:

Article

Total synthesis of the potential anticancer vaccine KH-1 adenocarcinoma antigen.

Published in:

Nature, 1997, v. 387, n. 6629, p. 164, doi. 10.1038/387164a0

By:

Deshpande, Prashant P.;
Danishefsky, Samuel J.

Publication type:

Article

Toward Homogeneous Erythropoietin: Application of Metal-Free Dethiylation in the Chemical Synthesis of the Ala79-Arg166 Glycopeptide Domain.

Published in:

Israel Journal of Chemistry, 2011, v. 51, n. 8/9, p. 968, doi. 10.1002/ijch.201100077

By:

Dong, Suwei;
Shang, Shiying;
Tan, Zhongping;
Danishefsky, Samuel J.

Publication type:

Article

A Synthetic Pathway to Either Enantiomer of Merrilactone A.

Published in:

Angewandte Chemie, 2005, v. 117, n. 10, p. 1535, doi. 10.1002/ange.200462509

By:

Zhaoyang Meng;
Samuel J. Danishefsky

Publication type:

Article

In Pursuit of Carbohydrate-Based HIV Vaccines, Part 2: The Total Synthesis of High-Mannose-Type gp120 FragmentsEvaluation of Strategies Directed to Maximal Convergence ( This work was supported by the National Institutes of Health (CA-28824). US Army Breast Cancer Foundation postdoctoral fellowship support is gratefully acknowledged by X.G. (BC022120) and V.D. (BC020513). We thank Ms. Anna Dudkina and Ms. Sylvi Rusli (NMR Core Facility, CA-02848) for mass spectrometric analyses, Dr. George Sukenic for NMR spectroscopic analyses, and Dr. J. David Warren for help in the preparation of starting materials. We also thank Dr. Justin S. Miller, Dr. Tom Muir, Mr. Michael Hahn, and Mr. Matthew Sekedat for their generous help in the preparation of the peptides. )

Published in:

Angewandte Chemie, 2004, v. 116, n. 19, p. 2616, doi. 10.1002/ange.200353626

By:

Xudong Geng;
Vadim Y. Dudkin;
Mihirbaran Mandal;
Samuel J. Danishefsky

Publication type:

Article

Toward Fully Synthetic Homogeneous Glycoproteins: A High Mannose Core Containing Glycopeptide Carrying Full H-Type 2 Human Blood Group Specificity.

Published in:

Angewandte Chemie, 2001, v. 113, n. 9, p. 1778, doi. 10.1002/1521-3757(20010504)113:9<1778::AID-ANGE17780>3.0.CO;2-K

By:

Wang, Zhi-Guang;
Zhang, Xufang;
Visser, Michael;
Live, David;
Zatorski, Andrzej;
Iserloh, Ulrich;
Lloyd, Kenneth O.;
Danishefsky, Samuel J.

Publication type:

Article

Die Totalsynthese von (±)-Mitomycin K.

Published in:

Angewandte Chemie, 1992, v. 104, n. 7, p. 934, doi. 10.1002/ange.19921040743

By:

Benbow, John W.;
Schulte, Gayle K.;
Danishefsky, Samuel J.

Publication type:

Article

A preclinical study comparing approaches for augmenting the immunogenicity of a heptavalent KLH-conjugate vaccine against epithelial cancers.

Published in:

Cancer Immunology, Immunotherapy, 2003, v. 52, n. 10, p. 608, doi. 10.1007/s00262-003-0399-2

By:

Ragupathi, Govind;
Koide, Fusataka;
Sathyan, Natarajan;
Kagan, Ella;
Spassova, Maria;
Bornmann, William;
Gregor, Polly;
Reis, Celso A.;
Clausen, Henrik;
Danishefsky, Samuel J.;
Livingston, Philip O.

Publication type:

Article

Constructing an adenocarcinoma vaccine: Immunization of mice with synthetic KH-1 nonasaccharide stimulates anti-KH-1 and anti-Le.

Published in:

International Journal of Cancer, 2002, v. 99, n. 2, p. 207, doi. 10.1002/ijc.10305

By:

Ragupathi, Govindaswami;
Deshpande, Prashant P.;
Coltart, Don M.;
Kim, Hyunjin M.;
Williams, Lawrence J.;
Danishefsky, Samuel J.;
Livingston, Philip O.

Publication type:

Article

Immunization of ovarian cancer patients with a synthetic Lewis.

Published in:

International Journal of Cancer, 2000, v. 87, n. 1, p. 79, doi. 10.1002/1097-0215(20000701)87:1<79::AID-IJC12>3.0.CO;2-L

By:

Sabbatini, Paul J.;
Kudryashov, Valery;
Ragupathi, Govindaswami;
Danishefsky, Samuel J.;
Livingston, Philip O.;
Bornmann, William;
Spassova, Maria;
Zatorski, Andrzej;
Spriggs, David;
Aghajanian, Carol;
Soignet, Steven;
Peyton, Madeline;
O'Flaherty, Catherine;
Curtin, John;
Lloyd, Kenneth O.

Publication type:

Article

A Phase I Study of Unimolecular Pentavalent (Globo-H-GM2-sTn-TF-Tn) Immunization of Patients with Epithelial Ovarian, Fallopian Tube, or Peritoneal Cancer in First Remission.

Published in:

Cancers, 2016, v. 8, n. 4, p. 46, doi. 10.3390/cancers8040046

By:

O'Cearbhaill, Roisin E.;
Ragupathi, Govind;
Jianglong Zhu;
Qian Wan;
Mironov, Svetlana;
Guangbin Yang;
Spassova, Maria K.;
Iasonos, Alexia;
Kravetz, Sara;
Ouerfelli, Ouathek;
Spriggs, David R.;
Danishefsky, Samuel J.;
Sabbatini, Paul J.

Publication type:

Article

From the Laboratory to the Clinic: A Retrospective on Fully Synthetic Carbohydrate-Based Anticancer Vaccines.

Published in:

Angewandte Chemie International Edition, 2000, v. 39, n. 5, p. 836, doi. 10.1002/(SICI)1521-3773(20000303)39:5<836::AID-ANIE836>3.0.CO;2-I

By:

Danishefsky, Samuel J.;
Allen, Jennifer R.

Publication type:

Article

The Total Synthesis of Frondosin B.

Published in:

Angewandte Chemie International Edition, 2000, v. 39, n. 4, p. 761, doi. 10.1002/(SICI)1521-3773(20000218)39:4<761::AID-ANIE761>3.0.CO;2-I

By:

Inoue, Masayuki;
Frontier, Alison J.;
Danishefsky, Samuel J.

Publication type:

Article

Total Synthesis of (+)-Halichlorine: An Inhibitor of VCAM-1 Expression.

Published in:

Angewandte Chemie International Edition, 1999, v. 38, n. 23, p. 3542, doi. 10.1002/(SICI)1521-3773(19991203)38:23<3542::AID-ANIE3542>3.0.CO;2-I

By:

Trauner, Dirk;
Schwarz, Jacob B.;
Danishefsky, Samuel J.

Publication type:

Article

Discovery Through Total Synthesis-Epimerization at C7 in the CP Compounds: Is (7 S)-CP-263,114 a Fermentation Product?

Published in:

Angewandte Chemie International Edition, 1999, v. 38, n. 21, p. 3197, doi. 10.1002/(SICI)1521-3773(19991102)38:21<3197::AID-ANIE3197>3.0.CO;2-6

By:

Meng, Dongfang;
Tan, Qiang;
Danishefsky, Samuel J.

Publication type:

Article

Stereospecific Sulfur-Mediated Cleavage of a Spirocyclobutanone: Synthesis of a Fully Functional Precursor to the CP Compounds.

Published in:

Angewandte Chemie International Edition, 1999, v. 38, n. 10, p. 1485, doi. 10.1002/(SICI)1521-3773(19990517)38:10<1485::AID-ANIE1485>3.0.CO;2-1

By:

Meng, Dongfang;
Danishefsky, Samuel J.

Publication type:

Article

A Fully Synthetic Globo H Carbohydrate Vaccine Induces a Focused Humoral Response in Prostate Cancer Patients: A Proof of Principle.

Published in:

Angewandte Chemie International Edition, 1999, v. 38, n. 4, p. 563, doi. 10.1002/(SICI)1521-3773(19990215)38:4<563::AID-ANIE563>3.0.CO;2-3

By:

Ragupathi, Govindaswami;
Slovin, Susan F.;
Adluri, Sucharita;
Sames, Dalibor;
Kim, In Jong;
Kim, Hyunjin M.;
Spassova, Maria;
Bornmann, William G.;
Lloyd, Kenneth O.;
Scher, Howard I.;
Livingston, Philip O.;
Danishefsky, Samuel J.

Publication type:

Article

Studies in the Total Synthesis of Himastatin: A Revision of the Stereochemical Assignment.

Published in:

Angewandte Chemie International Edition, 1998, v. 37, n. 21, p. 2993, doi. 10.1002/(SICI)1521-3773(19981116)37:21<2993::AID-ANIE2993>3.0.CO;2-I

By:

Kamenecka, Theodore M.;
Danishefsky, Samuel J.

Publication type:

Article

Total Synthesis of Himastatin: Confirmation of the Revised Stereostructure.

Published in:

Angewandte Chemie International Edition, 1998, v. 37, n. 21, p. 2995, doi. 10.1002/(SICI)1521-3773(19981116)37:21<2995::AID-ANIE2995>3.0.CO;2-6

By:

Kamenecka, Theodore M.;
Danishefsky, Samuel J.

Publication type:

Article

A Novel Aldol Condensation with 2-Methyl-4-pentenal and Its Application to an Improved Total Synthesis of Epothilone B.

Published in:

Angewandte Chemie International Edition, 1998, v. 37, n. 19, p. 2675, doi. 10.1002/(SICI)1521-3773(19981016)37:19<2675::AID-ANIE2675>3.0.CO;2-O

By:

Balog, Aaron;
Harris, Christina;
Savin, Kenneth;
Zhang, Xiu-Guo;
Chou, Ting-Chao;
Danishefsky, Samuel J.

Publication type:

Article

A Stereospecific Geminal Alkylation Scheme En Route To CP-225, 917 and CP-263,114.

Published in:

Angewandte Chemie International Edition, 1998, v. 37, n. 13/14, p. 1880, doi. 10.1002/(SICI)1521-3773(19980803)37:13/14<1880::AID-ANIE1880>3.0.CO;2-5

By:

Kwon, Ohyun;
Su, Dai-Shi;
Meng, Dongfang;
Deng, Wei;
D'Amico, Derin C.;
Danishefsky, Samuel J.

Publication type:

Article

Total Syntheses of CP-225,917 and CP-263,114: Creation of a Matrix Structure By Sequential Aldol Condensation and Intramolecular Heck Ring Closure.

Published in:

Angewandte Chemie International Edition, 1998, v. 37, n. 13/14, p. 1877, doi. 10.1002/(SICI)1521-3773(19980803)37:13/14<1877::AID-ANIE1877>3.0.CO;2-2

By:

Kwon, Ohyun;
Su, Dai-Shi;
Meng, Dongfang;
Deng, Wei;
D'Amico, Derin C.;
Danishefsky, Samuel J.

Publication type:

Article

The Total Synthesis of Spirotryprostatin A.

Published in:

Angewandte Chemie International Edition, 1998, v. 37, n. 8, p. 1138, doi. 10.1002/(SICI)1521-3773(19980504)37:8<1138::AID-ANIE1138>3.0.CO;2-N

By:

Edmondson, Scott D.;
Danishefsky, Samuel J.

Publication type:

Article

Amidoglycosylation of Polymer-Bound Glycals: A Complete Solid-Phase Synthesis of the Oligosaccharide Domain of the Lewis.

Published in:

Angewandte Chemie International Edition, 1998, v. 37, n. 6, p. 786, doi. 10.1002/(SICI)1521-3773(19980403)37:6<786::AID-ANIE786>3.0.CO;2-F

By:

Zheng, Changsheng;
Seeberger, Peter H.;
Danishefsky, Samuel J.

Publication type:

Article

The Total Synthesis of Eleutherobin: A Surprise Ending.

Published in:

Angewandte Chemie International Edition, 1998, v. 37, n. 6, p. 789, doi. 10.1002/(SICI)1521-3773(19980403)37:6<789::AID-ANIE789>3.0.CO;2-3

By:

Chen, Xiao-Tao;
Zhou, Bishan;
Bhattacharya, Samit K.;
Gutteridge, Clare E.;
Pettus, Thomas R. R.;
Danishefsky, Samuel J.

Publication type:

Article

A Convergent Route for the Total Synthesis of the Eleuthesides.

Published in:

Angewandte Chemie International Edition, 1998, v. 37, n. 1/2, p. 185, doi. 10.1002/(SICI)1521-3773(19980202)37:1/2<185::AID-ANIE185>3.0.CO;2-L

By:

Chen, Xiao-Tao;
Gutteridge, Clare E.;
Bhattacharya, Samit K.;
Zhou, Bishan;
Pettus, Thomas R. R.;
Hascall, Tony;
Danishefsky, Samuel J.

Publication type:

Article

Structure-Activity Relationship of the Epothilones and the First In Vivo Comparison with Paclitaxel.

Published in:

Angewandte Chemie International Edition, 1997, v. 36, n. 19, p. 2093, doi. 10.1002/anie.199720931

By:

Su, Dai-Shi;
Balog, Aaron;
Meng, Dongfang;
Bertinato, Peter;
Danishefsky, Samuel J.;
Zheng, Yu-Huang;
Chou, Ting-Chao;
He, Lifeng;
Horwitz, Susan B.

Publication type:

Article

Total Synthesis of (-)-Epothilone B: An Extension of the Suzuki Coupling Method and Insights into Structure-Activity Relationships of the Epothilones.

Published in:

Angewandte Chemie International Edition, 1997, v. 36, n. 7, p. 757, doi. 10.1002/anie.199707571

By:

Su, Dai-Shi;
Meng, Dongfang;
Bertinato, Peter;
Balog, Aaron;
Sorensen, Erik J.;
Danishefsky, Samuel J.;
Zheng, Yu-Huang;
Chou, Ting-Chao;
He, Lifeng;
Horwitz, Susan B.

Publication type:

Article

Monitoring the Progress of Solid-Phase Oligosaccharide Synthesis by High-Resolution Magic Angle Spinning NMR: Observations of Enhanced Selectivity for β-Glycoside Formation from α-1,2-Anhydrosugar Donors in Solid-Phase Couplings.

Published in:

Angewandte Chemie International Edition, 1997, v. 36, n. 5, p. 491, doi. 10.1002/anie.199704911

By:

Seeberger, Peter H.;
Beebe, Xenia;
Sukenick, George D.;
Pochapsky, Susan;
Danishefsky, Samuel J.

Publication type:

Article

Immunization of Mice with a Fully Synthetic Globo H Antigen Results in Antibodies against Human Cancer Cells: A Combined Chemical-Immunological Approach to the Fashioning of an Anticancer Vaccine.

Published in:

Angewandte Chemie International Edition, 1997, v. 36, n. 1/2, p. 125, doi. 10.1002/anie.199701251

By:

Ragupathi, Govindaswami;
Park, Tae Kyo;
Zhang, Shengle;
Kim, In Jong;
Graber, Linda;
Adluri, Sucharita;
Lloyd, Kenneth O.;
Danishefsky, Samuel J.;
Livingston, Philip O.

Publication type:

Article

Synthesis and a Preliminary DNA Binding Study of Hybrids of the Carbohydrate Domain of Calicheamicin γ.

Published in:

Angewandte Chemie International Edition, 1996, v. 35, n. 23/24, p. 2797, doi. 10.1002/anie.199627971

By:

Depew, Kristopher M.;
Zeman, Steven M.;
Boyer, Serge H.;
Denhart, Derek J.;
Ikemoto, Norihiro;
Danishefsky, Samuel J.;
Crothers, Donald M.

Publication type:

Article

Total Synthesis of (-)-Epothilone A.

Published in:

Angewandte Chemie International Edition, 1996, v. 35, n. 23/24, p. 2801, doi. 10.1002/anie.199628011

By:

Balog, Aaron;
Meng, Dongfang;
Kamenecka, Ted;
Bertinato, Peter;
Su, Dai-Shi;
Sorensen, Erik J.;
Danishefsky, Samuel J.

Publication type:

Article

Glycals in Organic Synthesis: The Evolution of Comprehensive Strategies for the Assembly of Oligosaccharides and Glycoconjugates of Biological Consequence.

Published in:

Angewandte Chemie International Edition, 1996, v. 35, n. 13/14, p. 1380, doi. 10.1002/anie.199613801

By:

Danishefsky, Samuel J.;
Bilodeau, Mark T.

Publication type:

Article

A Total Synthesis of Taxol.

Published in:

Angewandte Chemie International Edition, 1995, v. 34, n. 16, p. 1723, doi. 10.1002/anie.199517231

By:

Masters, John J.;
Link, J. T.;
Snyder, Lawrence B.;
Young, Wendy B.;
Danishefsky, Samuel J.

Publication type:

Article

Total Synthesis of (±)-Dynemicin A.

Published in:

Angewandte Chemie International Edition, 1995, v. 34, n. 16, p. 1721, doi. 10.1002/anie.199517211

By:

Shair, Matthew D.;
Yoon, Tae-young;
Danishefsky, Samuel J.

Publication type:

Article