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Roles of IκB kinases and TANK-binding kinase 1 in hepatic lipid metabolism and nonalcoholic fatty liver disease.
- Published in:
- Experimental & Molecular Medicine EMM, 2021, v. 53, n. 11, p. 1697, doi. 10.1038/s12276-021-00712-w
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- Article
Chop/Ddit3 depletion in β cells alleviates ER stress and corrects hepatic steatosis in mice.
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- Science Translational Medicine, 2021, v. 13, n. 604, p. 1, doi. 10.1126/scitranslmed.aba9796
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- Article
FGF21 is required for the metabolic benefits of IKKε/TBK1 inhibition.
- Published in:
- 2021
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- Publication type:
- journal article
NBR1 is a critical step in the repression of thermogenesis of p62-deficient adipocytes through PPARγ.
- Published in:
- Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-23085-0
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- Article
Insulin signaling in health and disease.
- Published in:
- 2021
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- Publication type:
- journal article
Synthesis of deuterium‐labelled amlexanox and its metabolic stability against mouse, rat, and human microsomes.
- Published in:
- Journal of Labelled Compounds & Radiopharmaceuticals, 2019, v. 62, n. 5, p. 202, doi. 10.1002/jlcr.3716
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- Publication type:
- Article
Phosphorylation of the exocyst protein Exo84 by TBK1 promotes insulin-stimulated GLUT4 trafficking.
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- Science Signaling, 2017, v. 10, n. 471, p. 1, doi. 10.1126/scisignal.aah5085
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- Article
Inflammatory mechanisms linking obesity and metabolic disease.
- Published in:
- 2017
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- Publication type:
- journal article
New therapeutic approaches for the treatment of obesity.
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- Science Translational Medicine, 2016, v. 8, n. 323, p. 1, doi. 10.1126/scitranslmed.aad1811
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- Article
Gene Expression Signature in Adipose Tissue of Acromegaly Patients.
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- PLoS ONE, 2015, v. 10, n. 6, p. 1, doi. 10.1371/journal.pone.0129359
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- Article
Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance.
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- Nature Medicine, 2015, v. 21, n. 2, p. 159, doi. 10.1038/nm.3760
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- Article
A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis.
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- Nature Communications, 2015, v. 6, n. 1, p. 6047, doi. 10.1038/ncomms7047
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- Publication type:
- Article
Metabolic Crosstalk: Molecular Links Between Glycogen and Lipid Metabolism in Obesity.
- Published in:
- Diabetes, 2014, v. 63, n. 9, p. 2935, doi. 10.2337/db13-1531
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- Article
Countering inflammatory signals in obesity.
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- Nature Immunology, 2014, v. 15, n. 5, p. 410, doi. 10.1038/ni.2874
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- Publication type:
- Article
Otopetrin 1 Protects Mice From Obesity-Associated Metabolic Dysfunction Through Attenuating Adipose Tissue Inflammation.
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- Diabetes, 2014, v. 63, n. 4, p. 1340, doi. 10.2337/db13-1139
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- Publication type:
- Article
SRA Regulates Adipogenesis by Modulating p38/JNK Phosphorylation and Stimulating Insulin Receptor Gene Expression and Downstream Signaling.
- Published in:
- PLoS ONE, 2014, v. 9, n. 4, p. 1, doi. 10.1371/journal.pone.0095416
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- Publication type:
- Article
An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice.
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- Nature Medicine, 2013, v. 19, n. 3, p. 313, doi. 10.1038/nm.3082
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- Publication type:
- Article
TC10 Is Regulated by Caveolin in 3T3-L1 Adipocytes.
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- PLoS ONE, 2012, v. 7, n. 8, p. 1, doi. 10.1371/journal.pone.0042451
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- Article
Regulation of glucose transport by insulin: traffic control of GLUT4.
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- Nature Reviews Molecular Cell Biology, 2012, v. 13, n. 6, p. 383, doi. 10.1038/nrm3351
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- Publication type:
- Article
Inflammatory links between obesity and metabolic disease.
- Published in:
- 2011
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- Publication type:
- journal article
Exocyst function regulated by effector phosphorylation.
- Published in:
- Nature Cell Biology, 2011, v. 13, n. 5, p. 580, doi. 10.1038/ncb2226
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- Publication type:
- Article
T-ing up inflammation in fat.
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- Nature Medicine, 2009, v. 15, n. 8, p. 846, doi. 10.1038/nm0809-846
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- Publication type:
- Article
Distinct mutations in the glycogen debranching enzyme found in glycogen storage disease type III lead to impairment in diverse cellular functions.
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- Human Molecular Genetics, 2009, v. 18, n. 11, p. 2045, doi. 10.1093/hmg/ddp128
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- Article
Von Gierke's Disease Adopts an Orphan (and Its Partner).
- Published in:
- Science Signaling, 2009, v. 2, n. 58, p. 1, doi. 10.1126/scisignal.258pe8
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- Publication type:
- Article
Phenotypic Switching of Adipose Tissue Macrophages With Obesity Is Generated by Spatiotemporal Differences in Macrophage Subtypes.
- Published in:
- Diabetes, 2008, v. 57, n. 12, p. 3239, doi. 10.2337/db08-0872
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- Publication type:
- Article
Diet-Induced Obesity Generates Tissue-Specific Alterations In Macrophage Activation State.
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- Diabetes, 2007, v. 56, p. A71
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- Publication type:
- Article
Bone marrow–specific Cap gene deletion protects against high-fat diet–induced insulin resistance.
- Published in:
- Nature Medicine, 2007, v. 13, n. 4, p. 455, doi. 10.1038/nm1550
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- Publication type:
- Article
Increased Inflammatory Properties of Adipose Tissue Macrophages Recruited During Diet-Induced Obesity.
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- Diabetes, 2007, v. 56, n. 1, p. 16, doi. 10.2337/db06-1076
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- Publication type:
- Article
Obesity induces a phenotypic switch in adipose tissue macrophage polarization.
- Published in:
- 2007
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- Publication type:
- journal article
CAP interacts with cytoskeletal proteins and regulates adhesion-mediated ERK activation and motility.
- Published in:
- EMBO Journal, 2006, v. 25, n. 22, p. 5284, doi. 10.1038/sj.emboj.7601406
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- Article
Lipid phosphatases as drug discovery targets for type 2 diabetes.
- Published in:
- 2006
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- Publication type:
- journal article
More TORC for the gluconeogenic engine.
- Published in:
- BioEssays, 2006, v. 28, n. 3, p. 231, doi. 10.1002/bies.20375
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- Article
Staying in SHIP shape.
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- Nature Medicine, 2005, v. 11, n. 2, p. 123, doi. 10.1038/nm0205-123
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- Publication type:
- Article
Atypical protein kinase C (PKC&xgr;/&lambda') is a convergent downstream target of the insulin-stimulated phosphatidylinositol 3-kinase and TC10 signaling pathways.
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- Journal of Cell Biology, 2004, v. 164, n. 2, p. 279, doi. 10.1083/jcb.200306152
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- Publication type:
- Article
A TUG on glucose transport.
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- Nature Medicine, 2003, v. 9, n. 11, p. 1352, doi. 10.1038/nm1103-1352
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- Publication type:
- Article
The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin.
- Published in:
- Nature, 2003, v. 422, n. 6932, p. 629, doi. 10.1038/nature01533
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- Publication type:
- Article
Insulin signalling and the regulation of glucose and lipid metabolism.
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- Nature, 2001, v. 414, n. 6865, p. 799, doi. 10.1038/414799a
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- Publication type:
- Article
Lipid raft microdomain compartmentalization of TC10 is required for insulin signaling and GLUT4...
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- Journal of Cell Biology, 2001, v. 154, n. 4, p. 829, doi. 10.1083/jcb.200102078
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- Article
You are what you secrete.
- Published in:
- Nature Medicine, 2001, v. 7, n. 8, p. 887, doi. 10.1038/90911
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- Publication type:
- Article
Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10.
- Published in:
- Nature, 2001, v. 410, n. 6831, p. 944, doi. 10.1038/35073608
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- Publication type:
- Article
Spatial compartmentalization of signal transduction in insulin action.
- Published in:
- BioEssays, 2001, v. 23, n. 3, p. 215, doi. 10.1002/1521-1878(200103)23:3<215::AID-BIES1031>3.0.CO;2-S
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- Publication type:
- Article
Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo.
- Published in:
- Nature Medicine, 1999, v. 5, n. 7, p. 810, doi. 10.1038/10533
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- Publication type:
- Article
Mutational analysis of the coding regions of the genes encoding protein kinase B-alpha and -beta, phosphoinositide-dependent protein kinase-1, phosphatase targeting to glycogen, protein phosphatase inhibitor-1, and glycogenin: lessons from a search for genetic variability of the insulin-stimulated glycogen synthesis pathway of skeletal muscle in NIDDM patients.
- Published in:
- 1999
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- Publication type:
- journal article
Regulation of Secretion of Alzheimer Amyloid Precursor Protein by the Mitogen-Activated Protein Kinase Cascade.
- Published in:
- Journal of Neurochemistry, 1998, v. 70, n. 2, p. 524, doi. 10.1046/j.1471-4159.1998.70020524.x
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- Publication type:
- Article
Inducible expression of a mutant form of MEK1 in Swiss 3T3 cells.
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- Journal of Cellular Biochemistry, 1997, v. 67, n. 3, p. 367, doi. 10.1002/(SICI)1097-4644(19971201)67:3<367::AID-JCB8>3.0.CO;2-U
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- Publication type:
- Article
Cellular mechanisms of signal transduction for neurotrophins.
- Published in:
- BioEssays, 1994, v. 16, n. 6, p. 405, doi. 10.1002/bies.950160608
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- Publication type:
- Article
Diversity in Cellular Signaling for Nerve Growth Factor and Insulin: Variations On a Common Theme.
- Published in:
- Journal of Investigative Dermatology, 1992, v. 98, n. 6, p. 17S, doi. 10.1111/1523-1747.ep12462110
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- Publication type:
- Article
The specific protein phosphatase inhibitor okadaic acid differentially modulates insulin action.
- Published in:
- Journal of Cellular Biochemistry, 1991, v. 45, n. 4, p. 374, doi. 10.1002/jcb.240450411
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- Publication type:
- Article
Second messengers of insulin action.
- Published in:
- 1990
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- Publication type:
- journal article
Purification of putative insulin-sensitive cAMP phosphodiesterase or its catalytic domain from rat adipocytes.
- Published in:
- 1986
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- Publication type:
- journal article