Works by Salah, Eidarus

Results: 21

JmjC catalysed histone H2a N-methyl arginine demethylation and C4-arginine hydroxylation reveals importance of sequence-reactivity relationships.
Published in:
Communications Biology, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s42003-024-07183-5
By:
- Bonnici, Joanna;
- Oueini, Razanne;
- Salah, Eidarus;
- Johansson, Catrine;
- Pires, Elisabete;
- Abboud, Martine;
- Dawber, Robert S.;
- Tumber, Anthony;
- Rabe, Patrick;
- Saraç, Hilal;
- Schofield, Christopher J.;
- Kawamura, Akane
Publication type:
Article
Innenrücktitelbild: A Small‐Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine‐Flip Pocket for the Treatment of Obesity (Angew. Chem. 40/2024).
Published in:
Angewandte Chemie, 2024, v. 136, n. 40, p. 1, doi. 10.1002/ange.202414504
By:
- Wu, Yue;
- Chen, Yafen;
- Corner, Thomas P.;
- Nakashima, Yu;
- Salah, Eidarus;
- Li, Zhihong;
- Zhang, Linjian;
- Yang, Le;
- Tumber, Anthony;
- Sun, Zhuoli;
- Wen, Yukang;
- Zhong, Ailin;
- Yang, Fulai;
- Li, Xiang;
- Zhang, Zhihong;
- Schofield, Christopher J.;
- Zhang, Xiaojin
Publication type:
Article
A Small‐Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine‐Flip Pocket for the Treatment of Obesity.
Published in:
Angewandte Chemie, 2024, v. 136, n. 40, p. 1, doi. 10.1002/ange.202410438
By:
- Wu, Yue;
- Chen, Yafen;
- Corner, Thomas P.;
- Nakashima, Yu;
- Salah, Eidarus;
- Li, Zhihong;
- Zhang, Linjian;
- Yang, Le;
- Tumber, Anthony;
- Sun, Zhuoli;
- Wen, Yukang;
- Zhong, Ailin;
- Yang, Fulai;
- Li, Xiang;
- Zhang, Zhihong;
- Schofield, Christopher J.;
- Zhang, Xiaojin
Publication type:
Article
Conformational plasticity of the ULK3 kinase domain.
Published in:
Biochemical Journal, 2021, v. 478, n. 14, p. 2811, doi. 10.1042/BCJ20210257
By:
- Mathea, Sebastian;
- Salah, Eidarus;
- Tallant, Cynthia;
- Chatterjee, Deep;
- Berger, Benedict-Tilman;
- Konietzny, Rebecca;
- Müller, Susanne;
- Kessler, Benedikt M.;
- Knapp, Stefan
Publication type:
Article
Lessons from LIMK1 enzymology and their impact on inhibitor design.
Published in:
Biochemical Journal, 2019, v. 476, n. 21, p. 3197, doi. 10.1042/BCJ20190517
By:
- Salah, Eidarus;
- Chatterjee, Deep;
- Beltrami, Alessandra;
- Tumber, Anthony;
- Preuss, Franziska;
- Canning, Peter;
- Chaikuad, Apirat;
- Knaus, Petra;
- Knapp, Stefan;
- Bullock, Alex N.;
- Mathea, Sebastian
Publication type:
Article
The catalytic domains of all human KDM5 JmjC demethylases catalyse N‐methyl arginine demethylation.
Published in:
FEBS Letters, 2023, v. 597, n. 7, p. 933, doi. 10.1002/1873-3468.14586
By:
- Bonnici, Joanna;
- Oueini, Razanne;
- Salah, Eidarus;
- Johansson, Catrine;
- Schofield, Christopher J.;
- Kawamura, Akane
Publication type:
Article
Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy.
Published in:
Nature, 2014, v. 508, n. 7495, p. 222, doi. 10.1038/nature13194
By:
- Huber, Kilian V. M.;
- Salah, Eidarus;
- Radic, Branka;
- Gridling, Manuela;
- Elkins, Jonathan M.;
- Stukalov, Alexey;
- Jemth, Ann-Sofie;
- Göktürk, Camilla;
- Sanjiv, Kumar;
- Strömberg, Kia;
- Pham, Therese;
- Berglund, Ulrika Warpman;
- Colinge, Jacques;
- Bennett, Keiryn L.;
- Loizou, Joanna I.;
- Helleday, Thomas;
- Knapp, Stefan;
- Superti-Furga, Giulio
Publication type:
Article
2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-26673-2
By:
- Nakashima, Yu;
- Brewitz, Lennart;
- Tumber, Anthony;
- Salah, Eidarus;
- Schofield, Christopher J.
Publication type:
Article
Inside Back Cover: A Small‐Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine‐Flip Pocket for the Treatment of Obesity (Angew. Chem. Int. Ed. 40/2024).
Published in:
Angewandte Chemie International Edition, 2024, v. 63, n. 40, p. 1, doi. 10.1002/anie.202414504
By:
- Wu, Yue;
- Chen, Yafen;
- Corner, Thomas P.;
- Nakashima, Yu;
- Salah, Eidarus;
- Li, Zhihong;
- Zhang, Linjian;
- Yang, Le;
- Tumber, Anthony;
- Sun, Zhuoli;
- Wen, Yukang;
- Zhong, Ailin;
- Yang, Fulai;
- Li, Xiang;
- Zhang, Zhihong;
- Schofield, Christopher J.;
- Zhang, Xiaojin
Publication type:
Article
A Small‐Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine‐Flip Pocket for the Treatment of Obesity.
Published in:
Angewandte Chemie International Edition, 2024, v. 63, n. 40, p. 1, doi. 10.1002/anie.202410438
By:
- Wu, Yue;
- Chen, Yafen;
- Corner, Thomas P.;
- Nakashima, Yu;
- Salah, Eidarus;
- Li, Zhihong;
- Zhang, Linjian;
- Yang, Le;
- Tumber, Anthony;
- Sun, Zhuoli;
- Wen, Yukang;
- Zhong, Ailin;
- Yang, Fulai;
- Li, Xiang;
- Zhang, Zhihong;
- Schofield, Christopher J.;
- Zhang, Xiaojin
Publication type:
Article
Structure of the CaMKIIδ/Calmodulin Complex Reveals the Molecular Mechanism of CaMKII Kinase Activation.
Published in:
PLoS Biology, 2010, v. 8, n. 7, p. 1, doi. 10.1371/journal.pbio.1000426
By:
- Rellos, Peter;
- Pike, Ashley C. W.;
- Niesen, Frank H.;
- Salah, Eidarus;
- Wen Hwa Lee;
- von Delft, Frank;
- Knapp, Stefan
Publication type:
Article
Crystallographic and Selectivity Studies on the Approved HIF Prolyl Hydroxylase Inhibitors Desidustat and Enarodustat.
Published in:
ChemMedChem, 2024, v. 19, n. 24, p. 1, doi. 10.1002/cmdc.202400504
By:
- Corner, Thomas P.;
- Salah, Eidarus;
- Tumber, Anthony;
- Kaur, Samanpreet;
- Nakashima, Yu;
- Allen, Mark D.;
- Schnaubelt, Lara I.;
- Fiorini, Giorgia;
- Brewitz, Lennart;
- Schofield, Christopher J.
Publication type:
Article
Structure‐Activity Studies Reveal Scope for Optimisation of Ebselen‐Type Inhibition of SARS‐CoV‐2 Main Protease.
Published in:
ChemMedChem, 2022, v. 17, n. 4, p. 1, doi. 10.1002/cmdc.202100582
By:
- Thun‐Hohenstein, Siegfried T. D.;
- Suits, Timothy F.;
- Malla, Tika R.;
- Tumber, Anthony;
- Brewitz, Lennart;
- Choudhry, Hani;
- Salah, Eidarus;
- Schofield, Christopher J.
Publication type:
Article
Synthesis of Novel Pyridine‐Carboxylates as Small‐Molecule Inhibitors of Human Aspartate/Asparagine‐β‐Hydroxylase.
Published in:
ChemMedChem, 2020, v. 15, n. 13, p. 1139, doi. 10.1002/cmdc.202000147
By:
- Brewitz, Lennart;
- Tumber, Anthony;
- Thalhammer, Armin;
- Salah, Eidarus;
- Christensen, Kirsten E.;
- Schofield, Christopher J.
Publication type:
Article
Cyclic β²,³-amino acids improve the serum stability of macrocyclic peptide inhibitors targeting the SARS-CoV-2 main protease.
Published in:
Bulletin of the Chemical Society of Japan, 2024, v. 97, n. 5, p. 1, doi. 10.1093/bulcsj/uoae018
By:
- Takashi Miura;
- Malla, Tika R.;
- Brewitz, Lennart;
- Tumber, Anthony;
- Salah, Eidarus;
- Kang Ju Lee;
- Naohiro Terasaka;
- Owen, C. David;
- Damerell, Claire Strain;
- Lukacik, Petra;
- Walsh, Martin A.;
- Akane Kawamura;
- Schofield, Christopher J.;
- Takayuki Katoh;
- Hiroaki Suga
Publication type:
Article
Formaldehyde reacts with N-terminal proline residues to give bicyclic aminals.
Published in:
Communications Chemistry, 2023, v. 6, n. 1, p. 1, doi. 10.1038/s42004-022-00801-5
By:
- John, Tobias;
- Pires, Elisabete;
- Hester, Svenja S.;
- Salah, Eidarus;
- Hopkinson, Richard J.;
- Schofield, Christopher J.
Publication type:
Article
Reading and erasing of the phosphonium analogue of trimethyllysine by epigenetic proteins.
Published in:
Communications Chemistry, 2022, v. 5, n. 1, p. 1, doi. 10.1038/s42004-022-00640-4
By:
- Belle, Roman;
- Kamps, Jos J. A. G.;
- Poater, Jordi;
- Kumar, Kiran;
- Pieters, Bas J. G. E.;
- Salah, Eidarus;
- Claridge, Timothy D. W.;
- Paton, Robert S.;
- Bickelhaupt, F. Matthias;
- Kawamura, Akane;
- Schofield, Christopher J.;
- Mecinović, Jasmin
Publication type:
Article
Reading and erasing of the phosphonium analogue of trimethyllysine by epigenetic proteins.
Published in:
Communications Chemistry, 2022, v. 5, n. 1, p. 1, doi. 10.1038/s42004-022-00640-4
By:
- Belle, Roman;
- Kamps, Jos J. A. G.;
- Poater, Jordi;
- Kumar, Kiran;
- Pieters, Bas J. G. E.;
- Salah, Eidarus;
- Claridge, Timothy D. W.;
- Paton, Robert S.;
- Bickelhaupt, F. Matthias;
- Kawamura, Akane;
- Schofield, Christopher J.;
- Mecinović, Jasmin
Publication type:
Article
Quality control in oocytes by p63 is based on a spring-loaded activation mechanism on the molecular and cellular level.
Published in:
eLife, 2016, p. 1, doi. 10.7554/eLife.13909
By:
- Coutandin, Daniel;
- Osterburg, Christian;
- Srivastav, Ratnesh Kumar;
- Sumyk, Manuela;
- Kehrloesser, Sebastian;
- Gebel, Jakob;
- Tuppi, Marcel;
- Hannewald, Jens;
- Schäfer, Birgit;
- Salah, Eidarus;
- Mathea, Sebastian;
- Müller-Kuller, Uta;
- Doutch, James;
- Grez, Manuel;
- Knapp, Stefan;
- Dötsch, Volker
Publication type:
Article
Comprehensive characterization of the Published Kinase Inhibitor Set.
Published in:
Nature Biotechnology, 2016, v. 34, n. 1, p. 95, doi. 10.1038/nbt.3374
By:
- Elkins, Jonathan M;
- Fedele, Vita;
- Szklarz, Marta;
- Abdul Azeez, Kamal R;
- Salah, Eidarus;
- Mikolajczyk, Jowita;
- Romanov, Sergei;
- Sepetov, Nikolai;
- Huang, Xi-Ping;
- Roth, Bryan L;
- Al Haj Zen, Ayman;
- Fourches, Denis;
- Muratov, Eugene;
- Tropsha, Alex;
- Morris, Joel;
- Teicher, Beverly A;
- Kunkel, Mark;
- Polley, Eric;
- Lackey, Karen E;
- Atkinson, Francis L
Publication type:
Article
Substrate selectivity and inhibition of the human lysyl hydroxylase JMJD7.
Published in:
Protein Science: A Publication of the Protein Society, 2024, v. 33, n. 10, p. 1, doi. 10.1002/pro.5162
By:
- Bilgin, Nurgül;
- Tumber, Anthony;
- Dhingra, Siddhant;
- Salah, Eidarus;
- Al‐Salmy, Aziza;
- Martín, Sandra Pinzón;
- Wang, Yicheng;
- Schofield, Christopher J.;
- Mecinović, Jasmin
Publication type:
Article