Found: 31
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Trifluoromethyl Dihydrothiazine‐Based β‐Secretase (BACE1) Inhibitors with Robust Central β‐Amyloid Reduction and Minimal Covalent Binding Burden.
- Published in:
- ChemMedChem, 2019, v. 14, n. 22, p. 1894, doi. 10.1002/cmdc.201900478
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- Publication type:
- Article
PRECLINICAL MULTI-SPECIES PHARMACOKINETIC/PHARMACODYNAMIC ANALYSIS OF THE ORAL BACE INHIBITOR JNJ-54861911.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P266, doi. 10.1016/j.jalz.2017.06.142
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- Publication type:
- Article
P1-010: Native Aβ-oligomer-induced impairment of spatial working memory in mice
- Published in:
- 2008
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- Publication type:
- Abstract
P4-265: BACE1 inhibition reduces Abeta production and alters APP processing in non-transgenic mice
- Published in:
- 2006
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- Publication type:
- Abstract
P4-284: Effects of 3,5-bis(4-nitrophenoxy)-benzoic acid on PS/γ-secretase cleavage
- Published in:
- 2006
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- Publication type:
- Abstract
P3-251: Inhibition of Aβ production is possible without directly affecting secretases and notch signaling
- Published in:
- 2006
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- Publication type:
- Abstract
P1-057: Presenilin-1 I213T knock-in mutation accelerates Alzheimer’s phenotype in Tg2576 mice
- Published in:
- 2006
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- Publication type:
- Abstract
P4-284: Effects of 3,5-bis(4-nitrophenoxy)-benzoic acid on PS/γ-secretase cleavage
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P4-265: BACE1 inhibition reduces Abeta production and alters APP processing in non-transgenic mice
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P3-251: Inhibition of Aβ production is possible without directly affecting secretases and notch signaling
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P1-057: Presenilin-1 I213T knock-in mutation accelerates Alzheimer’s phenotype in Tg2576 mice
- Published in:
- 2006
- By:
- Publication type:
- Abstract
Age-Dependent Enhancement of Hippocampal Long-Term Potentiation and Impairment of Spatial Learning through the Rho-Associated Kinase Pathway in Protein Tyrosine Phosphatase Receptor Type Z-Deficient Mice.
- Published in:
- Journal of Neuroscience, 2005, v. 25, n. 5, p. 1081, doi. 10.1523/JNEUROSCI.2565.04.2005
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- Publication type:
- Article
HUB1, a Novel Krüppel Type Zinc Finger Protein, Represses the Human T Cell Leukemia Virus Type I Long Terminal Repeat-Mediated Expression.
- Published in:
- Nucleic Acids Research, 1997, v. 25, n. 24, p. 5025, doi. 10.1093/nar/25.24.5025
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- Publication type:
- Article
Mice deficient in protein tyrosine phosphatase receptor type Z (PTPRZ) show reduced responsivity to methamphetamine despite an enhanced response to novelty.
- Published in:
- PLoS ONE, 2019, v. 14, n. 8, p. 1, doi. 10.1371/journal.pone.0221205
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- Publication type:
- Article
Doc2α is an activity-dependent modulator of excitatory synaptic transmission.
- Published in:
- European Journal of Neuroscience, 1999, v. 11, n. 12, p. 4262, doi. 10.1046/j.1460-9568.1999.00855.x
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- Publication type:
- Article
Corrigendum to “Enhanced Antitumor Effects of an Engineered Measles Virus Edmonston Strain Expressing the Wild-type N, P, L Genes on Human Renal Cell Carcinoma”.
- Published in:
- 2010
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- Publication type:
- Correction Notice
Enhanced Antitumor Effects of an Engineered Measles Virus Edmonston Strain Expressing the Wild-type N, P, L Genes on Human Renal Cell Carcinoma.
- Published in:
- Molecular Therapy, 2010, v. 18, n. 3, p. 544, doi. 10.1038/mt.2009.296
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- Publication type:
- Article
Serial Analysis of Gene Expression in Progressing and Regressing Mouse Tumors Implicates the Involvement of RANTES and TARC in Antitumor Immune Responses.
- Published in:
- Molecular Therapy, 2006, v. 14, n. 4, p. 599, doi. 10.1016/j.ymthe.2006.04.014
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- Publication type:
- Article
280. RANTES and TARC Enhanced the Antitumor Immune Effects of GM-CSF.
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- Molecular Therapy, 2006, v. 13, p. S107, doi. 10.1016/j.ymthe.2006.08.334
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- Publication type:
- Article
154. Relationship between the Expression of Membrane Receptors (CAR, Integrin αvβ3 and Integrin αvβ5 ) and Adenoviral Transduction Efficiency
- Published in:
- 2005
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- Publication type:
- Abstract
Enhanced GABAergic synaptic transmission at VLPAG neurons and potent modulation by oxycodone in a bone cancer pain model.
- Published in:
- British Journal of Pharmacology, 2015, v. 172, n. 8, p. 2148, doi. 10.1111/bph.13039
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- Publication type:
- Article
G protein-gated inwardly rectifying potassium (KIR3) channels play a primary role in the antinociceptive effect of oxycodone, but not morphine, at supraspinal sites.
- Published in:
- 2014
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- Publication type:
- journal article
G protein-gated inwardly rectifying potassium (K<sub>IR</sub> 3) channels play a primary role in the antinociceptive effect of oxycodone, but not morphine, at supraspinal sites.
- Published in:
- British Journal of Pharmacology, 2014, v. 171, n. 1, p. 253, doi. 10.1111/bph.12441
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- Publication type:
- Article
Topological organization of CA3-to- CA1 excitation.
- Published in:
- European Journal of Neuroscience, 2015, v. 42, n. 5, p. 2135, doi. 10.1111/ejn.12969
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- Publication type:
- Article
Heterogeneous effects of antiepileptic drugs in an in vitro epilepsy model - a functional multineuron calcium imaging study.
- Published in:
- European Journal of Neuroscience, 2015, v. 42, n. 2, p. 1818, doi. 10.1111/ejn.12945
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- Publication type:
- Article
Deglycosylated anti-amyloid beta antibodies reduce microglial phagocytosis and cytokine production while retaining the capacity to induce amyloid beta sequestration.
- Published in:
- European Journal of Neuroscience, 2007, v. 26, n. 9, p. 2458, doi. 10.1111/j.1460-9568.2007.05852.x
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- Publication type:
- Article
The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between β-amyloid production and tau phosphorylation in Alzheimer disease.
- Published in:
- Human Molecular Genetics, 2007, v. 16, n. 1, p. 15, doi. 10.1093/hmg/ddl437
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- Publication type:
- Article
Reduced retinal function in amyloid precursor protein-over-expressing transgenic mice via attenuating glutamate- N-methyl-d-aspartate receptor signaling.
- Published in:
- Journal of Neurochemistry, 2008, v. 107, n. 1, p. 279, doi. 10.1111/j.1471-4159.2008.05606.x
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- Publication type:
- Article
Interleukin-1β up-regulates TACE to enhance α-cleavage of APP in neurons: resulting decrease in Aβ production.
- Published in:
- Journal of Neurochemistry, 2008, v. 104, n. 5, p. 1387, doi. 10.1111/j.1471-4159.2007.05127.x
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- Publication type:
- Article
BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type mice.
- Published in:
- Journal of Neurochemistry, 2006, v. 99, n. 6, p. 1555, doi. 10.1111/j.1471-4159.2006.04178.x
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- Publication type:
- Article
Human group IIA secretory phospholipase A[sub 2] potentiates Ca[sup 2+] influx through L-type voltage-sensitive Ca[sup 2+] channels in cultured rat cortical neurons.
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- Journal of Neurochemistry, 2003, v. 85, n. 3, p. 749, doi. 10.1046/j.1471-4159.2003.01712.x
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- Publication type:
- Article