Works by Sainas, Stefano

Results: 9

The Novel h DHODH Inhibitor MEDS433 Prevents Influenza Virus Replication by Blocking Pyrimidine Biosynthesis.

Published in:

Viruses (1999-4915), 2022, v. 14, n. 10, p. N.PAG, doi. 10.3390/v14102281

By:

Sibille, Giulia;
Luganini, Anna;
Sainas, Stefano;
Boschi, Donatella;
Lolli, Marco Lucio;
Gribaudo, Giorgio

Publication type:

Article

An alternative conformation of the N‐terminal loop of human dihydroorotate dehydrogenase drives binding to a potent antiproliferative agent.

Published in:

Acta Crystallographica: Section D, Structural Biology, 2024, v. 80, n. 6, p. 386, doi. 10.1107/S2059798324004066

By:

Alberti, Marta;
Poli, Giulio;
Broggini, Luca;
Sainas, Stefano;
Rizzi, Menico;
Boschi, Donatella;
Ferraris, Davide M.;
Martino, Elena;
Ricagno, Stefano;
Tuccinardi, Tiziano;
Lolli, Marco L.;
Miggiano, Riccardo

Publication type:

Article

Biochemical characterization of Mycobacterium tuberculosis dihydroorotate dehydrogenase and identification of a selective inhibitor.

Published in:

FEBS Letters, 2023, v. 597, n. 16, p. 2119, doi. 10.1002/1873-3468.14680

By:

Alberti, Marta;
Sainas, Stefano;
Ronchi, Erika;
Lolli, Marco L.;
Boschi, Donatella;
Rizzi, Menico;
Ferraris, Davide M.;
Miggiano, Riccardo

Publication type:

Article

The Synergism between DHODH Inhibitors and Dipyridamole Leads to Metabolic Lethality in Acute Myeloid Leukemia.

Published in:

Cancers, 2021, v. 13, n. 5, p. 1003, doi. 10.3390/cancers13051003

By:

Gaidano, Valentina;
Houshmand, Mohammad;
Vitale, Nicoletta;
Carrà, Giovanna;
Morotti, Alessandro;
Tenace, Valerio;
Rapelli, Stefania;
Sainas, Stefano;
Pippione, Agnese Chiara;
Giorgis, Marta;
Boschi, Donatella;
Lolli, Marco Lucio;
Cilloni, Daniela;
Cignetti, Alessandro;
Saglio, Giuseppe;
Circosta, Paola;
Wong, David

Publication type:

Article

A New NF-κB Inhibitor, MEDS-23, Reduces the Severity of Adverse Post-Ischemic Stroke Outcomes in Rats.

Published in:

Brain Sciences (2076-3425), 2022, v. 12, n. 1, p. 35, doi. 10.3390/brainsci12010035

By:

Rubin, Elina;
Pippione, Agnese C.;
Boyko, Matthew;
Einaudi, Giacomo;
Sainas, Stefano;
Collino, Massimo;
Cifani, Carlo;
Lolli, Marco L.;
Abu-Freha, Naim;
Kaplanski, Jacob;
Boschi, Donatella;
Azab, Abed N.

Publication type:

Article

Regioselective N‐Alkylation of Ethyl 4‐Benzyloxy‐1,2,3‐triazolecarboxylate: A Useful Tool for the Synthesis of Carboxylic Acid Bioisosteres.

Published in:

Journal of Heterocyclic Chemistry, 2019, v. 56, n. 2, p. 501, doi. 10.1002/jhet.3426

By:

Sainas, Stefano;
Pippione, Agnese C.;
Giraudo, Alessandro;
Martina, Katia;
Bosca, Federica;
Rolando, Barbara;
Barge, Alessandro;
Ducime, Alex;
Federico, Antonella;
Grossert, Stuart J.;
White, Robert L.;
Boschi, Donatella;
Lolli, Marco L.

Publication type:

Article

Identification of Human Dihydroorotate Dehydrogenase Inhibitor by a Pharmacophore-Based Virtual Screening Study.

Published in:

Molecules, 2022, v. 27, n. 12, p. 3660, doi. 10.3390/molecules27123660

By:

Galati, Salvatore;
Sainas, Stefano;
Giorgis, Marta;
Boschi, Donatella;
Lolli, Marco L.;
Ortore, Gabriella;
Poli, Giulio;
Tuccinardi, Tiziano

Publication type:

Article

The New Generation h DHODH Inhibitor MEDS433 Hinders the In Vitro Replication of SARS-CoV-2 and Other Human Coronaviruses.

Published in:

Microorganisms, 2021, v. 9, n. 8, p. 1731, doi. 10.3390/microorganisms9081731

By:

Calistri, Arianna;
Luganini, Anna;
Mognetti, Barbara;
Elder, Elizabeth;
Sibille, Giulia;
Conciatori, Valeria;
Del Vecchio, Claudia;
Sainas, Stefano;
Boschi, Donatella;
Montserrat, Nuria;
Mirazimi, Ali;
Lolli, Marco Lucio;
Gribaudo, Giorgio;
Parolin, Cristina

Publication type:

Article

Dihydroorotate dehydrogenase inhibition reveals metabolic vulnerability in chronic myeloid leukemia.

Published in:

Cell Death & Disease, 2022, v. 13, n. 6, p. 1, doi. 10.1038/s41419-022-05028-9

By:

Houshmand, Mohammad;
Vitale, Nicoletta;
Orso, Francesca;
Cignetti, Alessandro;
Molineris, Ivan;
Gaidano, Valentina;
Sainas, Stefano;
Giorgis, Marta;
Boschi, Donatella;
Fava, Carmen;
Passoni, Alice;
Gai, Marta;
Geuna, Massimo;
Sora, Federica;
Iurlo, Alessandra;
Abruzzese, Elisabetta;
Breccia, Massimo;
Mulas, Olga;
Caocci, Giovanni;
Castagnetti, Fausto

Publication type:

Article