Works by Safe, Stephen

Results: 151

Orphan nuclear receptor transcription factors as drug targets.

Published in:

Transcription (2154-1264), 2025, v. 16, n. 2/3, p. 224, doi. 10.1080/21541264.2025.2521766

By:

Safe, Stephen;
Oany, Arafat R.;
Tsui, Wai Ning;
Lee, Miok;
Srivastava, Vinod;
Upadhyay, Srijana;
Hailemariam, Amanuel;
Farkas, Evan;
Kakwan, Sarah;
Kearns, Caitrina;
Sivaram, Gargi

Publication type:

Article

Nuclear receptor 4A2 (NR4A2) is a druggable target for glioblastomas.

Published in:

Journal of Neuro-Oncology, 2020, v. 146, n. 1, p. 25, doi. 10.1007/s11060-019-03349-y

By:

Karki, Keshav;
Li, Xi;
Jin, Un-Ho;
Mohankumar, Kumaravel;
Zarei, Mahsa;
Michelhaugh, Sharon K.;
Mittal, Sandeep;
Tjalkens, Ronald;
Safe, Stephen

Publication type:

Article

Aryl hydrocarbon hydroxylase induction and its relationship to the toxicity of halogenated aryl hydrocarbons.

Published in:

Toxicological & Environmental Chemistry, 1981, v. 4, n. 1/2, p. 1, doi. 10.1080/02772248109356957

By:

Parkinson, Andrew;
Safe, Stephen

Publication type:

Article

Aryl Hydrocarbon Hydroxylase Induction and its Relationship to the Toxicity of Halogenated Aryl Hydrocarbons

Published in:

Toxicological & Environmental Chemistry, 1981, v. 4, n. 1/2, p. 1

By:

Parkinson, Andrew;
Safe, Stephen

Publication type:

Article

Comparative safety, pharmacokinetics, and off-target assessment of 1,1-bis(3′-indolyl)-1-(p-chlorophenyl) methane in mouse and dog: implications for therapeutic development.

Published in:

Toxicology Research, 2024, v. 13, n. 2, p. 1, doi. 10.1093/toxres/tfae059

By:

Rocha, Savannah M;
Gustafson, Daniel L;
Safe, Stephen;
Tjalkens, Ronald B

Publication type:

Article

Flavonoids Quercetin and Kaempferol Are NR4A1 Antagonists and Suppress Endometriosis in Female Mice.

Published in:

Endocrinology, 2023, v. 164, n. 10, p. 1, doi. 10.1210/endocr/bqad133

By:

Zhang, Lei;
Mohankumar, Kumaravel;
Martin, Gregory;
Mariyam, Fuada;
Park, Yuri;
Han, Sang Jun;
Safe, Stephen

Publication type:

Article

Bis-Indole–Derived Nuclear Receptor 4A1 (NR4A1, Nur77) Ligands as Inhibitors of Endometriosis.

Published in:

Endocrinology, 2020, v. 161, n. 4, p. 1, doi. 10.1210/endocr/bqaa027

By:

Mohankumar, Kumaravel;
Li, Xi;
Sung, Nuri;
Cho, Yeon Jean;
Han, Sang Jun;
Safe, Stephen

Publication type:

Article

Activation of COUP-TFI by a Novel Diindolylmethane Derivative.

Published in:

Cells (2073-4409), 2019, v. 8, n. 3, p. 220, doi. 10.3390/cells8030220

By:

Yoon, Kyungsil;
Chen, Chien-Cheng;
Orr, Asuka A.;
Barreto, Patricia N.;
Tamamis, Phanourios;
Safe, Stephen

Publication type:

Article

Resveratrol and Quercetin in Combination Have Anticancer Activity in Colon Cancer Cells and Repress Oncogenic microRNA-27a.

Published in:

Nutrition & Cancer, 2013, v. 65, n. 3, p. 494, doi. 10.1080/01635581.2012.725194

By:

Del Follo-Martinez, Armando;
Banerjee, Nivedita;
Li, Xiangrong;
Safe, Stephen;
Mertens-Talcott, Susanne

Publication type:

Article

Pharmacologic Doses of Ascorbic Acid Repress Specificity Protein (Sp) Transcription Factors and Sp-Regulated Genes in Colon Cancer Cells.

Published in:

Nutrition & Cancer, 2011, v. 63, n. 7, p. 1133, doi. 10.1080/01635581.2011.605984

By:

Pathi, SatyaS.;
Lei, Ping;
Sreevalsan, Sandeep;
Chadalapaka, Gayathri;
Jutooru, Indira;
Safe, Stephen

Publication type:

Article

Multiphoton spectral analysis of benzo[a]pyrene uptake and metabolism in breast epithelial cell lines.

Published in:

Journal of Toxicological Sciences, 2009, v. 34, n. 1, p. 13, doi. 10.2131/jts.34.13

By:

Barhoumi, Rola;
Catania, Jeffrey M.;
Parrish, Alan R.;
Awooda, Igbal;
Tiffany-Castiglioni, Evelyn;
Safe, Stephen;
Burghardt, Robert C.

Publication type:

Article

MicroRNA-223 is a crucial mediator of PPARγ-regulated alternative macrophage activation.

Published in:

2015

By:

Wei Ying;
Tseng, Alexander;
Cheng-An Chang, Richard;
Morin, Andrew;
Brehm, Tyler;
Triff, Karen;
Nair, Vijayalekshmi;
Guoqing Zhuang;
Hui Song;
Srikanth Kanameni;
Haiqing Wang;
Golding, Michael C.;
Bazer, Fuller W.;
Chapkin, Robert S.;
Safe, Stephen;
Beiyan Zhou;
Ying, Wei;
Chang, Richard Cheng-An;
Zhuang, Guoqing;
Song, Hui

Publication type:

journal article

Metformin-induced anticancer activities: recent insights.

Published in:

Biological Chemistry, 2018, v. 399, n. 4, p. 321, doi. 10.1515/hsz-2017-0271

By:

Safe, Stephen;
Nair, Vijayalekshmi;
Karki, Keshav

Publication type:

Article

Aryl hydrocarbon receptor agonists directly activate estrogen receptor α in MCF-7 breast cancer cells.

Published in:

Biological Chemistry, 2006, v. 387, n. 9, p. 1209, doi. 10.1515/BC.2006.149

By:

Shengxi Liu;
Abdelrahim, Maen;
Khan, Shaheen;
Ariazi, Eric;
Jordan, V. Craig;
Safe, Stephen

Publication type:

Article

Peroxisome proliferator-activated receptor γ-dependent activity of indole ring-substituted 1,1-bis(3′-indolyl)-1-( p-biphenyl)methanes in cancer cells.

Published in:

Cancer Chemotherapy & Pharmacology, 2010, v. 66, n. 1, p. 141, doi. 10.1007/s00280-009-1144-0

By:

Jingjing Guo;
Chintharlapalli, Sudhakar;
Syng-ook Lee;
Sung Dae Cho;
Ping Lei;
Papineni, Sabitha;
Safe, Stephen

Publication type:

Article

Peroxisome proliferator-activated receptor gamma-dependent activity of indole ring-substituted 1,1-bis(3'-indolyl)-1-(p-biphenyl)methanes in cancer cells.

Published in:

2010

By:

Guo J;
Chintharlapalli S;
Lee SO;
Cho SD;
Lei P;
Papineni S;
Safe S;
Guo, Jingjing;
Chintharlapalli, Sudhakar;
Lee, Syng-ook;
Cho, Sung Dae;
Lei, Ping;
Papineni, Sabitha;
Safe, Stephen

Publication type:

journal article

Editorial: Emerging anti-cancer compounds and immunomodulators for pancreatic cancer treatment.

Published in:

Frontiers in Oncology, 2024, p. 1, doi. 10.3389/fonc.2024.1411836

By:

DelGiorno, Kathleen E.;
Safe, Stephen;
Bailey-Lundberg, Jennifer M.

Publication type:

Article

PHYTOESTROGENS AND ANTHROPOGENIC ESTROGENIC COMPOUNDS.

Published in:

Environmental Toxicology & Chemistry, 1998, v. 17, n. 1, p. 119, doi. 10.1002/etc.5620170114

By:

Safe, Stephen H.;
Gaido, Kevin

Publication type:

Article

Mechanisms of Ligand-Induced Aryl Hydrocarbon Receptor-Mediated Biochemical and Toxic Responses.

Published in:

Toxicologic Pathology, 1998, v. 26, n. 5, p. 657, doi. 10.1177/019262339802600510

By:

Wilson, Cody L.;
Safe, Stephen

Publication type:

Article

Inhibition of Tumor-Necrosis-Factor-αDELETEInduced Endothelial Cell Activation by a New Class of PPAR-γ Agonists.

Published in:

Journal of Vascular Research, 2005, v. 42, n. 6, p. 509, doi. 10.1159/000088260

By:

Calabrò, Paolo;
Samudio, Ismael;
Safe, Stephen H.;
Willerson, James T.;
Yeh, Edward T. H.

Publication type:

Article

Involvement of Intestinal Epithelium Aryl Hydrocarbon Receptor Expression and 3, 3′-Diindolylmethane in Colonic Tertiary Lymphoid Tissue Formation.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 18, p. 10153, doi. 10.3390/ijms251810153

By:

Garcia-Villatoro, Erika L.;
Bomstein, Zachary S.;
Allred, Kimberly F.;
Callaway, Evelyn S.;
Safe, Stephen;
Chapkin, Robert S.;
Jayaraman, Arul;
Allred, Clinton D.

Publication type:

Article

Flavone and Hydroxyflavones Are Ligands That Bind the Orphan Nuclear Receptor 4A1 (NR4A1).

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 9, p. 8152, doi. 10.3390/ijms24098152

By:

Lee, Miok;
Upadhyay, Srijana;
Mariyam, Fuada;
Martin, Greg;
Hailemariam, Amanuel;
Lee, Kyongbum;
Jayaraman, Arul;
Chapkin, Robert S.;
Lee, Syng-Ook;
Safe, Stephen

Publication type:

Article

Specificity Proteins (Sp) and Cancer.

Published in:

2023

By:

Safe, Stephen

Publication type:

Literature Review

Health Benefits of Coffee Consumption for Cancer and Other Diseases and Mechanisms of Action.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 3, p. 2706, doi. 10.3390/ijms24032706

By:

Safe, Stephen;
Kothari, Jainish;
Hailemariam, Amanuel;
Upadhyay, Srijana;
Davidson, Laurie A.;
Chapkin, Robert S.

Publication type:

Article

Plant Alkaloid Tetrandrine Is a Nuclear Receptor 4A1 Antagonist and Inhibits Panc-1 Cell Growth In Vitro and In Vivo.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 9, p. 5280, doi. 10.3390/ijms23095280

By:

Lee, Hyo-Seon;
Kim, Dae Hwan;
Lee, In-Seon;
Park, Ji-Hyun;
Martin, Gregory;
Safe, Stephen;
Kim, Keuk-Jun;
Kim, Joung-Hee;
Jang, Byung Ik;
Lee, Syng-Ook

Publication type:

Article

Aryl Hydrocarbon Receptor (AHR) Ligands as Selective AHR Modulators (SAhRMs).

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 18, p. 6654, doi. 10.3390/ijms21186654

By:

Safe, Stephen;
Jin, Un-ho;
Park, Hyejin;
Chapkin, Robert S.;
Jayaraman, Arul

Publication type:

Article

Isolation and characterization of variant benzo[a]pyrene-resistant T47D human breast-cancer cells.

Published in:

International Journal of Cancer, 1996, v. 66, n. 1, p. 117, doi. 10.1002/(SICI)1097-0215(19960328)66:1<117::AID-IJC20>3.0.CO;2-9

By:

Moore, Michael;
Ruh, Mary;
Steinberg, Michael;
Safe, Stephen

Publication type:

Article

Role of metastasis-associated lung adenocarcinoma transcript-1 (MALAT-1) in pancreatic cancer.

Published in:

PLoS ONE, 2018, v. 13, n. 2, p. 1, doi. 10.1371/journal.pone.0192264

By:

Cheng, Yating;
Imanirad, Parisa;
Jutooru, Indira;
Hedrick, Erik;
Jin, Un-Ho;
Rodrigues Hoffman, Aline;
Leal de Araujo, Jeann;
Morpurgo, Benjamin;
Golovko, Andrei;
Safe, Stephen

Publication type:

Article

Evaluation of Spray BIO-Max DIM-P in Dogs for Oral Bioavailability and in Nu/nu Mice Bearing Orthotopic/Metastatic Lung Tumor Models for Anticancer Activity.

Published in:

Pharmaceutical Research, 2015, v. 32, n. 7, p. 2292, doi. 10.1007/s11095-015-1620-7

By:

Patel, Apurva;
Godugu, Chandraiah;
Wilson, Heather;
Safe, Stephen;
Singh, Mandip

Publication type:

Article

Loss of aryl hydrocarbon receptor potentiates FoxM1 signaling to enhance self‐renewal of colonic stem and progenitor cells.

Published in:

EMBO Journal, 2020, v. 39, n. 19, p. 1, doi. 10.15252/embj.2019104319

By:

Han, Huajun;
Davidson, Laurie A;
Fan, Yang‐Yi;
Goldsby, Jennifer S;
Yoon, Grace;
Jin, Un‐Ho;
Wright, Gus A;
Landrock, Kerstin K;
Weeks, Bradley R;
Wright, Rachel C;
Allred, Clinton D;
Jayaraman, Arul;
Ivanov, Ivan;
Roper, Jatin;
Safe, Stephen H;
Chapkin, Robert S

Publication type:

Article

Effect of diet and intestinal AhR expression on fecal microbiome and metabolomic profiles.

Published in:

Microbial Cell Factories, 2020, v. 19, n. 1, p. N.PAG, doi. 10.1186/s12934-020-01463-5

By:

Yang, Fang;
DeLuca, Jennifer A. A.;
Menon, Rani;
Garcia-Vilarato, Erika;
Callaway, Evelyn;
Landrock, Kerstin K.;
Lee, Kyongbum;
Safe, Stephen H.;
Chapkin, Robert S.;
Allred, Clinton D.;
Jayaraman, Arul

Publication type:

Article

Small molecule tolfenamic acid inhibits PC-3 cell proliferation and invasion in vitro, and tumor growth in orthotopic mouse model for prostate cancer.

Published in:

Prostate, 2012, v. 72, n. 15, p. 1648, doi. 10.1002/pros.22518

By:

Sankpal, Umesh T.;
Abdelrahim, Maen;
Connelly, Sarah F.;
Lee, Chris M.;
Madero-Visbal, Rafael;
Colon, Jimmie;
Smith, Joshua;
Safe, Stephen;
Maliakal, Pius;
Basha, Riyaz

Publication type:

Article

Antiandrogenic and growth inhibitory effects of ring-substituted analogs of 3,3′-diindolylmethane (Ring-DIMs) in hormone-responsive LNCaP human prostate cancer cells.

Published in:

Prostate, 2011, v. 71, n. 13, p. 1401, doi. 10.1002/pros.21356

By:

Abdelbaqi, Khalil;
Lack, Nathan;
Guns, Emma Tomlinson;
Kotha, Leela;
Safe, Stephen;
Sanderson, J. Thomas

Publication type:

Article

Cytotoxicity of pomegranate polyphenolics in breast cancer cells in vitro and vivo: potential role of miRNA-27a and miRNA-155 in cell survival and inflammation.

Published in:

Breast Cancer Research & Treatment, 2012, v. 136, n. 1, p. 21, doi. 10.1007/s10549-012-2224-0

By:

Banerjee, Nivedita;
Talcott, Stephen;
Safe, Stephen;
Mertens-Talcott, Susanne

Publication type:

Article

17β‐estradiol (E2) induces cdc25A gene expression in breast cancer cells by genomic and non‐genomic pathways.

Published in:

Journal of Cellular Biochemistry, 2006, v. 99, n. 1, p. 209, doi. 10.1002/jcb.20902

By:

Wan Ru Lee;
Chien‐Cheng Chen;
Shengxi Liu;
Stephen Safe

Publication type:

Article

Egr‐1 is activated by 17β‐estradiol in MCF‐7 cells by mitogen‐activated protein kinase‐dependent phosphorylation of ELK‐1.

Published in:

Journal of Cellular Biochemistry, 2004, v. 93, n. 5, p. 1063

By:

Chien‐Cheng Chen;
Wan‐Ru Lee;
Stephen Safe

Publication type:

Article

Comparative in vitro and in vivo genotoxicities of 7H-benzo[c]fluorene, manufactured gas plant residue (MGP), and MGP fractions.

Published in:

Environmental & Molecular Mutagenesis, 2004, v. 43, n. 3, p. 159

By:

Leslie Cizmas;
Guo-dong Zhou;
Stephen H. Safe;
Thomas J. McDonald;
Li Zhu

Publication type:

Article

Characterization of a bottlenose dolphin (Tursiops truncatus) kidneyepithelial cell line

Published in:

Marine Mammal Science, 1994, v. 10, n. 1, p. 52

By:

Safe, Stephen;
Busbee, David;
Carvan, III, Michael J.;
Santostefano, Michael

Publication type:

Article

Functional and physical interactions between the estrogen receptor Sp1 and nuclear aryl hydrocarbon receptor complexes.

Published in:

Nucleic Acids Research, 1998, v. 26, n. 12, p. 3044, doi. 10.1093/nar/26.12.3044

By:

Wang, Fan;
Hoivik, Debie;
Pollenz, Richard;
Safe, Stephen

Publication type:

Article

Omeprazole Inhibits Glioblastoma Cell Invasion and Tumor Growth.

Published in:

Cancers, 2020, v. 12, n. 8, p. 2097, doi. 10.3390/cancers12082097

By:

Jin, Un-Ho;
Michelhaugh, Sharon K.;
Polin, Lisa A.;
Shrestha, Rupesh;
Mittal, Sandeep;
Safe, Stephen

Publication type:

Article

Reconstruction of nuclear receptor network reveals that NR2E3 is a novel upstream regulator of ESR1 in breast cancer.

Published in:

EMBO Molecular Medicine, 2012, v. 4, n. 1, p. 52, doi. 10.1002/emmm.201100187

By:

Park, Yun-Yong;
Kim, Kyounghyun;
Kim, Sang-Bae;
Hennessy, Bryan T.;
Kim, Soo Mi;
Park, Eun Sung;
Lim, Jae Yun;
Li, Jane;
Lu, Yiling;
Gonzalez-Angulo, Ana Maria;
Jeong, Woojin;
Mills, Gordon B.;
Safe, Stephen;
Lee, Ju-Seog

Publication type:

Article

The drug resistance suppression induced by curcuminoids in colon cancer SW-480 cells is mediated by reactive oxygen species-induced disruption of the micro RNA-27a- ZBTB10- Sp axis.

Published in:

Molecular Nutrition & Food Research, 2013, v. 57, n. 9, p. 1638, doi. 10.1002/mnfr.201200609

By:

Noratto, Giuliana D.;
Jutooru, Indira;
Safe, Stephen;
Angel‐Morales, Gabriela;
Mertens‐Talcott, Susanne U.

Publication type:

Article

Development and Validation of in Vitro Induction Assays for Toxic Halogenated Aromatic Mixtures: A Review.

Published in:

Toxicology & Industrial Health, 1989, v. 5, n. 5, p. 757, doi. 10.1177/074823378900500513

By:

Safe, Stephen;
Mason, Grant;
Sawyer, Thomas;
Zacharewski, Tim;
Harris, Mark;
Yao, C.;
Keys, Barbara;
Farrell, Kathy;
Holcomb, Michael;
Davis, Deanne;
Safe, Lorna;
Piskorska-Pliszczynska, Jagoda;
Leece, Brian;
Denomme, Mary Anne;
Hutzinger, Otto;
Thoma, Heinz;
Chittim, Brock;
Madge, Jocelyn

Publication type:

Article

Cadmium's disguise dupes the estrogen receptor.

Published in:

Nature Medicine, 2003, v. 9, n. 8, p. 1000, doi. 10.1038/nm0803-1000

By:

Safe, Stephen

Publication type:

Article

Transforming Growth Factor β/NR4A1-Inducible Breast Cancer Cell Migration and Epithelial-to-Mesenchymal Transition Is p38α (Mitogen-Activated Protein Kinase 14) Dependent.

Published in:

Molecular & Cellular Biology, 2017, v. 37, n. 18, p. 1, doi. 10.1128/MCB.00306-17

By:

Hedrick, Erik;
Safe, Stephen

Publication type:

Article

NR4A1 Antagonists Inhibit β1-Integrin-Dependent Breast Cancer Cell Migration.

Published in:

Molecular & Cellular Biology, 2016, v. 36, n. 9, p. 1383, doi. 10.1128/MCB.00912-15

By:

Hedrick, Erik;
Lee, Syng-Ook;
Doddapaneni, Ravi;
Singh, Mandip;
Safe, Stephen

Publication type:

Article

Mechanism of Action of Phenethylisothiocyanate and Other Reactive Oxygen Species-Inducing Anticancer Agents.

Published in:

Molecular & Cellular Biology, 2014, v. 34, n. 13, p. 2382, doi. 10.1128/MCB.01602-13

By:

Jutooru, Indira;
Guthrie, Aaron S.;
Chadalapaka, Gayathri;
Pathi, Satya;
KyoungHyun Kim;
Burghardt, Robert;
Un-Ho Jin;
Safe, Stephen

Publication type:

Article

Autophagy inhibition improves the chemotherapeutic efficacy of cruciferous vegetable-derived diindolymethane in a murine prostate cancer xenograft model.

Published in:

Investigational New Drugs, 2018, v. 36, n. 4, p. 718, doi. 10.1007/s10637-018-0595-8

By:

Draz, Hossam;
Goldberg, Alexander A.;
Tomlinson Guns, Emma S.;
Fazli, Ladan;
Safe, Stephen;
Sanderson, J. Thomas

Publication type:

Article

Chemopreventive effects of tolfenamic acid against esophageal tumorigenesis in rats.

Published in:

Investigational New Drugs, 2012, v. 30, n. 3, p. 853, doi. 10.1007/s10637-010-9622-0

By:

Maliakal, Pius;
Abdelrahim, Maen;
Sankpal, Umesh;
Maliakal, Cima;
Baker, Cheryl;
Safe, Stephen;
Herrera, Luis;
Abudayyeh, Ala;
Kaja, Sumanth;
Basha, Riyaz

Publication type:

Article

Tolfenamic acid decreases c-Met expression through Sp proteins degradation and inhibits lung cancer cells growth and tumor formation in orthotopic mice.

Published in:

Investigational New Drugs, 2011, v. 29, n. 1, p. 41, doi. 10.1007/s10637-009-9331-8

By:

Colon, Jimmie;
Basha, Md.;
Madero-Visbal, Rafael;
Konduri, Santhi;
Baker, Cheryl;
Herrera, Luis;
Safe, Stephen;
Sheikh-Hamad, David;
Abudayyeh, Ala;
Alvarado, Beatrice;
Abdelrahim, Maen

Publication type:

Article