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Strategy for a multicenter phase I clinical trial to evaluate globin gene transfer in β-thalassemia.
- Published in:
- Annals of the New York Academy of Sciences, 2010, v. 1202, n. 1, p. 52, doi. 10.1111/j.1749-6632.2010.05597.x
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- Publication type:
- Article
Safe harbours for the integration of new DNA in the human genome.
- Published in:
- 2012
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- Publication type:
- Opinion
Ectopic activation of the miR-200c–EpCAM axis enhances antitumor T cell responses in models of adoptive cell therapy.
- Published in:
- Science Translational Medicine, 2021, v. 13, n. 611, p. 1, doi. 10.1126/scitranslmed.abg4328
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- Publication type:
- Article
The tyrosine kinase inhibitor dasatinib acts as a pharmacologic on/off switch for CAR T cells.
- Published in:
- Science Translational Medicine, 2019, v. 11, n. 499, p. 1, doi. 10.1126/scitranslmed.aau5907
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- Publication type:
- Article
[<sup>131</sup>I]FIAU labeling of genetically transduced, tumor-reactive lymphocytes: cell-level dosimetry and dose-dependent toxicity.
- Published in:
- European Journal of Nuclear Medicine & Molecular Imaging, 2006, v. 33, n. 9, p. 988, doi. 10.1007/s00259-005-0057-3
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- Publication type:
- Article
ASGCT and JSGT Joint Position Statement on Human Genomic Editing.
- Published in:
- Molecular Therapy, 2015, v. 23, n. 8, p. 1282, doi. 10.1038/mt.2015.118
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- Publication type:
- Article
Genome Editing Technologies: Defining a Path to Clinic.
- Published in:
- Molecular Therapy, 2015, v. 23, n. 5, p. 796, doi. 10.1038/mt.2015.54
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- Publication type:
- Article
T-Cell Immunotherapy: Looking Forward.
- Published in:
- Molecular Therapy, 2014, v. 22, n. 9, p. 1564, doi. 10.1038/mt.2014.148
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- Publication type:
- Article
CARs on Track in the Clinic.
- Published in:
- 2011
- By:
- Publication type:
- Proceeding
The Need for Genetically Engineering Therapeutic Pluripotent Stem Cells.
- Published in:
- 2010
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- Publication type:
- Editorial
Treatment of Chronic Lymphocytic Leukemia With Genetically Targeted Autologous T Cells: Case Report of an Unforeseen Adverse Event in a Phase I Clinical Trial.
- Published in:
- 2010
- By:
- Publication type:
- Letter
Chimeric Antigen Receptors Combining 4-1BB and CD28 Signaling Domains Augment PI<sub>3</sub>kinase/AKT/Bcl-X<sub>L</sub> Activation and CD8<sup>+</sup> T Cell–mediated Tumor Eradication.
- Published in:
- Molecular Therapy, 2010, v. 18, n. 2, p. 413, doi. 10.1038/mt.2009.210
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- Publication type:
- Article
Supplying Clotting Factors From Hematopoietic Stem Cell–derived Erythroid and Megakaryocytic Lineage Cells.
- Published in:
- Molecular Therapy, 2009, v. 17, n. 12, p. 1994, doi. 10.1038/mt.2009.238
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- Publication type:
- Article
Erythroid-specific Human Factor IX Delivery From In Vivo Selected Hematopoietic Stem Cells Following Nonmyeloablative Conditioning in Hemophilia B Mice.
- Published in:
- Molecular Therapy, 2008, v. 16, n. 10, p. 1745, doi. 10.1038/mt.2008.161
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- Publication type:
- Article
A “Vector Drain” in US Gene Therapy Development?
- Published in:
- Molecular Therapy, 2008, v. 16, n. 5, p. 801, doi. 10.1038/mt.2008.71
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- Publication type:
- Article
The Genetic Engineering of Hematopoietic Stem Cells: the Rise of Lentiviral Vectors, the Conundrum of the LTR, and the Promise of Lineage-restricted Vectors.
- Published in:
- Molecular Therapy, 2007, v. 15, n. 3, p. 445, doi. 10.1038/sj.mt.6300060
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- Publication type:
- Article
1055. High Levels of Human Factor IX Expression in Hemophilia B Mice after Adult Stem Cell-Based Gene Therapy Combined with Non-Myeloablative Conditioning.
- Published in:
- Molecular Therapy, 2006, v. 13, p. S404, doi. 10.1016/j.ymthe.2006.08.1151
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- Publication type:
- Article
269. Integrated CD28 and 4-1BB Signals Strongly Potentiate CD8+ T Cell Mediated radication of Metastatic Prostate Cancer.
- Published in:
- Molecular Therapy, 2006, v. 13, p. S103, doi. 10.1016/j.ymthe.2006.08.323
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- Publication type:
- Article
763. Multimodality Imaging of Genetically Modified Lymphocytes In Vivo.
- Published in:
- Molecular Therapy, 2006, v. 13, p. S295, doi. 10.1016/j.ymthe.2006.08.848
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- Publication type:
- Article
799. In Vitro and In Vivo Characterization of “Second-Generation” Co-Stimulatory Chimeric Antigen Receptors (CARs) Targeting the CD19 Antigen Present on B Cell Malignancies
- Published in:
- 2005
- By:
- Publication type:
- Abstract
707. Transduction and Expansion of T Lymphocytes Genetically Engineered To Target the CD19 Antigen for the Treatment of CLL Using Xcyte™ Dynabeads®
- Published in:
- 2005
- By:
- Publication type:
- Abstract
604. Long-Term, Erythroid-Specific Expression of Human Factor IX in Hemophilic Mice Engrafted with Lentiviral Vector-Transduced Hematopoietic Stem Cells
- Published in:
- 2005
- By:
- Publication type:
- Abstract
558. cGMP Production of Plasmid DNA for Phase I Clinical Studies in an Academic Center
- Published in:
- 2005
- By:
- Publication type:
- Abstract
277. Large-Scale Generation of Genetically Modified Human CD34+ Progenitor Cell-Derived Langerhans Cells Using a Closed Culture System Suitable for Clinical Immunotherapy
- Published in:
- 2005
- By:
- Publication type:
- Abstract
4. Optimization of Globin Lentiviral Vector Design for the Treatment of β-Thalassemia
- Published in:
- 2005
- By:
- Publication type:
- Abstract
Multiple stages of malignant transformation of human endothelial cells modelled by co-expression of telomerase reverse transcriptase, SV40 T antigen and oncogenic N-ras.
- Published in:
- Oncogene, 2002, v. 21, n. 27, p. 4200, doi. 10.1038/sj.onc.1205425
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- Publication type:
- Article
Phase I trial: CD19-Targeted CAR T-Cells in Patients with Residual CLL Following Initial Purine Analog-Based Therapy.
- Published in:
- Clinical Lymphoma, Myeloma & Leukemia, 2016, v. 16, p. S48, doi. 10.1016/j.clml.2016.07.069
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- Publication type:
- Article
Prevention of type I diabetes in NOD mice by adjuvant immunotherapy.
- Published in:
- 1990
- By:
- Publication type:
- journal article
Adeno-associated virus type 2 preferentially integrates single genome copies with defined breakpoints.
- Published in:
- Virology Journal, 2014, v. 11, n. 1, p. 1, doi. 10.1186/1743-422X-11-15
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- Publication type:
- Article
Cas9‐Cleavage Sequences in Size‐Reduced Plasmids Enhance Nonviral Genome Targeting of CARs in Primary Human T Cells.
- Published in:
- Small Methods, 2021, v. 5, n. 7, p. 1, doi. 10.1002/smtd.202100071
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- Publication type:
- Article
Fulminant experimental autoimmune encephalo-myelitis induced by retrovirally mediated TCR gene transfer.
- Published in:
- European Journal of Immunology, 2005, v. 35, n. 6, p. 1822, doi. 10.1002/eji.200526123
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- Publication type:
- Article
Prostate-specific membrane antigen retargeted measles virotherapy for the treatment of prostate cancer.
- Published in:
- Prostate, 2009, v. 69, n. 10, p. 1128, doi. 10.1002/pros.20962
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- Publication type:
- Article
Animal models and molecular imaging tools to investigate lymph node metastases.
- Published in:
- Journal of Molecular Medicine, 2011, v. 89, n. 8, p. 753, doi. 10.1007/s00109-011-0764-0
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- Publication type:
- Article
Development of a New Reporter Gene System--dsRed/Xanthine Phosphoribosyltransferase--Xanthine for Molecular Imaging of Processes Behind the Intact Blood-Brain Barrier.
- Published in:
- Molecular Imaging, 2003, v. 2, n. 2, p. 93, doi. 10.1162/153535003322331984
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- Publication type:
- Article
CAR T cells: Building on the CD19 paradigm.
- Published in:
- European Journal of Immunology, 2021, v. 51, n. 9, p. 2151, doi. 10.1002/eji.202049064
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- Publication type:
- Article
Progress Toward the Genetic Treatment of the β- Thalassemias.
- Published in:
- Annals of the New York Academy of Sciences, 2005, v. 1054, n. 1, p. 78, doi. 10.1196/annals.1345.010
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- Publication type:
- Article
Chronic inflammation in tumor stroma is an independent predictor of prolonged survival in epithelioid malignant pleural mesothelioma patients.
- Published in:
- Cancer Immunology, Immunotherapy, 2011, v. 60, n. 12, p. 1721, doi. 10.1007/s00262-011-1073-8
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- Publication type:
- Article
Immune responses and immunotherapeutic interventions in malignant pleural mesothelioma.
- Published in:
- Cancer Immunology, Immunotherapy, 2011, v. 60, n. 11, p. 1509, doi. 10.1007/s00262-011-1103-6
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- Publication type:
- Article
Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs.
- Published in:
- Nature, 2009, v. 461, n. 7262, p. 402, doi. 10.1038/nature08320
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- Publication type:
- Article
Occurrence of leukaemia following gene therapy of X-linked SCID.
- Published in:
- Nature Reviews Cancer, 2003, v. 3, n. 7, p. 477, doi. 10.1038/nrc1122
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- Publication type:
- Article
Targeting tumours with genetically enhanced T lymphocytes.
- Published in:
- 2003
- By:
- Publication type:
- journal article
Early experience using salvage radiotherapy for relapsed/refractory non‐Hodgkin lymphomas after CD19 chimeric antigen receptor (CAR) T cell therapy.
- Published in:
- British Journal of Haematology, 2020, v. 190, n. 1, p. 45, doi. 10.1111/bjh.16541
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- Publication type:
- Article
Genetic strategies for the treatment of sickle cell anaemia.
- Published in:
- British Journal of Haematology, 2011, v. 154, n. 6, p. 715, doi. 10.1111/j.1365-2141.2011.08773.x
- By:
- Publication type:
- Article
Globin gene transfer for the treatment of severe hemoglobinopathies: a paradigm for stem cell-based gene therapy.
- Published in:
- Journal of Gene Medicine, 2002, v. 4, n. 2, p. 113, doi. 10.1002/jgm.266
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- Publication type:
- Article
Activation conditions determine susceptibility of murine primary T-lymphocytes to retroviral infection.
- Published in:
- Journal of Gene Medicine, 1999, v. 1, n. 5, p. 341, doi. 10.1002/(SICI)1521-2254(199909/10)1:5<341::AID-JGM58>3.0.CO;2-J
- By:
- Publication type:
- Article
Tumor-Targeted Human T Cells Expressing CD28-Based Chimeric Antigen Receptors Circumvent CTLA-4 Inhibition.
- Published in:
- PLoS ONE, 2015, v. 10, n. 6, p. 1, doi. 10.1371/journal.pone.0130518
- By:
- Publication type:
- Article
Adenoviral Transduction of Human Acid Sphingomyelinase into Neo-Angiogenic Endothelium Radiosensitizes Tumor Cure.
- Published in:
- PLoS ONE, 2013, v. 8, n. 8, p. 1, doi. 10.1371/journal.pone.0069025
- By:
- Publication type:
- Article
CD19 CAR-Targeted T Cells Induce Long-Term Remission and B Cell Aplasia in an Immunocompetent Mouse Model of B Cell Acute Lymphoblastic Leukemia.
- Published in:
- PLoS ONE, 2013, v. 8, n. 4, p. 1, doi. 10.1371/journal.pone.0061338
- By:
- Publication type:
- Article
An In Vivo Platform for Tumor Biomarker Assessment.
- Published in:
- PLoS ONE, 2011, v. 6, n. 10, p. 1, doi. 10.1371/journal.pone.0026722
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- Publication type:
- Article
Author Correction: Tumor immunotherapy across MHC barriers using allogeneic T-cell precursors.
- Published in:
- 2024
- By:
- Publication type:
- Correction Notice