Works matching AU SHEPHERD, Peter R.
Results: 53
Efficacy of Providing the PI3K p110α Inhibitor BYL719 (Alpelisib) to Middle-Aged Mice in Their Diet.
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- Biomolecules (2218-273X), 2021, v. 11, n. 2, p. 150, doi. 10.3390/biom11020150
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- Article
For Better or Worse: The Potential for Dose Limiting the On-Target Toxicity of PI 3-Kinase Inhibitors.
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- Biomolecules (2218-273X), 2019, v. 9, n. 9, p. 402, doi. 10.3390/biom9090402
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- Article
Glucagon phosphorylates serine 552 of β-catenin leading to increased expression of cyclin D1 and c-Myc in the isolated rat liver.
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- Archives of Physiology & Biochemistry, 2015, v. 121, n. 3, p. 88, doi. 10.3109/13813455.2015.1048693
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- Article
Stratified glucose-lowering response to vildagliptin and pioglitazone by obesity and hypertriglyceridemia in a randomized crossover trial.
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- Frontiers in Endocrinology, 2023, v. 13, p. 1, doi. 10.3389/fendo.2022.1091421
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- Article
Genomic and signalling pathway characterization of the NZM panel of melanoma cell lines: A valuable model for studying the impact of genetic diversity in melanoma.
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- Pigment Cell & Melanoma Research, 2021, v. 34, n. 1, p. 136, doi. 10.1111/pcmr.12908
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- Article
Phosphorylation of glycosyl-phosphatidylinositol by phosphatidylinositol 3-kinase changes its properties as a substrate for phospholipases
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- FEBS Letters, 2005, v. 579, n. 1, p. 59, doi. 10.1016/j.febslet.2004.11.035
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- Article
ATP-competitive inhibitors of PI3K enzymes demonstrate an isoform selective dual action by controlling membrane binding.
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- Biochemical Journal, 2024, v. 481, n. 23, p. 1787, doi. 10.1042/BCJ20240479
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- Article
A role for PAK1 mediated phosphorylation of β-catenin Ser552 in the regulation of insulin secretion.
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- Biochemical Journal, 2021, v. 478, n. 8, p. 1605, doi. 10.1042/BCJ20200862
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- Article
α-catenin isoforms are regulated by glucose and involved in regulating insulin secretion in rat clonal β-cell models.
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- Biochemical Journal, 2020, v. 477, n. 4, p. 763, doi. 10.1042/BCJ20190832
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- Article
A role for β‐catenin in diet‐induced skeletal muscle insulin resistance.
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- Physiological Reports, 2023, v. 11, n. 4, p. 1, doi. 10.14814/phy2.15536
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- Article
A Polynesian-specific SLC22A3 variant associates with low plasma lipoprotein(a) concentrations independent of apo(a) isoform size in males.
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- Bioscience Reports, 2024, v. 44, n. 7, p. 1, doi. 10.1042/BSR20240403
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- Article
Evidence that RXFP4 is located in enterochromaffin cells and can regulate production and release of serotonin.
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- Bioscience Reports, 2023, v. 43, n. 4, p. 1, doi. 10.1042/BSR20221956
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- Publication type:
- Article
Glucose regulates expression of pro-inflammatory genes, IL-1β and IL-12, through a mechanism involving hexosamine biosynthesis pathway-dependent regulation of α-E catenin.
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- Bioscience Reports, 2021, v. 41, n. 7, p. 1, doi. 10.1042/BSR20211066
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- Article
Prolonged treatment with a PI3K p110a inhibitor causes sex- and tissue-dependent changes in antioxidant content, but does not affect mitochondrial function.
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- Bioscience Reports, 2020, v. 40, n. 10, p. 1, doi. 10.1042/BSR20201128
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- Article
The role of adherens junction proteins in the regulation of insulin secretion.
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- Bioscience Reports, 2018, v. 38, n. 2, p. 1, doi. 10.1042/BSR20170989
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- Article
Enzyme activity effects of N-terminal His-tag attached to catalytic sub-unit of phosphoinositide-3-kinase.
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- Bioscience Reports, 2013, v. 33, n. 6, p. 857, doi. 10.1042/BSR20130075
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- Article
Derivation of induced pluripotent stem cell lines from New Zealand donors.
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- Journal of the Royal Society of New Zealand, 2022, v. 52, n. 1, p. 54, doi. 10.1080/03036758.2020.1830808
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- Article
The phosphoinositide 3′-kinase p110δ modulates contractile protein production and IL-6 release in human airway smooth muscle.
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- Journal of Cellular Physiology, 2012, v. 227, n. 8, p. 3044, doi. 10.1002/jcp.23046
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- Article
Insights into the role of JAK2-I724T variant in myeloproliferative neoplasms from a unique cohort of New Zealand patients.
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- Hematology, 2024, v. 29, n. 1, p. 1, doi. 10.1080/16078454.2023.2297597
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- Article
β‐Catenin is required for optimal exercise‐ and contraction‐stimulated skeletal muscle glucose uptake.
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- Journal of Physiology, 2021, v. 599, n. 16, p. 3897, doi. 10.1113/JP281352
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- Article
Limited Metabolic Effect of the CREBRF R457Q Obesity Variant in Mice.
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- Cells (2073-4409), 2022, v. 11, n. 3, p. 497, doi. 10.3390/cells11030497
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- Article
Synthesis and Evaluation of Imidazo[1,2‐a]pyridine Analogues of the ZSTK474 Class of Phosphatidylinositol 3‐Kinase Inhibitors.
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- Chemistry - An Asian Journal, 2019, v. 14, n. 8, p. 1249, doi. 10.1002/asia.201801762
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- Article
NVP-BEZ235, A Dual Pan Class I PI3 Kinase and mTOR Inhibitor, Promotes Osteogenic Differentiation in Human Mesenchymal Stromal Cells.
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- Journal of Bone & Mineral Research, 2010, v. 25, n. 10, p. 2126, doi. 10.1002/jbmr.114
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- Article
Insulin and leptin acutely regulate cholesterol ester metabolism in macrophages by novel signaling pathways.
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- 2001
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- journal article
Human small intestine facilitative fructose/glucose transporter (GLUT5) is also present in insulin-responsive tissues and brain. Investigation of biochemical characteristics and translocation.
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- 1992
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- Publication type:
- journal article
Protein Kinase Activity of Phosphoinositide 3-Kinase Regulates Cytokine-Dependent Cell Survival.
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- PLoS Biology, 2013, v. 11, n. 3, p. 1, doi. 10.1371/journal.pbio.1001515
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- Article
Combining properties of different classes of PI3Kα inhibitors to understand the molecular features that confer selectivity.
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- Biochemical Journal, 2017, v. 474, n. 13, p. 2261, doi. 10.1042/BCJ20161098
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- Article
Niclosamide blocks glucagon phosphorylation of Ser<sup>552</sup> on β-catenin in primary rat hepatocytes via PKA signalling.
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- Biochemical Journal, 2016, v. 473, n. 9, p. 1247, doi. 10.1042/BCJ20160121
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- Article
Biochemical Journal strengthens links in Asia.
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- Biochemical Journal, 2014, v. 464, n. 1, p. 1, doi. 10.1042/BJ20140874
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- Article
Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle.
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- Biochemical Journal, 2013, v. 455, n. 2, p. 195, doi. 10.1042/BJ20130644
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- Article
Identification of a pathway by which glucose regulates ß-catenin signalling via the cAMP/protein kinase A pathway in ß-cell models.
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- Biochemical Journal, 2013, v. 449, n. 3, p. 803, doi. 10.1042/BJ20121454
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- Article
Hypothalamic glycogen synthase kinase 3ß has a central role in the regulation of food intake and glucose metabolism.
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- Biochemical Journal, 2012, v. 447, n. 1, p. 175, doi. 10.1042/BJ20120834
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- Article
Definition of the binding mode of a new class of phosphoinositide 3-kinase α-selective inhibitors using in vitro mutagenesis of non-conserved amino acids and kinetic analysis.
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- Biochemical Journal, 2012, v. 444, n. 3, p. 529, doi. 10.1042/BJ20120499
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- Article
Over-expression of GLUT4 selectively in adipose tissue in transgenic mice: Implications for nutrient partitioning.
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- Proceedings of the Nutrition Society, 1995, v. 55, n. 1B, p. 191, doi. 10.1079/PNS19960020
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- Article
Extended treatment with selective phosphatidylinositol 3-kinase and m TOR inhibitors has effects on metabolism, growth, behaviour and bone strength.
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- FEBS Journal, 2013, v. 280, n. 21, p. 5337, doi. 10.1111/febs.12428
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- Article
Targeted inhibition of dominant PI3-kinase catalytic isoforms increase expression of stem cell genes in glioblastoma cancer stem cell models.
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- International Journal of Oncology, 2016, v. 49, n. 1, p. 207, doi. 10.3892/ijo.2016.3510
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- Article
The TSC1-2 tumor suppressor controls insulin-Pl3k signaling via regulation of IRS proteins.
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- Journal of Cell Biology, 2004, v. 166, n. 2, p. 213, doi. 10.1083/jcb.200403069
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- Article
Niclosamide reduces glucagon sensitivity via hepatic PKA inhibition in obese mice: Implications for glucose metabolism improvements in type 2 diabetes.
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- Scientific Reports, 2017, p. 40159, doi. 10.1038/srep40159
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- Article
Conditional Deletion of β-Catenin in the Mediobasal Hypothalamus Impairs Adaptive Energy Expenditure in Response to High-Fat Diet and Exacerbates Diet-Induced Obesity.
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- Journal of Neuroscience, 2024, v. 44, n. 14, p. 1, doi. 10.1523/JNEUROSCI.1666-23.2024
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- Article
PI 3-kinase p110ß: a new target for antithrombotic therapy.
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- Nature Medicine, 2005, v. 11, n. 5, p. 507, doi. 10.1038/nm1232
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- Article
Variable‐Length Ester‐Based Staples for α‐Helical Peptides by Using A Double Thiol‐ene Reaction.
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- Chemistry - A European Journal, 2020, v. 26, n. 47, p. 10826, doi. 10.1002/chem.202001478
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- Article
G Protein-Coupled Receptor-Mediated Activation of p110b by Gβγ Is Required for Cellular Transformation and Invasiveness.
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- Science Signaling, 2012, v. 5, n. 253, p. 1, doi. 10.1126/scisignal.2003264
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- Article
Structure, function and inhibition of the phosphoinositide 3-kinase p110α enzyme.
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- Biochemical Society Transactions, 2014, v. 42, n. 1, p. 120, doi. 10.1042/BST20130255
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- Article
Leptin Rapidly Improves Glucose Homeostasis in Obese Mice by Increasing Hypothalamic Insulin Sensitivity.
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- Journal of Neuroscience, 2010, v. 30, n. 48, p. 16180, doi. 10.1523/JNEUROSCI.3202-10.2010
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- Article
The population-specific Thr44Met OCT3 coding variant affects metformin pharmacokinetics with subsequent effects on insulin sensitivity in C57Bl/6J mice.
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- Diabetologia, 2025, v. 68, n. 3, p. 537, doi. 10.1007/s00125-024-06287-1
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- Article
The CREBRF diabetes-protective rs373863828-A allele is associated with enhanced early insulin release in men of Māori and Pacific ancestry.
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- Diabetologia, 2021, v. 64, n. 12, p. 2779, doi. 10.1007/s00125-021-05552-x
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- Article
Inhibitors of pan-PI3K signaling synergize with BARF or MEK inhibitors to prevent BRA4F-mutant melanoma cell growth.
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- Frontiers in Oncology, 2015, p. 1, doi. 10.3389/fonc.2015.00135
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- Article
Targeting Class I<sub>A</sub> PI3K Isoforms Selectively Impairs Cell Growth, Survival, and Migration in Glioblastoma.
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- PLoS ONE, 2014, v. 9, n. 4, p. 1, doi. 10.1371/journal.pone.0094132
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- Article
Oncogenic Mutations of p110α Isoform of PI 3-Kinase Upregulate Its Protein Kinase Activity.
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- PLoS ONE, 2013, v. 8, n. 8, p. 1, doi. 10.1371/journal.pone.0071337
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- Article
Adiponectin Haploinsufficiency Promotes Mammary Tumor Development in MMTV-PyVT Mice by Modulation of Phosphatase and Tensin Homolog Activities.
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- PLoS ONE, 2009, v. 4, n. 3, p. 1, doi. 10.1371/journal.pone.0004968
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- Article