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The clinical drug candidate anle138b binds in a cavity of lipidic α-synuclein fibrils.
- Published in:
- Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-32797-w
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- Publication type:
- Article
Correction: Migrations of young spotted seals (Phoca largha) from Peter the Great Bay, Sea of Japan/East Sea, and the pattern of their use of seasonal habitats.
- Published in:
- 2021
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- Publication type:
- Correction Notice
[11C]MODAG-001—towards a PET tracer targeting α-synuclein aggregates.
- Published in:
- European Journal of Nuclear Medicine & Molecular Imaging, 2021, v. 48, n. 6, p. 1759, doi. 10.1007/s00259-020-05133-x
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- Publication type:
- Article
Migrations of young spotted seals (Phoca largha) from Peter the Great Bay, Sea of Japan/East Sea, and the pattern of their use of seasonal habitats.
- Published in:
- PLoS ONE, 2021, v. 16, n. 1, p. 1, doi. 10.1371/journal.pone.0244232
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- Publication type:
- Article
Targeting α-synuclein by PD03 AFFITOPE® and Anle138b rescues neurodegenerative pathology in a model of multiple system atrophy: clinical relevance.
- Published in:
- Translational Neurodegeneration, 2020, v. 9, n. 1, p. N.PAG, doi. 10.1186/s40035-020-00217-y
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- Publication type:
- Article
Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization.
- Published in:
- Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-69744-y
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- Publication type:
- Article
<sup>11</sup>C Radiolabeling of anle253b: a Putative PET Tracer for Parkinson's Disease That Binds to α‐Synuclein Fibrils in vitro and Crosses the Blood‐Brain Barrier.
- Published in:
- ChemMedChem, 2020, v. 15, n. 5, p. 411, doi. 10.1002/cmdc.201900689
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- Publication type:
- Article
The small molecule inhibitor anle145c thermodynamically traps human islet amyloid peptide in the form of non-cytotoxic oligomers.
- Published in:
- Scientific Reports, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41598-019-54919-z
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- Publication type:
- Article
Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson's disease model.
- Published in:
- Acta Neuropathologica, 2019, v. 138, n. 4, p. 575, doi. 10.1007/s00401-019-02023-x
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- Publication type:
- Article
Late-stage Anle138b treatment ameliorates tau pathology and metabolic decline in a mouse model of human Alzheimer's disease tau.
- Published in:
- Alzheimer's Research & Therapy, 2019, v. 11, n. 1, p. N.PAG, doi. 10.1186/s13195-019-0522-z
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- Publication type:
- Article
Iron-mediated aggregation and toxicity in a novel neuronal cell culture model with inducible alpha-synuclein expression.
- Published in:
- Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-45298-6
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- Publication type:
- Article
Anle138b modulates α-synuclein oligomerization and prevents motor decline and neurodegeneration in a mouse model of multiple system atrophy.
- Published in:
- 2019
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- Publication type:
- journal article
Bigg's Killer Whales (Orcinus orca) in the Kuril Islands.
- Published in:
- Aquatic Mammals, 2018, v. 44, n. 3, p. 267, doi. 10.1578/AM.44.3.2018.267
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- Publication type:
- Article
The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology.
- Published in:
- EMBO Molecular Medicine, 2018, v. 10, n. 1, p. 32, doi. 10.15252/emmm.201707825
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- Publication type:
- Article
Infanticide and cannibalism in Steller sea lions ( Eumetopias jubatus).
- Published in:
- Marine Mammal Science, 2018, v. 34, n. 1, p. 200, doi. 10.1111/mms.12437
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- Publication type:
- Article
Digitizing mass spectrometry data to explore the chemical diversity and distribution of marine cyanobacteria and algae.
- Published in:
- eLife, 2017, p. 1, doi. 10.7554/eLife.24214
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- Publication type:
- Article
The bacterial SRP receptor, FtsY, is activated on binding to the translocon.
- Published in:
- Molecular Microbiology, 2016, v. 102, n. 1, p. 152, doi. 10.1111/mmi.13452
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- Publication type:
- Article
Anle138b Partly Ameliorates Motor Deficits Despite Failure of Neuroprotection in a Model of Advanced Multiple System Atrophy.
- Published in:
- Frontiers in Neuroscience, 2016, p. 1, doi. 10.3389/fnins.2016.00099
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- Publication type:
- Article
Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies.
- Published in:
- Acta Neuropathologica, 2015, v. 130, n. 5, p. 619, doi. 10.1007/s00401-015-1483-3
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- Publication type:
- Article
Age Specific Survival Rates of Steller Sea Lions at Rookeries with Divergent Population Trends in the Russian Far East.
- Published in:
- PLoS ONE, 2015, v. 10, n. 5, p. 1, doi. 10.1371/journal.pone.0127292
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- Publication type:
- Article
The oligomer modulator anle138b inhibits disease progression in a Parkinson mouse model even with treatment started after disease onset.
- Published in:
- 2014
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- Publication type:
- Letter
Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease.
- Published in:
- Acta Neuropathologica, 2013, v. 125, n. 6, p. 795, doi. 10.1007/s00401-013-1114-9
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- Publication type:
- Article