Works by Rummel, Andreas

Results: 41

N -Glycosylation Profile of Abrin Certified EU Reference Material.

Published in:

Toxins, 2025, v. 17, n. 3, p. 108, doi. 10.3390/toxins17030108

By:

Josuran, Roland;
Wenger, Andreas;
Worbs, Sylvia;
Kampa, Bettina;
Rummel, Andreas;
Dorner, Brigitte G.;
Gerber, Sabina

Publication type:

Article

Presynaptic targeting of botulinum neurotoxin type A requires a tripartite PSG‐Syt1‐SV2 plasma membrane nanocluster for synaptic vesicle entry.

Published in:

EMBO Journal, 2023, v. 42, n. 13, p. 1, doi. 10.15252/embj.2022112095

By:

Joensuu, Merja;
Syed, Parnayan;
Saber, Saber H;
Lanoue, Vanessa;
Wallis, Tristan P;
Rae, James;
Blum, Ailisa;
Gormal, Rachel S;
Small, Christopher;
Sanders, Shanley;
Jiang, Anmin;
Mahrhold, Stefan;
Krez, Nadja;
Cousin, Michael A;
Cooper‐White, Ruby;
Cooper‐White, Justin J;
Collins, Brett M;
Parton, Robert G;
Balistreri, Giuseppe;
Rummel, Andreas

Publication type:

Article

The H<sub>CC</sub>-domain of botulinum neurotoxins A and B exhibits a singular ganglioside binding site displaying serotype specific carbohydrate interaction.

Published in:

Molecular Microbiology, 2004, v. 51, n. 3, p. 631, doi. 10.1046/j.1365-2958.2003.03872.x

By:

Rummel, Andreas;
Mahrhold, Stefan;
Bigalke, Hans;
Binz, Thomas

Publication type:

Article

Human-Relevant Sensitivity of iPSC-Derived Human Motor Neurons to BoNT/A1 and B1.

Published in:

Toxins, 2021, v. 13, n. 8, p. 585, doi. 10.3390/toxins13080585

By:

Schenke, Maren;
Prause, Hélène-Christine;
Bergforth, Wiebke;
Przykopanski, Adina;
Rummel, Andreas;
Klawonn, Frank;
Seeger, Bettina

Publication type:

Article

Innovative and Highly Sensitive Detection of Clostridium perfringens Enterotoxin Based on Receptor Interaction and Monoclonal Antibodies.

Published in:

Toxins, 2021, v. 13, n. 4, p. 266, doi. 10.3390/toxins13040266

By:

Neumann, Thea;
Krüger, Maren;
Weisemann, Jasmin;
Mahrhold, Stefan;
Stern, Daniel;
Dorner, Martin B.;
Feraudet-Tarisse, Cécile;
Pöhlmann, Christopher;
Schulz, Katharina;
Messelhäußer, Ute;
Rimek, Dagmar;
Gessler, Frank;
Elßner, Thomas;
Simon, Stéphanie;
Rummel, Andreas;
Dorner, Brigitte G.

Publication type:

Article

The 25 kDa H CN Domain of Clostridial Neurotoxins Is Indispensable for Their Neurotoxicity.

Published in:

Toxins, 2020, v. 12, n. 12, p. 743, doi. 10.3390/toxins12120743

By:

Deppe, Julian;
Weisemann, Jasmin;
Mahrhold, Stefan;
Rummel, Andreas

Publication type:

Article

Optimization of SNAP-25 and VAMP-2 Cleavage by Botulinum Neurotoxin Serotypes A–F Employing Taguchi Design-of-Experiments.

Published in:

Toxins, 2019, v. 11, n. 10, p. 588, doi. 10.3390/toxins11100588

By:

von Berg, Laura;
Stern, Daniel;
Weisemann, Jasmin;
Rummel, Andreas;
Dorner, Martin Bernhard;
Dorner, Brigitte Gertrud

Publication type:

Article

Botulinum Neurotoxin F Subtypes Cleaving the VAMP-2 Q58–K59 Peptide Bond Exhibit Unique Catalytic Properties and Substrate Specificities.

Published in:

Toxins, 2018, v. 10, n. 8, p. 311, doi. 10.3390/toxins10080311

By:

Sikorra, Stefan;
Skiba, Martin;
Dorner, Martin B.;
Weisemann, Jasmin;
Weil, Mirjam;
Valdezate, Sylvia;
Davletov, Bazbek;
Rummel, Andreas;
Dorner, Brigitte G.;
Binz, Thomas

Publication type:

Article

An Interview with Cesare Montecucco.

Published in:

2018

By:

Holford, Mandë;
Rummel, Andreas

Publication type:

Interview

Crystal Structure of the Receptor-Binding Domain of Botulinum Neurotoxin Type HA, Also Known as Type FA or H.

Published in:

Toxins, 2017, v. 9, n. 3, p. 93, doi. 10.3390/toxins9030093

By:

Yao, Guorui;
Lam, Kwok-ho;
Perry, Kay;
Weisemann, Jasmin;
Rummel, Andreas;
Rongsheng Jin

Publication type:

Article

Botulinum Neurotoxin Serotype A Recognizes Its Protein Receptor SV2 by a Different Mechanism than Botulinum Neurotoxin B Synaptotagmin.

Published in:

Toxins, 2016, v. 8, n. 5, p. 154, doi. 10.3390/toxins8050154

By:

Weisemann, Jasmin;
Stern, Daniel;
Mahrhold, Stefan;
Dorner, Brigitte G.;
Rummel, Andreas

Publication type:

Article

Preface Biological Toxins--Ancient Molecules Posing a Current Threat.

Published in:

Toxins, 2015, v. 7, n. 12, p. 5320, doi. 10.3390/toxins7124888

By:

Dorner, Brigitte G.;
Rummel, Andreas

Publication type:

Article

Generation and Characterization of Six Recombinant Botulinum Neurotoxins as Reference Material to Serve in an International Proficiency Test.

Published in:

Toxins, 2015, v. 7, n. 12, p. 5035, doi. 10.3390/toxins7124861

By:

Weisemann, Jasmin;
Krez, Nadja;
Fiebig, Uwe;
Worbs, Sylvia;
Skiba, Martin;
Endermann, Tanja;
Dorner, Martin B.;
Bergström, Tomas;
Muñoz, Amalia;
Zegers, Ingrid;
Müller, Christian;
Jenkinson, Stephen P.;
Avondet, Marc-Andre;
Delbrassinne, Laurence;
Denayer, Sarah;
Zeleny, Reinhard;
Schimmel, Heinz;
Åstot, Crister;
Dorner, Brigitte G.;
Rummel, Andreas

Publication type:

Article

Qualitative and Quantitative Detection of Botulinum Neurotoxins from Complex Matrices: Results of the First International Proficiency Test.

Published in:

Toxins, 2015, v. 7, n. 12, p. 4935, doi. 10.3390/toxins7124857

By:

Worbs, Sylvia;
Fiebig, Uwe;
Zeleny, Reinhard;
Schimmel, Heinz;
Rummel, Andreas;
Luginbühl, Werner;
Dorner, Brigitte G.

Publication type:

Article

Botulinum Neurotoxins: Qualitative and Quantitative Analysis Using the Mouse Phrenic Nerve Hemidiaphragm Assay (MPN).

Published in:

Toxins, 2015, v. 7, n. 12, p. 4895, doi. 10.3390/toxins7124855

By:

Bigalke, Hans;
Rummel, Andreas

Publication type:

Article

The biological activity of botulinum neurotoxin type C is dependent upon novel types of ganglioside binding sites.

Published in:

Molecular Microbiology, 2011, v. 81, n. 1, p. 143, doi. 10.1111/j.1365-2958.2011.07682.x

By:

Strotmeier, Jasmin;
Gu, Shenyan;
Jutzi, Stephan;
Mahrhold, Stefan;
Zhou, Jie;
Pich, Andreas;
Eichner, Timo;
Bigalke, Hans;
Rummel, Andreas;
Jin, Rongsheng;
Binz, Thomas

Publication type:

Article

A viral-fusion-peptide-like molecular switch drives membrane insertion of botulinum neurotoxin A1.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-07789-4

By:

Lam, Kwok-ho;
Guo, Zhuojun;
Krez, Nadja;
Matsui, Tsutomu;
Perry, Kay;
Weisemann, Jasmin;
Rummel, Andreas;
Bowen, Mark E.;
Jin, Rongsheng

Publication type:

Article

Only the complex N559-glycan in the synaptic vesicle glycoprotein 2C mediates high affinity binding to botulinum neurotoxin serotype A1.

Published in:

Biochemical Journal, 2016, v. 473, n. 17, p. 2645, doi. 10.1042/BCJ20160439

By:

Mahrhold, Stefan;
Bergström, Tomas;
Stern, Daniel;
Dorner, Brigitte Gertrud;
Åstot, Crister;
Rummel, Andreas

Publication type:

Article

Identification of the SV2 protein receptor-binding site of botulinum neurotoxin type E.

Published in:

Biochemical Journal, 2013, v. 453, n. 1, p. 37, doi. 10.1042/BJ20130391

By:

MAHRHOLD, Stefan;
STROTMEIER, Jasmin;
GARCIA-RODRIGUEZ, Consuelo;
Jianlong LOU;
MARKS, James D.;
RUMMEL, Andreas;
BINZ, Thomas

Publication type:

Article

Functional detection of botulinum neurotoxin serotypes A to F by monoclonal neoepitope-specific antibodies and suspension array technology.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-41722-z

By:

von Berg, Laura;
Stern, Daniel;
Pauly, Diana;
Mahrhold, Stefan;
Weisemann, Jasmin;
Jentsch, Lisa;
Hansbauer, Eva-Maria;
Müller, Christian;
Avondet, Marc A.;
Rummel, Andreas;
Dorner, Martin B.;
Dorner, Brigitte G.

Publication type:

Article

Construction and validation of safe Clostridium botulinum Group II surrogate strain producing inactive botulinum neurotoxin type E toxoid.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-05008-1

By:

Nowakowska, Maria B.;
Selby, Katja;
Przykopanski, Adina;
Krüger, Maren;
Krez, Nadja;
Dorner, Brigitte G.;
Dorner, Martin B.;
Jin, Rongsheng;
Minton, Nigel P.;
Rummel, Andreas;
Lindström, Miia

Publication type:

Article

Crystal structures of OrfX1, OrfX2 and the OrfX1–OrfX3 complex from the orfX gene cluster of botulinum neurotoxin E1.

Published in:

FEBS Letters, 2023, v. 597, n. 4, p. 524, doi. 10.1002/1873-3468.14576

By:

Gao, Linfeng;
Lam, Kwok‐ho;
Liu, Shun;
Przykopanski, Adina;
Lübke, Johanna;
Qi, Ruifeng;
Krüger, Maren;
Nowakowska, Maria B.;
Selby, Katja;
Douillard, François P.;
Dorner, Martin B.;
Perry, Kay;
Lindström, Miia;
Dorner, Brigitte G.;
Rummel, Andreas;
Jin, Rongsheng

Publication type:

Article

Identification of the synaptic vesicle glycoprotein 2 receptor binding site in botulinum neurotoxin A.

Published in:

FEBS Letters, 2014, v. 588, n. 7, p. 1087, doi. 10.1016/j.febslet.2014.02.034

By:

Strotmeier, Jasmin;
Mahrhold, Stefan;
Krez, Nadja;
Janzen, Constantin;
Lou, Jianlong;
Marks, James D.;
Binz, Thomas;
Rummel, Andreas

Publication type:

Article

Neutralisation of specific surface carboxylates speeds up translocation of botulinum neurotoxin type B enzymatic domain.

Published in:

FEBS Letters, 2013, v. 587, n. 23, p. 3831, doi. 10.1016/j.febslet.2013.10.010

By:

Pirazzini, Marco;
Henke, Tina;
Rossetto, Ornella;
Mahrhold, Stefan;
Krez, Nadja;
Rummel, Andreas;
Montecucco, Cesare;
Binz, Thomas

Publication type:

Article

Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity.

Published in:

PLoS Pathogens, 2013, v. 9, n. 10, p. 1, doi. 10.1371/journal.ppat.1003690

By:

Lee, Kwangkook;
Gu, Shenyan;
Jin, Lei;
Le, Thi Tuc Nghi;
Cheng, Luisa W.;
Strotmeier, Jasmin;
Kruel, Anna Magdalena;
Yao, Guorui;
Perry, Kay;
Rummel, Andreas;
Jin, Rongsheng

Publication type:

Article

Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity.

Published in:

Nature, 2006, v. 444, n. 7122, p. 1092, doi. 10.1038/nature05387

By:

Jin, Rongsheng;
Rummel, Andreas;
Binz, Thomas;
Brunger, Axel T.

Publication type:

Article

Isolation and Functional Characterization of the Novel Clostridium botulinum Neurotoxin A8 Subtype.

Published in:

PLoS ONE, 2015, v. 10, n. 2, p. 1, doi. 10.1371/journal.pone.0116381

By:

Kull, Skadi;
Schulz, K. Melanie;
Strotmeier, Jasmin Weisemann née;
Kirchner, Sebastian;
Schreiber, Tanja;
Bollenbach, Alexander;
Dabrowski, P. Wojtek;
Nitsche, Andreas;
Kalb, Suzanne R.;
Dorner, Martin B.;
Barr, John R.;
Rummel, Andreas;
Dorner, Brigitte G.

Publication type:

Article

Exchange of the H<sub>CC</sub> domain mediating double receptor recognition improves the pharmacodynamic properties of botulinum neurotoxin.

Published in:

FEBS Journal, 2011, v. 278, n. 23, p. 4506, doi. 10.1111/j.1742-4658.2011.08196.x

By:

Rummel, Andreas;
Mahrhold, Stefan;
Bigalke, Hans;
Binz, Thomas

Publication type:

Article

The NanoWorkstation: Complementing FIB-SEM Tools with Micromanipulators.

Published in:

2019

By:

Smith, Andrew J.;
Rummel, Andreas;
Kemmler, Matthias;
Schock, Klaus;
Kleindiek, Stephan

Publication type:

Abstract

The NanoWorkstation: Complementing FIB-SEM Tools with Micromanipulators.

Published in:

2018

By:

Smith, Andrew J.;
Rummel, Andreas;
Kemmler, Matthias;
Schock, Klaus;
Kleindiek, Stephan

Publication type:

Abstract

In Situ Nanoprobing Tools for Fault Localization and Defect Characterization.

Published in:

Microscopy & Microanalysis, 2017, v. 23, p. 1432, doi. 10.1017/S1431927617007826

By:

Smith, Andrew J.;
Rummel, Andreas;
Kemmler, Matthias;
Schock, Klaus;
Kleindiek, Stephan

Publication type:

Article

Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-37860-8

By:

Liu, Zheng;
Lee, Pyung-Gang;
Krez, Nadja;
Lam, Kwok-ho;
Liu, Hao;
Przykopanski, Adina;
Chen, Peng;
Yao, Guorui;
Zhang, Sicai;
Tremblay, Jacqueline M.;
Perry, Kay;
Shoemaker, Charles B.;
Rummel, Andreas;
Dong, Min;
Jin, Rongsheng

Publication type:

Article

Human synaptotagmin-II is not a high affinity receptor for botulinum neurotoxin B and G: Increased therapeutic dosage and immunogenicity

Published in:

FEBS Letters, 2012, v. 586, n. 4, p. 310, doi. 10.1016/j.febslet.2011.12.037

By:

Strotmeier, Jasmin;
Willjes, Gesche;
Binz, Thomas;
Rummel, Andreas

Publication type:

Article

The synaptic vesicle protein 2C mediates the uptake of botulinum neurotoxin A into phrenic nerves

Published in:

FEBS Letters, 2006, v. 580, n. 8, p. 2011, doi. 10.1016/j.febslet.2006.02.074

By:

Mahrhold, Stefan;
Rummel, Andreas;
Bigalke, Hans;
Davletov, Bazbek;
Binz, Thomas

Publication type:

Article

NANOPROBING AT LOW BEAM ENERGY, ADDRESSING CURRENT AND FUTURE NODES.

Published in:

Electronic Device Failure Analysis, 2022, v. 24, n. 2, p. 12, doi. 10.31399/asm.edfa.2022-2.p012

By:

Rummel, Andreas;
Smith, Andrew Jonathan

Publication type:

Article

LOCATING FAILURES IN CURRENT DEVICE NODES: EBIC/EBAC, CURRENT IMAGING AND NANOPROBING.

Published in:

Electronic Device Failure Analysis, 2018, v. 20, n. 3, p. 24, doi. 10.31399/asm.edfa.2018-3.p024

By:

Kleindiek, Stephan;
Ring, Rosalinda M.;
Schock, Klaus;
Rummel, Andreas;
Zschornack, Michael;
Limbecker, Pascal;
Meyer, Andreas;
Newkirk, Randy;
Davidson, Kevin;
Kemmler, Matthias

Publication type:

Article

A lipid-binding loop of botulinum neurotoxin serotypes B, DC and G is an essential feature to confer their exquisite potency.

Published in:

PLoS Pathogens, 2018, v. 14, n. 5, p. 1, doi. 10.1371/journal.ppat.1007048

By:

Stern, Daniel;
Weisemann, Jasmin;
Le Blanc, Alexander;
von Berg, Laura;
Mahrhold, Stefan;
Piesker, Janett;
Laue, Michael;
Luppa, Peter B.;
Dorner, Martin Bernhard;
Dorner, Brigitte Gertrud;
Rummel, Andreas

Publication type:

Article

Botulinum neurotoxin C mutants reveal different effects of syntaxin or SNAP-25 proteolysis on neuromuscular transmission.

Published in:

PLoS Pathogens, 2017, v. 13, n. 8, p. 1, doi. 10.1371/journal.ppat.1006567

By:

Zanetti, Giulia;
Sikorra, Stefan;
Rummel, Andreas;
Krez, Nadja;
Duregotti, Elisa;
Negro, Samuele;
Henke, Tina;
Rossetto, Ornella;
Binz, Thomas;
Pirazzini, Marco

Publication type:

Article

Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptor.

Published in:

Journal of Neurochemistry, 2009, v. 110, n. 6, p. 1942, doi. 10.1111/j.1471-4159.2009.06298.x

By:

Rummel, Andreas;
H#x00E4;fner, Kirstin;
Mahrhold, Stefan;
Darashchonak, Natallia;
Holt, Matthew;
Jahn, Reinhard;
Beermann, Silke;
Karnath, Tino;
Bigalke, Hans;
Binz, Thomas

Publication type:

Article

Cell entry strategy of clostridial neurotoxins.

Published in:

Journal of Neurochemistry, 2009, v. 109, n. 6, p. 1584, doi. 10.1111/j.1471-4159.2009.06093.x

By:

Binz, Thomas;
Rummel, Andreas

Publication type:

Article

Botulinum neurotoxin type D enables cytosolic delivery of enzymatically active cargo proteins to neurones via unfolded translocation intermediates.

Published in:

Journal of Neurochemistry, 2004, v. 91, n. 6, p. 1461, doi. 10.1111/j.1471-4159.2004.02844.x

By:

Bade, Steffen;
Rummel, Andreas;
Reisinger, Clemens;
Karnath, Tino;
Ahnert-Hilger, Gudrun;
Bigalke, Hans;
Binz, Thomas

Publication type:

Article