Works by Ruderman, Neil B.

Results: 52

SIRT4 controls the balance between lipid synthesis and catabolism by repressing malonyl-CoA decarboxylase.

Published in:

2012

By:

Laurent, Gaëlle;
German, Natalie J.;
Saha, Asish K.;
de Boer, Vincent C. J.;
Fischer, Frank;
Boanca, Gina;
Dephoure, Noah;
Vaitheesvaran, Bhavapriya;
Davies, Michael;
Gygi, Steven P.;
Muoio, Deborah M.;
Kurland, Irwin J.;
Steegborn, Clemens;
Ruderman, Neil B.;
Haigis, Marcia C.

Publication type:

Abstract

Knockdown of GSK3β increases basal autophagy and AMPK signalling in nutrient-laden human aortic endothelial cells.

Published in:

Bioscience Reports, 2016, v. 36, n. 5, p. 1, doi. 10.1042/BSR20160174

By:

Weikel, Karen A.;
Cacicedo, José M.;
Ruderman, Neil B.;
Yasuo Ido

Publication type:

Article

AMPK, insulin resistance, and the metabolic syndrome.

Published in:

Journal of Clinical Investigation, 2013, v. 123, n. 7, p. 2764, doi. 10.1172/JCI67227

By:

Ruderman, Neil B.;
Carling, David;
Prentki, Marc;
Cacicedo, José M.

Publication type:

Article

Pancreatic β-Cell Dysfunction in Diet-Induced Obese Mice: Roles of AMP-Kinase, Protein Kinase Cε, Mitochondrial and Cholesterol Metabolism, and Alterations in Gene Expression.

Published in:

PLoS ONE, 2016, v. 11, n. 4, p. 1, doi. 10.1371/journal.pone.0153017

By:

Pepin, Émilie;
Al-Mass, Anfal;
Attané, Camille;
Zhang, Kezhuo;
Lamontagne, Julien;
Lussier, Roxane;
Madiraju, S. R. Murthy;
Joly, Erik;
Ruderman, Neil B.;
Sladek, Robert;
Prentki, Marc;
Peyot, Marie-Line

Publication type:

Article

Why Might Thiazolidinediones Increase Exercise Capacity in Patients With Type 2 Diabetes?

Published in:

2005

By:

LeBrasseur, Nathan K.;
Ruderman, Neil B.

Publication type:

Editorial

Cutting the Gordian Knot.

Published in:

Diabetes Care, 1999, v. 22, n. 11, p. 1912, doi. 10.2337/diacare.22.11.1912

By:

Mcdonnell, Marie E.;
Ruderman, Neil B.

Publication type:

Article

Insulin Resistance in Type 2 Diabetes: Association with Truncal Obesity, Impaired Fitness, and Atypical Malonyl Coenzyme A Regulation.

Published in:

Journal of Clinical Endocrinology & Metabolism, 2003, v. 88, n. 1, p. 82, doi. 10.1210/jc.2002-020330

By:

BÅVENHOLM, PETER N.;
KUHL, JEANETTE;
PIGON, JAN;
SAHA, ASISH K.;
RUDERMAN, NEIL B.;
EFENDIC, SUAD

Publication type:

Article

Effect of acute insulin deprivation on rat liver glucokinase.

Published in:

1968

By:

Ruderman, Neil B.;
Lauris, Vilma;
Ruderman, N B;
Lauris, V

Publication type:

journal article

AMPK activation: a therapeutic target for type 2 diabetes ?

Published in:

Diabetes, Metabolic Syndrome & Obesity: Targets & Therapy, 2014, v. 7, p. 241, doi. 10.2147/DMSO.S43731

By:

Coughlan, Kimberly A.;
Valentine, Rudy J.;
Ruderman, Neil B.;
Saha, Asish K.

Publication type:

Article

Insulin resistance due to nutrient excess.

Published in:

Cell Cycle, 2011, v. 10, n. 20, p. 3447, doi. 10.4161/cc.10.20.17886

By:

Saha, Asish K.;
Xu, X. Julia;
Balon, Thomas W.;
Brandon, Amanda;
Kraegen, Edward W.;
Ruderman, Neil B.

Publication type:

Article

Malonyl-CoA decarboxylase is present in the cytosolic, mitochondrial and peroxisomal compartments of rat hepatocytes

Published in:

FEBS Letters, 2005, v. 579, n. 29, p. 6581, doi. 10.1016/j.febslet.2005.10.050

By:

Joly, Erik;
Bendayan, Moise;
Roduit, Raphaël;
Saha, Asish K.;
Ruderman, Neil B.;
Prentki, Marc

Publication type:

Article

Metabolic and hormonal interactions between muscle and adipose tissue.

Published in:

Proceedings of the Nutrition Society, 2004, v. 63, n. 2, p. 381, doi. 10.1079/PNS2004356

By:

Tomas, Eva;
Kelly, Meghan;
Xiang, Xiaoqin;
Tsao, Tsu-Shuen;
Keller, Charlotte;
Keller, Pernille;
Luo, Zhijun;
Lodish, Harvey;
Saha, Asish K.;
Unger, Roger;
Ruderman, Neil B.

Publication type:

Article

An Electron Microscopic Study of Lipoprotein Production and Release by the Isolated Perfused Rat Liver.∗.

Published in:

Proceedings of the Society for Experimental Biology & Medicine, 1966, v. 123, n. 1, p. 4, doi. 10.3181/00379727-123-31388

By:

Jones, Albert L.;
Ruderman, Neil B.;
Herrera, M. Guillermo

Publication type:

Article

Increased subcutaneous adipose tissue expression of genes involved in glycerolipid-fatty acid cycling in obese insulin-resistant versus -sensitive individuals.

Published in:

2014

By:

Gauthier, Marie-Soleil;
Pérusse, Joelle R;
Lavoie, Marie-Eve;
Sladek, Robert;
Madiraju, S R Murthy;
Ruderman, Neil B;
Coulombe, Benoit;
Prentki, Marc;
Rabasa-Lhoret, Rémi;
Lavoie, Marie-Ève

Publication type:

journal article

Hyperglycemia and Insulin Resistance: Possible Mechanisms.

Published in:

Annals of the New York Academy of Sciences, 2002, v. 967, n. 1, p. 43, doi. 10.1111/j.1749-6632.2002.tb04262.x

By:

TOMÁS, EVA;
LIN, YEN-SHOU;
DAGHER, ZEINA;
SAHA, ASISH;
LUO, ZHIJUN;
IDO, YASUO;
RUDERMAN, NEIL B.

Publication type:

Article

Metabolic Syndrome: Adenosine Monophosphate-activated Protein Kinase and Malonyl Coenzyme A.

Published in:

Obesity (19307381), 2006, v. 14, p. 25S, doi. 10.1038/oby.2006.279

By:

Ruderman, Neil B.;
Saha, Asish K.

Publication type:

Article

Insulin Resistance due to Nutrient Excess: Mechanisms of AMPK Downregulation.

Published in:

FASEB Journal, 2013, v. 27, p. 701.2, doi. 10.1096/fasebj.27.1_supplement.701.2

By:

Saha, Asish K;
Balon, Thomas W;
Coughlan, Kimberly A;
Ruderman, Neil B

Publication type:

Article

Response to Comments on Nolan et al. Insulin Resistance as a Physiological Defense Against Metabolic Stress: Implications for the Management of Subsets of Type 2 Diabetes. Diabetes 2015;64:673-686.

Published in:

2015

By:

Nolan, Christopher J.;
Ruderman, Neil B.;
Kahn, Steven E.;
Pedersen, Oluf;
Prentki, Marc

Publication type:

Letter

Insulin Resistance as a Physiological Defense Against Metabolic Stress: Implications for the Management of Subsets of Type 2 Diabetes.

Published in:

Diabetes, 2015, v. 64, n. 3, p. 673, doi. 10.2337/db14-0694

By:

Nolan, Christopher J.;
Ruderman, Neil B.;
Kahn, Steven E.;
Pedersen, Oluf;
Prentki, Marc

Publication type:

Article

Pioglitazone Acutely Reduces Energy Metabolism and Insulin Secretion in Rats.

Published in:

Diabetes, 2013, v. 62, n. 6, p. 2122, doi. 10.2337/db12-0428

By:

Lamontagne, Julien;
Jalbert-Arsenault, Élise;
Pepin, Émilie;
Peyot, Marie-Line;
Ruderman, Neil B.;
Nolan, Christopher J.;
Joly, Erik;
Madiraju, S. R. Murthy;
Poitout, Vincent;
Prentki, Marc

Publication type:

Article

Activation of AMP-activated protein kinase by interleukin-6 in rat skeletal muscle: association with changes in cAMP, energy state, and endogenous fuel mobilization.

Published in:

2009

By:

Kelly M;
Gauthier MS;
Saha AK;
Ruderman NB;
Kelly, Meghan;
Gauthier, Marie-Soleil;
Saha, Asish K;
Ruderman, Neil B

Publication type:

journal article

Activation of AMP-Activated Protein Kinase by Interleukin-6 in Rat Skeletal Muscle.

Published in:

Diabetes, 2009, v. 58, n. 9, p. 1953, doi. 10.2337/db08-1293

By:

Kelly, Meghan;
Gauthier, Marie-Soleil;
Saha, Asish K.;
Ruderman, Neil B.

Publication type:

Article

Chronic Inhibition of AMP-activated Protein Kinase (AMPK) Augments Oxidative Stress, and Stimulates Basal and TNF-Alpha-Induced NF-kappaB Transactivation.

Published in:

Diabetes, 2007, v. 56, p. A515

By:

Cacicedo, Jose M.;
Gauthier, Marie-Soleil;
Ruderman, Neil B.;
Ido, Yasuo

Publication type:

Article

Interleukin-6 Activation of AMPK Involves Both Jak-Stat and Cyclic AMP-Mediated Signaling.

Published in:

Diabetes, 2007, v. 56, p. A510

By:

Kelly, Meghan;
Saha, Asish K.;
Ruderman, Neil B.

Publication type:

Article

AMP-Activated Protein Kinase Activity Is Altered by Changes in Redox State in HepG2 Cells by a SIRT1-Dependent Mechanism.

Published in:

Diabetes, 2007, v. 56, p. A394

By:

Suchankova, Gabriela;
Saha, Asish K.;
Ido, Yasuo;
Ruderman, Neil B.

Publication type:

Article

Lipolysis Decreases the Energy State and Activates AMP-Activated Protein Kinase (AMPK) in the Adipocyte.

Published in:

Diabetes, 2007, v. 56, p. A355

By:

Gauthier, Marie-Soleil;
Miyoshi, Hideaki;
Souza, Sandra C.;
Saha, Asish K.;
Greenberg, Andrew S.;
Ruderman, Neil B.

Publication type:

Article

Pharmacological Blockade of Acety1-CoA Carboxylase System Prevents Insulin Resistance and PKC θ Activation in Incubated Rat Muscle.

Published in:

Diabetes, 2007, v. 56, p. A333

By:

Saha, Asish K.;
Deoliveira, Rosangela;
Harwood Jr., H. James;
Ruderman, Neil B.

Publication type:

Article

Interleukin-6 regulation of AMP-activated protein kinase. Potential role in the systemic response to exercise and prevention of the metabolic syndrome.

Published in:

2006

By:

Ruderman NB;
Keller C;
Richard A;
Saha AK;
Luo Z;
Xiang X;
Giralt M;
Ritov VB;
Menshikova EV;
Kelley DE;
Hidalgo J;
Pedersen BK;
Kelly M;
Ruderman, Neil B;
Keller, Charlotte;
Richard, Ann-Marie;
Saha, Asish K;
Luo, Zhijun;
Xiang, Xiaoqin;
Giralt, Mercedes

Publication type:

journal article

Palmitate-induced apoptosis in cultured bovine retinal pericytes: roles of NAD(P)H oxidase, oxidant stress, and ceramide.

Published in:

2005

By:

Cacicedo, Jose M.;
Benjachareowong, Sunun;
Chou, Eva;
Ruderman, Neil B.;
Ido, Yasuo

Publication type:

journal article

Glucose autoregulates its uptake in skeletal muscle: involvement of AMP-activated protein kinase.

Published in:

2003

By:

Itani, Samar I;
Saha, Asish K;
Kurowski, Theodore G;
Coffin, Heather R;
Tornheim, Keith;
Ruderman, Neil B

Publication type:

journal article

Glucose Autoregulates Its Uptake in Skeletal Muscle.

Published in:

Diabetes, 2003, v. 52, n. 7, p. 1635, doi. 10.2337/diabetes.52.7.1635

By:

Itani, Samar I.;
Saha, Asish K.;
Kurowski, Theodore G.;
Coffin, Heather R.;
Tornheim, Keith;
Ruderman, Neil B.

Publication type:

Article

AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats.

Published in:

2002

By:

Iglesias, Miguel A.;
Ye, Ji-Ming;
Frangioudakis, Georgia;
Saha, Asish K.;
Tomas, Eva;
Ruderman, Neil B.;
Cooney, Gregory J.;
Kraegen, Edward W.

Publication type:

journal article

Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha.

Published in:

2002

By:

Itani, Samar I.;
Ruderman, Neil B.;
Schmieder, Frank;
Boden, Guenther

Publication type:

journal article

Fatty Acid Oxidation and the Regulation of Malonyl-CoA in Human Muscle.

Published in:

Diabetes, 2000, v. 49, n. 7, p. 1078, doi. 10.2337/diabetes.49.7.1078

By:

Bavenholm, Peter N.;
Pigon, Jan;
Saha, Asish K.;
Ruderman, Neil B.;
Efendic, Suad

Publication type:

Article

Hyperglycemia inhibits insulin activation of Akt/protein kinase B but not phosphatidylinositol 3-kinase in rat skeletal muscle.

Published in:

1999

By:

Kurowski, Theodore G.;
Lin, Yenshou;
Luo, Zhijun;
Tsichlis, Phillip N.;
Buse, Maria G.;
Heydrick, Stanley J.;
Ruderman, Neil B.;
Kurowski, T G;
Lin, Y;
Luo, Z;
Tsichlis, P N;
Buse, M G;
Heydrick, S J;
Ruderman, N B

Publication type:

journal article

Regulation of muscle malonyl-CoA levels in the nutritionally insulin-resistant desert gerbil, Psammomys obesus.

Published in:

Diabetes/Metabolism Research & Reviews, 2002, v. 18, n. 3, p. 217, doi. 10.1002/dmrr.288

By:

Shafrir, Eleazar;
Ziv, Ehud;
Saha, Asish K.;
Ruderman, Neil B.

Publication type:

Article

Nutrient Excess and AMPK Downregulation in Incubated Skeletal Muscle and Muscle of Glucose Infused Rats.

Published in:

PLoS ONE, 2015, v. 10, n. 5, p. 1, doi. 10.1371/journal.pone.0127388

By:

Coughlan, Kimberly A.;
Balon, Thomas W.;
Valentine, Rudy J.;
Petrocelli, Robert;
Schultz, Vera;
Brandon, Amanda;
Cooney, Gregory J.;
Kraegen, Edward W.;
Ruderman, Neil B.;
Saha, Asish K.

Publication type:

Article

Overexpression of SIRT1 in Rat Skeletal Muscle Does Not Alter Glucose Induced Insulin Resistance.

Published in:

PLoS ONE, 2015, v. 10, n. 3, p. 1, doi. 10.1371/journal.pone.0121959

By:

Brandon, Amanda E.;
Tid-Ang, Jennifer;
Wright, Lauren E.;
Stuart, Ella;
Suryana, Eurwin;
Bentley, Nicholas;
Turner, Nigel;
Cooney, Gregory J.;
Ruderman, Neil B.;
Kraegen, Edward W.

Publication type:

Article

Resveratrol Prevents Oxidative Stress-Induced Senescence and Proliferative Dysfunction by Activating the AMPK-FOXO3 Cascade in Cultured Primary Human Keratinocytes.

Published in:

PLoS ONE, 2015, v. 10, n. 2, p. 1, doi. 10.1371/journal.pone.0115341

By:

Ido, Yasuo;
Duranton, Albert;
Lan, Fan;
Weikel, Karen A.;
Breton, Lionel;
Ruderman, Neil B.

Publication type:

Article

Glucagon-Like Peptide-1 (GLP-1) Analog Liraglutide Inhibits Endothelial Cell Inflammation through a Calcium and AMPK Dependent Mechanism.

Published in:

PLoS ONE, 2014, v. 9, n. 5, p. 1, doi. 10.1371/journal.pone.0097554

By:

Krasner, Nadia M.;
Ido, Yasuo;
Ruderman, Neil B.;
Cacicedo, Jose M.

Publication type:

Article

Acute Activation of AMP-Activated Protein Kinase Prevents H<sub>2</sub>O<sub>2</sub>-Induced Premature Senescence in Primary Human Keratinocytes.

Published in:

PLoS ONE, 2012, v. 7, n. 4, p. 1, doi. 10.1371/journal.pone.0035092

By:

Ido, Yasuo;
Duranton, Albert;
Lan, Fan;
Cacicedo, Jose M.;
Chen, Tai C.;
Breton, Lionel;
Ruderman, Neil B.

Publication type:

Article

Use of glucocorticoids in the palliative treatment of metastatic brain tumors.

Published in:

Cancer (0008543X), 1965, v. 18, n. 3, p. 298, doi. 10.1002/1097-0142(196503)18:3<298::AID-CNCR2820180306>3.0.CO;2-H

By:

Ruderman, Neil B.;
Hall, Thomas C.

Publication type:

Article

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation.

Published in:

Nature, 2010, v. 464, n. 7285, p. 121, doi. 10.1038/nature08778

By:

Hirschey, Matthew D.;
Shimazu, Tadahiro;
Goetzman, Eric;
Enxuan Jing;
Schwer, Bjoern;
Lombard, David B.;
Grueter, Carrie A.;
Harris, Charles;
Biddinger, Sudha;
Ilkayeva, Olga R.;
Stevens, Robert D.;
Yu Li;
Saha, Asish K.;
Ruderman, Neil B.;
Bain, James R.;
Newgard, Christopher B.;
Farese, Jr., Robert V.;
Alt, Frederick W.;
Kahn, C. Ronald;
Verdin, Eric

Publication type:

Article

Ten-year experience with an exercise-based outpatient life-style modification program in the treatment of diabetes mellitus.

Published in:

1992

By:

Schneider, Stephen H.;
Khachadurian, Avedis K.;
Amorosa, Louis F.;
Clemow, Lynn;
Ruderman, Neil B.;
Schneider, S H;
Khachadurian, A K;
Amorosa, L F;
Clemow, L;
Ruderman, N B

Publication type:

journal article

Diabetes, exercise, and atherosclerosis.

Published in:

1992

By:

Ruderman, Neil B.;
Schneider, Stephen H.;
Ruderman, N B;
Schneider, S H

Publication type:

journal article

Enhanced stimulation of diacylglycerol and lipid synthesis by insulin in denervated muscle. Altered protein kinase C activity and possible link to insulin resistance.

Published in:

1991

By:

Heydrick, Stanley J.;
Ruderman, Neil B.;
Kurowski, Theodore G.;
Adams, Heather B.;
Chen, Kim S.;
Heydrick, S J;
Ruderman, N B;
Kurowski, T G;
Adams, H B;
Chen, K S

Publication type:

journal article

Partial Characterization of an Insulin-dependent Serum Factor that Regulates Ornithine Decarboxylase in Skeletal Muscle.

Published in:

Diabetes, 1982, v. 31, n. 6, p. 500, doi. 10.2337/diab.31.6.500

By:

Conover, Cheryl;
Rozovski, S. Jaime;
Ruderman, Neil B.

Publication type:

Article

Regulation of Ornithine Decarboxylase in Skeletal Muscle.

Published in:

Diabetes, 1981, v. 30, n. 8, p. 678, doi. 10.2337/diab.30.8.678

By:

Conover, Cheryl A.;
Rozovski, S. Jaime;
Ruderman, Neil B.

Publication type:

Article

The effect of physical training on glucose tolerance and plasma lipids in maturity-onset diabetes.

Published in:

1979

By:

Ruderman, Neil B.;
Ganda, Om P.;
Johansen, Klaus;
Ruderman, N B;
Ganda, O P;
Johansen, K

Publication type:

journal article

Substrate utilization in perfused skeletal muscle.

Published in:

1979

By:

Ruderman, Neil B.;
Goodman, Michael N.;
Conover, Cheryl A.;
Berger, Michael;
Ruderman, N B;
Goodman, M N;
Conover, C A;
Berger, M

Publication type:

journal article