Works by Ruddock, Lloyd W.

Results: 30

Design of an alternate antibody fragment format that can be produced in the cytoplasm of Escherichia coli.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-41525-3

By:

Tungekar, Aatir A.;
Ruddock, Lloyd W.

Publication type:

Article

Exome Sequencing Reveals a Phenotype Modifying Variant in ZNF528 in Primary Osteoporosis With a COL1A2 Deletion.

Published in:

Journal of Bone & Mineral Research, 2020, v. 35, n. 12, p. 2381, doi. 10.1002/jbmr.4145

By:

Skarp, Sini;
Xia, Ji‐Han;
Zhang, Qin;
Löija, Marika;
Costantini, Alice;
Ruddock, Lloyd W;
Mäkitie, Outi;
Wei, Gong‐Hong;
Männikkö, Minna

Publication type:

Article

Systematic screening of soluble expression of antibody fragments in the cytoplasm of E. coli.

Published in:

Microbial Cell Factories, 2016, v. 15, p. 1, doi. 10.1186/s12934-016-0419-5

By:

Gaciarz, Anna;
Veijola, Johanna;
Yuko Uchida;
Saaranen, Mirva J.;
Chunguang Wang;
Hörkkö, Sohvi;
Ruddock, Lloyd W.

Publication type:

Article

Pre-expression of a sulfhydryl oxidase significantly increases the yields of eukaryotic disulfide bond containing proteins expressed in the cytoplasm of E.coli.

Published in:

Microbial Cell Factories, 2011, v. 10, n. 1, p. 1, doi. 10.1186/1475-2859-10-1

By:

Nguyen, Van Dat;
Hatahet, Feras;
Salo, Kirsi E. H.;
Enlund, Eveliina;
Chi Zhang;
Ruddock, Lloyd W.

Publication type:

Article

Disruption of reducing pathways is not essentialfor efficient disulfide bond formation in thecytoplasm of E. coli.

Published in:

Microbial Cell Factories, 2010, v. 9, p. 67, doi. 10.1186/1475-2859-9-67

By:

Hatahet, Feras;
Nguyen, Van Dat;
Salo, Kirsi E. H.;
Ruddock, Lloyd W.

Publication type:

Article

Highly efficient export of a disulfide‐bonded protein to the periplasm and medium by the Tat pathway using CyDisCo in Escherichia coli.

Published in:

MicrobiologyOpen, 2023, v. 12, n. 2, p. 1, doi. 10.1002/mbo3.1350

By:

Arauzo‐Aguilera, Klaudia;
Saaranen, Mirva J.;
Robinson, Colin;
Ruddock, Lloyd W.

Publication type:

Article

Glutathione S-transferase omega in the lung and sputum supernatants of COPD patients.

Published in:

Respiratory Research, 2007, v. 8, p. 48, doi. 10.1186/1465-9921-8-48

By:

Harju, Terttu H.;
Peltoniemi, Mirva J.;
Rytilä, Paula H.;
Soini, Ylermi;
Salmenkivi, Kaisa M.;
Board, Philip G.;
Ruddock, Lloyd W.;
Kinnula, Vuokko L.

Publication type:

Article

Modulation of glutaredoxin in the lung and sputum of cigarette smokers and chronic obstructive pulmonary disease.

Published in:

Respiratory Research, 2006, v. 7, p. 133, doi. 10.1186/1465-9921-7-133

By:

Peltoniemi, Mirva J.;
Rytilä, Paula H.;
Harju, Terttu H.;
Soini, Ylermi M.;
Salmenkivi, Kaisa M.;
Ruddock, Lloyd W.;
Kinnula, Vuokko L.

Publication type:

Article

The human protein disulphide isomerase family: substrate interactions and functional properties.

Published in:

EMBO Reports, 2005, v. 6, n. 1, p. 28, doi. 10.1038/sj.embor.7400311

By:

Ellgaard, Lars;
Ruddock, Lloyd W.

Publication type:

Article

Protein disulfide isomerases exploit synergy between catalytic and specific binding domains.

Published in:

EMBO Reports, 2002, v. 3, n. 2, p. 136, doi. 10.1093/embo-reports/kvf035

By:

Freedman, Robert B.;
Klappa, Peter;
Ruddock, Lloyd W.

Publication type:

Article

Biallelic mutations in human NHLRC2 enhance myofibroblast differentiation in FINCA disease.

Published in:

Human Molecular Genetics, 2018, v. 27, n. 24, p. 4288, doi. 10.1093/hmg/ddy298

By:

Paakkola, Teija;
Salokas, Kari;
Miinalainen, Ilkka;
Lehtonen, Siri;
Manninen, Aki;
Kaakinen, Mika;
Ruddock, Lloyd W;
Varjosalo, Markku;
Kaarteenaho, Riitta;
Uusimaa, Johanna

Publication type:

Article

Introduction of a More Glutaredoxin-like Active Site to PDI Results in Competition between Protein Substrate and Glutathione Binding.

Published in:

Antioxidants, 2022, v. 11, n. 10, p. N.PAG, doi. 10.3390/antiox11101920

By:

Saaranen, Mirva J.;
Alanen, Heli I.;
Salo, Kirsi E. H.;
Nji, Emmanuel;
Kärkkäinen, Pekka;
Schmotz, Constanze;
Ruddock, Lloyd W.

Publication type:

Article

Structural analysis of human NHLRC2, mutations of which are associated with FINCA disease.

Published in:

PLoS ONE, 2018, p. 1, doi. 10.1371/journal.pone.0202391

By:

Biterova, Ekaterina;
Ignatyev, Alexander;
Uusimaa, Johanna;
Hinttala, Reetta;
Ruddock, Lloyd W.

Publication type:

Article

Applications of catalyzed cytoplasmic disulfide bond formation.

Published in:

Biochemical Society Transactions, 2019, v. 47, n. 5, p. 1223, doi. 10.1042/BST20190088

By:

Saaranen, Mirva J.;
Ruddock, Lloyd W.

Publication type:

Article

Complementarity determining regions and frameworks contribute to the disulfide bond independent folding of intrinsically stable scFv.

Published in:

PLoS ONE, 2017, v. 12, n. 12, p. 1, doi. 10.1371/journal.pone.0189964

By:

Gąciarz, Anna;
Ruddock, Lloyd W.

Publication type:

Article

The b' domain provides the principal peptide-binding site of protein disulfide isomerase but all domains contribute to binding of misfolded proteins.

Published in:

EMBO Journal, 1998, v. 17, n. 4, p. 927, doi. 10.1093/emboj/17.4.927

By:

Klappa, Peter;
Ruddock, Lloyd W.;
Darby, Nigel J.;
Freeman, Robert B.

Publication type:

Article

Efficient Production of Fc Fusion Proteins in the Cytoplasm of Escherichia coli : Dissecting and Mitigating Redox Heterogeneity.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 23, p. 14740, doi. 10.3390/ijms232314740

By:

Tungekar, Aatir A.;
Ruddock, Lloyd W.

Publication type:

Article

Production of Extracellular Matrix Proteins in the Cytoplasm of E. coli: Making Giants in Tiny Factories.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 3, p. 688, doi. 10.3390/ijms21030688

By:

Sohail, Anil A.;
Gaikwad, Madhuri;
Khadka, Prakash;
Saaranen, Mirva J.;
Ruddock, Lloyd W.

Publication type:

Article

Mechanistic insights into the ROS‐mediated inactivation of human aldehyde oxidase.

Published in:

FEBS Letters, 2023, v. 597, n. 13, p. 1792, doi. 10.1002/1873-3468.14669

By:

Esmaeeli, Mariam;
Nimtz, Manfred;
Jänsch, Lothar;
Ruddock, Lloyd W.;
Leimkühler, Silke

Publication type:

Article

Protein Disulfide-Isomerase Interacts with a Substrate Protein at All Stages along Its Folding Pathway.

Published in:

PLoS ONE, 2014, v. 9, n. 1, p. 1, doi. 10.1371/journal.pone.0082511

By:

Irvine, Alistair G.;
Wallis, A. Katrine;
Sanghera, Narinder;
Rowe, Michelle L.;
Ruddock, Lloyd W.;
Howard, Mark J.;
Williamson, Richard A.;
Blindauer, Claudia A.;
Freedman, Robert B.

Publication type:

Article

So you want to express your protein in Escherichia coli?

Published in:

Essays in Biochemistry, 2021, v. 65, n. 2, p. 247, doi. 10.1042/EBC20200170

By:

Tungekar, Aatir A.;
Castillo-Corujo, Angel;
Ruddock, Lloyd W.

Publication type:

Article

Bacitracin is not a specific inhibitor of protein disulfide isomerase.

Published in:

FEBS Journal, 2010, v. 277, n. 11, p. 2454, doi. 10.1111/j.1742-4658.2010.07660.x

By:

Karala, Anna-Riikka;
Ruddock, Lloyd W.

Publication type:

Article

Substrate recognition by the protein disulfide isomerases.

Published in:

FEBS Journal, 2007, v. 274, n. 20, p. 5223, doi. 10.1111/j.1742-4658.2007.06058.x

By:

Hatahet, Feras;
Ruddock, Lloyd W.

Publication type:

Article

Crystal structure of human anterior gradient protein 3.

Published in:

Acta Crystallographica: Section F, Structural Biology Communications, 2018, v. 74, n. 7, p. 425, doi. 10.1107/S2053230X18009093

By:

Nguyen, Van Dat;
Biterova, Ekaterina;
Salin, Mikko;
Wierenga, Rik K.;
Ruddock, Lloyd W.

Publication type:

Article

Production of neutralizing antibody fragment variants in the cytoplasm of E. coli for rapid screening: SARS-CoV-2 a case study.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-31369-2

By:

Tungekar, Aatir A.;
Recacha, Rosario;
Ruddock, Lloyd W.

Publication type:

Article

Efficient soluble expression of disulfide bonded proteins in the cytoplasm of Escherichia coli in fed-batch fermentations on chemically defined minimal media.

Published in:

Microbial Cell Factories, 2017, v. 16, p. 1, doi. 10.1186/s12934-017-0721-x

By:

Gąciarz, Anna;
Khatri, Narendar Kumar;
Velez-Suberbie, M. Lourdes;
Saaranen, Mirva J.;
Yuko Uchida;
Keshavarz-Moore, Eli;
Ruddock, Lloyd W.

Publication type:

Article

Efficient export of prefolded, disulfide-bonded recombinant proteins to the periplasm by the Tat pathway in Escherichia coli CyDisCo strains.

Published in:

Biotechnology Progress, 2014, v. 30, n. 2, p. 281, doi. 10.1002/btpr.1858

By:

Matos, Cristina F. R. O.;
Robinson, Colin;
Alanen, Heli I.;
Prus, Piotr;
Uchida, Yuko;
Ruddock, Lloyd W.;
Freedman, Robert B.;
Keshavarz‐Moore, Eli

Publication type:

Article

Biophysical and structural studies of fibulin-2.

Published in:

Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-64931-7

By:

Sohail, Anil A.;
Koski, M. Kristian;
Ruddock, Lloyd W.

Publication type:

Article

The ligand-binding b′ domain of human protein disulphide-isomerase mediates homodimerization.

Published in:

Protein Science: A Publication of the Protein Society, 2009, v. 18, n. 12, p. 2569, doi. 10.1002/pro.270

By:

Wallis, Anne Katrine;
Sidhu, Ateesh;
Byrne, Lee J.;
Howard, Mark J.;
Ruddock, Lloyd W.;
Williamson, Richard A.;
Freedman, Robert B.

Publication type:

Article

Specificity in substrate binding by protein folding catalysts: Tyrosine and tryptophan residues are the recognition motifs for the binding of peptides to the pancreas-specific protein disulfide isomerase PDIp.

Published in:

Protein Science: A Publication of the Protein Society, 2000, v. 9, n. 4, p. 758

By:

RUDDOCK, LLOYD W.;
FREEDMAN, ROBERT B.;
KLAPPA, PETER

Publication type:

Article