Works by Rudd, Christopher E.

Results: 59

CTLA-4 and PD-1 Control of T-Cell Motility and Migration: Implications for Tumor Immunotherapy.

Published in:

Frontiers in Immunology, 2018, p. N.PAG, doi. 10.3389/fimmu.2018.02737

By:

Brunner-Weinzierl, Monika C.;
Rudd, Christopher E.

Publication type:

Article

CTLA-4 co-receptor impacts on the function of Treg and CD8.

Published in:

European Journal of Immunology, 2009, v. 39, n. 3, p. 687, doi. 10.1002/eji.200939261

By:

Rudd, Christopher E.

Publication type:

Article

CTLA-4 disrupts ZAP70 microcluster formation with reduced T cell/APC dwell times and calcium mobilization.

Published in:

European Journal of Immunology, 2008, v. 38, n. 1, p. 40, doi. 10.1002/eji.200737423

By:

Schneider, Helga;
Smith, Xin;
Liu, Hebin;
Bismuth, Georges;
Rudd, Christopher E.

Publication type:

Article

Association of T cell antigen CD7 with type II phosphatidylinositol-4 kinase, a key component in pathways of inositol phosphate turnover.

Published in:

European Journal of Immunology, 2003, v. 33, n. 1, p. 46, doi. 10.1002/immu.200390006

By:

Subrahmanyam, Gosukonda;
Rudd, Christopher E.;
Schneider, Helga

Publication type:

Article

A regulatory role for cytoplasmic YVKM motif in CTLA-4 inhibition of TCR signaling.

Published in:

European Journal of Immunology, 2001, v. 31, n. 7, p. 2042, doi. 10.1002/1521-4141(200107)31:7<2042::AID-IMMU2042>3.0.CO;2-D

By:

Schneider, Helga;
Dias, Silvy da Rocha;
Hu, Hui;
Rudd, Christopher E.

Publication type:

Article

T cell antigen CD28 binds to the GRB-2/SOS complex, regulators of p21.

Published in:

European Journal of Immunology, 1995, v. 25, n. 4, p. 1044, doi. 10.1002/eji.1830250428

By:

Schneider, Helga;
Cai, Yun-Cai;
Prasad, K. V. S.;
Shoelson, Steven E.;
Rudd, Christopher E.

Publication type:

Article

Association of a 70-kDa tyrosine phosphoprotein with the CD16:ζ:γ complex expressed in human natural killer cells.

Published in:

European Journal of Immunology, 1993, v. 23, n. 8, p. 1872, doi. 10.1002/eji.1830230821

By:

Vivier, Eric;
da Silva, Antonio J.;
Ackerly, Melissa;
Levine, Herbert;
Rudd, Christopher E.;
Anderson, Paul

Publication type:

Article

Functional characterization of the CD45R (2H4) molecule on CD8 (T8) cells in the autologous mixed lymphocyte reaction system.

Published in:

European Journal of Immunology, 1989, v. 19, n. 4, p. 747, doi. 10.1002/eji.1830190427

By:

Takeuchi, Tsutomu;
Rudd, Christopher E.;
Tanaka, Shinsuke;
Rothstein, David M.;
Schlossman, Stuart F.;
Morimoto, Chikao

Publication type:

Article

Isoelectric focusing of bovine major histocompatibility complex class II molecules.

Published in:

European Journal of Immunology, 1989, v. 19, n. 3, p. 567, doi. 10.1002/eji.1830190326

By:

Watkins, David I.;
Shadduck, John A.;
Rudd, Christopher E.;
Stone, Marc E.;
Lewin, Harris A.;
Letvin, Norman L.

Publication type:

Article

Role of the 2H4 molecule in the activation of suppressor inducer function.

Published in:

European Journal of Immunology, 1988, v. 18, n. 5, p. 731, doi. 10.1002/eji.1830180512

By:

Morimoto, Chikao;
Matsuyama, Takami;
Rudd, Christopher E.;
Forsgren, Arne;
Letvin, Norman L.;
Schlossman, Stuart F.

Publication type:

Article

Induction of suppression following autologous mixed lymphocyte reaction; role of a novel 2H4 antigen.

Published in:

European Journal of Immunology, 1987, v. 17, n. 1, p. 97, doi. 10.1002/eji.1830170117

By:

Takeuchi, Tsutomu;
Rudd, Christopher E.;
Schlossman, Stuart F.;
Morimoto, Chikao

Publication type:

Article

Function of the LFA-1 and T4 molecules in the direct activation of resting human B lymphocytes by T lymphocytes.

Published in:

European Journal of Immunology, 1986, v. 16, n. 12, p. 1539, doi. 10.1002/eji.1830161212

By:

Tedder, Thomas F.;
Schmidt, Reinhold E.;
Rudd, Christopher E.;
Kornacki, Mary M.;
Ritz, Jerome;
Schlossman, Stuart F.

Publication type:

Article

The Chemokine CXCL12 Generates Costimulatory Signals in T Cells to Enhance Phosphorylation and Clustering of the Adaptor Protein SLP-76.

Published in:

Science Signaling, 2013, v. 6, n. 286, p. 1, doi. 10.1126/scisignal.2004018

By:

Smith, Xin;
Schneider, Helga;
Köhler, Karsten;
Liu, Hebin;
Yuning Lu;
Rudd, Christopher E.

Publication type:

Article

Dynamics of Subsynaptic Vesicles and Surface Microclusters at the Immunological Synapse.

Published in:

Science Signaling, 2010, v. 3, n. 121, p. 1, doi. 10.1126/scisignal.2000645

By:

Purbhoo, Marco A.;
Hebin Liu;
Oddos, Stephane;
Owen, Dylan M.;
Neil, Mark A. A.;
Pageon, Sophie V.;
French, Paul M. W.;
Rudd, Christopher E.;
Davis, Daniel M.

Publication type:

Article

Glycogen synthase kinase 3 (GSK-3) controls T-cell motility and interactions with antigen presenting cells.

Published in:

BMC Research Notes, 2020, v. 13, n. 1, p. 1, doi. 10.1186/s13104-020-04971-0

By:

Taylor, Alison;
Rudd, Christopher E.

Publication type:

Article

Programmed cell death 1 ligand (PD-L1) on T cells generates Treg suppression from memory.

Published in:

PLoS Biology, 2021, v. 19, n. 5, p. 1, doi. 10.1371/journal.pbio.3001272

By:

Kazanova, Alexandra;
Rudd, Christopher E.

Publication type:

Article

Editorial: T-Cell Signaling Networks in Health and Disease.

Published in:

Frontiers in Immunology, 2022, v. 13, p. 1, doi. 10.3389/fimmu.2022.875580

By:

Rudd, Christopher E.;
Merida, Isabel;
Hawse, William

Publication type:

Article

ADAP and SKAP55 deficiency suppresses PD-1 expression in CD8+ cytotoxic T lymphocytes for enhanced anti-tumor immunotherapy.

Published in:

EMBO Molecular Medicine, 2015, v. 7, n. 6, p. 754, doi. 10.15252/emmm.201404578

By:

Li, Chunyang;
Li, Weiyun;
Xiao, Jun;
Jiao, Shaozhuo;
Teng, Fei;
Xue, Shengjie;
Zhang, Chi;
Sheng, Chun;
Leng, Qibin;
Rudd, Christopher E;
Wei, Bin;
Wang, Hongyan

Publication type:

Article

T-cell signalling and immune system disorders.

Published in:

Expert Reviews in Molecular Medicine, 2005, v. 7, n. 29, p. 1, doi. 10.1017/S1462399405010264

By:

Wilkinson, Beverley;
Downey, Jocelyn S.;
Rudd, Christopher E.

Publication type:

Article

Aiming for the Sweet Spot: Glyco-Immune Checkpoints and γδ T Cells in Targeted Immunotherapy.

Published in:

Frontiers in Immunology, 2020, v. 11, p. N.PAG, doi. 10.3389/fimmu.2020.564499

By:

Bartish, Margarita;
del Rincón, Sonia V.;
Rudd, Christopher E.;
Saragovi, H. Uri

Publication type:

Article

GSK-3 Inhibition as a Therapeutic Approach Against SARs CoV2: Dual Benefit of Inhibiting Viral Replication While Potentiating the Immune Response.

Published in:

Frontiers in Immunology, 2020, v. 11, p. 1, doi. 10.3389/fimmu.2020.01638

By:

Rudd, Christopher E.

Publication type:

Article

Targeting EGFR, RSK1, RAF1, PARP2 and LIN28B for several cancer type therapies with newly synthesized pyrazole derivatives via a computational study.

Published in:

Journal of Biomolecular Structure & Dynamics, 2023, v. 41, n. 9, p. 4194, doi. 10.1080/07391102.2022.2064915

By:

Bennani, Fatima Ezzahra;
Doudach, Latifa;
Karrouchi, Khalid;
Tarib, Abdelilah;
Rudd, Christopher E;
Ansar, M'hammed;
Faouzi, My El Abbes

Publication type:

Article

Decreased progenitor TCF1 + T-cells correlate with COVID-19 disease severity.

Published in:

Communications Biology, 2024, v. 7, n. 1, p. 1, doi. 10.1038/s42003-024-05922-2

By:

Tu, Thai Hien;
Grunbaum, Ami;
Santinon, François;
Kazanova, Alexandra;
Rozza, Nicholas;
Kremer, Richard;
Mihalcioiu, Catalin;
Rudd, Christopher E.

Publication type:

Article

GTPase-activating protein Rasal1 associates with ZAP-70 of the TCR and negatively regulates T-cell tumor immunity.

Published in:

Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-12544-4

By:

Thaker, Youg Raj;
Raab, Monika;
Strebhardt, Klaus;
Rudd, Christopher E.

Publication type:

Article

SHP-1 Acts as a Key Regulator of Alloresponses by Modulating LFA-1-Mediated Adhesion in Primary Murine T Cells.

Published in:

Molecular & Cellular Biology, 2016, v. 36, n. 24, p. 3113, doi. 10.1128/MCB.00294-16

By:

Sauer, Martin G.;
Herbst, Jessica;
Diekmann, Ulf;
Rudd, Christopher E.;
Kardinal, Christian

Publication type:

Article

Rab8 Binding to Immune Cell-Specific Adaptor LAX Facilitates Formation of trans-Golgi Network-Proximal CTLA-4 Vesicles for Surface Expression.

Published in:

Molecular & Cellular Biology, 2014, v. 34, n. 8, p. 1486, doi. 10.1128/MCB.01331-13

By:

Banton, Matthew C.;
Inder, Kerry L.;
Valk, Elke;
Rudd, Christopher E.;
Schneider, Helga

Publication type:

Article

CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.

Published in:

Nature, 2015, v. 517, n. 7534, p. 386, doi. 10.1038/nature13848

By:

Huang, Yu-Hwa;
Zhu, Chen;
Kondo, Yasuyuki;
Anderson, Ana C.;
Gandhi, Amit;
Russell, Andrew;
Dougan, Stephanie K.;
Petersen, Britt-Sabina;
Melum, Espen;
Pertel, Thomas;
Clayton, Kiera L.;
Raab, Monika;
Chen, Qiang;
Beauchemin, Nicole;
Yazaki, Paul J.;
Pyzik, Michal;
Ostrowski, Mario A.;
Glickman, Jonathan N.;
Rudd, Christopher E.;
Ploegh, Hidde L.

Publication type:

Article

Immune adaptor SKAP1 acts a scaffold for Polo-like kinase 1 (PLK1) for the optimal cell cycling of T-cells.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-45627-9

By:

Raab, Monika;
Strebhardt, Klaus;
Rudd, Christopher E.

Publication type:

Article

Commentary: Does Lithium Deserve a Place in the Treatment Against COVID-19? A Preliminary Observational Study in Six Patients, Case Report.

Published in:

Frontiers in Pharmacology, 2020, v. 11, p. N.PAG, doi. 10.3389/fphar.2020.613734

By:

Rudd, Christopher E.

Publication type:

Article

Mucosal Regulatory T Cells and T Helper 17 Cells in HIV-Associated Immune Activation.

Published in:

Frontiers in Immunology, 2016, p. 1, doi. 10.3389/fimmu.2016.00228

By:

Pandiyan, Pushpa;
Younes, Souheil-Antoine;
Ribeiro, Susan Pereira;
Talla, Aarthi;
McDonald, David;
Bhaskaran, Natarajan;
Levine, Alan D.;
Weinberg, Aaron;
Sekaly, Rafick P.;
Rudd, Christopher E.;
Rosenthal, Kenneth Lee;
Klatt, Nichole

Publication type:

Article

Distinct Mechanisms regulate lck spatial Organization in activated T cells.

Published in:

Frontiers in Immunology, 2016, p. 1, doi. 10.3389/fimmu.2016.00083

By:

Kapoor-Kaushik, Natasha;
Hinde, Elizabeth;
Compeer, Ewoud B.;
Yamamoto, Yui;
Kraus, Felix;
Zhengmin Yang;
Lou, Jieqiong;
Pageon, Sophie V.;
Tabarin, Thibault;
Gaus, Katharina;
Rossy, Jérémie;
Rudd, Christopher E.

Publication type:

Article

The Role of Chemokines in Shaping the Balance Between CD4+ T Cell Subsets and Its Therapeutic Implications in Autoimmune and Cancer Diseases.

Published in:

Frontiers in Immunology, 2015, v. 6, p. 1, doi. 10.3389/fimmu.2015.00609

By:

Karin, Nathan;
Wildbaum, Gizi;
Rudd, Christopher E.;
Castro, António Gil

Publication type:

Article

Diverse mechanisms regulate the surface expression of immunotherapeutic target CTLA-4.

Published in:

Frontiers in Immunology, 2014, v. 5, p. 1, doi. 10.3389/fimmu.2014.00619

By:

Schneider, Helga;
Rudd, Christopher E.;
Verhagen, Johan;
Kok-Fai Kong

Publication type:

Article

Demonstration of functional heterogeneity of T lymphocytes and identification of their two major subsets.

Published in:

2014

By:

Kisielow, Paweł;
Rudd, Christopher E.;
Smith, Kendall A.

Publication type:

Opinion

How does the kinase Lck phosphorylate the T cell receptor? Spatial organization as a regulatory mechanism.

Published in:

Frontiers in Immunology, 2012, v. 3, p. 1, doi. 10.3389/fimmu.2012.00167

By:

Rossy, Jérémie;
Williamson, David J.;
Gaus, Katharina;
Dustin, Michael;
Michael Dustin;
Rudd, Christopher E.

Publication type:

Article

A new perspective in cancer immunotherapy: PD-1 on myeloid cells takes center stage in orchestrating immune checkpoint blockade.

Published in:

Science Immunology, 2020, v. 5, n. 43, p. 1, doi. 10.1126/sciimmunol.aaz8128

By:

Rudd, Christopher E.

Publication type:

Article

Immune adaptor protein SKAP1 (SKAP-55) forms homodimers as mediated by the N-terminal region.

Published in:

BMC Research Notes, 2018, v. 11, n. 1, p. N.PAG, doi. 10.1186/s13104-018-3976-3

By:

Raab, Monika;
Strebhardt, Klaus;
Rudd, Christopher E.

Publication type:

Article

Positive and negative adaptors in T-cell signalling.

Published in:

Immunology, 2004, v. 111, n. 4, p. 368, doi. 10.1111/j.0019-2805.2004.01832.x

By:

Wilkinson, Beverley;
Hongyan Wang;
Rudd, Christopher E.

Publication type:

Article

SH3 domain recognition of a proline-independent tyrosine-based RKxxYxxY motif in immune cell adaptor SKAP55.

Published in:

2000

By:

Kang, Hyun;
Freund, Christian;
Duke-Cohan, Jonathan S.;
Musacchio, Andrea;
Wagner, Gerhard;
Rudd, Christopher E.

Publication type:

Arts/Entertainment Review

LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation.

Published in:

Nature Communications, 2017, v. 8, n. 7, p. 16001, doi. 10.1038/ncomms16001

By:

Raab, Monika;
Lu, Yuning;
Kohler, Karsten;
Smith, Xin;
Strebhardt, Klaus;
Rudd, Christopher E.

Publication type:

Article

Hydroxychloroquine (HCQ) decreases the benefit of anti-PD-1 immune checkpoint blockade in tumor immunotherapy.

Published in:

PLoS ONE, 2021, v. 16, n. 6, p. 1, doi. 10.1371/journal.pone.0251731

By:

Krueger, Janna;
Santinon, Francois;
Kazanova, Alexandra;
Issa, Mark E.;
Larrivee, Bruno;
Kremer, Richard;
Milhalcioiu, Catalin;
Rudd, Christopher E.

Publication type:

Article

Multi-functional adaptor SKAP1: regulator of integrin activation, the stop-signal, and the proliferation of T cells.

Published in:

Frontiers in Immunology, 2023, p. 1, doi. 10.3389/fimmu.2023.1192838

By:

Chen Liu;
Raab, Monika;
Yirui Gui;
Rudd, Christopher E.

Publication type:

Article

CTLA-4 Activation of Phosphatidylinositol 3-Kinase (PI 3- K) and Protein Kinase B (PKB/AKT) Sustains T-Cell Anergy without Cell Death.

Published in:

PLoS ONE, 2008, v. 3, n. 12, p. 1, doi. 10.1371/journal.pone.0003842

By:

Schneider, Helga;
Valk, Elke;
Leung, Rufina;
Rudd, Christopher E.

Publication type:

Article

Adaptor SKAP-55 Binds p21ras Activating Exchange Factor RasGRP1 and Negatively Regulates the p21ras-ERK Pathway in T-Cells.

Published in:

PLoS ONE, 2008, v. 3, n. 3, p. 1, doi. 10.1371/journal.pone.0001718

By:

Schneider, Helga;
Hongyan Wang;
Raab, Monika;
Valk, Elke;
Smith, Xin;
Lovatt, Matt;
Zhonglin Wu;
Maqueira-Iglesias, Braudel;
Strebhardt, Klaus;
Rudd, Christopher E.

Publication type:

Article

The reverse stop-signal model for CTLA4 function.

Published in:

2008

By:

Rudd, Christopher E.

Publication type:

research

Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling.

Published in:

2003

By:

Rudd, Christopher E.;
Schneider, Helga

Publication type:

journal article

CD28 and CTLA-4 coreceptor expression and signal transduction.

Published in:

Immunological Reviews, 2009, v. 229, n. 1, p. 12, doi. 10.1111/j.1600-065X.2009.00770.x

By:

Rudd, Christopher E.;
Taylor, Alison;
Schneider, Helga

Publication type:

Article

Independent CD28 signaling via VAV and SLP-76: a model for in trans costimulation.

Published in:

Immunological Reviews, 2003, v. 192, n. 1, p. 32, doi. 10.1034/j.1600-065X.2003.00005.x

By:

Rudd, Christopher E.;
Raab, Monika

Publication type:

Article

Direct AKT activation in tumor-infiltrating lymphocytes markedly increases interferon-γ (IFN-γ) for the regression of tumors resistant to PD-1 checkpoint blockade.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-23016-z

By:

Santinon, François;
Ezzahra, Bennani Fatima;
Bachais, Meriem;
Sarabia Pacis, Alain;
Rudd, Christopher E.

Publication type:

Article

T-cell signaling and immunopathologies.

Published in:

2010

By:

Rudd, Christopher E.

Publication type:

Editorial