Works matching AU Rubinsztein, David C


Results: 165
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    Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.

    Published in:
    Nature Genetics, 2013, v. 45, n. 6, p. 712, doi. 10.1038/ng0613-712a
    By:
    • Harold, Denise;
    • Abraham, Richard;
    • Hollingworth, Paul;
    • Sims, Rebecca;
    • Gerrish, Amy;
    • Hamshere, Marian L;
    • Pahwa, Jaspreet Singh;
    • Moskvina, Valentina;
    • Dowzell, Kimberley;
    • Williams, Amy;
    • Jones, Nicola;
    • Thomas, Charlene;
    • Stretton, Alexandra;
    • Morgan, Angharad R;
    • Lovestone, Simon;
    • Powell, John;
    • Proitsi, Petroula;
    • Lupton, Michelle K;
    • Brayne, Carol;
    • Rubinsztein, David C
    Publication type:
    Article
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    Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.

    Published in:
    Nature Genetics, 2009, v. 41, n. 10, p. 1088, doi. 10.1038/ng.440
    By:
    • Harold, Denise;
    • Abraham, Richard;
    • Hollingworth, Paul;
    • Sims, Rebecca;
    • Gerrish, Amy;
    • Hamshere, Marian L.;
    • Pahwa, Jaspreet Singh;
    • Moskvina, Valentina;
    • Dowzell, Kimberley;
    • Williams, Amy;
    • Jones, Nicola;
    • Thomas, Charlene;
    • Stretton, Alexandra;
    • Morgan, Angharad R.;
    • Lovestone, Simon;
    • Powell, John;
    • Proitsi, Petroula;
    • Lupton, Michelle K.;
    • Brayne, Carol;
    • Rubinsztein, David C.
    Publication type:
    Article
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    Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.

    Published in:
    2009
    By:
    • Harold, Denise;
    • Abraham, Richard;
    • Hollingworth, Paul;
    • Sims, Rebecca;
    • Gerrish, Amy;
    • Hamshere, Marian L.;
    • Pahwa, Jaspreet Singh;
    • Moskvina, Valentina;
    • Dowzell, Kimberley;
    • Williams, Amy;
    • Jones, Nicola;
    • Thomas, Charlene;
    • Stretton, Alexandra;
    • Morgan, Angharad R.;
    • Lovestone, Simon;
    • Powell, John;
    • Proitsi, Petroula;
    • Lupton, Michelle K.;
    • Brayne, Carol;
    • Rubinsztein, David C.
    Publication type:
    Correction Notice
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    α-2 macroglobulin polymorphism and Alzheimer disease risk in the UK.

    Published in:
    Nature Genetics, 1999, v. 22, n. 1, p. 16, doi. 10.1038/8724
    By:
    • Dow, David J.;
    • Lindsey, Nicola;
    • Cairns, Nigel J.;
    • Brayne, Carol;
    • Robinson, Damian;
    • Huppert, Felicia A.;
    • Paykel, Eugene S.;
    • Xuereb, John;
    • Wilcock, Gordon;
    • Whittaker, Joanne L.;
    • Rubinsztein, David C.
    Publication type:
    Article
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    α-Synuclein impairs macroautophagy: implications for Parkinson's disease.

    Published in:
    Journal of Cell Biology, 2010, v. 190, n. 6, p. 1023, doi. 10.1083/jcb.201003122
    By:
    • Winslow, Ashley R.;
    • Chen, Chien-Wen;
    • Corrochano, Silvia;
    • Acevedo-Arozena, Abraham;
    • Gordon, David E.;
    • Peden, Andrew A.;
    • Lichtenberg, Maike;
    • Menzies, Fiona M.;
    • Ravikumar, Brinda;
    • Imarisio, Sara;
    • Brown, Steve;
    • O'Kane, Cahir J.;
    • Rubinsztein, David C.
    Publication type:
    Article
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    Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance.

    Published in:
    Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-31905-0
    By:
    • Wrobel, Lidia;
    • Hill, Sandra M.;
    • Djajadikerta, Alvin;
    • Fernandez-Estevez, Marian;
    • Karabiyik, Cansu;
    • Ashkenazi, Avraham;
    • Barratt, Victoria J.;
    • Stamatakou, Eleanna;
    • Gunnarsson, Anders;
    • Rasmusson, Timothy;
    • Miele, Eric W.;
    • Beaton, Nigel;
    • Bruderer, Roland;
    • Feng, Yuehan;
    • Reiter, Lukas;
    • Castaldi, M. Paola;
    • Jarvis, Rebecca;
    • Tan, Keith;
    • Bürli, Roland W.;
    • Rubinsztein, David C.
    Publication type:
    Article
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    Chemotherapy for the Brain: The Antitumor Antibiotic Mithramycin Prolongs Survival in a Mouse Model of Huntington's Disease.

    Published in:
    Journal of Neuroscience, 2004, v. 24, n. 46, p. 10335, doi. 10.1523/JNEUROSCI.2599-04.2004
    By:
    • Ferrante, Robert J.;
    • Ryu, Hoon;
    • Kubilus, James K.;
    • Lee, Junghee;
    • Smith, Karen;
    • D'Mello, Santosh;
    • Sugars, Katharine L.;
    • Rubinsztein, David C.;
    • Lu, Peiyuan;
    • Langley, Brett;
    • Browne, Susan;
    • Beal, M. Flint;
    • Hewett, Sandra;
    • Kristal, Bruce S.;
    • Stavrovskaya, Irina G.;
    • Ratan, Rajiv R.
    Publication type:
    Article
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    PSMC5 insufficiency and P320R mutation impair proteasome function.

    Published in:
    Human Molecular Genetics, 2024, v. 33, n. 17, p. 1506, doi. 10.1093/hmg/ddae085
    By:
    • Yu, Zhong-Qiu;
    • Carmichael, Jenny;
    • Collins, Galen A;
    • D'Agostino, Maria Daniela;
    • Lessard, Mathieu;
    • Firth, Helen V;
    • Harijan, Pooja;
    • Fry, Andrew E;
    • Dean, John;
    • Zhang, Jiuchun;
    • Kini, Usha;
    • Goldberg, Alfred L;
    • Rubinsztein, David C
    Publication type:
    Article
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    A genetic modifier suggests that endurance exercise exacerbates Huntington's disease.

    Published in:
    Human Molecular Genetics, 2018, v. 27, n. 10, p. 1723, doi. 10.1093/hmg/ddy077
    By:
    • Corrochano, Silvia;
    • Blanco, Gonzalo;
    • Williams, Debbie;
    • Wettstein, Jessica;
    • Simon, Michelle;
    • Kumar, Saumya;
    • Moir, Lee;
    • Agnew, Thomas;
    • Stewart, Michelle;
    • Landman, Allison;
    • Kotiadis, Vassilios N.;
    • Duchen, Michael R.;
    • Wackerhage, Henning;
    • Rubinsztein, David C.;
    • Brown, Steve D. M.;
    • Acevedo-Arozena, Abraham
    Publication type:
    Article
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    Myc inhibition impairs autophagosome formation.

    Published in:
    Human Molecular Genetics, 2013, v. 22, n. 25, p. 5237, doi. 10.1093/hmg/ddt381
    By:
    • Toh, Pearl P. C.;
    • Luo, Shouqing;
    • Menzies, Fiona M.;
    • Raskó, Tamás;
    • Wanker, Erich E.;
    • Rubinsztein, David C.
    Publication type:
    Article
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    IGF-1 receptor antagonism inhibits autophagy.

    Published in:
    Human Molecular Genetics, 2013, v. 22, n. 22, p. 4528, doi. 10.1093/hmg/ddt300
    By:
    • Renna, Maurizio;
    • Bento, Carla F.;
    • Fleming, Angeleen;
    • Menzies, Fiona M.;
    • Siddiqi, Farah H.;
    • Ravikumar, Brinda;
    • Puri, Claudia;
    • Garcia-Arencibia, Moises;
    • Sadiq, Oana;
    • Corrochano, Silvia;
    • Carter, Sarah;
    • Brown, Steve D.M.;
    • Acevedo-Arozena, Abraham;
    • Rubinsztein, David C.
    Publication type:
    Article
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    International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis.

    Published in:
    Autophagy, 2024, v. 20, n. 6, p. 1213, doi. 10.1080/15548627.2024.2319901
    By:
    • Chen, Xin;
    • Tsvetkov, Andrey S.;
    • Shen, Han-Ming;
    • Isidoro, Ciro;
    • Ktistakis, Nicholas T.;
    • Linkermann, Andreas;
    • Koopman, Werner J.H.;
    • Simon, Hans-Uwe;
    • Galluzzi, Lorenzo;
    • Luo, Shouqing;
    • Xu, Daqian;
    • Gu, Wei;
    • Peulen, Olivier;
    • Cai, Qian;
    • Rubinsztein, David C.;
    • Chi, Jen-Tsan;
    • Zhang, Donna D.;
    • Li, Changfeng;
    • Toyokuni, Shinya;
    • Liu, Jinbao
    Publication type:
    Article
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    A novel Atg5-shRNA mouse model enables temporal control of Autophagy in vivo.

    Published in:
    Autophagy, 2018, v. 14, n. 7, p. 1256, doi. 10.1080/15548627.2018.1458172
    By:
    • Cassidy, Liam D.;
    • Young, Andrew R. J.;
    • Pérez-Mancera, Pedro A.;
    • Nimmervoll, Birgit;
    • Jaulim, Adil;
    • Hung-Chang Chen;
    • McIntyre, Dominick J. O.;
    • Brais, Rebecca;
    • Ricketts, Thomas;
    • Pacey, Simon;
    • De La Roche, Maike;
    • Gilbertson, Richard J.;
    • Rubinsztein, David C.;
    • Narita, Masashi
    Publication type:
    Article
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    Polyglutamine tracts regulate autophagy.

    Published in:
    Autophagy, 2017, v. 13, n. 9, p. 1613, doi. 10.1080/15548627.2017.1336278
    By:
    • Ashkenazi, Avraham;
    • Bento, Carla F.;
    • Ricketts, Thomas;
    • Vicinanza, Mariella;
    • Siddiqi, Farah;
    • Pavel, Mariana;
    • Squitieri, Ferdinando;
    • Hardenberg, Maarten C.;
    • Imarisio, Sara;
    • Menzies, Fiona M.;
    • Rubinsztein, David C.
    Publication type:
    Article
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    A152T tau allele causes neurodegeneration that can be ameliorated in a zebrafish model by autophagy induction.

    Published in:
    2017
    By:
    • Lopez, Ana;
    • Lee, Suzee E.;
    • Wojta, Kevin;
    • Ramos, Eliana Marisa;
    • Klein, Eric;
    • Chen, Jason;
    • Boxer, Adam L.;
    • Gorno-Tempini, Maria Luisa;
    • Geschwind, Daniel H.;
    • Schlotawa, Lars;
    • Ogryzko, Nikolay V.;
    • Bigio, Eileen H.;
    • Rogalski, Emily;
    • Weintraub, Sandra;
    • Mesulam, Marsel M.;
    • Consortium, Tauopathy Genetics;
    • Fleming, Angeleen;
    • Coppola, Giovanni;
    • Miller, Bruce L.;
    • Rubinsztein, David C.
    Publication type:
    journal article
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    Four Components Describe Behavioral Symptoms in 1,120 Individuals with Late-Onset Alzheimer's Disease.

    Published in:
    Journal of the American Geriatrics Society, 2006, v. 54, n. 9, p. 1348, doi. 10.1111/j.1532-5415.2006.00854.x
    By:
    • Hollingworth, Paul;
    • Hamshere, Marian L.;
    • Moskvina, Valentina;
    • Dowzell, Kimberley;
    • Moore, Pamela J.;
    • Foy, Catherine;
    • Archer, Nicola;
    • Lynch, Aoibhinn;
    • Lovestone, Simon;
    • Brayne, Carol;
    • Rubinsztein, David C.;
    • Lawlor, Brian;
    • Gill, Mike;
    • Owen, Michael J.;
    • Williams, Julie
    Publication type:
    Article
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    Meeting Summary of The NYO3 5th NO-Age/AD Meeting and the 1st Norway–UK Joint Meeting on Aging and Dementia: Recent Progress on the Mechanisms and Interventional Strategies.

    Published in:
    Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2024, v. 79, n. 4, p. 1, doi. 10.1093/gerona/glae029
    By:
    • Wang, He-Ling;
    • Siow, Richard;
    • Schmauck-Medina, Tomas;
    • Zhang, Jianying;
    • Sandset, Per Morten;
    • Filshie, Clare;
    • Lund, Øystein;
    • Partridge, Linda;
    • Bergersen, Linda Hildegard;
    • Rasmussen, Lene Juel;
    • Palikaras, Konstantinos;
    • Sotiropoulos, Ioannis;
    • Storm-Mathisen, Jon;
    • Rubinsztein, David C;
    • Spillantini, Maria Grazia;
    • Zeeuw, Chris I De;
    • Watne, Leiv Otto;
    • Vyhnalek, Martin;
    • Veverova, Katerina;
    • Liang, Kristina Xiao
    Publication type:
    Article
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    Palmitoylation of huntingtin by HIP14is essential for its trafficking and function.

    Published in:
    Nature Neuroscience, 2006, v. 9, n. 6, p. 824, doi. 10.1038/nn1702
    By:
    • Yanai, Anat;
    • Kun Huang;
    • Rujun Kang;
    • Singaraja, Roshni R.;
    • Arstikaitis, Pamela;
    • Lu Gan;
    • Orban, Paul C.;
    • Mullard, Asher;
    • Cowan, Catherine M.;
    • Raymond, Lynn A.;
    • Drisdel, Renaldo C.;
    • Green, William N.;
    • Ravikumar, Brinda;
    • Rubinsztein, David C.;
    • El-Husseini, Alaa;
    • Hayden, Michael R.
    Publication type:
    Article