Works by Rowland-Yeo, Karen

Results: 43

The use of quantitative clinical pharmacology approaches to support moxidectin dosing recommendations in lactation.

Published in:

PLoS Neglected Tropical Diseases, 2024, v. 18, n. 8, p. 1, doi. 10.1371/journal.pntd.0012351

By:

Wood, Nolan D.;
Smith, Danelle;
Kinrade, Sally A.;
Sullivan, Mark T.;
Rayner, Craig R.;
Wesche, David;
Patel, Kashyap;
Rowland-Yeo, Karen

Publication type:

Article

Effects of Strong CYP3A Inhibition and Induction on the Pharmacokinetics of Ixazomib, an Oral Proteasome Inhibitor: Results of Drug‐Drug Interaction Studies in Patients With Advanced Solid Tumors or Lymphoma and a Physiologically Based Pharmacokinetic Analysis

Published in:

Journal of Clinical Pharmacology, 2018, v. 58, n. 2, p. 180, doi. 10.1002/jcph.988

By:

Gupta, Neeraj;
Hanley, Michael J.;
Venkatakrishnan, Karthik;
Bessudo, Alberto;
Rasco, Drew W.;
Sharma, Sunil;
O'Neil, Bert H.;
Wang, Bingxia;
Liu, Guohui;
Ke, Alice;
Patel, Chirag;
Rowland Yeo, Karen;
Xia, Cindy;
Zhang, Xiaoquan;
Esseltine, Dixie‐Lee;
Nemunaitis, John

Publication type:

Article

Emerging Areas of Research in the Assessment of Pharmacokinetics in Patients With Chronic Kidney Disease.

Published in:

Journal of Clinical Pharmacology, 2015, v. 55, n. 3, p. 241, doi. 10.1002/jcph.444

By:

Tortorici, Michael A.;
Cutler, David L.;
Hazra, Anasuya;
Nolin, Thomas D.;
Rowland‐Yeo, Karen;
Venkatakrishnan, Karthik

Publication type:

Article

Advancing the utilization of real‐world data and real‐world evidence in clinical pharmacology and translational research—Proceedings from the ASCPT 2023 preconference workshop.

Published in:

CTS: Clinical & Translational Science, 2024, v. 17, n. 4, p. 1, doi. 10.1111/cts.13785

By:

Liu, Jing;
Rowland‐Yeo, Karen;
Winterstein, Almut;
Dagenais, Simon;
Liu, Qi;
Barrett, Jeffrey S.;
Zhu, Rui;
Ghobadi, Cyrus;
Datta‐Mannan, Amita;
Hsu, Joy;
Menon, Sujatha;
Ahmed, Mariam;
Manchandani, Pooja;
Ravenstijn, Paulien

Publication type:

Article

Protein binding of aspirin and salicylate measured by in vivo ultrafiltration<sup>*</sup>.

Published in:

Clinical Pharmacology & Therapeutics, 1998, v. 63, n. 3, p. 285, doi. 10.1016/S0009-9236(98)90160-6

By:

Ghahramani, Parviz;
Rowland-Yeo, Karen;
Yeo, Wilfred W.;
Jackson, Peter R.;
Ramsay, Lawrence E.

Publication type:

Article

Advancing inclusive healthcare through PBPK modelling: predicting the impact of CYP genotypes and enzyme ontogenies on infant exposures of venlafaxine and its active metabolite O-desmethylvenlafaxine in lactation.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2025, v. 52, n. 2, p. 1, doi. 10.1007/s10928-025-09969-4

By:

Pan, Xian;
Rowland Yeo, Karen

Publication type:

Article

PBPK‐Led Assessment of Antimalarial Drug Concentrations in Breastmilk: A Strategy for Optimal Use of Prediction Methods to Guide Decision Making in an Understudied Population.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2025, v. 14, n. 4, p. 738, doi. 10.1002/psp4.13311

By:

Almond, Lisa M.;
Abduljalil, Khaled;
Pansari, Amita;
Kusmider, Beata;
Jones, Hannah M.;
Rowland Yeo, Karen;
Gardner, Iain;
Faisal, Muhammad;
Marrast, Anne Claire;
El Gaaloul, Myriam;
Möhrle, Jörg J.;
Abla, Nada

Publication type:

Article

Recent applications of pharmacometrics and systems pharmacology approaches to improve and optimize drug therapy for pregnant and lactating women.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2024, v. 13, n. 11, p. 1815, doi. 10.1002/psp4.13269

By:

Jayachandran, Priya;
Knöchel, Jane;
Cicali, Brian;
Rowland Yeo, Karen

Publication type:

Article

Using PBPK modeling to supplement clinical data and support the safe and effective use of dolutegravir in pregnant and lactating women.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2024, v. 13, n. 11, p. 1924, doi. 10.1002/psp4.13251

By:

Ning, Jia;
Pansari, Amita;
Rowland Yeo, Karen;
Heikkinen, Aki T.;
Waitt, Catriona;
Almond, Lisa M.

Publication type:

Article

Medicines in pregnancy: A clinical pharmacology extrapolation framework to address knowledge gaps.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2024, v. 13, n. 11, p. 1830, doi. 10.1002/psp4.13242

By:

Coppola, Paola;
Berglund, Eva Gil;
Rowland Yeo, Karen

Publication type:

Article

A tutorial on physiologically based pharmacokinetic approaches in lactation research.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2024, v. 13, n. 11, p. 1841, doi. 10.1002/psp4.13232

By:

Pansari, Amita;
Pan, Xian;
Almond, Lisa M.;
Rowland‐Yeo, Karen

Publication type:

Article

Development and application of a PBPK modeling strategy to support antimalarial drug development.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2023, v. 12, n. 9, p. 1335, doi. 10.1002/psp4.13013

By:

Abla, Nada;
Howgate, Eleanor;
Rowland‐Yeo, Karen;
Dickins, Maurice;
Bergagnini‐Kolev, Mackenzie C.;
Chen, Kuan‐Fu;
McFeely, Savannah;
Bonner, Jennifer J.;
Santos, Laura G. A.;
Gobeau, Nathalie;
Burt, Howard;
Barter, Zoe;
Jones, Hannah M.;
Wesche, David;
Charman, Susan A.;
Möhrle, Jörg J.;
Burrows, Jeremy N.;
Almond, Lisa M.

Publication type:

Article

PBPK modeling of ivermectin—Considerations for the purpose of developing alternative routes to optimize its safety profile.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2023, v. 12, n. 5, p. 598, doi. 10.1002/psp4.12950

By:

Rowland Yeo, Karen;
Wesche, David

Publication type:

Article

Prediction of CYP‐mediated DDIs involving inhibition: Approaches to address the requirements for system qualification of the Simcyp Simulator.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2022, v. 11, n. 7, p. 822, doi. 10.1002/psp4.12794

By:

Kilford, Peter J.;
Chen, Kuan‐Fu;
Crewe, Kim;
Gardner, Iain;
Hatley, Oliver;
Ke, Alice Ban;
Neuhoff, Sibylle;
Zhang, Mian;
Rowland Yeo, Karen

Publication type:

Article

Addressing drug safety of maternal therapy during breastfeeding using physiologically‐based pharmacokinetic modeling.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2022, v. 11, n. 5, p. 535, doi. 10.1002/psp4.12802

By:

Pan, Xian;
Rowland Yeo, Karen

Publication type:

Article

Increasing application of pediatric physiologically based pharmacokinetic models across academic and industry organizations.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2022, v. 11, n. 3, p. 373, doi. 10.1002/psp4.12764

By:

Johnson, Trevor N.;
Small, Ben G.;
Rowland Yeo, Karen

Publication type:

Article

A best practice framework for applying physiologically‐based pharmacokinetic modeling to pediatric drug development.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2021, v. 10, n. 9, p. 967, doi. 10.1002/psp4.12678

By:

Johnson, Trevor N.;
Small, Ben G.;
Berglund, Eva Gil;
Rowland Yeo, Karen

Publication type:

Article

Using physiologically‐based pharmacokinetic modeling for predicting the effects of hepatic impairment on the pharmacokinetics of olanzapine and samidorphan given as a combination tablet.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2021, v. 10, n. 9, p. 1071, doi. 10.1002/psp4.12675

By:

Sun, Lei;
Barter, Zoe;
von Moltke, Lisa;
Rowland Yeo, Karen

Publication type:

Article

CPT: Pharmacometrics & Systems Pharmacology – Inception, Maturation, and Future Vision.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2021, v. 10, n. 7, p. 649, doi. 10.1002/psp4.12680

By:

Rowland Yeo, Karen;
Hennig, Stefanie;
Krishnaswami, Sriram;
Strydom, Natasha;
Ayyar, Vivaswath S.;
French, Jonathan;
Sinha, Vikram;
Sobie, Eric;
Zhao, Ping;
Friberg, Lena E.;
Mentré, France

Publication type:

Article

Physiologically‐Based Pharmacokinetic Modeling for Predicting Drug Interactions of a Combination of Olanzapine and Samidorphan.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2020, v. 9, n. 2, p. 106, doi. 10.1002/psp4.12488

By:

Sun, Lei;
Moltke, Lisa;
Rowland Yeo, Karen

Publication type:

Article

Assessment of algorithms for predicting drug-drug interactions via inhibition mechanisms: comparison of dynamic and static models.

Published in:

British Journal of Clinical Pharmacology, 2011, v. 71, n. 1, p. 72, doi. 10.1111/j.1365-2125.2010.03799.x

By:

Guest, Eleanor J.;
Rowland-Yeo, Karen;
Rostami-Hodjegan, Amin;
Tucker, Geoffrey T.;
Houston, J. Brian;
Galetin, Aleksandra

Publication type:

Article

Application of Physiologically Based Pharmacokinetic Modeling to Predict the Effect of Renal Impairment on the Pharmacokinetics of Olanzapine and Samidorphan Given in Combination.

Published in:

Clinical Pharmacokinetics, 2021, v. 60, n. 5, p. 637, doi. 10.1007/s40262-020-00969-w

By:

Sun, Lei;
von Moltke, Lisa;
Rowland Yeo, Karen

Publication type:

Article

Response to "Ethnic-specific in vitro-in vivo extrapolation and physiologically based pharmacokinetic approaches to predict cytochrome P450-mediated pharmacokinetics in Chinese population: opportunities and challenges".

Published in:

2014

By:

Barter, Zoe E;
Tucker, Geoffrey T;
Rowland-Yeo, Karen

Publication type:

Letter

Response to 'Ethnic-Specific In Vitro-In Vivo Extrapolation and Physiologically Based Pharmacokinetic Approaches to Predict Cytochrome P450-Mediated Pharmacokinetics in Chinese Population: Opportunities and Challenges'.

Published in:

2014

By:

Barter, Zoe;
Tucker, Geoffrey;
Rowland-Yeo, Karen

Publication type:

Letter to the Editor

Differences in Cytochrome P450-Mediated Pharmacokinetics Between Chinese and Caucasian Populations Predicted by Mechanistic Physiologically Based Pharmacokinetic Modelling.

Published in:

Clinical Pharmacokinetics, 2013, v. 52, n. 12, p. 1085, doi. 10.1007/s40262-013-0089-y

By:

Barter, Zoe E.;
Tucker, Geoffrey T.;
Rowland-Yeo, Karen

Publication type:

Article

The impact of experimental design on assessing mechanism-based inactivation of CYP2D6 by MDMA (Ecstasy).

Published in:

Journal of Psychopharmacology, 2006, v. 20, n. 6, p. 834, doi. 10.1177/0269881106062902

By:

Van, Linh M.;
Heydari, Amir;
Jiansong Yang;
Hargreaves, Judith;
Rowland-Yeo, Karen;
Lennard, Martin S.;
Tucker, Geoffrey T.;
Rostami-Hodjegan, Amin

Publication type:

Article

Dose Optimization Informed by PBPK Modeling: State‐of‐the Art and Future.

Published in:

Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 3, p. 563, doi. 10.1002/cpt.3289

By:

Rowland Yeo, Karen;
Gil Berglund, Eva;
Chen, Yuan

Publication type:

Article

Creation of Novel Sensitive Probe Substrate and Moderate Inhibitor Models for a Comprehensive Prediction of CYP2C8 Interactions for Tucatinib.

Published in:

Clinical Pharmacology & Therapeutics, 2024, v. 115, n. 2, p. 299, doi. 10.1002/cpt.3104

By:

Templeton, Ian E.;
Rowland‐Yeo, Karen;
Jones, Hannah M.;
Endres, Christopher J.;
Topletz‐Erickson, Ariel R.;
Sun, Hao;
Lee, Anthony J.

Publication type:

Article

Physiologically Based Pharmacokinetic Modeling to Determine the Impact of CYP2B6 Genotype on Efavirenz Exposure in Children, Mothers and Breastfeeding Infants.

Published in:

Clinical Pharmacology & Therapeutics, 2023, v. 114, n. 1, p. 182, doi. 10.1002/cpt.2912

By:

Pan, Xian;
Rowland Yeo, Karen

Publication type:

Article

Another Step Toward Qualification of Pediatric Physiologically Based Pharmacokinetic Models to Facilitate Inclusivity and Diversity in Pediatric Clinical Studies.

Published in:

Clinical Pharmacology & Therapeutics, 2023, v. 113, n. 3, p. 735, doi. 10.1002/cpt.2777

By:

Small, Ben G.;
Johnson, Trevor N.;
Rowland Yeo, Karen

Publication type:

Article

An Integrated Approach for Assessing the Impact of Renal Impairment on Pharmacokinetics of Drugs in Development: Pivotal Role of PBPK Modelling.

Published in:

Clinical Pharmacology & Therapeutics, 2021, v. 110, n. 5, p. 1168, doi. 10.1002/cpt.2243

By:

Rowland Yeo, Karen;
Gil Berglund, Eva

Publication type:

Article

Model‐Informed Drug Development for Anti‐Infectives: State of the Art and Future.

Published in:

Clinical Pharmacology & Therapeutics, 2021, v. 109, n. 4, p. 867, doi. 10.1002/cpt.2198

By:

Rayner, Craig R.;
Smith, Patrick F.;
Andes, David;
Andrews, Kayla;
Derendorf, Hartmut;
Friberg, Lena E.;
Hanna, Debra;
Lepak, Alex;
Mills, Edward;
Polasek, Thomas M.;
Roberts, Jason A.;
Schuck, Virna;
Shelton, Mark J.;
Wesche, David;
Rowland‐Yeo, Karen

Publication type:

Article

Physiologically‐Based Pharmacokinetic Models as Enablers of Precision Dosing in Drug Development: Pivotal Role of the Human Mass Balance Study.

Published in:

Clinical Pharmacology & Therapeutics, 2021, v. 109, n. 1, p. 51, doi. 10.1002/cpt.2092

By:

Rowland Yeo, Karen;
Venkatakrishnan, Karthik

Publication type:

Article

Impact of Disease on Plasma and Lung Exposure of Chloroquine, Hydroxychloroquine and Azithromycin: Application of PBPK Modeling.

Published in:

Clinical Pharmacology & Therapeutics, 2020, v. 108, n. 5, p. 976, doi. 10.1002/cpt.1955

By:

Rowland Yeo, Karen;
Zhang, Mian;
Pan, Xian;
Ban Ke, Alice;
Jones, Hannah M.;
Wesche, David;
Almond, Lisa M.

Publication type:

Article

Risk–Benefit Assessment of Ethinylestradiol Using a Physiologically Based Pharmacokinetic Modeling Approach.

Published in:

Clinical Pharmacology & Therapeutics, 2018, v. 104, n. 6, p. 1229, doi. 10.1002/cpt.1085

By:

Ezuruike, Udoamaka;
Humphries, Helen;
Dickins, Maurice;
Neuhoff, Sibylle;
Gardner, Iain;
Rowland Yeo, Karen

Publication type:

Article

The absorption kinetics of ketoconazole plays a major role in explaining the reported variability in the level of interaction with midazolam: Interplay between formulation and inhibition of gut wall and liver metabolism.

Published in:

Biopharmaceutics & Drug Disposition, 2017, v. 38, n. 3, p. 260, doi. 10.1002/bdd.2058

By:

Liu, Bo;
Crewe, H. Kim;
Ozdemir, Mahmut;
Rowland Yeo, Karen;
Tucker, Geoffrey;
Rostami‐Hodjegan, Amin

Publication type:

Article

Application of a systems approach to the bottom-up assessment of pharmacokinetics in obese patients: expected variations in clearance.

Published in:

2011

By:

Ghobadi C;
Johnson TN;
Aarabi M;
Almond LM;
Allabi AC;
Rowland-Yeo K;
Jamei M;
Rostami-Hodjegan A;
Ghobadi, Cyrus;
Johnson, Trevor N;
Aarabi, Mohsen;
Almond, Lisa M;
Allabi, Aurel Constant;
Rowland-Yeo, Karen;
Jamei, Masoud;
Rostami-Hodjegan, Amin

Publication type:

journal article

Application of a Systems Approach to the Bottom-Up Assessment of Pharmacokinetics in Obese Patients.

Published in:

Clinical Pharmacokinetics, 2011, v. 50, n. 12, p. 809, doi. 10.2165/11594420-000000000-00000

By:

Ghobadi, Cyrus;
Johnson, Trevor N.;
Aarabi, Mohsen;
Almond, Lisa M.;
Allabi, Aurel Constant;
Rowland-Yeo, Karen;
Jamei, Masoud;
Rostami-Hodjegan, Amin

Publication type:

Article

A Semi-Mechanistic Model to Predict the Effects of Liver Cirrhosis on Drug Clearance.

Published in:

Clinical Pharmacokinetics, 2010, v. 49, n. 3, p. 189, doi. 10.2165/11318160-000000000-00000

By:

Johnson, Trevor N.;
Boussery, Koen;
Rowland-Yeo, Karen;
Tucker, Geoffrey T.;
Rostami-Hodjegan, Amin

Publication type:

Article

Physiologically Based Pharmacokinetic Modelling to Predict Imatinib Exposures in Cancer Patients with Renal Dysfunction: A Case Study.

Published in:

Pharmaceutics, 2023, v. 15, n. 7, p. 1922, doi. 10.3390/pharmaceutics15071922

By:

Rowland Yeo, Karen;
Hatley, Oliver;
Small, Ben G.;
Johnson, Trevor N.

Publication type:

Article

Prediction of drug clearance in a smoking population: modeling the impact of variable cigarette consumption on the induction of CYP1A2.

Published in:

European Journal of Clinical Pharmacology, 2012, v. 68, n. 6, p. 951, doi. 10.1007/s00228-011-1189-y

By:

Plowchalk, David;
Rowland Yeo, Karen

Publication type:

Article

Addressing health equity for breastfeeding women: primaquine for Plasmodium vivax radical cure.

Published in:

Malaria Journal, 2024, v. 23, n. 1, p. 1, doi. 10.1186/s12936-024-05112-9

By:

Abla, Nada;
Marrast, Anne Claire;
Jambert, Elodie;
Richardson, Naomi;
Duparc, Stephan;
Almond, Lisa;
Rowland Yeo, Karen;
Pan, Xian;
Tarning, Joel;
Zhao, Ping;
Culpepper, Janice;
Waitt, Catriona;
Koldeweij, Charlotte;
Cole, Susan;
Butler, Andrew S.;
Khier, Sonia;
Möhrle, Jörg J.;
El Gaaloul, Myriam

Publication type:

Article

Using human recombinant UDP-glucuronosyltransferase isoforms and a relative activity factor approach to model total body clearance of laropiprant (MK-0524) in humans.

Published in:

Xenobiotica, 2013, v. 43, n. 12, p. 1027, doi. 10.3109/00498254.2013.791761

By:

Gibson, Christopher R.;
Lu, Ping;
Maciolek, Cheri;
Wudarski, Christen;
Barter, Zoe;
Rowland-Yeo, Karen;
Stroh, Mark;
Lai, Eseng;
Nicoll-Griffith, Deborah A.

Publication type:

Article