Works by Rou-Gang Xie

Results: 27

Locus Coeruleus Noradrenergic‐Spinal Projections Contribute to Electroacupuncture‐Mediated Antinociception in Postoperative Pain in Mice.

Published in:

Advanced Science, 2025, v. 12, n. 25, p. 1, doi. 10.1002/advs.202501182

By:

Chu, Wen‐Guang;
Zhang, Ru;
Li, Hai‐Tao;
Li, Ying‐Chun;
Ding, Hui;
Li, Zhen‐Zhen;
Han, Wen‐Juan;
Wang, Fei;
Zheng, Xing‐Xing;
Mao, Hong‐Hui;
Yuan, Hua;
Wu, Sheng‐Xi;
Xie, Rou‐Gang;
Luo, Ceng

Publication type:

Article

Presynaptically Localized Cyclic GMP-Dependent Protein Kinase 1 Is a Key Determinant of Spinal Synaptic Potentiation and Pain Hypersensitivity.

Published in:

PLoS Biology, 2012, v. 10, n. 3, p. 1, doi. 10.1371/journal.pbio.1001283

By:

Ceng Luo;
Gangadharan, Vijayan;
Bali, Kiran Kumar;
Rou-Gang Xie;
Agarwal, Nitin;
Kurejova, Martina;
Tappe-Theodor, Anke;
Tegeder, Irmgard;
Feil, Susanne;
Lewin, Gary;
Polgar, Erika;
Todd, Andrew J.;
Schlossmann, Jens;
Hofmann, Franz;
Da-Lu Liu;
San-Jue Hu;
Feil, Robert;
Kuner, Thomas;
Kuner, Rohini

Publication type:

Article

Peripheral BDNF Regulates Somatosensory–Sympathetic Coupling in Brachial Plexus Avulsion-Induced Neuropathic Pain.

Published in:

Neuroscience Bulletin, 2023, v. 39, n. 12, p. 1789, doi. 10.1007/s12264-023-01075-0

By:

Xian, Hang;
Guo, Huan;
Liu, Yuan-Ying;
Zhang, Jian-Lei;
Hu, Wen-Chao;
Yu, Ming-Jun;
Zhao, Rui;
Xie, Rou-Gang;
Zhang, Hang;
Cong, Rui

Publication type:

Article

Tweety-Homolog 1 Facilitates Pain via Enhancement of Nociceptor Excitability and Spinal Synaptic Transmission.

Published in:

Neuroscience Bulletin, 2021, v. 37, n. 4, p. 478, doi. 10.1007/s12264-020-00617-0

By:

Han, Wen-Juan;
Ma, Sui-Bin;
Wu, Wen-Bin;
Wang, Fu-Dong;
Cao, Xiu-Li;
Wang, Dong-Hao;
Wu, Hai-Ning;
Xie, Rou-Gang;
Li, Zhen-Zhen;
Wang, Fei;
Wu, Sheng-Xi;
Zheng, Min-Hua;
Luo, Ceng;
Han, Hua

Publication type:

Article

Spinal CCL2 Promotes Pain Sensitization by Rapid Enhancement of NMDA-Induced Currents Through the ERK-GluN2B Pathway in Mouse Lamina II Neurons.

Published in:

Neuroscience Bulletin, 2020, v. 36, n. 11, p. 1344, doi. 10.1007/s12264-020-00557-9

By:

Zhang, Hui;
Ma, Sui-Bin;
Gao, Yong-Jing;
Xing, Jun-Ling;
Xian, Hang;
Li, Zhen-Zhen;
Shen, Shu-Ning;
Wu, Sheng-Xi;
Luo, Ceng;
Xie, Rou-Gang

Publication type:

Article

Spinal CCL2 Promotes Central Sensitization, Long-Term Potentiation, and Inflammatory Pain via CCR2: Further Insights into Molecular, Synaptic, and Cellular Mechanisms.

Published in:

Neuroscience Bulletin, 2018, v. 34, n. 1, p. 13, doi. 10.1007/s12264-017-0106-5

By:

Xie, Rou-Gang;
Gao, Yong-Jing;
Park, Chul-Kyu;
Lu, Ning;
Luo, Ceng;
Wang, Wen-Ting;
Wu, Sheng-Xi;
Ji, Ru-Rong

Publication type:

Article

Presynaptic NMDARs on spinal nociceptor terminals state-dependently modulate synaptic transmission and pain.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-28429-y

By:

Xie, Rou-Gang;
Chu, Wen-Guang;
Liu, Da-Lu;
Wang, Xu;
Ma, Sui-Bin;
Wang, Fei;
Wang, Fu-Dong;
Lin, Zhen;
Wu, Wen-Bin;
Lu, Na;
Liu, Ying-Ying;
Han, Wen-Juan;
Zhang, Hui;
Bai, Zhan-Tao;
Hu, San-Jue;
Tao, Hui-Ren;
Kuner, Thomas;
Zhang, Xu;
Kuner, Rohini;
Wu, Sheng-Xi

Publication type:

Article

Peripheral CCL2 induces inflammatory pain via regulation of Ih currents in small diameter DRG neurons.

Published in:

Frontiers in Molecular Neuroscience, 2023, p. 1, doi. 10.3389/fnmol.2023.1144614

By:

Lamei Li;
Yuanying Liu;
Wenchao Hu;
Jing Yang;
Suibin Ma;
Zhicheng Tian;
Zixuan Cao;
Kunqing Pan;
Ming Jiang;
Xia Liu;
Shengxi Wu;
Ceng Luo;
Rou-Gang Xie

Publication type:

Article

Extracellular matrix protein laminin β1 regulates pain sensitivity and anxiodepression-like behaviors in mice.

Published in:

2021

By:

Zhen-Zhen Li;
Wen-Juan Han;
Zhi-Chuan Sun;
Yun Chen;
Jun-Yi Sun;
Guo-Hong Cai;
Wan-Neng Liu;
Tao-Zhi Wang;
Yang-Dan Xie;
Hong-Hui Mao;
Fei Wang;
Sui-Bin Ma;
Fu-Dong Wang;
Rou-Gang Xie;
Sheng-Xi Wu;
Ceng Luo;
Li, Zhen-Zhen;
Han, Wen-Juan;
Sun, Zhi-Chuan;
Chen, Yun

Publication type:

journal article

Endocannabinoid signaling in hypothalamic circuits regulates arousal from general anesthesia in mice.

Published in:

2017

By:

Haixing Zhong;
Li Tong;
Ning Gu;
Fang Gao;
Yacheng Lu;
Rou-gang Xie;
Jingjing Liu;
Xin Li;
Bergeron, Richard;
Pomeranz, Lisa E.;
Mackie, Ken;
Feng Wang;
Chun-Xia Luo;
Yan Ren;
Sheng-Xi Wu;
Zhongcong Xie;
Lin Xu;
Jinlian Li;
Hailong Dong;
Lize Xiong

Publication type:

journal article

Intrathecal bone marrow stromal cells inhibit neuropathic pain via TGF-β secretion.

Published in:

Journal of Clinical Investigation, 2015, v. 125, n. 8, p. 3226, doi. 10.1172/JCI80883

By:

Gang Chen;
Chul-Kyu Park;
Rou-Gang Xie;
Ru-Rong Ji

Publication type:

Article

CCL2 facilitates spinal synaptic transmission and pain via interaction with presynaptic CCR2 in spinal nociceptor terminals.

Published in:

Molecular Brain, 2020, v. 13, n. 1, p. N.PAG, doi. 10.1186/s13041-020-00701-6

By:

Ma, Sui-Bin;
Xian, Hang;
Wu, Wen-Bin;
Ma, Shuo-Yao;
Liu, Yu-Ke;
Liang, Yu-Tong;
Guo, Huan;
Kang, Jun-Jun;
Liu, Ying-Ying;
Zhang, Hui;
Wu, Sheng-Xi;
Luo, Ceng;
Xie, Rou-Gang

Publication type:

Article

Characterization of Different Types of Excitability in Large Somatosensory Neurons and Its Plastic Changes in Pathological Pain States.

Published in:

International Journal of Molecular Sciences, 2018, v. 19, n. 1, p. 161, doi. 10.3390/ijms19010161

By:

Xie, Rou-Gang;
Chu, Wen-Guang;
Hu, San-Jue;
Luo, Ceng

Publication type:

Article

Loss of NR1 Subunit of NMDARs in Primary Sensory Neurons Leads to Hyperexcitability and Pain Hypersensitivity: Involvement of Ca2+ -Activated Small Conductance Potassium Channels.

Published in:

Journal of Neuroscience, 2013, v. 33, n. 33, p. 13425, doi. 10.1523/JNEUROSCI.0454-13.2013

By:

Pagadala, Promila;
Park, Chul-Kyu;
Bang, Sangsu;
Xu, Zheng-Zhong;
Xie, Rou-Gang;
Liu, Tong;
Han, Bao-Xia;
Tracey Jr, W. Daniel;
Wang, Fan;
Ji, Ru-Rong

Publication type:

Article

Chronic cervical radiculopathic pain is associated with increased excitability and hyperpolarization-activated current (Ih) in large-diameter dorsal root ganglion neurons.

Published in:

Molecular Pain, 2017, v. 13, p. 1, doi. 10.1177/1744806917707127

By:

Da-Lu Liu;
Xu Wang;
Wen-Guang Chu;
Na Lu;
Wen-Juan Han;
Yi-Kang Du;
San-Jue Hu;
Zhan-Tao Bai;
Sheng-Xi Wu;
Rou-Gang Xie;
Ceng Luo

Publication type:

Article

β-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain.

Published in:

Nature Communications, 2016, v. 7, n. 8, p. 12531, doi. 10.1038/ncomms12531

By:

Chen, Gang;
Xie, Rou-Gang;
Gao, Yong-Jing;
Xu, Zhen-Zhong;
Zhao, Lin-Xia;
Bang, Sangsu;
Berta, Temugin;
Park, Chul-Kyu;
Lay, Mark;
Chen, Wei;
Ji, Ru-Rong

Publication type:

Article

A role for Kalirin-7 in nociceptive sensitization via activity-dependent modulation of spinal synapses.

Published in:

Nature Communications, 2015, v. 6, n. 4, p. 6820, doi. 10.1038/ncomms7820

By:

Lu, Jianning;
Luo, Ceng;
Bali, Kiran Kumar;
Xie, Rou-Gang;
Mains, Richard E.;
Eipper, Betty A.;
Kuner, Rohini

Publication type:

Article

Nociceptor-localized KCC2 suppresses brachial plexus avulsion-induced neuropathic pain and related central sensitization.

Published in:

Cell & Bioscience, 2025, v. 15, n. 1, p. 1, doi. 10.1186/s13578-025-01354-5

By:

Xian, Hang;
Guo, Huan;
Liu, Yuan-Ying;
Ma, Sui-Bin;
Zhao, Rui;
Zhang, Jian-Lei;
Zhang, Hang;
Xie, Rou-Gang;
Guo, Xu-Cheng;
Ren, Jie;
Wu, Sheng-Xi;
Luo, Ceng;
Cong, Rui

Publication type:

Article

Brachial plexus avulsion induced changes in gut microbiota promotes pain related anxiety-like behavior in mice.

Published in:

Frontiers in Neurology, 2023, v. 14, p. 01, doi. 10.3389/fneur.2023.1084494

By:

Jian-lei Zhang;
Hang Xian;
Rui Zhao;
Ceng Luo;
Rou-gang Xie;
Tong Tian;
Rui Cong

Publication type:

Article

Ermin is a p116RIP‐interacting protein promoting oligodendroglial differentiation and myelin maintenance.

Published in:

Glia (0894-1491), 2020, v. 68, n. 11, p. 2264, doi. 10.1002/glia.23838

By:

Wang, Shan;
Wang, Tao;
Liu, Tao;
Xie, Rou‐Gang;
Zhao, Xiang‐Hui;
Wang, Lei;
Yang, Qian;
Jia, Lin‐Tao;
Han, Jing

Publication type:

Article

Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice.

Published in:

Brain: A Journal of Neurology, 2014, v. 137, n. 8, p. 2193, doi. 10.1093/brain/awu140

By:

Chen, Gang;
Park, Chul-Kyu;
Xie, Rou-Gang;
Berta, Temugin;
Nedergaard, Maiken;
Ji, Ru-Rong

Publication type:

Article

Reduced conduction failure of the main axon of polymodal nociceptive C-fibres contributes to painful diabetic neuropathy in rats.

Published in:

Brain: A Journal of Neurology, 2012, v. 135, n. 2, p. 359, doi. 10.1093/brain/awr345

By:

Sun, Wei;
Miao, Bei;
Wang, Xiu-Chao;
Duan, Jian-Hong;
Wang, Wen-Ting;
Kuang, Fang;
Xie, Rou-Gang;
Xing, Jun-Ling;
Xu, Hui;
Song, Xue-Jun;
Luo, Ceng;
Hu, San-Jue

Publication type:

Article

TRPC1/4/5 channels contribute to morphine‐induced analgesic tolerance and hyperalgesia by enhancing spinal synaptic potentiation and structural plasticity.

Published in:

FASEB Journal, 2020, v. 34, n. 6, p. 8526, doi. 10.1096/fj.202000154RR

By:

Chu, Wen‐Guang;
Wang, Fu‐Dong;
Sun, Zhi‐Chuan;
Ma, Sui‐Bin;
Wang, Xu;
Han, Wen‐Juan;
Wang, Fei;
Bai, Zhan‐Tao;
Wu, Sheng‐Xi;
Freichel, Marc;
Xie, Rou‐Gang;
Luo, Ceng

Publication type:

Article

Blockade of Persistent Sodium Currents Contributes to the Riluzole-Induced Inhibition of Spontaneous Activity and Oscillations in Injured DRG Neurons.

Published in:

PLoS ONE, 2011, v. 6, n. 4, p. 1, doi. 10.1371/journal.pone.0018681

By:

Rou-Gang Xie;
Da-Wei Zheng;
Jun-Ling Xing;
Xu-Jie Zhang;
Ying Song;
Ya-Bin Xie;
Fang Kuang;
Hui Dong;
Si-Wei You;
Hui Xu;
San-Jue Hu

Publication type:

Article

CCL2 Potentiates Inflammation Pain and Related Anxiety-Like Behavior Through NMDA Signaling in Anterior Cingulate Cortex.

Published in:

Molecular Neurobiology, 2024, v. 61, n. 8, p. 4976, doi. 10.1007/s12035-023-03881-z

By:

Guo, Huan;
Hu, Wen-chao;
Xian, Hang;
Shi, Yun-xin;
Liu, Yuan-ying;
Ma, Sui-bin;
Pan, Kun-qing;
Wu, Sheng-xi;
Xu, Li-yan;
Luo, Ceng;
Xie, Rou-gang

Publication type:

Article

Gastrodin protects against chronic inflammatory pain by inhibiting spinal synaptic potentiation.

Published in:

Scientific Reports, 2016, p. 37251, doi. 10.1038/srep37251

By:

Xiao, Mei-Mei;
Zhang, Yu-Qi;
Wang, Wen-Ting;
Han, Wen-Juan;
Lin, Zhen;
Xie, Rou-Gang;
Cao, Zhi;
Lu, Na;
Hu, San-Jue;
Wu, Sheng-Xi;
Dong, Hui;
Luo, Ceng

Publication type:

Article

Upregulation of Ih expressed in IB4-negative Aδ nociceptive DRG neurons contributes to mechanical hypersensitivity associated with cervical radiculopathic pain.

Published in:

Scientific Reports, 2015, p. 16713, doi. 10.1038/srep16713

By:

Kong, Wei-Wei;
Liu, Da-Lu;
Lu, Na;
Han, Wen-Juan;
Chen, Rong-Gui;
Xie, Rou-Gang;
Hu, San-Jue;
Luo, Ceng;
Cong, Rui;
Zhang, Yu-Fei

Publication type:

Article

Works by Rou-Gang Xie

Locus Coeruleus Noradrenergic‐Spinal Projections Contribute to Electroacupuncture‐Mediated Antinociception in Postoperative Pain in Mice.

Presynaptically Localized Cyclic GMP-Dependent Protein Kinase 1 Is a Key Determinant of Spinal Synaptic Potentiation and Pain Hypersensitivity.

Peripheral BDNF Regulates Somatosensory–Sympathetic Coupling in Brachial Plexus Avulsion-Induced Neuropathic Pain.

Tweety-Homolog 1 Facilitates Pain via Enhancement of Nociceptor Excitability and Spinal Synaptic Transmission.

Spinal CCL2 Promotes Pain Sensitization by Rapid Enhancement of NMDA-Induced Currents Through the ERK-GluN2B Pathway in Mouse Lamina II Neurons.

Spinal CCL2 Promotes Central Sensitization, Long-Term Potentiation, and Inflammatory Pain via CCR2: Further Insights into Molecular, Synaptic, and Cellular Mechanisms.

Presynaptic NMDARs on spinal nociceptor terminals state-dependently modulate synaptic transmission and pain.

Peripheral CCL2 induces inflammatory pain via regulation of I<sub>h</sub> currents in small diameter DRG neurons.

Extracellular matrix protein laminin β1 regulates pain sensitivity and anxiodepression-like behaviors in mice.

Endocannabinoid signaling in hypothalamic circuits regulates arousal from general anesthesia in mice.

Intrathecal bone marrow stromal cells inhibit neuropathic pain via TGF-β secretion.

CCL2 facilitates spinal synaptic transmission and pain via interaction with presynaptic CCR2 in spinal nociceptor terminals.

Characterization of Different Types of Excitability in Large Somatosensory Neurons and Its Plastic Changes in Pathological Pain States.

Loss of NR1 Subunit of NMDARs in Primary Sensory Neurons Leads to Hyperexcitability and Pain Hypersensitivity: Involvement of Ca<sup>2+</sup> -Activated Small Conductance Potassium Channels.

Chronic cervical radiculopathic pain is associated with increased excitability and hyperpolarization-activated current (I<sub>h</sub>) in large-diameter dorsal root ganglion neurons.

β-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain.

A role for Kalirin-7 in nociceptive sensitization via activity-dependent modulation of spinal synapses.

Nociceptor-localized KCC2 suppresses brachial plexus avulsion-induced neuropathic pain and related central sensitization.

Brachial plexus avulsion induced changes in gut microbiota promotes pain related anxiety-like behavior in mice.

Ermin is a p116<sup>RIP</sup>‐interacting protein promoting oligodendroglial differentiation and myelin maintenance.

Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice.

Reduced conduction failure of the main axon of polymodal nociceptive C-fibres contributes to painful diabetic neuropathy in rats.

TRPC1/4/5 channels contribute to morphine‐induced analgesic tolerance and hyperalgesia by enhancing spinal synaptic potentiation and structural plasticity.

Blockade of Persistent Sodium Currents Contributes to the Riluzole-Induced Inhibition of Spontaneous Activity and Oscillations in Injured DRG Neurons.

CCL2 Potentiates Inflammation Pain and Related Anxiety-Like Behavior Through NMDA Signaling in Anterior Cingulate Cortex.

Gastrodin protects against chronic inflammatory pain by inhibiting spinal synaptic potentiation.

Upregulation of I<sub>h</sub> expressed in IB4-negative Aδ nociceptive DRG neurons contributes to mechanical hypersensitivity associated with cervical radiculopathic pain.