Works by Rothman, Douglas L.

Results: 171

Reduced removal of waste products from energy metabolism takes center stage in human brain aging.

Published in:

Scientific Reports, 2025, v. 15, n. 1, p. 1, doi. 10.1038/s41598-025-90342-3

By:

Mangia, Silvia;
DiNuzzo, Mauro;
Ponticorvo, Sara;
Dienel, Gerald A.;
Behar, Kevin L.;
Benveniste, Helene;
Hyder, Fahmeed;
Giove, Federico;
Herculano-Houzel, Suzana;
Petroff, Ognen A.;
Eberly, Lynn E.;
Filip, Pavel;
Michaeli, Shalom;
Rothman, Douglas L.

Publication type:

Article

1H Magnetic Resonance Spectroscopy to Understand the Biological Basis of ALS, Diagnose Patients Earlier, and Monitor Disease Progression.

Published in:

Frontiers in Neurology, 2021, v. 12, p. 1, doi. 10.3389/fneur.2021.701170

By:

Caldwell, Sarah;
Rothman, Douglas L.

Publication type:

Article

Medial prefrontal cortex neurotransmitter abnormalities in posttraumatic stress disorder with and without comorbidity to major depression.

Published in:

NMR in Biomedicine, 2024, v. 37, n. 11, p. 1, doi. 10.1002/nbm.5220

By:

Swanberg, Kelley M.;
Prinsen, Hetty;
Averill, Christopher L.;
Campos, Leonardo;
Kurada, Abhinav V.;
Krystal, John H.;
Petrakis, Ismene L.;
Averill, Lynnette A.;
Rothman, Douglas L.;
Abdallah, Chadi G.;
Juchem, Christoph

Publication type:

Article

Measurement of neuro‐energetics and neurotransmission in the rat olfactory bulb using 1H and 1H–[13C] NMR spectroscopy.

Published in:

NMR in Biomedicine, 2024, v. 37, n. 6, p. 1, doi. 10.1002/nbm.4957

By:

Chowdhury, Golam M. I.;
Behar, Kevin L.;
Mason, Graeme F.;
Rothman, Douglas L.;
de Graaf, Robin A.

Publication type:

Article

The early days of ex vivo 1H, 13C, and 31P nuclear magnetic resonance in the laboratory of Dr. Robert G. Shulman from 1975 to 1995.

Published in:

NMR in Biomedicine, 2023, v. 36, n. 4, p. 1, doi. 10.1002/nbm.4879

By:

Rothman, Douglas L.;
Behar, Kevin L.;
Petroff, Ognen A. C.;
Shulman, Robert G.

Publication type:

Article

In vivo 13C and 1H‐[13C] MRS studies of neuroenergetics and neurotransmitter cycling, applications to neurological and psychiatric disease and brain cancer.

Published in:

NMR in Biomedicine, 2019, v. 32, n. 10, p. 1, doi. 10.1002/nbm.4172

By:

Rothman, Douglas L.;
Graaf, Robin A.;
Hyder, Fahmeed;
Mason, Graeme F.;
Behar, Kevin L.;
De Feyter, Henk M.

Publication type:

Article

In vivo detection and automatic analysis of GABA in the mouse brain with MEGA‐PRESS at 9.4 T.

Published in:

NMR in Biomedicine, 2018, v. 31, n. 1, p. 1, doi. 10.1002/nbm.3837

By:

Guo, Jia;
Gang, Zhu;
Sun, Yanping;
Laine, Andrew;
Small, Scott A.;
Rothman, Douglas L.

Publication type:

Article

Imaging the intratumoral-peritumoral extracellular pH gradient of gliomas.

Published in:

NMR in Biomedicine, 2016, v. 29, n. 3, p. 309, doi. 10.1002/nbm.3466

By:

Coman, Daniel;
Huang, Yuegao;
Rao, Jyotsna U.;
De Feyter, Henk M.;
Rothman, Douglas L.;
Juchem, Christoph;
Hyder, Fahmeed

Publication type:

Article

In vivo three-dimensional molecular imaging with Biosensor Imaging of Redundant Deviation in Shifts (BIRDS) at high spatiotemporal resolution.

Published in:

NMR in Biomedicine, 2013, v. 26, n. 11, p. 1589, doi. 10.1002/nbm.2995

By:

Coman, Daniel;
Graaf, Robin A.;
Rothman, Douglas L.;
Hyder, Fahmeed

Publication type:

Article

A lanthanide complex with dual biosensing properties: CEST (chemical exchange saturation transfer) and BIRDS (biosensor imaging of redundant deviation in shifts) with europium DOTA-tetraglycinate.

Published in:

NMR in Biomedicine, 2011, v. 24, n. 10, p. 1216, doi. 10.1002/nbm.1677

By:

Coman, Daniel;
Kiefer, Garry E.;
Rothman, Douglas L.;
Sherry, A. Dean;
Hyder, Fahmeed

Publication type:

Article

State of the art direct 13C and indirect 1H-[13C] NMR spectroscopy in vivo. A practical guide.

Published in:

NMR in Biomedicine, 2011, v. 24, n. 8, p. 958, doi. 10.1002/nbm.1761

By:

de Graaf, Robin A.;
Rothman, Douglas L.;
Behar, Kevin L.

Publication type:

Article

13C MRS studies of neuroenergetics and neurotransmitter cycling in humans.

Published in:

NMR in Biomedicine, 2011, v. 24, n. 8, p. 943, doi. 10.1002/nbm.1772

By:

Rothman, Douglas L.;
De Feyter, Henk M.;
Graaf, Robin A.;
Mason, Graeme F.;
Behar, Kevin L.

Publication type:

Article

Neurodevelopment of C57B/L6 mouse brain assessed by in vivo diffusion tensor imaging.

Published in:

NMR in Biomedicine, 2007, v. 20, n. 3, p. 375, doi. 10.1002/nbm.1130

By:

Chahboune, Halima;
R. Ment, Laura;
B. Stewart, William;
Ma, Xiaoxian;
Rothman, Douglas L.;
Hyder, Fahmeed

Publication type:

Article

In vivo 1H-[13C]-NMR spectroscopy of cerebral metabolism.

Published in:

NMR in Biomedicine, 2003, v. 16, n. 6/7, p. 339, doi. 10.1002/nbm.847

By:

Robin A. de Graaf;
Graeme F. Mason;
Anant B. Patel;
Kevin L. Behar;
Douglas L. Rothman

Publication type:

Article

Adiabatic RARE imaging.

Published in:

NMR in Biomedicine, 2003, v. 16, n. 1, p. 29, doi. 10.1002/nbm.811

By:

de Graaf, Robin A.;
Rothman, Douglas L.;
Behar, Kevin L.

Publication type:

Article

Lactate efflux and the neuroenergetic basis of brain function.

Published in:

NMR in Biomedicine, 2001, v. 14, n. 7/8, p. 389, doi. 10.1002/nbm.741

By:

Shulman, Robert G.;
Hyder, Fahmeed;
Rothman, Douglas L.

Publication type:

Article

Quantitative functional imaging of the brain: towards mapping neuronal activity by BOLD fMRI.

Published in:

NMR in Biomedicine, 2001, v. 14, n. 7/8, p. 413, doi. 10.1002/nbm.733

By:

Hyder, Fahmeed;
Kida, Ikuhiro;
Behar, Kevin L.;
Kennan, Richard P.;
Maciejewski, Paul K.;
Rothman, Douglas L.

Publication type:

Article

Studies of metabolic compartmentation and glucose transport using in vivo MRS.

Published in:

NMR in Biomedicine, 2001, v. 14, n. 2, p. 149, doi. 10.1002/nbm.692

By:

Rothman, Douglas L.

Publication type:

Article

Dynamic shim updating: A new approach towards optimized whole brain shimming.

Published in:

Magnetic Resonance in Medicine, 1996, v. 36, n. 1, p. 159, doi. 10.1002/mrm.1910360125

By:

Blamire, Andrew M.;
Rothman, Douglas L.;
Nixon, Terry

Publication type:

Article

Short echo time proton magnetic resonance spectroscopic imaging of macromolecule and metabolite signal intensities in the human brain.

Published in:

Magnetic Resonance in Medicine, 1996, v. 35, n. 5, p. 633, doi. 10.1002/mrm.1910350502

By:

Hwang, Jong-Hee;
Graham, Glenn D.;
Behar, Kevin L.;
Alger, Jeffry R.;
Prichard, James W.;
Rothman, Douglas L.

Publication type:

Article

Analysis of macromolecule resonances in 1H NMR spectra of human brain.

Published in:

Magnetic Resonance in Medicine, 1994, v. 32, n. 3, p. 294, doi. 10.1002/mrm.1910320304

By:

Behar, Kevin L.;
Rothman, Douglas L.;
Spencer, Dennis D.;
Petroff, Ognen A. C.

Publication type:

Article

Validation of 13C NMR measurements of liver glycogen in vivo.

Published in:

Magnetic Resonance in Medicine, 1994, v. 31, n. 6, p. 583, doi. 10.1002/mrm.1910310602

By:

Gruetter, Rolf;
Magnusson, Inger;
Rothman, Douglas L.;
Avison, Malcolm J.;
Shulman, Robert G.;
Shulman, Gerald I.

Publication type:

Article

Validation of 13c nmr measurement of human skeletal muscle glycogen by direct biochemical assay of needle biopsy samples.

Published in:

Magnetic Resonance in Medicine, 1992, v. 27, n. 1, p. 13, doi. 10.1002/mrm.1910270103

By:

Taylor, Roy;
Price, Thomas B.;
Rothman, Douglas L.;
Shulman, Robert G.;
Shulman, Gerald I.

Publication type:

Article

Detection and assignment of the glucose signal in 1h nmr difference spectra of the human brain.

Published in:

Magnetic Resonance in Medicine, 1992, v. 27, n. 1, p. 183, doi. 10.1002/mrm.1910270118

By:

Gruetter, Rolf;
Rothman, Douglas L.;
Novotny, Edward J.;
Shulman, Gerald I.;
Prichard, James W.;
Shulman, Robert G.

Publication type:

Article

Localized 13C NMR spectroscopy of myo-inositol in the human brain in vivo.

Published in:

Magnetic Resonance in Medicine, 1992, v. 25, n. 1, p. 204, doi. 10.1002/mrm.1910250121

By:

Gruetter, Rolf;
Rothman, Douglas L.;
Novotny, Edward J.;
Hulman, Robert G.

Publication type:

Article

Direct carbon versus proton heteronuclear editing of 2-13C ethanol in rabbit brain in vivo: A sensitivity comparison.

Published in:

Magnetic Resonance in Medicine, 1990, v. 16, n. 3, p. 431, doi. 10.1002/mrm.1910160310

By:

Novotny, Edward J.;
Ogino, Takashi;
Rothman, Douglas L.;
Petroff, Ognen A. C.;
Prichard, James W.;
Shulman, Robert G.

Publication type:

Article

Application of multipulse NMR to observe 13C-labeled metabolites in biological systems.

Published in:

Magnetic Resonance in Medicine, 1985, v. 2, n. 1, p. 56, doi. 10.1002/mrm.1910020107

By:

Bendall, M. Robin;
Hollander, Jan A. Den;
Arias-Mendoza, Fernando;
Rothman, Douglas L.;
Behar, Kevin L.;
Shulman, Robert G.

Publication type:

Article

Resting-state functional MRI of the nose as a novel investigational window into the nervous system.

Published in:

Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-77615-z

By:

Ponticorvo, Sara;
Paasonen, Jaakko;
Stenroos, Petteri;
Salo, Raimo A.;
Tanila, Heikki;
Filip, Pavel;
Rothman, Douglas L.;
Eberly, Lynn E.;
Garwood, Michael;
Metzger, Gregory J.;
Gröhn, Olli;
Michaeli, Shalom;
Mangia, Silvia

Publication type:

Article

Overexpression of UCP3 decreases mitochondrial efficiency in mouse skeletal muscle in vivo.

Published in:

FEBS Letters, 2023, v. 597, n. 2, p. 309, doi. 10.1002/1873-3468.14494

By:

Codella, Roberto;
Alves, Tiago C.;
Befroy, Douglas E.;
Choi, Cheol Soo;
Luzi, Livio;
Rothman, Douglas L.;
Kibbey, Richard G.;
Shulman, Gerald I.

Publication type:

Article

Rates of pyruvate carboxylase, glutamate and GABA neurotransmitter cycling, and glucose oxidation in multiple brain regions of the awake rat using a combination of [2- 13 C]/[1- 13 C]glucose infusion and 1 H-[ 13 C]NMR ex vivo.

Published in:

Journal of Cerebral Blood Flow & Metabolism, 2022, v. 42, n. 8, p. 1507, doi. 10.1177/0271678X221074211

By:

McNair, Laura M;
Mason, Graeme F;
Chowdhury, Golam MI;
Jiang, Lihong;
Ma, Xiaoxian;
Rothman, Douglas L;
Waagepetersen, Helle S;
Behar, Kevin L

Publication type:

Article

Human brain functional MRS reveals interplay of metabolites implicated in neurotransmission and neuroenergetics.

Published in:

Journal of Cerebral Blood Flow & Metabolism, 2022, v. 42, n. 6, p. 911, doi. 10.1177/0271678X221076570

By:

Koush, Yury;
Rothman, Douglas L;
Behar, Kevin L;
de Graaf, Robin A;
Hyder, Fahmeed

Publication type:

Article

Glucose sparing by glycogenolysis (GSG) determines the relationship between brain metabolism and neurotransmission.

Published in:

Journal of Cerebral Blood Flow & Metabolism, 2022, v. 42, n. 5, p. 844, doi. 10.1177/0271678X211064399

By:

Rothman, Douglas L;
Dienel, Gerald A;
Behar, Kevin L;
Hyder, Fahmeed;
DiNuzzo, Mauro;
Giove, Federico;
Mangia, Silvia

Publication type:

Article

Metabolic underpinnings of activated and deactivated cortical areas in human brain.

Published in:

Journal of Cerebral Blood Flow & Metabolism, 2021, v. 41, n. 5, p. 986, doi. 10.1177/0271678X21989186

By:

Koush, Yury;
de Graaf, Robin A;
Kupers, Ron;
Dricot, Laurence;
Ptito, Maurice;
Behar, Kevin L;
Rothman, Douglas L;
Hyder, Fahmeed

Publication type:

Article

Diffuse white matter loss in a transgenic rat model of cerebral amyloid angiopathy.

Published in:

Journal of Cerebral Blood Flow & Metabolism, 2021, v. 41, n. 5, p. 1103, doi. 10.1177/0271678X20944226

By:

Lee, Hedok;
Xu, Feng;
Liu, Xiaodan;
Koundal, Sunil;
Zhu, Xiaoyue;
Davis, Judianne;
Yanez, David;
Schrader, Joseph;
Stanisavljevic, Aleksandra;
Rothman, Douglas L;
Wardlaw, Joanna;
Van Nostrand, William E;
Benveniste, Helene

Publication type:

Article

Evaluating the gray and white matter energy budgets of human brain function.

Published in:

Journal of Cerebral Blood Flow & Metabolism, 2018, v. 38, n. 8, p. 1339, doi. 10.1177/0271678X17708691

By:

Yu, Yuguo;
Herman, Peter;
Rothman, Douglas L.;
Agarwal, Divyansh;
Hyder, Fahmeed

Publication type:

Article

Microdialysate concentration changes do not provide sufficient information to evaluate metabolic effects of lactate supplementation in brain-injured patients.

Published in:

Journal of Cerebral Blood Flow & Metabolism, 2016, v. 36, n. 11, p. 1844, doi. 10.1177/0271678X16666552

By:

Dienel, Gerald A.;
Rothman, Douglas L.;
Nordström, Carl-Henrik

Publication type:

Article

Metabolic demands of neural-hemodynamic associated and disassociated areas in brain.

Published in:

Journal of Cerebral Blood Flow & Metabolism, 2016, v. 36, n. 10, p. 1695, doi. 10.1177/0271678X16664531

By:

Sanganahalli, Basavaraju G.;
Herman, Peter;
Rothman, Douglas L.;
Blumenfeld, Hal;
Hyder, Fahmeed

Publication type:

Article

Uniform distributions of glucose oxidation and oxygen extraction in gray matter of normal human brain: No evidence of regional differences of aerobic glycolysis.

Published in:

Journal of Cerebral Blood Flow & Metabolism, 2016, v. 36, n. 5, p. 903, doi. 10.1177/0271678X15625349

By:

Hyder, Fahmeed;
Herman, Peter;
Bailey, Christopher J.;
Møller, Arne;
Globinsky, Ronen;
Fulbright, Robert K.;
Rothman, Douglas L.;
Gjedde, Albert

Publication type:

Article

Insights from neuroenergetics into the interpretation of functional neuroimaging: an alternative empirical model for studying the brain's support of behavior.

Published in:

Journal of Cerebral Blood Flow & Metabolism, 2014, v. 34, n. 11, p. 1721, doi. 10.1038/jcbfm.2014.145

By:

Shulman, Robert G;
Hyder, Fahmeed;
Rothman, Douglas L

Publication type:

Article

Characterization of cerebral glutamine uptake from blood in the mouse brain: implications for metabolic modeling of 13C NMR data.

Published in:

Journal of Cerebral Blood Flow & Metabolism, 2014, v. 34, n. 10, p. 1666, doi. 10.1038/jcbfm.2014.129

By:

Bagga, Puneet;
Behar, Kevin L;
Mason, Graeme F;
De Feyter, Henk M;
Rothman, Douglas L;
Patel, Anant B

Publication type:

Article

Caloric restriction impedes age-related decline of mitochondrial function and neuronal activity.

Published in:

Journal of Cerebral Blood Flow & Metabolism, 2014, v. 34, n. 9, p. 1440, doi. 10.1038/jcbfm.2014.114

By:

Lin, Ai-Ling;
Coman, Daniel;
Jiang, Lihong;
Rothman, Douglas L;
Hyder, Fahmeed

Publication type:

Article

The contribution of ketone bodies to basal and activity-dependent neuronal oxidation in vivo.

Published in:

Journal of Cerebral Blood Flow & Metabolism, 2014, v. 34, n. 7, p. 1233, doi. 10.1038/jcbfm.2014.77

By:

Chowdhury, Golam MI;
Jiang, Lihong;
Rothman, Douglas L;
Behar, Kevin L

Publication type:

Article

Glutamatergic function in the resting awake human brain is supported by uniformly high oxidative energy.

Published in:

Journal of Cerebral Blood Flow & Metabolism, 2014, v. 34, n. 2, p. 368, doi. 10.1038/jcbfm.2013.205

By:

Hyder, Fahmeed;
Fulbright, Robert K;
Shulman, Robert G;
Rothman, Douglas L

Publication type:

Article

Glutamatergic function in the resting awake human brain is supported by uniformly high oxidative energy.

Published in:

Journal of Cerebral Blood Flow & Metabolism, 2013, v. 33, n. 3, p. 339, doi. 10.1038/jcbfm.2012.207

By:

Hyder, Fahmeed;
Fulbright, Robert K;
Shulman, Robert G;
Rothman, Douglas L

Publication type:

Article

Lactate preserves neuronal metabolism and function following antecedent recurrent hypoglycemia.

Published in:

Journal of Clinical Investigation, 2013, v. 123, n. 5, p. 1988, doi. 10.1172/JCI65105

By:

Herzog, Raimund I.;
Lihong Jiang;
Herman, Peter;
Chen Zhao;
Sanganahalli, Basavaraju G.;
Mason, Graeme F.;
Hyder, Fahmeed;
Rothman, Douglas L.;
Sherwin, Robert S.;
Behar, Kevin L.

Publication type:

Article

Resistance to thyroid hormone is associated with raised energy expenditure, muscle mitochondrial uncoupling, and hyperphagia.

Published in:

2010

By:

Mitchell, Catherine S.;
Savage, David B.;
Dufour, Sylvie;
Schoenmakers, Nadia;
Murgatroyd, Peter;
Befroy, Douglas;
Halsall, David;
Northcott, Samantha;
Raymond-Barker, Philippa;
Curran, Suzanne;
Henning, Elana;
Keogh, Julia;
Owen, Penny;
Lazarus, John;
Rothman, Douglas L.;
Farooqi, I. Sadaf;
Shulman, Gerald I.;
Chatterjee, Krishna;
Petersen, Kitt Falk

Publication type:

journal article

Deficits in brain glucose transport among younger adults with obesity.

Published in:

Obesity (19307381), 2024, v. 32, n. 7, p. 1329, doi. 10.1002/oby.24034

By:

Gunawan, Felona;
Matson, Brooke C.;
Coppoli, Anastasia;
Jiang, Lihong;
Ding, Yuyan;
Perry, Rachel;
Sanchez‐Rangel, Elizabeth;
DeAguiar, Renata Belfort;
Behar, Kevin L.;
Rothman, Douglas L.;
Mason, Graeme F.;
Hwang, Janice J.

Publication type:

Article

Why Hippocampal Glutamate Levels Are Elevated in Schizophrenia.

Published in:

JAMA Psychiatry, 2023, v. 80, n. 3, p. 274, doi. 10.1001/jamapsychiatry.2022.3849

By:

Guo, Jia;
Rothman, Douglas L.;
Small, Scott A.

Publication type:

Article

Utility of Imaging-Based Biomarkers for Glutamate-Targeted Drug Development in Psychotic Disorders: A Randomized Clinical Trial.

Published in:

2018

By:

Javitt, Daniel C.;
Carter, Cameron S.;
Krystal, John H.;
Kantrowitz, Joshua T.;
Girgis, Ragy R.;
Kegeles, Lawrence S.;
Ragland, John D.;
Maddock, Richard J.;
Lesh, Tyler A.;
Tanase, Costin;
Corlett, Philip R.;
Rothman, Douglas L.;
Mason, Graeme;
Qiu, Maolin;
Robinson, James;
Potter, William Z.;
Carlson, Marlene;
Wall, Melanie M.;
Choo, Tse-Hwei;
Grinband, Jack

Publication type:

journal article

GABA, Resting-State Connectivity and the Developing Brain.

Published in:

Neonatology (16617800), 2014, v. 106, n. 2, p. 149, doi. 10.1159/000362433

By:

Kwon, Soo Hyun;
Scheinost, Dustin;
Lacadie, Cheryl;
Benjamin, Jennifer;
Myers, Eliza H.;
Qiu, Maolin;
Schneider, Karen C.;
Rothman, Douglas L.;
Constable, R. Todd;
Ment, Laura R.

Publication type:

Article