Works matching AU Roth, Bryan L.

Results: 104

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome.

Published in:

Nature Structural & Molecular Biology, 2015, v. 22, n. 5, p. 362, doi. 10.1038/nsmb.3014

By:

Kroeze, Wesley K;
Sassano, Maria F;
Huang, Xi-Ping;
Lansu, Katherine;
McCorvy, John D;
Giguère, Patrick M;
Sciaky, Noah;
Roth, Bryan L

Publication type:

Article

HTS navigator: freely accessible cheminformatics software for analyzing high-throughput screening data.

Published in:

Bioinformatics, 2014, v. 30, n. 4, p. 588, doi. 10.1093/bioinformatics/btt718

By:

Fourches, Denis;
Sassano, Maria F.;
Roth, Bryan L.;
Tropsha, Alexander

Publication type:

Article

Chemogenetics--A Transformational and Translational Platform.

Published in:

JAMA Neurology, 2015, v. 72, n. 11, p. 1361, doi. 10.1001/jamaneurol.2015.1921

By:

English, Justin G.;
Roth, Bryan L.

Publication type:

Article

Correction: The Ketamine Analogue Methoxetamine and 3- and 4-Methoxy Analogues of Phencyclidine Are High Affinity and Selective Ligands for the Glutamate NMDA Receptor.

Published in:

2018

By:

Roth, Bryan L.;
Gibbons, Simon;
Arunotayanun, Warunya;
Huang, Xi-Ping;
Setola, Vincent;
Treble, Ric;
Iversen, Les

Publication type:

Correction Notice

Rat Brain Protein Kinase C: Purification, Antibody Production, and Quantification in Discrete Regions of Hippocampus.

Published in:

Journal of Neurochemistry, 1989, v. 52, n. 1, p. 215, doi. 10.1111/j.1471-4159.1989.tb10919.x

By:

Roth, Bryan L.;
Mehegan, John P.;
Jacobowitz, David M.;
Robey, Frank;
Iadarola, Michael J.

Publication type:

Article

5-Hydroxytryptamine Uptake and Imipramine Binding Sites in Neurotumor NCB-20 Cells.

Published in:

Journal of Neurochemistry, 1985, v. 45, n. 3, p. 920, doi. 10.1111/j.1471-4159.1985.tb04081.x

By:

Nakaki, Toshio;
Roth, Bryan L.;
Chuang, De-Maw;
Costa, Erminio

Publication type:

Article

Microsomal Opiate Receptors: Characterization of Smooth Microsomal and Synaptic Membrane Opiate Receptors.

Published in:

Journal of Neurochemistry, 1984, v. 42, n. 6, p. 1677, doi. 10.1111/j.1471-4159.1984.tb12759.x

By:

Roth, Bryan L.;
Coscia, Carmine J.

Publication type:

Article

Secretin Receptors on Neuroblastoma Cell Membranes: Characterization of 125I-Labeled Secretin Binding and Association with Adenylate Cyclase.

Published in:

Journal of Neurochemistry, 1984, v. 42, n. 4, p. 1145, doi. 10.1111/j.1471-4159.1984.tb12723.x

By:

Roth, Bryan L.;
Beinfeld, Margery C.;
Howlett, Allyn C.

Publication type:

Article

Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65.

Published in:

Nature, 2015, v. 527, n. 7579, p. 477, doi. 10.1038/nature15699

By:

Huang, Xi-Ping;
Karpiak, Joel;
Kroeze, Wesley K.;
Zhu, Hu;
Chen, Xin;
Moy, Sheryl S.;
Saddoris, Kara A.;
Nikolova, Viktoriya D.;
Farrell, Martilias S.;
Wang, Sheng;
Mangano, Thomas J.;
Deshpande, Deepak A.;
Jiang, Alice;
Penn, Raymond B.;
Jin, Jian;
Koller, Beverly H.;
Kenakin, Terry;
Shoichet, Brian K.;
Roth, Bryan L.

Publication type:

Article

LSD-stimulated behaviors in mice require β-arrestin 2 but not β-arrestin 1.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-96736-3

By:

Rodriguiz, Ramona M.;
Nadkarni, Vineet;
Means, Christopher R.;
Pogorelov, Vladimir M.;
Chiu, Yi-Ting;
Roth, Bryan L.;
Wetsel, William C.

Publication type:

Article

Selective κ Opioid Antagonists nor-BNI, GNTI and JDTic Have Low Affinities for Non-Opioid Receptors and Transporters.

Published in:

PLoS ONE, 2013, v. 8, n. 8, p. 1, doi. 10.1371/journal.pone.0070701

By:

Munro, Thomas A.;
Huang, Xi-Ping;
Inglese, Carmela;
Perrone, Maria Grazia;
Van't Veer, Ashlee;
Carroll, F. Ivy;
Béguin, Cécile;
Carlezon Jr, William A.;
Colabufo, Nicola A.;
Cohen, Bruce M.;
Roth, Bryan L.

Publication type:

Article

The Ketamine Analogue Methoxetamine and 3- and 4-Methoxy Analogues of Phencyclidine Are High Affinity and Selective Ligands for the Glutamate NMDA Receptor.

Published in:

PLoS ONE, 2013, v. 8, n. 3, p. 1, doi. 10.1371/journal.pone.0059334

By:

Roth, Bryan L.;
Gibbons, Simon;
Arunotayanun, Warunya;
Huang, Xi-Ping;
Setola, Vincent;
Treble, Ric;
Iversen, Les

Publication type:

Article

Quantitative Analysis of Focused A-To-I RNA Editing Sites by Ultra-High- Throughput Sequencing in Psychiatric Disorders.

Published in:

PLoS ONE, 2012, v. 7, n. 8, p. 1, doi. 10.1371/journal.pone.0043227

By:

Hu Zhu;
Urban, Daniel J.;
Blashka, Jared;
McPheeters, Matthew T.;
Kroeze, Wesley K.;
Mieczkowski, Piotr;
Overholser, James C.;
Jurjus, George J.;
Dieter, Lesa;
Mahajan, Gouri J.;
Rajkowska, Grazyna;
Zefeng Wang;
Sullivan, Patrick F.;
Stockmeier, Craig A.;
Roth, Bryan L.;
Lewin, Alfred

Publication type:

Article

Securinine, a Myeloid Differentiation Agent with Therapeutic Potential for AML.

Published in:

PLoS ONE, 2011, v. 6, n. 6, p. 1, doi. 10.1371/journal.pone.0021203

By:

Gupta, Kalpana;
Chakrabarti, Amitabha;
Rana, Sonia;
Ramdeo, Ritu;
Roth, Bryan L.;
Agarwal, Munna L.;
Tse, William;
Agarwal, Mukesh K.;
Wald, David N.

Publication type:

Article

Structural insights into angiotensin receptor signaling modulation by balanced and biased agonists.

Published in:

EMBO Journal, 2023, v. 42, n. 11, p. 1, doi. 10.15252/embj.2022112940

By:

Zhang, Dongqi;
Liu, Yongfeng;
Zaidi, Saheem A;
Xu, Lingyi;
Zhan, Yuting;
Chen, Anqi;
Guo, Jiangtao;
Huang, Xi‐Ping;
Roth, Bryan L;
Katritch, Vsevolod;
Cherezov, Vadim;
Zhang, Haitao

Publication type:

Article

Biased signaling of the proton-sensing receptor OGR1 by benzodiazepines.

Published in:

FASEB Journal, 2018, v. 32, n. 2, p. 862, doi. 10.1096/fj.201700555R

By:

Pera, Tonio;
Deshpande, Deepak A.;
Ippolito, Michael;
Bin Wang;
Gavrila, Adelina;
Michael, James V.;
Nayak, Ajay P.;
Tompkins, Eric;
Farrell, Eleni;
Kroeze, Wesley K.;
Roth, Bryan L.;
Panettieri Jr., Reynold A.;
Benovic, Jeffrey L.;
An, Steven S.;
Dulin, Nickolai O.;
Penn, Raymond B.

Publication type:

Article

Protamine is an antagonist of apelin receptor, and its activity is reversed by heparin.

Published in:

FASEB Journal, 2017, v. 31, n. 6, p. 2507, doi. 10.1096/fj.201601074R

By:

Le Gonidec, Sophie;
Chaves-Almagro, Carline;
Yushi Bai;
Hye Jin Kang;
Smith, Allyson;
Wanecq, Estelle;
Xi-Ping Huang;
Prats, Hervé;
Knibiehler, Bernard;
Roth, Bryan L.;
Barak, Larry S.;
Caron, Marc G.;
Valet, Philippe;
Audigier, Yves;
Masri, Bernard

Publication type:

Article

Identification of Human Ether-à-go-goRelated Gene Modulators by Three Screening Platforms in an Academic Drug-Discovery Setting.

Published in:

Assay & Drug Development Technologies, 2010, v. 8, n. 6, p. 727, doi. 10.1089/adt.2010.0331

By:

Xi-Ping Huang;
Thomas Mangano;
Sandy Hufeisen;
Vincent Setola;
Bryan L. Roth

Publication type:

Article

Cre-dependent DREADD (Designer Receptors Exclusively Activated by Designer Drugs) mice.

Published in:

Genesis: The Journal of Genetics & Development, 2016, v. 54, n. 8, p. 439, doi. 10.1002/dvg.22949

By:

Zhu, Hu;
Aryal, Dipendra K.;
Olsen, Reid H.J.;
Urban, Daniel J.;
Swearingen, Amanda;
Forbes, Stacy;
Roth, Bryan L.;
Hochgeschwender, Ute

Publication type:

Article

HypoRiPPAtlas as an Atlas of hypothetical natural products for mass spectrometry database search.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-39905-4

By:

Lee, Yi-Yuan;
Guler, Mustafa;
Chigumba, Desnor N.;
Wang, Shen;
Mittal, Neel;
Miller, Cameron;
Krummenacher, Benjamin;
Liu, Haodong;
Cao, Liu;
Kannan, Aditya;
Narayan, Keshav;
Slocum, Samuel T.;
Roth, Bryan L.;
Gurevich, Alexey;
Behsaz, Bahar;
Kersten, Roland D.;
Mohimani, Hosein

Publication type:

Article

Structural insights into the human niacin receptor HCA2-Gi signalling complex.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-37177-6

By:

Yang, Yang;
Kang, Hye Jin;
Gao, Ruogu;
Wang, Jingjing;
Han, Gye Won;
DiBerto, Jeffrey F.;
Wu, Lijie;
Tong, Jiahui;
Qu, Lu;
Wu, Yiran;
Pileski, Ryan;
Li, Xuemei;
Zhang, Xuejun Cai;
Zhao, Suwen;
Kenakin, Terry;
Wang, Quan;
Stevens, Raymond C.;
Peng, Wei;
Roth, Bryan L.;
Rao, Zihe

Publication type:

Article

MRGPRX4 mediates phospho-drug–associated pruritus in a humanized mouse model.

Published in:

Science Translational Medicine, 2024, v. 16, n. 746, p. 1, doi. 10.1126/scitranslmed.adk8198

By:

Chien, Daphne Chun-Che;
Limjunyawong, Nathachit;
Cao, Can;
Meixiong, James;
Peng, Qi;
Ho, Cheng-Ying;
Fay, Jonathan F.;
Roth, Bryan L.;
Dong, Xinzhong

Publication type:

Article

Three putative N‐glycosylation sites within the murine 5‐HT3A receptor sequence affect plasma membrane targeting, ligand binding, and calcium influx in heterologous mammalian cells.

Published in:

Journal of Neuroscience Research, 2004, v. 77, n. 4, p. 498, doi. 10.1002/jnr.20185

By:

Phillip L. Quirk;
Suma Rao;
Bryan L. Roth;
Ruth E. Siegel

Publication type:

Article

Direct-Pathway Striatal Neurons Regulate the Retention of Decision-Making Strategies.

Published in:

Journal of Neuroscience, 2013, v. 33, n. 28, p. 11668, doi. 10.1523/JNEUROSCI.4783-12.2013

By:

Ferguson, Susan M.;
Phillips, Paul E. M.;
Roth, Bryan L.;
Wess, Jürgen;
Neumaie, John F.

Publication type:

Article

A proximity proteomics pipeline with improved reproducibility and throughput.

Published in:

Molecular Systems Biology, 2024, v. 20, n. 8, p. 952, doi. 10.1038/s44320-024-00049-2

By:

Zhong, Xiaofang;
Li, Qiongyu;
Polacco, Benjamin J;
Patil, Trupti;
Marley, Aaron;
Foussard, Helene;
Khare, Prachi;
Vartak, Rasika;
Xu, Jiewei;
DiBerto, Jeffrey F;
Roth, Bryan L;
Eckhardt, Manon;
von Zastrow, Mark;
Krogan, Nevan J;
Hüttenhain, Ruth

Publication type:

Article

Lorcaserin and pimavanserin: emerging selectivity of serotonin receptor subtype-targeted drugs.

Published in:

2013

By:

Meltzer, Herbert Y;
Roth, Bryan L

Publication type:

journal article

Lorcaserin and pimavanserin: emerging selectivity of serotonin receptor subtype--targeted drugs.

Published in:

Journal of Clinical Investigation, 2013, v. 123, n. 12, p. 4986, doi. 10.1172/JCI70678

By:

Meltzer, Herbert Y.;
Roth, Bryan L.

Publication type:

Article

Rapid, reversible activation of AgRP neurons drives feeding behavior in mice.

Published in:

2011

By:

Krashes, Michael J.;
Shuichi Koda;
ChianPing Ye;
Rogan, Sarah C.;
Adams, Andrew C.;
Cusher, Daniel S.;
Maratos-Flier, Eleftheria;
Roth, Bryan L.;
Lowell, Bradford B.;
Koda, Shuichi;
Ye, ChianPing

Publication type:

journal article

Finding New Tricks For Old Drugs: An Efficient Route For Public-Sector Drug Discovery.

Published in:

Nature Reviews Drug Discovery, 2005, v. 4, n. 12, p. 1005, doi. 10.1038/nrd1900

By:

O'Connor, Kerry A.;
Roth, Bryan L.

Publication type:

Article

Opinion: Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia.

Published in:

Nature Reviews Drug Discovery, 2004, v. 3, n. 4, p. 353, doi. 10.1038/nrd1346

By:

Roth, Bryan L.;
Sheffler, Douglas J.;
Kroeze, Wesley K.

Publication type:

Article

DREADD: A Chemogenetic GPCR Signaling Platform.

Published in:

International Journal of Neuropsychopharmacology, 2015, v. 18, n. 1, p. 1, doi. 10.1093/ijnp/pyu007

By:

Hu Zhu;
Roth, Bryan L.

Publication type:

Article

Vision and olfaction say UNC-le to G proteins.

Published in:

Nature Neuroscience, 2011, v. 14, n. 7, p. 805, doi. 10.1038/nn.2863

By:

Vardy, Eyal;
Roth, Bryan L.

Publication type:

Article

Transient neuronal inhibition reveals opposing roles of indirect and direct pathways in sensitization.

Published in:

Nature Neuroscience, 2011, v. 14, n. 1, p. 22, doi. 10.1038/nn.2703

By:

Ferguson, Susan M.;
Eskenazi, Daniel;
Ishikawa, Masago;
Wanat, Matthew J.;
Phillips, Paul E. M.;
Yan Dong;
Roth, Bryan L.;
Neumaier, John F.

Publication type:

Article

CRF receptor 1 regulates anxiety behavior via sensitization of 5-HT2 receptor signaling.

Published in:

Nature Neuroscience, 2010, v. 13, n. 5, p. 622, doi. 10.1038/nn.2529

By:

Magalhaes, Ana C.;
Holmes, Kevin D.;
Dale, Lianne B.;
Comps-Agrar, Laetitia;
Lee, Dennis;
Yadav, Prem N.;
Drysdale, Linsay;
Poulter, Michael O.;
Roth, Bryan L.;
Pin, Jean-Philippe;
Anisman, Hymie;
Ferguson, Stephen S. G.

Publication type:

Article

The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand.

Published in:

Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-02084-0

By:

Chan, John D.;
Gunaratne, Gihan S.;
Yang Yang;
Marchant, Jonathan S.;
Cupit, Pauline M.;
Abagyan, Ruben;
McCorvy, John D.;
Roth, Bryan L.;
Stoltz, Kristen;
Dosa, Peter I.;
Webb, Thomas R.;
Cunningham, Charles

Publication type:

Article

Relating protein pharmacology by ligand chemistry.

Published in:

Nature Biotechnology, 2007, v. 25, n. 2, p. 197, doi. 10.1038/nbt1284

By:

Keiser, Michael J.;
Roth, Bryan L.;
Armbruster, Blaine N.;
Ernsberger, Paul;
Irwin, John J.;
Shoichet, Brian K.

Publication type:

Article

Psilocybin for depression and anxiety associated with life-threatening illnesses.

Published in:

2016

By:

McCorvy, John D.;
Olsen, Reid H. J.;
Roth, Bryan L.;
Olsen, Reid Hj

Publication type:

journal article

Screening the receptorome.

Published in:

Journal of Psychopharmacology, 2006, v. 20, n. 4S, p. 41, doi. 10.1177/1359786806066045

By:

Kroeze, Wesley K.;
Roth, Bryan L.

Publication type:

Article

Synthesis and Evaluation of 18F-FE-PEO in Rodents: An 18F-Labeled Full Agonist for Opioid Receptor Imaging.

Published in:

Journal of Nuclear Medicine, 2013, v. 54, n. 2, p. 229, doi. 10.2967/jnumed.112.108688

By:

Riss, Patrick J.;
Hong, Young T.;
Marton, János;
Caprioli, Daniele;
Williamson, David J.;
Ferrari, Valentina;
Saigal, Neil;
Roth, Bryan L.;
Henriksen, Gjermund;
Fryer, Tim D.;
Dalley, Jeffrey W.;
Aigbirhio, Franklin I.

Publication type:

Article

Novel Diketopiperazine Enhances Motor and Cognitive Recovery After Traumatic Brain Injury in Rats and Shows Neuroprotection In Vitro and In Vivo.

Published in:

Journal of Cerebral Blood Flow & Metabolism, 2003, v. 23, n. 3, p. 342, doi. 10.1097/01.WCB.0000046143.31247.FD

By:

Faden, Alan I;
Knoblach, Susan M;
Cernak, Ibolja;
Fan, Lei;
Vink, Robert;
Araldi, Gian Luca;
Fricke, Stanley T;
Roth, Bryan L;
Kozikowski, Alan P

Publication type:

Article

In Silico Molecular Comparisons of C. elegans and Mammalian Pharmacology Identify Distinct Targets That Regulate Feeding.

Published in:

PLoS Biology, 2013, v. 11, n. 11, p. 1, doi. 10.1371/journal.pbio.1001712

By:

Lemieux, George A.;
Keiser, Michael J.;
Sassano, Maria F.;
Laggner, Christian;
Mayer, Fahima;
Bainton, Roland J.;
Werb, Zena;
Roth, Bryan L.;
Shoichet, Brian K.;
Ashrafi, Kaveh

Publication type:

Article

Receptor Reserve Moderates Mesolimbic Responses to Opioids in a Humanized Mouse Model of the OPRM1 A118G Polymorphism.

Published in:

Neuropsychopharmacology, 2015, v. 40, n. 11, p. 2614, doi. 10.1038/npp.2015.109

By:

Robinson, J Elliott;
Vardy, Eyal;
DiBerto, Jeffrey F;
Chefer, Vladimir I;
White, Kate L;
Fish, Eric W;
Chen, Meng;
Gigante, Eduardo;
Krouse, Michael C;
Sun, Hui;
Thorsell, Annika;
Roth, Bryan L;
Heilig, Markus;
Malanga, C J

Publication type:

Article

Chemogenetic Inactivation of Ventral Hippocampal Glutamatergic Neurons Disrupts Consolidation of Contextual Fear Memory.

Published in:

Neuropsychopharmacology, 2014, v. 39, n. 8, p. 1880, doi. 10.1038/npp.2014.35

By:

Zhu, Hu;
Pleil, Kristen E;
Urban, Daniel J;
Moy, Sheryl S;
Kash, Thomas L;
Roth, Bryan L

Publication type:

Article

Noradrenergic Synaptic Function in the Bed Nucleus of the Stria Terminalis Varies in Animal Models of Anxiety and Addiction.

Published in:

Neuropsychopharmacology, 2013, v. 38, n. 9, p. 1665, doi. 10.1038/npp.2013.63

By:

McElligott, Zoé A;
Fox, Megan E;
Walsh, Paul L;
Urban, Daniel J;
Ferrel, Martilias S;
Roth, Bryan L;
Wightman, R Mark

Publication type:

Article

A Gαs DREADD Mouse for Selective Modulation of cAMP Production in Striatopallidal Neurons.

Published in:

Neuropsychopharmacology, 2013, v. 38, n. 5, p. 854, doi. 10.1038/npp.2012.251

By:

Farrell, Martilias S;
Pei, Ying;
Wan, Yehong;
Yadav, Prem N;
Daigle, Tanya L;
Urban, Daniel J;
Lee, Hyeong-Min;
Sciaky, Noah;
Simmons, Arkeen;
Nonneman, Randal J;
Huang, Xi-Ping;
Hufeisen, Sandy J;
Guettier, Jean-Marc;
Moy, Sheryl S;
Wess, Jürgen;
Caron, Marc G;
Calakos, Nicole;
Roth, Bryan L

Publication type:

Article

The Presynaptic Component of the Serotonergic System is Required for Clozapine's Efficacy.

Published in:

Neuropsychopharmacology, 2011, v. 36, n. 3, p. 638, doi. 10.1038/npp.2010.195

By:

Yadav, Prem N.;
Abbas, Atheir I.;
Farrell, Martilias S.;
Setola, Vincent;
Sciaky, Noah;
Huang, Xi-Ping;
Kroeze, Wesley K.;
Crawford, LaTasha K.;
Piel, David A.;
Keiser, Michael J.;
Irwin, John J.;
Shoichet, Brian K.;
Deneris, Evan S.;
Gingrich, Jay;
Beck, Sheryl G.;
Roth, Bryan L.

Publication type:

Article

Allosteric Antipsychotics: M4 Muscarinic Potentiators as Novel Treatments for Schizophrenia.

Published in:

2010

By:

Farrell, Martilias;
Roth, Bryan L.

Publication type:

Opinion

N-Desalkylquetiapine, a Potent Norepinephrine Reuptake Inhibitor and Partial 5-HT1A Agonist, as a Putative Mediator of Quetiapine's Antidepressant Activity.

Published in:

Neuropsychopharmacology, 2008, v. 33, n. 11, p. 2303, doi. 10.1038/sj.npp.1301646

By:

Jensen, Niels H.;
Rodriguiz, Ramona M.;
Caron, Marc G.;
Wetsel, William C.;
Rothman, Richard B.;
Roth, Bryan L.

Publication type:

Article

Opportunities and Challenges of Psychiatric Drug Discovery: Roles for Scientists in Academic, Industry, and Government Settings.

Published in:

Neuropsychopharmacology, 2008, v. 33, n. 10, p. 2048, doi. 10.1038/sj.npp.1301638

By:

Conn, P. Jeffrey;
Roth, Bryan L.

Publication type:

Article

Opportunities and Challenges of Psychiatric Drug Discovery: Roles for Scientists in Academic, Industry, and Government Settings.

Published in:

2008

By:

Conn, P. Jeffrey;
Roth, Bryan L.

Publication type:

Correction Notice