Works by Rostami-Hodjegan A

Results: 194

Anatomical, physiological and metabolic changes with gestational age during normal pregnancy: a database for parameters required in physiologically based pharmacokinetic modelling.

Published in:

2012

By:

Abduljalil K;
Furness P;
Johnson TN;
Rostami-Hodjegan A;
Soltani H;
Abduljalil, Khaled;
Furness, Penny;
Johnson, Trevor N;
Rostami-Hodjegan, Amin;
Soltani, Hora

Publication type:

journal article

Application of a systems approach to the bottom-up assessment of pharmacokinetics in obese patients: expected variations in clearance.

Published in:

2011

By:

Ghobadi C;
Johnson TN;
Aarabi M;
Almond LM;
Allabi AC;
Rowland-Yeo K;
Jamei M;
Rostami-Hodjegan A;
Ghobadi, Cyrus;
Johnson, Trevor N;
Aarabi, Mohsen;
Almond, Lisa M;
Allabi, Aurel Constant;
Rowland-Yeo, Karen;
Jamei, Masoud;
Rostami-Hodjegan, Amin

Publication type:

journal article

Pharmacotherapy in kidney disease: what it takes to move from general guidance to specific recommendations to stratified subgroups of patients - the tale of autosomal dominant polycystic kidney disease (ADPKD).

Published in:

Expert Opinion on Drug Metabolism & Toxicology, 2025, v. 21, n. 6, p. 677, doi. 10.1080/17425255.2025.2501127

By:

Tillmann, Annika C.;
Rostami-Hodjegan, Amin;
Barber, Jill;
Al-Majdoub, Zubida M.

Publication type:

Article

Evaluation of Adefovir PBPK Model to Assess Biomarker‐Informed OAT1 Drug–Drug Interaction and Effect of Chronic Kidney Disease.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2025, v. 14, n. 5, p. 964, doi. 10.1002/psp4.70010

By:

Tan, Shawn Pei Feng;
Wu, Huaying;
Rostami‐Hodjegan, Amin;
Scotcher, Daniel;
Galetin, Aleksandra

Publication type:

Article

Resurgence in the use of physiologically based pharmacokinetic models in pediatric clinical pharmacology: parallel shift in incorporating the knowledge of biological elements and increased applicability to drug development and clinical practice.

Published in:

Pediatric Anesthesia, 2011, v. 21, n. 3, p. 291, doi. 10.1111/j.1460-9592.2010.03323.x

By:

Johnson, Trevor N.;
Rostami-Hodjegan, Amin

Publication type:

Article

A mechanistic pharmacokinetic model to assess modified oral drug bioavailability post bariatric surgery in morbidly obese patients: interplay between CYP3A gut wall metabolism, permeability and dissolution.

Published in:

Journal of Pharmacy & Pharmacology, 2012, v. 64, n. 7, p. 1008, doi. 10.1111/j.2042-7158.2012.01538.x

By:

Darwich, Adam S.;
Pade, Devendra;
Ammori, Basil J.;
Jamei, Masoud;
Ashcroft, Darren M.;
Rostami-Hodjegan, Amin

Publication type:

Article

Mechanism-based inactivation of human cytochrome P450 enzymes: strategies for diagnosis and drug-drug interaction risk assessment.

Published in:

Xenobiotica, 2007, v. 37, n. 10/11, p. 1225, doi. 10.1080/00498250701670945

By:

Venkatakrishnan, K.;
Obach, R. S.;
Rostami-Hodjegan, A.

Publication type:

Article

Editorial.

Published in:

Xenobiotica, 2007, v. 37, n. 10/11, p. 1013, doi. 10.1080/00498250701649873

By:

GIBSON, G. GORDON;
ROSTAMI-HODJEGAN, AMIN

Publication type:

Article

Prediction of metabolic drug clearance in humans: In vitro–in vivo extrapolation vs allometric scaling.

Published in:

Xenobiotica, 2006, v. 36, n. 7, p. 567, doi. 10.1080/00498250600761662

By:

Shiran, M. R.;
Proctor, N. J.;
Howgate, E. M.;
Rowland-Yeo, K.;
Tucker, G. T.;
Rostami-Hodjegan, A.

Publication type:

Article

Prediction of in vivo drug clearance from in vitro data. II: Potential inter-ethnic differences.

Published in:

Xenobiotica, 2006, v. 36, n. 6, p. 499, doi. 10.1080/00498250600683262

By:

Inoue, S.;
Howgate, E. M.;
Rowland-Yeo, K.;
Shimada, T.;
Yamazaki, H.;
Tucker, G. T.;
Rostami-Hodjegan, A.

Publication type:

Article

Prediction of in vivo drug clearance from in vitro data. I: Impact of inter-individual variability.

Published in:

Xenobiotica, 2006, v. 36, n. 6, p. 473, doi. 10.1080/00498250600683197

By:

Howgate, E. M.;
Rowland Yeo, K.;
Proctor, N. J.;
Tucker, G. T.;
Rostami-Hodjegan, A.

Publication type:

Article

Predicting drug clearance from recombinantly expressed CYPs: intersystem extrapolation factors.

Published in:

Xenobiotica, 2004, v. 34, n. 2, p. 151, doi. 10.1080/00498250310001646353

By:

Proctor, N.J.;
Tucker, G.T.;
Rostami-Hodjegan, A.

Publication type:

Article

Determination of drug-metabolizing enzyme activity in vivo : pharmacokinetic and statistical issues.

Published in:

Xenobiotica, 1998, v. 28, n. 12, p. 1255, doi. 10.1080/004982598238895

By:

Tucker, G. T.;
Rostami-Hodjegan, A.;
Jackson, P. R.

Publication type:

Article

GASP and FASP are Complementary for LC–MS/MS Proteomic Analysis of Drug‐Metabolizing Enzymes and Transporters in Pig Liver.

Published in:

Proteomics, 2018, v. 18, n. 24, p. N.PAG, doi. 10.1002/pmic.201800200

By:

Howard, Martyn;
Achour, Brahim;
Al‐Majdoub, Zubida;
Rostami‐Hodjegan, Amin;
Barber, Jill

Publication type:

Article

Application of Physiologically Based Pharmacokinetic (PBPK) Modeling Within a Bayesian Framework to Identify Poor Metabolizers of Efavirenz (PM), Using a Test Dose of Efavirenz.

Published in:

Frontiers in Pharmacology, 2018, p. 1, doi. 10.3389/fphar.2018.00247

By:

Chetty, Manoranjenni;
Cain, Theresa;
Wedagedera, Janak;
Rostami-Hodjegan, Amin;
Jamei, Masoud

Publication type:

Article

Sequence- and schedule-dependent enhancement of zoledronic acid induced apoptosis by doxorubicin in breast and prostate cancer cells.

Published in:

International Journal of Cancer, 2005, v. 113, n. 3, p. 364, doi. 10.1002/ijc.20602

By:

Neville-Webbe, Helen L.;
Rostami-Hodjegan, Amin;
Evans, Catherine A.;
Coleman, Robert E.;
Holen, Ingunn

Publication type:

Article

Precision dosing in clinical medicine: present and future.

Published in:

2018

By:

Polasek, Thomas M.;
Shakib, Sepehr;
Rostami-Hodjegan, Amin

Publication type:

Editorial

Predicting drug-drug interactions: application of physiologically based pharmacokinetic models under a systems biology approach.

Published in:

Expert Review of Clinical Pharmacology, 2013, v. 6, n. 2, p. 143, doi. 10.1586/ECP.13.4

By:

Yeo, Karen Rowland;
Jamei, Masoud;
Rostami-Hodjegan, Amin

Publication type:

Article

Modeling and predicting drug pharmacokinetics in patients with renal impairment.

Published in:

Expert Review of Clinical Pharmacology, 2011, v. 4, n. 2, p. 261, doi. 10.1586/ecp.10.143

By:

Yeo, Karen Rowland;
Aarabi, Mohsen;
Jamei, Masoud;
Rostami-Hodjegan, Amin

Publication type:

Article

Does "Birth" as an Event Impact Maturation Trajectory of Renal Clearance via Glomerular Filtration? Reexamining Data in Preterm and Full‐Term Neonates by Avoiding the Creatinine Bias.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 2, p. 159, doi. 10.1002/jcph.1725

By:

Salem, Farzaneh;
Johnson, Trevor N.;
Hodgkinson, Arran B. J.;
Ogungbenro, Kayode;
Rostami‐Hodjegan, Amin

Publication type:

Article

Physiologically Based Pharmacokinetics as a Component of Model‐Informed Drug Development: Where We Were, Where We Are, and Where We Are Heading.

Published in:

Journal of Clinical Pharmacology, 2020, v. 60, p. S12, doi. 10.1002/jcph.1654

By:

Rostami‐Hodjegan, Amin;
Toon, Stephen

Publication type:

Article

Physiologically Based Pharmacokinetics as a Component of Model‐Informed Drug Development: Where We Were, Where We Are, and Where We Are Heading.

Published in:

Journal of Clinical Pharmacology, 2020, v. 60, p. S12, doi. 10.1002/jcph.1654

By:

Rostami‐Hodjegan, Amin;
Toon, Stephen

Publication type:

Article

Core Entrustable Professional Activities in Clinical Pharmacology: Pearls for Clinical Practice: Drug-Drug and Food-Drug Interactions.

Published in:

Journal of Clinical Pharmacology, 2018, v. 58, n. 6, p. 67, doi. 10.1002/jcph.1088

By:

Hermann, Robert;
Derendorf, Hartmut;
Richter, Oliver;
Rostami‐Hodjegan, Amin

Publication type:

Article

Utility of Model-Based Approaches for Informing Dosing Recommendations in Specific Populations: Report From the Public AAPS Workshop.

Published in:

Journal of Clinical Pharmacology, 2017, v. 57, n. 1, p. 105, doi. 10.1002/jcph.787

By:

Younis, Islam R.;
Robert Powell, J.;
Rostami‐Hodjegan, Amin;
Corrigan, Brian;
Stockbridge, Norman;
Sinha, Vikram;
Zhao, Ping;
Jadhav, Pravin;
Flamion, Bruno;
Cook, Jack

Publication type:

Article

A proposal for scientific framework enabling specific population drug dosing recommendations.

Published in:

Journal of Clinical Pharmacology, 2015, v. 55, n. 10, p. 1073, doi. 10.1002/jcph.579

By:

Jadhav, Pravin R.;
Cook, Jack;
Sinha, Vikram;
Zhao, Ping;
Rostami‐Hodjegan, Amin;
Sahasrabudhe, Vaishali;
Stockbridge, Norman;
Powell, J. Robert

Publication type:

Article

Precision criteria to derive sample size when designing pediatric pharmacokinetic studies: Which measure of variability should be used?

Published in:

Journal of Clinical Pharmacology, 2014, v. 54, n. 3, p. 311, doi. 10.1002/jcph.206

By:

Salem, Farzaneh;
Ogungbenro, Kayode;
Vajjah, Pavan;
Johnson, Trevor N.;
Aarons, Leon;
Rostami‐Hodjegan, Amin

Publication type:

Article

Age Related Changes in Fractional Elimination Pathways for Drugs: Assessing the Impact of Variable Ontogeny on Metabolic Drug-Drug Interactions.

Published in:

Journal of Clinical Pharmacology, 2013, v. 53, n. 8, p. 857, doi. 10.1002/jcph.100

By:

Salem, Farzaneh;
Johnson, Trevor N.;
Barter, Zoe E.;
Leeder, J. Steven;
Rostami‐Hodjegan, Amin

Publication type:

Article

Do Children Have the Same Vulnerability to Metabolic Drug-Drug Interactions as Adults? A Critical Analysis of the Literature.

Published in:

Journal of Clinical Pharmacology, 2013, v. 53, n. 5, p. 559, doi. 10.1002/jcph.13

By:

Salem, Farzaneh;
Rostami‐Hodjegan, Amin;
Johnson, Trevor N.

Publication type:

Article

Do Children Have the Same Vulnerability to Metabolic Drug-Drug Interactions as Adults? A Critical Analysis of the Literature.

Published in:

Journal of Clinical Pharmacology, 2013, v. 53, n. 4, p. 456, doi. 10.1002/jcph.13

By:

Salem, Farzaneh;
Rostami-Hodjegan, Amin;
Johnson, Trevor N.

Publication type:

Article

Single-Dose Pharmacokinetic Study of Clomiphene Citrate Isomers in Anovular Patients With Polycystic Ovary Disease.

Published in:

Journal of Clinical Pharmacology, 2009, v. 49, n. 2, p. 147, doi. 10.1177/0091270008328096

By:

Ghobadi, Cyrus;
Mirhosseini, Nahid;
Shiran, Mohammad Reza;
Moghadamnia, Ali;
Lennard, Martin S.;
Ledger, William L.;
Rostami-Hodjegan, Amin

Publication type:

Article

Incorporating In Vitro Information on Drug Metabolism Into Clinical Trial Simulations to Assess the Effect of CYP2D6 Polymorphism on Pharmacokinetics and Pharmacodynamics: Dextromethorphan as a Model Application.

Published in:

Journal of Clinical Pharmacology, 2007, v. 47, n. 2, p. 175, doi. 10.1177/0091270006294279

By:

Gemma GLD Dickinson;
Saeed SR Rezaee;
Nicholas NJP Proctor;
Martin MSL Lennard;
Geoffrey GTT Tucker;
Amin AR Rostami-Hodjegan

Publication type:

Article

Assessment of In Vivo CYP2D6 Activity: Differential Sensitivity of Commonly Used Probes to Urine pH.

Published in:

Journal of Clinical Pharmacology, 2004, v. 44, n. 12, p. 1398, doi. 10.1177/0091270004269582

By:

Özdemir, Mahmut;
Crewe, Kim H.;
Tucker, Geoffrey T.;
Rostami-Hodjegan, Amin

Publication type:

Article

Dose adjustment in orphan disease populations: the quest to fulfill the requirements of physiologically based pharmacokinetics.

Published in:

Expert Opinion on Drug Metabolism & Toxicology, 2018, v. 14, n. 12, p. 1315, doi. 10.1080/17425255.2018.1546288

By:

Howard, Martyn;
Barber, Jill;
Alizai, Naved;
Rostami-Hodjegan, Amin

Publication type:

Article

Linking in vitro–in vivo extrapolations with physiologically based modeling to inform drug and formulation development.

Published in:

Biopharmaceutics & Drug Disposition, 2023, v. 44, n. 4, p. 289, doi. 10.1002/bdd.2375

By:

Cristofoletti, Rodrigo;
Rostami‐Hodjegan, Amin

Publication type:

Article

In‐depth analysis of patterns in selection of different physiologically‐based pharmacokinetic modeling tools: Part II — Assessment of model reusability and comparison between open and non‐open source‐code software.

Published in:

Biopharmaceutics & Drug Disposition, 2023, v. 44, n. 4, p. 292, doi. 10.1002/bdd.2360

By:

Aldibani, Hamza Khaled Abdelmajed;
Rajput, Arham Jamaal;
Rostami‐Hodjegan, Amin

Publication type:

Article

In‐depth analysis of patterns in selection of different physiologically based pharmacokinetic modeling tools: Part I – Applications and rationale behind the use of open source‐code software.

Published in:

Biopharmaceutics & Drug Disposition, 2023, v. 44, n. 3, p. 274, doi. 10.1002/bdd.2357

By:

Rajput, Arham Jamaal;
Aldibani, Hamza Khaled Abdelmajed;
Rostami‐Hodjegan, Amin

Publication type:

Article

A New Rapidly Absorbed Paracetamol Tablet Containing Sodium Bicarbonate. I. A Four-Way Crossover Study to Compare the Concentration–Time Profile of Paracetamol from the New Paracetamol/Sodium Bicarbonate Tablet and a Conventional Paracetamol...

Published in:

Drug Development & Industrial Pharmacy, 2002, v. 28, n. 5, p. 523, doi. 10.1081/DDC-120003448

By:

Rostami-Hodjegan, A.;
Shiran, M. R.;
Ayesh, R.;
Grattan, T. J.;
Burnett, I.;
Darby-Dowman, A.;
Tucker, G. T.

Publication type:

Article

A New Rapidly Absorbed Paracetamol Tablet Containing Sodium Bicarbonate. II. Dissolution Studies and In Vitro/In Vivo Correlation.

Published in:

Drug Development & Industrial Pharmacy, 2002, v. 28, n. 5, p. 533, doi. 10.1081/DDC-120003449

By:

Rostami-Hodjegan, A.;
Shiran, M. R.;
Tucker, G. T.;
Conway, B. R.;
Irwin, W. J.;
Shaw, L. R.;
Grattan, T. J.

Publication type:

Article

Response from authors.

Published in:

2007

By:

Seivewright, N.;
Dickinson, G. L.;
Rostami-Hodjegan, A.;
Lagundoye, O.;
Lennard, M. S.

Publication type:

Letter

A six-year evaluation of methadone prescribing practices at a substance misuse treatment centre in the UK.

Published in:

Journal of Clinical Pharmacy & Therapeutics, 2006, v. 31, n. 5, p. 477, doi. 10.1111/j.1365-2710.2006.00767.x

By:

Dickinson, G. L.;
Rostami-Hodjegan, A.;
Lagundoye, O.;
Seivewright, N.;
Pratt, P.;
Lennard, M. S.

Publication type:

Article

Editorial: Precision Medicine: Impact of Cytochromes P450 and Transporters Genetic Polymorphisms, Drug-Drug Interactions, Disease on Safety and Efficacy of Drugs.

Published in:

Frontiers in Pharmacology, 2022, v. 12, p. 1, doi. 10.3389/fphar.2021.834717

By:

Daali, Youssef;
Rostami-Hodjegan, Amin;
Samer, Caroline F.

Publication type:

Article

Population-based pharmacokinetic approach for methadone monitoring of opiate addicts: potential clinical utility.

Published in:

Addiction, 2000, v. 95, n. 12, p. 1771, doi. 10.1046/j.1360-0443.2000.951217717.x

By:

Wolff, K.;
Rostami-Hodjegan, A.;
Hay, A. W. M.;
Raistrick, D.;
Tucker, G.

Publication type:

Article

Seeing what is behind the smokescreen: A systematic review of methodological aspects of smoking interaction studies over the last three decades and implications for future clinical trials.

Published in:

CTS: Clinical & Translational Science, 2023, v. 16, n. 5, p. 742, doi. 10.1111/cts.13494

By:

Hermann, Robert;
Rostami‐Hodjegan, Amin;
Zhao, Ping;
Ragueneau‐Majlessi, Isabelle

Publication type:

Article

Revisiting Principles Behind Drug Clearance and Organ Extraction.

Published in:

Clinical Pharmacology & Therapeutics, 2018, v. 103, n. 3, p. 388, doi. 10.1002/cpt.964

By:

Rostami‐hodjegan, Amin

Publication type:

Article

Reverse Translation in PBPK and QSP: Going Backwards in Order to Go Forward With Confidence.

Published in:

Clinical Pharmacology & Therapeutics, 2018, v. 103, n. 2, p. 224, doi. 10.1002/cpt.904

By:

Rostami‐Hodjegan, Amin

Publication type:

Article

Systematic and quantitative assessment of the effect of chronic kidney disease on CYP2D6 and CYP3A4/5.

Published in:

Clinical Pharmacology & Therapeutics, 2016, v. 100, n. 1, p. 75, doi. 10.1002/cpt.337

By:

Yoshida, K;
Sun, B;
Zhang, L;
Zhao, P;
Abernethy, DR;
Nolin, TD;
Rostami‐Hodjegan, A;
Zineh, I;
Huang, S‐M

Publication type:

Article

Identification of the Effect of Multiple Polymorphisms on the Pharmacokinetics of Simvastatin and Simvastatin Acid Using a Population-Modeling Approach.

Published in:

Clinical Pharmacology & Therapeutics, 2014, v. 96, n. 1, p. 90, doi. 10.1038/clpt.2014.55

By:

Tsamandouras, N;
Dickinson, G;
Guo, Y;
Hall, S;
Rostami‐Hodjegan, A;
Galetin, A;
Aarons, L

Publication type:

Article

A Physiologically Based Pharmacokinetic Modeling Approach to Predict Disease-Drug Interactions: Suppression of CYP3A by IL-6.

Published in:

Clinical Pharmacology & Therapeutics, 2013, v. 94, n. 2, p. 260, doi. 10.1038/clpt.2013.79

By:

Machavaram, K K;
Almond, L M;
Rostami‐Hodjegan, A;
Gardner, I;
Jamei, M;
Tay, S;
Wong, S;
Joshi, A;
Kenny, J R

Publication type:

Article

Response to 'The Link Between Pharmacodynamics and Physiologically Based Pharmacokinetic Models'.

Published in:

Clinical Pharmacology & Therapeutics, 2013, v. 93, n. 2, p. 152, doi. 10.1038/clpt.2012.216

By:

Rostami‐Hodjegan, A

Publication type:

Article

Physiologically Based Pharmacokinetics Joined With In Vitro-In Vivo Extrapolation of ADME: A Marriage Under the Arch of Systems Pharmacology.

Published in:

Clinical Pharmacology & Therapeutics, 2012, v. 92, n. 1, p. 50, doi. 10.1038/clpt.2012.65

By:

Rostami-Hodjegan, A

Publication type:

Article