Works by Rostami-Hodjegan, Amin

Results: 150

Pharmacotherapy in kidney disease: what it takes to move from general guidance to specific recommendations to stratified subgroups of patients - the tale of autosomal dominant polycystic kidney disease (ADPKD).

Published in:

Expert Opinion on Drug Metabolism & Toxicology, 2025, v. 21, n. 6, p. 677, doi. 10.1080/17425255.2025.2501127

By:

Tillmann, Annika C.;
Rostami-Hodjegan, Amin;
Barber, Jill;
Al-Majdoub, Zubida M.

Publication type:

Article

Evaluation of Adefovir PBPK Model to Assess Biomarker‐Informed OAT1 Drug–Drug Interaction and Effect of Chronic Kidney Disease.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2025, v. 14, n. 5, p. 964, doi. 10.1002/psp4.70010

By:

Tan, Shawn Pei Feng;
Wu, Huaying;
Rostami‐Hodjegan, Amin;
Scotcher, Daniel;
Galetin, Aleksandra

Publication type:

Article

Resurgence in the use of physiologically based pharmacokinetic models in pediatric clinical pharmacology: parallel shift in incorporating the knowledge of biological elements and increased applicability to drug development and clinical practice.

Published in:

Pediatric Anesthesia, 2011, v. 21, n. 3, p. 291, doi. 10.1111/j.1460-9592.2010.03323.x

By:

Johnson, Trevor N.;
Rostami-Hodjegan, Amin

Publication type:

Article

A mechanistic pharmacokinetic model to assess modified oral drug bioavailability post bariatric surgery in morbidly obese patients: interplay between CYP3A gut wall metabolism, permeability and dissolution.

Published in:

Journal of Pharmacy & Pharmacology, 2012, v. 64, n. 7, p. 1008, doi. 10.1111/j.2042-7158.2012.01538.x

By:

Darwich, Adam S.;
Pade, Devendra;
Ammori, Basil J.;
Jamei, Masoud;
Ashcroft, Darren M.;
Rostami-Hodjegan, Amin

Publication type:

Article

Editorial.

Published in:

Xenobiotica, 2007, v. 37, n. 10/11, p. 1013, doi. 10.1080/00498250701649873

By:

GIBSON, G. GORDON;
ROSTAMI-HODJEGAN, AMIN

Publication type:

Article

GASP and FASP are Complementary for LC–MS/MS Proteomic Analysis of Drug‐Metabolizing Enzymes and Transporters in Pig Liver.

Published in:

Proteomics, 2018, v. 18, n. 24, p. N.PAG, doi. 10.1002/pmic.201800200

By:

Howard, Martyn;
Achour, Brahim;
Al‐Majdoub, Zubida;
Rostami‐Hodjegan, Amin;
Barber, Jill

Publication type:

Article

Application of Physiologically Based Pharmacokinetic (PBPK) Modeling Within a Bayesian Framework to Identify Poor Metabolizers of Efavirenz (PM), Using a Test Dose of Efavirenz.

Published in:

Frontiers in Pharmacology, 2018, p. 1, doi. 10.3389/fphar.2018.00247

By:

Chetty, Manoranjenni;
Cain, Theresa;
Wedagedera, Janak;
Rostami-Hodjegan, Amin;
Jamei, Masoud

Publication type:

Article

Sequence- and schedule-dependent enhancement of zoledronic acid induced apoptosis by doxorubicin in breast and prostate cancer cells.

Published in:

International Journal of Cancer, 2005, v. 113, n. 3, p. 364, doi. 10.1002/ijc.20602

By:

Neville-Webbe, Helen L.;
Rostami-Hodjegan, Amin;
Evans, Catherine A.;
Coleman, Robert E.;
Holen, Ingunn

Publication type:

Article

Precision dosing in clinical medicine: present and future.

Published in:

2018

By:

Polasek, Thomas M.;
Shakib, Sepehr;
Rostami-Hodjegan, Amin

Publication type:

Editorial

Predicting drug-drug interactions: application of physiologically based pharmacokinetic models under a systems biology approach.

Published in:

Expert Review of Clinical Pharmacology, 2013, v. 6, n. 2, p. 143, doi. 10.1586/ECP.13.4

By:

Yeo, Karen Rowland;
Jamei, Masoud;
Rostami-Hodjegan, Amin

Publication type:

Article

Modeling and predicting drug pharmacokinetics in patients with renal impairment.

Published in:

Expert Review of Clinical Pharmacology, 2011, v. 4, n. 2, p. 261, doi. 10.1586/ecp.10.143

By:

Yeo, Karen Rowland;
Aarabi, Mohsen;
Jamei, Masoud;
Rostami-Hodjegan, Amin

Publication type:

Article

Does "Birth" as an Event Impact Maturation Trajectory of Renal Clearance via Glomerular Filtration? Reexamining Data in Preterm and Full‐Term Neonates by Avoiding the Creatinine Bias.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 2, p. 159, doi. 10.1002/jcph.1725

By:

Salem, Farzaneh;
Johnson, Trevor N.;
Hodgkinson, Arran B. J.;
Ogungbenro, Kayode;
Rostami‐Hodjegan, Amin

Publication type:

Article

Physiologically Based Pharmacokinetics as a Component of Model‐Informed Drug Development: Where We Were, Where We Are, and Where We Are Heading.

Published in:

Journal of Clinical Pharmacology, 2020, v. 60, p. S12, doi. 10.1002/jcph.1654

By:

Rostami‐Hodjegan, Amin;
Toon, Stephen

Publication type:

Article

Physiologically Based Pharmacokinetics as a Component of Model‐Informed Drug Development: Where We Were, Where We Are, and Where We Are Heading.

Published in:

Journal of Clinical Pharmacology, 2020, v. 60, p. S12, doi. 10.1002/jcph.1654

By:

Rostami‐Hodjegan, Amin;
Toon, Stephen

Publication type:

Article

Core Entrustable Professional Activities in Clinical Pharmacology: Pearls for Clinical Practice: Drug-Drug and Food-Drug Interactions.

Published in:

Journal of Clinical Pharmacology, 2018, v. 58, n. 6, p. 67, doi. 10.1002/jcph.1088

By:

Hermann, Robert;
Derendorf, Hartmut;
Richter, Oliver;
Rostami‐Hodjegan, Amin

Publication type:

Article

Utility of Model-Based Approaches for Informing Dosing Recommendations in Specific Populations: Report From the Public AAPS Workshop.

Published in:

Journal of Clinical Pharmacology, 2017, v. 57, n. 1, p. 105, doi. 10.1002/jcph.787

By:

Younis, Islam R.;
Robert Powell, J.;
Rostami‐Hodjegan, Amin;
Corrigan, Brian;
Stockbridge, Norman;
Sinha, Vikram;
Zhao, Ping;
Jadhav, Pravin;
Flamion, Bruno;
Cook, Jack

Publication type:

Article

A proposal for scientific framework enabling specific population drug dosing recommendations.

Published in:

Journal of Clinical Pharmacology, 2015, v. 55, n. 10, p. 1073, doi. 10.1002/jcph.579

By:

Jadhav, Pravin R.;
Cook, Jack;
Sinha, Vikram;
Zhao, Ping;
Rostami‐Hodjegan, Amin;
Sahasrabudhe, Vaishali;
Stockbridge, Norman;
Powell, J. Robert

Publication type:

Article

Precision criteria to derive sample size when designing pediatric pharmacokinetic studies: Which measure of variability should be used?

Published in:

Journal of Clinical Pharmacology, 2014, v. 54, n. 3, p. 311, doi. 10.1002/jcph.206

By:

Salem, Farzaneh;
Ogungbenro, Kayode;
Vajjah, Pavan;
Johnson, Trevor N.;
Aarons, Leon;
Rostami‐Hodjegan, Amin

Publication type:

Article

Age Related Changes in Fractional Elimination Pathways for Drugs: Assessing the Impact of Variable Ontogeny on Metabolic Drug-Drug Interactions.

Published in:

Journal of Clinical Pharmacology, 2013, v. 53, n. 8, p. 857, doi. 10.1002/jcph.100

By:

Salem, Farzaneh;
Johnson, Trevor N.;
Barter, Zoe E.;
Leeder, J. Steven;
Rostami‐Hodjegan, Amin

Publication type:

Article

Do Children Have the Same Vulnerability to Metabolic Drug-Drug Interactions as Adults? A Critical Analysis of the Literature.

Published in:

Journal of Clinical Pharmacology, 2013, v. 53, n. 5, p. 559, doi. 10.1002/jcph.13

By:

Salem, Farzaneh;
Rostami‐Hodjegan, Amin;
Johnson, Trevor N.

Publication type:

Article

Do Children Have the Same Vulnerability to Metabolic Drug-Drug Interactions as Adults? A Critical Analysis of the Literature.

Published in:

Journal of Clinical Pharmacology, 2013, v. 53, n. 4, p. 456, doi. 10.1002/jcph.13

By:

Salem, Farzaneh;
Rostami-Hodjegan, Amin;
Johnson, Trevor N.

Publication type:

Article

Single-Dose Pharmacokinetic Study of Clomiphene Citrate Isomers in Anovular Patients With Polycystic Ovary Disease.

Published in:

Journal of Clinical Pharmacology, 2009, v. 49, n. 2, p. 147, doi. 10.1177/0091270008328096

By:

Ghobadi, Cyrus;
Mirhosseini, Nahid;
Shiran, Mohammad Reza;
Moghadamnia, Ali;
Lennard, Martin S.;
Ledger, William L.;
Rostami-Hodjegan, Amin

Publication type:

Article

Incorporating In Vitro Information on Drug Metabolism Into Clinical Trial Simulations to Assess the Effect of CYP2D6 Polymorphism on Pharmacokinetics and Pharmacodynamics: Dextromethorphan as a Model Application.

Published in:

Journal of Clinical Pharmacology, 2007, v. 47, n. 2, p. 175, doi. 10.1177/0091270006294279

By:

Gemma GLD Dickinson;
Saeed SR Rezaee;
Nicholas NJP Proctor;
Martin MSL Lennard;
Geoffrey GTT Tucker;
Amin AR Rostami-Hodjegan

Publication type:

Article

Assessment of In Vivo CYP2D6 Activity: Differential Sensitivity of Commonly Used Probes to Urine pH.

Published in:

Journal of Clinical Pharmacology, 2004, v. 44, n. 12, p. 1398, doi. 10.1177/0091270004269582

By:

Özdemir, Mahmut;
Crewe, Kim H.;
Tucker, Geoffrey T.;
Rostami-Hodjegan, Amin

Publication type:

Article

Dose adjustment in orphan disease populations: the quest to fulfill the requirements of physiologically based pharmacokinetics.

Published in:

Expert Opinion on Drug Metabolism & Toxicology, 2018, v. 14, n. 12, p. 1315, doi. 10.1080/17425255.2018.1546288

By:

Howard, Martyn;
Barber, Jill;
Alizai, Naved;
Rostami-Hodjegan, Amin

Publication type:

Article

Linking in vitro–in vivo extrapolations with physiologically based modeling to inform drug and formulation development.

Published in:

Biopharmaceutics & Drug Disposition, 2023, v. 44, n. 4, p. 289, doi. 10.1002/bdd.2375

By:

Cristofoletti, Rodrigo;
Rostami‐Hodjegan, Amin

Publication type:

Article

In‐depth analysis of patterns in selection of different physiologically‐based pharmacokinetic modeling tools: Part II — Assessment of model reusability and comparison between open and non‐open source‐code software.

Published in:

Biopharmaceutics & Drug Disposition, 2023, v. 44, n. 4, p. 292, doi. 10.1002/bdd.2360

By:

Aldibani, Hamza Khaled Abdelmajed;
Rajput, Arham Jamaal;
Rostami‐Hodjegan, Amin

Publication type:

Article

In‐depth analysis of patterns in selection of different physiologically based pharmacokinetic modeling tools: Part I – Applications and rationale behind the use of open source‐code software.

Published in:

Biopharmaceutics & Drug Disposition, 2023, v. 44, n. 3, p. 274, doi. 10.1002/bdd.2357

By:

Rajput, Arham Jamaal;
Aldibani, Hamza Khaled Abdelmajed;
Rostami‐Hodjegan, Amin

Publication type:

Article

Editorial: Precision Medicine: Impact of Cytochromes P450 and Transporters Genetic Polymorphisms, Drug-Drug Interactions, Disease on Safety and Efficacy of Drugs.

Published in:

Frontiers in Pharmacology, 2022, v. 12, p. 1, doi. 10.3389/fphar.2021.834717

By:

Daali, Youssef;
Rostami-Hodjegan, Amin;
Samer, Caroline F.

Publication type:

Article

Seeing what is behind the smokescreen: A systematic review of methodological aspects of smoking interaction studies over the last three decades and implications for future clinical trials.

Published in:

CTS: Clinical & Translational Science, 2023, v. 16, n. 5, p. 742, doi. 10.1111/cts.13494

By:

Hermann, Robert;
Rostami‐Hodjegan, Amin;
Zhao, Ping;
Ragueneau‐Majlessi, Isabelle

Publication type:

Article

Revisiting Principles Behind Drug Clearance and Organ Extraction.

Published in:

Clinical Pharmacology & Therapeutics, 2018, v. 103, n. 3, p. 388, doi. 10.1002/cpt.964

By:

Rostami‐hodjegan, Amin

Publication type:

Article

Reverse Translation in PBPK and QSP: Going Backwards in Order to Go Forward With Confidence.

Published in:

Clinical Pharmacology & Therapeutics, 2018, v. 103, n. 2, p. 224, doi. 10.1002/cpt.904

By:

Rostami‐Hodjegan, Amin

Publication type:

Article

Cytochrome P450 3A expression and activity in the human small intestine.

Published in:

Clinical Pharmacology & Therapeutics, 2004, v. 76, n. 4, p. 391, doi. 10.1016/j.clpt.2004.07.001

By:

Yang, Jiansong;
Tucker, Geoffrey T.;
Rostami-Hodjegan, Amin

Publication type:

Article

Accounting for inter-correlation between enzyme abundance: a simulation study to assess implications on global sensitivity analysis within physiologically-based pharmacokinetics.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2019, v. 46, n. 2, p. 137, doi. 10.1007/s10928-019-09627-6

By:

Melillo, Nicola;
Darwich, Adam S.;
Magni, Paolo;
Rostami-Hodjegan, Amin

Publication type:

Article

Incorporation of stochastic variability in mechanistic population pharmacokinetic models: handling the physiological constraints using normal transformations.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2015, v. 42, n. 4, p. 349, doi. 10.1007/s10928-015-9418-0

By:

Tsamandouras, Nikolaos;
Wendling, Thierry;
Rostami-Hodjegan, Amin;
Galetin, Aleksandra;
Aarons, Leon

Publication type:

Article

Simulation and prediction of in vivo drug metabolism in human populations from in vitro data.

Published in:

Nature Reviews Drug Discovery, 2007, v. 6, n. 2, p. 140, doi. 10.1038/nrd2173

By:

Rostami-Hodjegan, Amin;
Tucker, Geoffrey T.

Publication type:

Article

Prediction of the pharmacokinetics, pharmacodynamics, and efficacy of a monoclonal antibody, using a physiologically based pharmacokinetic FcRn model.

Published in:

Frontiers in Immunology, 2015, v. 5, p. 1, doi. 10.3389/fimmu.2014.00670

By:

Chetty, Manoranjenni;
Linzhong Li;
Rose, Rachel;
Machavaram, Krishna;
Jamei, Masoud;
Rostami-Hodjegan, Amin;
Gardner, Iain;
Frenkel, Dan;
Olive, Daniel

Publication type:

Article

A close examination of BCRP's role in lactation and methods for predicting drug distribution into milk.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2024, v. 13, n. 11, p. 1856, doi. 10.1002/psp4.13243

By:

Sychterz, Caroline;
Shen, Hong;
Zhang, Yueping;
Sinz, Michael;
Rostami‐Hodjegan, Amin;
Schmidt, Brian J.;
Gaohua, Lu;
Galetin, Aleksandra

Publication type:

Article

A guide to developing population files for physiologically‐based pharmacokinetic modeling in the Simcyp Simulator.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2024, v. 13, n. 9, p. 1429, doi. 10.1002/psp4.13202

By:

Curry, Liam;
Alrubia, Sarah;
Bois, Frederic Y.;
Clayton, Ruth;
El‐Khateeb, Eman;
Johnson, Trevor N.;
Faisal, Muhammad;
Neuhoff, Sibylle;
Wragg, Kris;
Rostami‐Hodjegan, Amin

Publication type:

Article

Virtual twins for model‐informed precision dosing of clozapine in patients with treatment‐resistant schizophrenia.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2024, v. 13, n. 3, p. 424, doi. 10.1002/psp4.13093

By:

Mostafa, Sam;
Rafizadeh, Reza;
Polasek, Thomas M.;
Bousman, Chad A.;
Rostami‐Hodjegan, Amin;
Stowe, Robert;
Carrion, Prescilla;
Sheffield, Leslie J.;
Kirkpatrick, Carl M. J.

Publication type:

Article

Delineating gene–environment effects using virtual twins of patients treated with clozapine.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2023, v. 12, n. 2, p. 168, doi. 10.1002/psp4.12886

By:

Mostafa, Sam;
Polasek, Thomas M.;
Bousman, Chad;
Rostami‐Hodjegan, Amin;
Sheffield, Leslie J.;
Everall, Ian;
Pantelis, Christos;
Kirkpatrick, Carl M. J.

Publication type:

Article

Opening a debate on open‐source modeling tools: Pouring fuel on fire versus extinguishing the flare of a healthy debate.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2021, v. 10, n. 5, p. 420, doi. 10.1002/psp4.12615

By:

Rostami‐Hodjegan, Amin;
Bois, Frederic Y.

Publication type:

Article

Population pharmacokinetic modeling and simulation to support qualification of pyridoxic acid as endogenous biomarker of OAT1/3 renal transporters.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2021, v. 10, n. 5, p. 467, doi. 10.1002/psp4.12610

By:

Ahmad, Amais;
Ogungbenro, Kayode;
Kunze, Annett;
Jacobs, Frank;
Snoeys, Jan;
Rostami‐Hodjegan, Amin;
Galetin, Aleksandra

Publication type:

Article

Application of the Nested Enzyme‐Within‐Enterocyte (NEWE) Turnover Model for Predicting the Time Course of Pharmacodynamic Effects.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2020, v. 9, n. 11, p. 617, doi. 10.1002/psp4.12557

By:

Takita, Hiroyuki;
Darwich, Adam S.;
Ahmad, Amais;
Rostami‐Hodjegan, Amin

Publication type:

Article

A Novel Physiologically Based Model of Creatinine Renal Disposition to Integrate Current Knowledge of Systems Parameters and Clinical Observations.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2020, v. 9, n. 6, p. 310, doi. 10.1002/psp4.12509

By:

Scotcher, Daniel;
Arya, Vikram;
Yang, Xinning;
Zhao, Ping;
Zhang, Lei;
Huang, Shiew‐Mei;
Rostami‐Hodjegan, Amin;
Galetin, Aleksandra

Publication type:

Article

Mechanistic Models as Framework for Understanding Biomarker Disposition: Prediction of Creatinine‐Drug Interactions.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2020, v. 9, n. 5, p. 282, doi. 10.1002/psp4.12508

By:

Scotcher, Daniel;
Arya, Vikram;
Yang, Xinning;
Zhao, Ping;
Zhang, Lei;
Huang, Shiew‐Mei;
Rostami‐Hodjegan, Amin;
Galetin, Aleksandra

Publication type:

Article

Assessing Potential Drug–Drug Interactions Between Dabigatran Etexilate and a P‐Glycoprotein Inhibitor in Renal Impairment Populations Using Physiologically Based Pharmacokinetic Modeling.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2019, v. 8, n. 2, p. 118, doi. 10.1002/psp4.12382

By:

Doki, Kosuke;
Neuhoff, Sibylle;
Rostami‐Hodjegan, Amin;
Homma, Masato

Publication type:

Article

First‐Pass CYP3A‐Mediated Metabolism of Midazolam in the Gut Wall and Liver in Preterm Neonates.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2018, v. 7, n. 6, p. 374, doi. 10.1002/psp4.12295

By:

Brussee, Janneke M.;
Yu, Huixin;
Krekels, Elke H. J.;
de Roos, Berend;
Brill, Margreke J. E.;
van den Anker, Johannes N.;
Rostami‐Hodjegan, Amin;
de Wildt, Saskia N.;
Knibbe, Catherijne A. J.

Publication type:

Article

Drugs Being Eliminated via the Same Pathway Will Not Always Require Similar Pediatric Dose Adjustments.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2018, v. 7, n. 3, p. 175, doi. 10.1002/psp4.12273

By:

Calvier, Elisa A. M.;
Krekels, Elke H. J.;
Yu, Huixin;
Välitalo, Pyry A. J.;
Johnson, Trevor N.;
Rostami‐Hodjegan, Amin;
Tibboel, Dick;
van der Graaf, Piet H.;
Danhof, Meindert;
Knibbe, Catherijne A. J.

Publication type:

Article

Weight-related dosing, timing and monitoring hydrocortisone replacement therapy in patients with adrenal insufficiency.

Published in:

Clinical Endocrinology, 2004, v. 61, n. 3, p. 367, doi. 10.1111/j.1365-2265.2004.02106.x

By:

Mah, Peak M.;
Jenkins, Richard C.;
Rostami-Hodjegan, Amin;
Newell-Price, John;
Doane, Anita;
Ibbotson, Victoria;
Tuckerf, Geoffrey T.;
Ross, Richard J.

Publication type:

Article