Works matching AU Rostami-Hodjegan, Amin

Results: 152

The quest to define cancer-specific systems parameters for personalized dosing in oncology.

Published in:

Expert Opinion on Drug Metabolism & Toxicology, 2025, v. 21, n. 5, p. 599, doi. 10.1080/17425255.2025.2476560

By:

Vasilogianni, Areti-Maria;
Achour, Brahim;
Al-Majdoub, Zubida M.;
Peters, Sheila Annie;
Barber, Jill;
Rostami-Hodjegan, Amin

Publication type:

Article

Advances in Physiologically Based Pharmacokinetic (PBPK) Modeling and its Regulatory Utility to Support Oral Drug Product Development and Harmonization.

Published in:

Pharmaceutical Research, 2025, v. 42, n. 5, p. 819, doi. 10.1007/s11095-025-03849-9

By:

Cheng, Yi-Hsien;
Thomas, Sherin;
Tsang, Yu Chung;
Almeida, Susana;
Ashraf, Muhammad;
Fotaki, Nikoletta;
Heimbach, Tycho;
Patel, Nikunjkumar;
Shah, Harshil;
Jiang, Xiaojian;
Kim, Myong-Jin;
Moody, Rebecca;
Rostami‐Hodjegan, Amin;
Singh, Romi;
Zhao, Liang;
Babiskin, Andrew;
Wu, Fang

Publication type:

Article

Does previous response to clomifene citrate influence the selection of gonadotropin dosage given in subsequent superovulation treatment cycles?

Published in:

Journal of Assisted Reproduction & Genetics, 2006, v. 23, n. 11/12, p. 427, doi. 10.1007/s10815-006-9065-x

By:

Tien Huu Nguyen;
Lennard, Martin S.;
Ghobadi, Cyrus;
Rostami-Hodjegan, Amin;
Ledger, William L.

Publication type:

Article

Application of in vitro-in vivo extrapolation (IVIVE) and physiologically based pharmacokinetic (PBPK) modelling to investigate the impact of the CYP2C8 polymorphism on rosiglitazone exposure.

Published in:

European Journal of Clinical Pharmacology, 2013, v. 69, n. 6, p. 1311, doi. 10.1007/s00228-012-1467-3

By:

Yeo, Karen;
Kenny, Jane;
Rostami-Hodjegan, Amin

Publication type:

Article

Assessment of inter-individual variability in predicted phenytoin clearance.

Published in:

European Journal of Clinical Pharmacology, 2009, v. 65, n. 12, p. 1203, doi. 10.1007/s00228-009-0703-y

By:

Polasek, Thomas M.;
Polak, Sebastian;
Doogue, Matthew P.;
Rostami-Hodjegan, Amin;
Miners, John O.

Publication type:

Article

Changes to methadone clearance during pregnancy.

Published in:

European Journal of Clinical Pharmacology, 2005, v. 61, n. 10, p. 763, doi. 10.1007/s00228-005-0035-5

By:

Kim Wolff;
Boys, Annabel;
Rostami-Hodjegan, Amin;
Hay, Alastair;
Raistrick, Duncan

Publication type:

Article

Does "Birth" as an Event Impact Maturation Trajectory of Renal Clearance via Glomerular Filtration? Reexamining Data in Preterm and Full‐Term Neonates by Avoiding the Creatinine Bias.

Published in:

Journal of Clinical Pharmacology, 2021, v. 61, n. 2, p. 159, doi. 10.1002/jcph.1725

By:

Salem, Farzaneh;
Johnson, Trevor N.;
Hodgkinson, Arran B. J.;
Ogungbenro, Kayode;
Rostami‐Hodjegan, Amin

Publication type:

Article

Physiologically Based Pharmacokinetics as a Component of Model‐Informed Drug Development: Where We Were, Where We Are, and Where We Are Heading.

Published in:

Journal of Clinical Pharmacology, 2020, v. 60, p. S12, doi. 10.1002/jcph.1654

By:

Rostami‐Hodjegan, Amin;
Toon, Stephen

Publication type:

Article

Physiologically Based Pharmacokinetics as a Component of Model‐Informed Drug Development: Where We Were, Where We Are, and Where We Are Heading.

Published in:

Journal of Clinical Pharmacology, 2020, v. 60, p. S12, doi. 10.1002/jcph.1654

By:

Rostami‐Hodjegan, Amin;
Toon, Stephen

Publication type:

Article

Proteomic characterisation of drug metabolising enzymes and drug transporters in pig liver.

Published in:

Xenobiotica, 2020, v. 50, n. 10, p. 1208, doi. 10.1080/00498254.2020.1763513

By:

Elmorsi, Yasmine;
Al Feteisi, Hajar;
Al-Majdoub, Zubida M.;
Barber, Jill;
Rostami-Hodjegan, Amin;
Achour, Brahim

Publication type:

Article

Modified-release hydrocortisone to provide circadian cortisol profiles.

Published in:

2009

By:

Debono, Miguel;
Ghobadi, Cyrus;
Rostami-Hodjegan, Amin;
Huatan, Hiep;
Campbell, Michael J;
Newell-Price, John;
Darzy, Ken;
Merke, Deborah P;
Arlt, Wiebke;
Ross, Richard J

Publication type:

journal article

Evaluation of Adefovir PBPK Model to Assess Biomarker‐Informed OAT1 Drug–Drug Interaction and Effect of Chronic Kidney Disease.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2025, v. 14, n. 5, p. 964, doi. 10.1002/psp4.70010

By:

Tan, Shawn Pei Feng;
Wu, Huaying;
Rostami‐Hodjegan, Amin;
Scotcher, Daniel;
Galetin, Aleksandra

Publication type:

Article

A close examination of BCRP's role in lactation and methods for predicting drug distribution into milk.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2024, v. 13, n. 11, p. 1856, doi. 10.1002/psp4.13243

By:

Sychterz, Caroline;
Shen, Hong;
Zhang, Yueping;
Sinz, Michael;
Rostami‐Hodjegan, Amin;
Schmidt, Brian J.;
Gaohua, Lu;
Galetin, Aleksandra

Publication type:

Article

A guide to developing population files for physiologically‐based pharmacokinetic modeling in the Simcyp Simulator.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2024, v. 13, n. 9, p. 1429, doi. 10.1002/psp4.13202

By:

Curry, Liam;
Alrubia, Sarah;
Bois, Frederic Y.;
Clayton, Ruth;
El‐Khateeb, Eman;
Johnson, Trevor N.;
Faisal, Muhammad;
Neuhoff, Sibylle;
Wragg, Kris;
Rostami‐Hodjegan, Amin

Publication type:

Article

Virtual twins for model‐informed precision dosing of clozapine in patients with treatment‐resistant schizophrenia.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2024, v. 13, n. 3, p. 424, doi. 10.1002/psp4.13093

By:

Mostafa, Sam;
Rafizadeh, Reza;
Polasek, Thomas M.;
Bousman, Chad A.;
Rostami‐Hodjegan, Amin;
Stowe, Robert;
Carrion, Prescilla;
Sheffield, Leslie J.;
Kirkpatrick, Carl M. J.

Publication type:

Article

Delineating gene–environment effects using virtual twins of patients treated with clozapine.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2023, v. 12, n. 2, p. 168, doi. 10.1002/psp4.12886

By:

Mostafa, Sam;
Polasek, Thomas M.;
Bousman, Chad;
Rostami‐Hodjegan, Amin;
Sheffield, Leslie J.;
Everall, Ian;
Pantelis, Christos;
Kirkpatrick, Carl M. J.

Publication type:

Article

Opening a debate on open‐source modeling tools: Pouring fuel on fire versus extinguishing the flare of a healthy debate.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2021, v. 10, n. 5, p. 420, doi. 10.1002/psp4.12615

By:

Rostami‐Hodjegan, Amin;
Bois, Frederic Y.

Publication type:

Article

Population pharmacokinetic modeling and simulation to support qualification of pyridoxic acid as endogenous biomarker of OAT1/3 renal transporters.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2021, v. 10, n. 5, p. 467, doi. 10.1002/psp4.12610

By:

Ahmad, Amais;
Ogungbenro, Kayode;
Kunze, Annett;
Jacobs, Frank;
Snoeys, Jan;
Rostami‐Hodjegan, Amin;
Galetin, Aleksandra

Publication type:

Article

Application of the Nested Enzyme‐Within‐Enterocyte (NEWE) Turnover Model for Predicting the Time Course of Pharmacodynamic Effects.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2020, v. 9, n. 11, p. 617, doi. 10.1002/psp4.12557

By:

Takita, Hiroyuki;
Darwich, Adam S.;
Ahmad, Amais;
Rostami‐Hodjegan, Amin

Publication type:

Article

A Novel Physiologically Based Model of Creatinine Renal Disposition to Integrate Current Knowledge of Systems Parameters and Clinical Observations.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2020, v. 9, n. 6, p. 310, doi. 10.1002/psp4.12509

By:

Scotcher, Daniel;
Arya, Vikram;
Yang, Xinning;
Zhao, Ping;
Zhang, Lei;
Huang, Shiew‐Mei;
Rostami‐Hodjegan, Amin;
Galetin, Aleksandra

Publication type:

Article

Mechanistic Models as Framework for Understanding Biomarker Disposition: Prediction of Creatinine‐Drug Interactions.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2020, v. 9, n. 5, p. 282, doi. 10.1002/psp4.12508

By:

Scotcher, Daniel;
Arya, Vikram;
Yang, Xinning;
Zhao, Ping;
Zhang, Lei;
Huang, Shiew‐Mei;
Rostami‐Hodjegan, Amin;
Galetin, Aleksandra

Publication type:

Article

Assessing Potential Drug–Drug Interactions Between Dabigatran Etexilate and a P‐Glycoprotein Inhibitor in Renal Impairment Populations Using Physiologically Based Pharmacokinetic Modeling.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2019, v. 8, n. 2, p. 118, doi. 10.1002/psp4.12382

By:

Doki, Kosuke;
Neuhoff, Sibylle;
Rostami‐Hodjegan, Amin;
Homma, Masato

Publication type:

Article

First‐Pass CYP3A‐Mediated Metabolism of Midazolam in the Gut Wall and Liver in Preterm Neonates.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2018, v. 7, n. 6, p. 374, doi. 10.1002/psp4.12295

By:

Brussee, Janneke M.;
Yu, Huixin;
Krekels, Elke H. J.;
de Roos, Berend;
Brill, Margreke J. E.;
van den Anker, Johannes N.;
Rostami‐Hodjegan, Amin;
de Wildt, Saskia N.;
Knibbe, Catherijne A. J.

Publication type:

Article

Drugs Being Eliminated via the Same Pathway Will Not Always Require Similar Pediatric Dose Adjustments.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2018, v. 7, n. 3, p. 175, doi. 10.1002/psp4.12273

By:

Calvier, Elisa A. M.;
Krekels, Elke H. J.;
Yu, Huixin;
Välitalo, Pyry A. J.;
Johnson, Trevor N.;
Rostami‐Hodjegan, Amin;
Tibboel, Dick;
van der Graaf, Piet H.;
Danhof, Meindert;
Knibbe, Catherijne A. J.

Publication type:

Article

Toward Dynamic Prescribing Information: Codevelopment of Companion Model‐Informed Precision Dosing Tools in Drug Development.

Published in:

Clinical Pharmacology in Drug Development, 2019, v. 8, n. 4, p. 418, doi. 10.1002/cpdd.638

By:

Polasek, Thomas M.;
Rayner, Craig R.;
Peck, Richard W.;
Rowland, Andrew;
Kimko, Holly;
Rostami‐Hodjegan, Amin

Publication type:

Article

Applications of linking PBPK and PD models to predict the impact of genotypic variability, formulation differences, differences in target binding capacity and target site drug concentrations on drug responses and variability.

Published in:

Frontiers in Pharmacology, 2014, v. 5, p. 1, doi. 10.3389/fphar.2014.00258

By:

Chetty, Manoranjenni;
Rose, Rachel H.;
Abduljalil, Khaled;
Patel, Nikunjkumar;
Gaohua Lu;
Cain, Theresa;
Jamei, Masoud;
Rostami-Hodjegan, Amin;
Bruno, Valeria;
Hempel, Georg

Publication type:

Article

Review article: time to revisit Child‐Pugh score as the basis for predicting drug clearance in hepatic impairment.

Published in:

Alimentary Pharmacology & Therapeutics, 2021, v. 54, n. 4, p. 388, doi. 10.1111/apt.16489

By:

El‐Khateeb, Eman;
Darwich, Adam S.;
Achour, Brahim;
Athwal, Varinder;
Rostami‐Hodjegan, Amin

Publication type:

Article

Bringing Microphysiological Systems to Practical Use: Evaluation of transporter‐mediated DDI and Renal Clearance.

Published in:

FASEB Journal, 2021, v. 35, p. N.PAG, doi. 10.1096/fasebj.2021.35.S1.03468

By:

van der Made, Thomas;
Moss, Darren;
Scotcher, Daniel;
Rostami‐Hodjegan, Amin;
Galetin, Aleksandra

Publication type:

Article

Prediction of the clearance of eleven drugs and associated variability in neonates, infants and children.

Published in:

2006

By:

Johnson, Trevor N.;
Rostami-Hodjegan, Amin;
Tucker, Geoffrey T.

Publication type:

journal article

Accounting for inter-correlation between enzyme abundance: a simulation study to assess implications on global sensitivity analysis within physiologically-based pharmacokinetics.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2019, v. 46, n. 2, p. 137, doi. 10.1007/s10928-019-09627-6

By:

Melillo, Nicola;
Darwich, Adam S.;
Magni, Paolo;
Rostami-Hodjegan, Amin

Publication type:

Article

Incorporation of stochastic variability in mechanistic population pharmacokinetic models: handling the physiological constraints using normal transformations.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2015, v. 42, n. 4, p. 349, doi. 10.1007/s10928-015-9418-0

By:

Tsamandouras, Nikolaos;
Wendling, Thierry;
Rostami-Hodjegan, Amin;
Galetin, Aleksandra;
Aarons, Leon

Publication type:

Article

Simulation and prediction of in vivo drug metabolism in human populations from in vitro data.

Published in:

Nature Reviews Drug Discovery, 2007, v. 6, n. 2, p. 140, doi. 10.1038/nrd2173

By:

Rostami-Hodjegan, Amin;
Tucker, Geoffrey T.

Publication type:

Article

Core Entrustable Professional Activities in Clinical Pharmacology: Pearls for Clinical Practice: Drug-Drug and Food-Drug Interactions.

Published in:

Journal of Clinical Pharmacology, 2018, v. 58, n. 6, p. 67, doi. 10.1002/jcph.1088

By:

Hermann, Robert;
Derendorf, Hartmut;
Richter, Oliver;
Rostami‐Hodjegan, Amin

Publication type:

Article

Utility of Model-Based Approaches for Informing Dosing Recommendations in Specific Populations: Report From the Public AAPS Workshop.

Published in:

Journal of Clinical Pharmacology, 2017, v. 57, n. 1, p. 105, doi. 10.1002/jcph.787

By:

Younis, Islam R.;
Robert Powell, J.;
Rostami‐Hodjegan, Amin;
Corrigan, Brian;
Stockbridge, Norman;
Sinha, Vikram;
Zhao, Ping;
Jadhav, Pravin;
Flamion, Bruno;
Cook, Jack

Publication type:

Article

A proposal for scientific framework enabling specific population drug dosing recommendations.

Published in:

Journal of Clinical Pharmacology, 2015, v. 55, n. 10, p. 1073, doi. 10.1002/jcph.579

By:

Jadhav, Pravin R.;
Cook, Jack;
Sinha, Vikram;
Zhao, Ping;
Rostami‐Hodjegan, Amin;
Sahasrabudhe, Vaishali;
Stockbridge, Norman;
Powell, J. Robert

Publication type:

Article

Precision criteria to derive sample size when designing pediatric pharmacokinetic studies: Which measure of variability should be used?

Published in:

Journal of Clinical Pharmacology, 2014, v. 54, n. 3, p. 311, doi. 10.1002/jcph.206

By:

Salem, Farzaneh;
Ogungbenro, Kayode;
Vajjah, Pavan;
Johnson, Trevor N.;
Aarons, Leon;
Rostami‐Hodjegan, Amin

Publication type:

Article

Age Related Changes in Fractional Elimination Pathways for Drugs: Assessing the Impact of Variable Ontogeny on Metabolic Drug-Drug Interactions.

Published in:

Journal of Clinical Pharmacology, 2013, v. 53, n. 8, p. 857, doi. 10.1002/jcph.100

By:

Salem, Farzaneh;
Johnson, Trevor N.;
Barter, Zoe E.;
Leeder, J. Steven;
Rostami‐Hodjegan, Amin

Publication type:

Article

Do Children Have the Same Vulnerability to Metabolic Drug-Drug Interactions as Adults? A Critical Analysis of the Literature.

Published in:

Journal of Clinical Pharmacology, 2013, v. 53, n. 5, p. 559, doi. 10.1002/jcph.13

By:

Salem, Farzaneh;
Rostami‐Hodjegan, Amin;
Johnson, Trevor N.

Publication type:

Article

Do Children Have the Same Vulnerability to Metabolic Drug-Drug Interactions as Adults? A Critical Analysis of the Literature.

Published in:

Journal of Clinical Pharmacology, 2013, v. 53, n. 4, p. 456, doi. 10.1002/jcph.13

By:

Salem, Farzaneh;
Rostami-Hodjegan, Amin;
Johnson, Trevor N.

Publication type:

Article

Single-Dose Pharmacokinetic Study of Clomiphene Citrate Isomers in Anovular Patients With Polycystic Ovary Disease.

Published in:

Journal of Clinical Pharmacology, 2009, v. 49, n. 2, p. 147, doi. 10.1177/0091270008328096

By:

Ghobadi, Cyrus;
Mirhosseini, Nahid;
Shiran, Mohammad Reza;
Moghadamnia, Ali;
Lennard, Martin S.;
Ledger, William L.;
Rostami-Hodjegan, Amin

Publication type:

Article

Incorporating In Vitro Information on Drug Metabolism Into Clinical Trial Simulations to Assess the Effect of CYP2D6 Polymorphism on Pharmacokinetics and Pharmacodynamics: Dextromethorphan as a Model Application.

Published in:

Journal of Clinical Pharmacology, 2007, v. 47, n. 2, p. 175, doi. 10.1177/0091270006294279

By:

Gemma GLD Dickinson;
Saeed SR Rezaee;
Nicholas NJP Proctor;
Martin MSL Lennard;
Geoffrey GTT Tucker;
Amin AR Rostami-Hodjegan

Publication type:

Article

Assessment of In Vivo CYP2D6 Activity: Differential Sensitivity of Commonly Used Probes to Urine pH.

Published in:

Journal of Clinical Pharmacology, 2004, v. 44, n. 12, p. 1398, doi. 10.1177/0091270004269582

By:

Özdemir, Mahmut;
Crewe, Kim H.;
Tucker, Geoffrey T.;
Rostami-Hodjegan, Amin

Publication type:

Article

Pharmacotherapy in kidney disease: what it takes to move from general guidance to specific recommendations to stratified subgroups of patients - the tale of autosomal dominant polycystic kidney disease (ADPKD).

Published in:

Expert Opinion on Drug Metabolism & Toxicology, 2025, v. 21, n. 6, p. 677, doi. 10.1080/17425255.2025.2501127

By:

Tillmann, Annika C.;
Rostami-Hodjegan, Amin;
Barber, Jill;
Al-Majdoub, Zubida M.

Publication type:

Article

Dose adjustment in orphan disease populations: the quest to fulfill the requirements of physiologically based pharmacokinetics.

Published in:

Expert Opinion on Drug Metabolism & Toxicology, 2018, v. 14, n. 12, p. 1315, doi. 10.1080/17425255.2018.1546288

By:

Howard, Martyn;
Barber, Jill;
Alizai, Naved;
Rostami-Hodjegan, Amin

Publication type:

Article

Implications of mechanism-based inhibition of CYP2D6 for the pharmacokinetics and toxicity of MDMA.

Published in:

Journal of Psychopharmacology, 2006, v. 20, n. 6, p. 842, doi. 10.1177/0269881106065907

By:

Jiansong Yang;
Jamei, Masoud;
Heydari, Amir;
Yeo, Karen R.;
De la Torre, Rafael;
Farré, Magí;
Tucker, Geoffrey T.;
Rostami-Hodjegan, Amin

Publication type:

Article

The impact of experimental design on assessing mechanism-based inactivation of CYP2D6 by MDMA (Ecstasy).

Published in:

Journal of Psychopharmacology, 2006, v. 20, n. 6, p. 834, doi. 10.1177/0269881106062902

By:

Van, Linh M.;
Heydari, Amir;
Jiansong Yang;
Hargreaves, Judith;
Rowland-Yeo, Karen;
Lennard, Martin S.;
Tucker, Geoffrey T.;
Rostami-Hodjegan, Amin

Publication type:

Article

Assessing the efficiency of mixed effects modelling in quantifying metabolism based drug-drug interactions: using in vitro data as an aid to assess study power.

Published in:

Pharmaceutical Statistics, 2009, v. 8, n. 3, p. 186, doi. 10.1002/pst.373

By:

Johnson, Trevor N.;
Kerbusch, Thomas;
Jones, Barry;
Tucker, Geoffrey T.;
Rostami-Hodjegan, Amin;
Milligan, Peter A.

Publication type:

Article

Quantification of Proteins Involved in Intestinal Epithelial Handling of Xenobiotics.

Published in:

Clinical Pharmacology & Therapeutics, 2021, v. 109, n. 4, p. 1136, doi. 10.1002/cpt.2097

By:

Al‐Majdoub, Zubida M.;
Couto, Narciso;
Achour, Brahim;
Harwood, Matthew D.;
Carlson, Gordon;
Warhurst, Geoffrey;
Barber, Jill;
Rostami‐Hodjegan, Amin

Publication type:

Article

Liquid Biopsy Enables Quantification of the Abundance and Interindividual Variability of Hepatic Enzymes and Transporters.

Published in:

Clinical Pharmacology & Therapeutics, 2021, v. 109, n. 1, p. 222, doi. 10.1002/cpt.2102

By:

Achour, Brahim;
Al‐Majdoub, Zubida M.;
Grybos‐Gajniak, Agnieszka;
Lea, Kristi;
Kilford, Peter;
Zhang, Mian;
Knight, David;
Barber, Jill;
Schageman, Jeoffrey;
Rostami‐Hodjegan, Amin

Publication type:

Article

Virtual Twins: Understanding the Data Required for Model‐Informed Precision Dosing.

Published in:

Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 4, p. 742, doi. 10.1002/cpt.1778

By:

Polasek, Thomas M.;
Rostami‐Hodjegan, Amin

Publication type:

Article