Works by Rossetto, Ornella

Results: 50

Botulinum neurotoxins: genetic, structural and mechanistic insights.

Published in:

Nature Reviews Microbiology, 2014, v. 12, n. 8, p. 535, doi. 10.1038/nrmicro3295

By:

Rossetto, Ornella;
Pirazzini, Marco;
Montecucco, Cesare

Publication type:

Article

Altered sensory processing and dendritic remodeling in hyperexcitable visual cortical networks.

Published in:

Brain Structure & Function, 2016, v. 221, n. 6, p. 2919, doi. 10.1007/s00429-015-1080-1

By:

Vannini, Eleonora;
Restani, Laura;
Pietrasanta, Marta;
Panarese, Alessandro;
Mazzoni, Alberto;
Rossetto, Ornella;
Middei, Silvia;
Micera, Silvestro;
Caleo, Matteo

Publication type:

Article

Transynaptic Action of Botulinum Neurotoxin Type A at Central Cholinergic Boutons.

Published in:

Journal of Neuroscience, 2018, v. 38, n. 48, p. 10329, doi. 10.1523/JNEUROSCI.0294-18.2018

By:

Spinelli, Matteo;
Colosimo, Francesca;
Restani, Laura;
Caleo, Matteo;
Rossetto, Ornella;
Matak, Ivica;
Lackovic, Zdravko

Publication type:

Article

Retrograde Transport and Central Effects of Botulinum Toxin.

Published in:

Journal of Neuroscience, 2018, v. 38, n. 48, p. i

By:

Caleo, Matteo;
Spinelli, Matteo;
Colosimo, Francesca;
Matak, Ivica;
Rossetto, Ornella

Publication type:

Article

Tetanus neurotoxin-induced epilepsy in mouse visual cortex.

Published in:

Epilepsia (Series 4), 2012, v. 53, n. 7, p. e132, doi. 10.1111/j.1528-1167.2012.03510.x

By:

Mainardi, Marco;
Pietrasanta, Marta;
Vannini, Eleonora;
Rossetto, Ornella;
Caleo, Matteo

Publication type:

Article

Toxicology and pharmacology of botulinum and tetanus neurotoxins: an update.

Published in:

Archives of Toxicology, 2022, v. 96, n. 6, p. 1521, doi. 10.1007/s00204-022-03271-9

By:

Pirazzini, Marco;
Montecucco, Cesare;
Rossetto, Ornella

Publication type:

Article

Novel Small Molecule Inhibitors That Prevent the Neuroparalysis of Tetanus Neurotoxin.

Published in:

Pharmaceuticals (14248247), 2021, v. 14, n. 11, p. 1134, doi. 10.3390/ph14111134

By:

Zanetti, Giulia;
Mattarei, Andrea;
Lista, Florigio;
Rossetto, Ornella;
Montecucco, Cesare;
Pirazzini, Marco

Publication type:

Article

Long-Distance Retrograde Effects of Botulinum Neurotoxin A.

Published in:

Journal of Neuroscience, 2008, v. 28, n. 14, p. 3689, doi. 10.1523/JNEUROSCI.0375-08.2008

By:

Antonucci, Flavia;
Rossi, Chiara;
Gianfranceschi, Laura;
Rossetto, Ornella;
Caleo, Matteo

Publication type:

Article

Transient Synaptic Silencing of Developing Striate Cortex Has Persistent Effects on Visual Function and Plasticity.

Published in:

Journal of Neuroscience, 2007, v. 27, n. 17, p. 4530, doi. 10.1523/JNEUROSCI.0772-07.2007

By:

Caleo, Matteo;
Restani, Laura;
Gianfranceschi, Laura;
Costantin, Laura;
Rossi, Chiara;
Rossetto, Ornella;
Montecucco, Cesare;
Maffei, Lamberto

Publication type:

Article

Antiepileptic Effects of Botulinum Neurotoxin E.

Published in:

Journal of Neuroscience, 2005, v. 25, n. 8, p. 1943, doi. 10.1523/JNEUROSCI.4402-04.2005

By:

Costantin, Laura;
Bozzi, Yuri;
Richichi, Cristina;
Viegi, Alessandro;
Antonucci, Flavia;
Funicello, Marcella;
Gobbi, Marco;
Mennini, Tiziana;
Rossetto, Ornella;
Montecucco, Cesare;
Maffei, Lamberto;
Vezzani, Annamaria;
Caleo, Matteo

Publication type:

Article

Detection of VAMP Proteolysis by Tetanus and Botulinum Neurotoxin Type B In Vivo with a Cleavage-Specific Antibody.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 8, p. 4355, doi. 10.3390/ijms23084355

By:

Fabris, Federico;
Šoštarić, Petra;
Matak, Ivica;
Binz, Thomas;
Toffan, Anna;
Simonato, Morena;
Montecucco, Cesare;
Pirazzini, Marco;
Rossetto, Ornella

Publication type:

Article

Latrotoxin-Induced Neuromuscular Junction Degeneration Reveals Urocortin 2 as a Critical Contributor to Motor Axon Terminal Regeneration.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 3, p. 1186, doi. 10.3390/ijms23031186

By:

D'Este, Giorgia;
Stazi, Marco;
Negro, Samuele;
Megighian, Aram;
Lista, Florigio;
Rossetto, Ornella;
Montecucco, Cesare;
Rigoni, Michela;
Pirazzini, Marco

Publication type:

Article

An Update on the Mechanism of Action of Tetanus and Botulinum Neurotoxins.

Published in:

Acta Chimica Slovenica, 2011, v. 58, n. 4, p. 702

By:

Rossetto, Ornella;
Pirazzini, Marco;
Bolognese, Paolo;
Rigoni, Michela;
Montecucco, Cesare

Publication type:

Article

Botulinum neurotoxin C mutants reveal different effects of syntaxin or SNAP-25 proteolysis on neuromuscular transmission.

Published in:

PLoS Pathogens, 2017, v. 13, n. 8, p. 1, doi. 10.1371/journal.ppat.1006567

By:

Zanetti, Giulia;
Sikorra, Stefan;
Rummel, Andreas;
Krez, Nadja;
Duregotti, Elisa;
Negro, Samuele;
Henke, Tina;
Rossetto, Ornella;
Binz, Thomas;
Pirazzini, Marco

Publication type:

Article

Entering neurons: botulinum toxins and synaptic vesicle recycling.

Published in:

EMBO Reports, 2006, v. 7, n. 10, p. 995, doi. 10.1038/sj.embor.7400796

By:

Verderio, Claudia;
Rossetto, Ornella;
Grumelli, Carlotta;
Frassoni, Carolina;
Montecucco, Cesare;
Matteoli, Michela

Publication type:

Article

Traffic of Botulinum Toxins A and E in Excitatory and Inhibitory Neurons.

Published in:

Traffic, 2007, v. 8, n. 2, p. 142, doi. 10.1111/j.1600-0854.2006.00520.x

By:

Verderio, Claudia;
Grumelli, Carlotta;
Raiteri, Luca;
Coco, Silvia;
Paluzzi, Silvio;
Caccin, Paola;
Rossetto, Ornella;
Bonanno, Giambattista;
Montecucco, Cesare;
Matteoli, Michela

Publication type:

Article

Evidence for Anterograde Transport and Transcytosis of Botulinum Neurotoxin A (BoNT/A).

Published in:

Journal of Neuroscience, 2011, v. 31, n. 44, p. 15650, doi. 10.1523/JNEUROSCI.2618-11.2011

By:

Restani, Laura;
Antonucci, Flavia;
Gianfranceschi, Laura;
Rossi, Chiara;
Rossetto, Ornella;
Caleo, Matteo

Publication type:

Article

Neutralisation of specific surface carboxylates speeds up translocation of botulinum neurotoxin type B enzymatic domain.

Published in:

FEBS Letters, 2013, v. 587, n. 23, p. 3831, doi. 10.1016/j.febslet.2013.10.010

By:

Pirazzini, Marco;
Henke, Tina;
Rossetto, Ornella;
Mahrhold, Stefan;
Krez, Nadja;
Rummel, Andreas;
Montecucco, Cesare;
Binz, Thomas

Publication type:

Article

The thioredoxin reductase-thioredoxin system is involved in the entry of tetanus and botulinum neurotoxins in the cytosol of nerve terminals

Published in:

FEBS Letters, 2013, v. 587, n. 2, p. 150, doi. 10.1016/j.febslet.2012.11.007

By:

Pirazzini, Marco;
Bordin, Fulvio;
Rossetto, Ornella;
Shone, Clifford C.;
Binz, Thomas;
Montecucco, Cesare

Publication type:

Article

Reversible skeletal neuromuscular paralysis induced by different lysophospholipids

Published in:

FEBS Letters, 2006, v. 580, n. 27, p. 6317, doi. 10.1016/j.febslet.2006.10.039

By:

Caccin, Paola;
Rigoni, Michela;
Bisceglie, Alessandra;
Rossetto, Ornella;
Montecucco, Cesare

Publication type:

Article

VAMP/synaptobrevin cleavage by tetanus and botulinum neurotoxins is strongly enhanced by acidic liposomes

Published in:

FEBS Letters, 2003, v. 542, n. 1-3, p. 132, doi. 10.1016/S0014-5793(03)00365-X

By:

Caccin, Paola;
Rossetto, Ornella;
Rigoni, Michela;
Johnson, Eric;
Schiavo, Giampietro;
Montecucco, Cesare

Publication type:

Article

Tetanus and tetanus neurotoxin: From peripheral uptake to central nervous tissue targets.

Published in:

Journal of Neurochemistry, 2021, v. 158, n. 6, p. 1244, doi. 10.1111/jnc.15330

By:

Megighian, Aram;
Pirazzini, Marco;
Fabris, Federico;
Rossetto, Ornella;
Montecucco, Cesare

Publication type:

Article

Botulinum Neurotoxins A and E Undergo Retrograde Axonal Transport in Primary Motor Neurons.

Published in:

PLoS Pathogens, 2012, v. 8, n. 12, p. 1, doi. 10.1371/journal.ppat.1003087

By:

Restani, Laura;
Giribaldi, Francesco;
Manich, Maria;
Bercsenyi, Kinga;
Menendez, Guillermo;
Rossetto, Ornella;
Caleo, Matteo;
Schiavo, Giampietro

Publication type:

Article

Different types of botulinum toxin in humans.

Published in:

Movement Disorders, 2004, v. 19, p. S53, doi. 10.1002/mds.20010

By:

Roberto Eleopra;
Valeria Tugnoli;
Rocco Quatrale;
Ornella Rossetto;
Cesare Montecucco

Publication type:

Article

Excitation–contraction coupling inhibitors potentiate the actions of botulinum neurotoxin type A at the neuromuscular junction.

Published in:

British Journal of Pharmacology, 2025, v. 182, n. 3, p. 564, doi. 10.1111/bph.17367

By:

Machicoane, Mickaël;
Tonellato, Marika;
Zainotto, Marica;
Onillon, Paul;
Stazi, Marco;
Corso, Mattia Dal;
Megighian, Aram;
Rossetto, Ornella;
Le Doussal, Jean‐Marc;
Pirazzini, Marco

Publication type:

Article

Taipoxin induces F-actin fragmentation and enhances release of catecholamines in bovine chromaffin cells.

Published in:

Journal of Neurochemistry, 2003, v. 85, n. 2, p. 329, doi. 10.1046/j.1471-4159.2003.01682.x

By:

Ñeco, Patricia;
Rossetto, Ornella;
Gil, Anabel;
Montecucco, Cesare;
Gutiérrez, Luis M.

Publication type:

Article

Entrapping of Impermeant Probes of Different Size into Nonpermeabilized Synaptosomes as a Method to Study Presynaptic Mechanisms.

Published in:

Journal of Neurochemistry, 2000, v. 74, n. 1, p. 423, doi. 10.1046/j.1471-4159.2000.0740423.x

By:

Raiteri, Maurizio;
Sala, Roberta;
Fassio, Anna;
Rossetto, Ornella;
Bonanno, Giambattista

Publication type:

Article

Internalization and Proteolytic Action of Botulinum Toxins in CNS Neurons and Astrocytes.

Published in:

Journal of Neurochemistry, 1999, v. 73, n. 1, p. 372, doi. 10.1046/j.1471-4159.1999.0730372.x

By:

Verderio, Claudia;
Coco, Silvia;
Rossetto, Ornella;
Montecucco, Cesare;
Matteoli, Michela

Publication type:

Article

Antibodies Against Rat Brain Vesicle-Associated Membrane Protein (Synaptobrevin) Prevent Inhibition of Acetylcholine Release by Tetanus Toxin or Botulinum Neurotoxin Type B.

Published in:

Journal of Neurochemistry, 1993, v. 61, n. 3, p. 1175, doi. 10.1111/j.1471-4159.1993.tb03640.x

By:

Poulain, Bernard;
Rossetto, Ornella;
Deloye, Florence;
Schiavo, Giampietro;
Tauc, Ladislav;
Montecucco, Cesare

Publication type:

Article

The role of the single interchains disulfide bond in tetanus and botulinum neurotoxins and the development of antitetanus and antibotulism drugs.

Published in:

Cellular Microbiology, 2019, v. 21, n. 11, p. N.PAG, doi. 10.1111/cmi.13037

By:

Rossetto, Ornella;
Pirazzini, Marco;
Lista, Florigio;
Montecucco, Cesare

Publication type:

Article

Hsp90 is involved in the entry of clostridial neurotoxins into the cytosol of nerve terminals.

Published in:

Cellular Microbiology, 2017, v. 19, n. 2, p. n/a, doi. 10.1111/cmi.12647

By:

Azarnia Tehran, Domenico;
Pirazzini, Marco;
Leka, Oneda;
Mattarei, Andrea;
Lista, Florigio;
Binz, Thomas;
Rossetto, Ornella;
Montecucco, Cesare

Publication type:

Article

Double anchorage to the membrane and intact inter-chain disulfide bond are required for the low pH induced entry of tetanus and botulinum neurotoxins into neurons.

Published in:

Cellular Microbiology, 2011, v. 13, n. 11, p. 1731, doi. 10.1111/j.1462-5822.2011.01654.x

By:

Pirazzini, Marco;
Rossetto, Ornella;
Bolognese, Paolo;
Shone, Clifford C.;
Montecucco, Cesare

Publication type:

Article

Challenges in searching for therapeutics against Botulinum Neurotoxins.

Published in:

Expert Opinion on Drug Discovery, 2017, v. 12, n. 5, p. 497, doi. 10.1080/17460441.2017.1303476

By:

Pirazzini, Marco;
Rossetto, Ornella

Publication type:

Article

Mass spectrometry analysis of the phospholipase A<sub>2</sub> activity of snake pre-synaptic neurotoxins in cultured neurons.

Published in:

Journal of Neurochemistry, 2009, v. 111, n. 3, p. 737, doi. 10.1111/j.1471-4159.2009.06365.x

By:

Paoli, Marco;
Rigoni, Michela;
Koster, Grielof;
Rossetto, Ornella;
Montecucco, Cesare;
Postle, Anthony D.

Publication type:

Article

Presynaptic enzymatic neurotoxins.

Published in:

Journal of Neurochemistry, 2006, v. 97, n. 6, p. 1534, doi. 10.1111/j.1471-4159.2006.03965.x

By:

Rossetto, Ornella;
Morbiato, Laura;
Caccin, Paola;
Rigoni, Michela;
Montecucco, Cesare

Publication type:

Article

Alternative splicing of the human gene SYBL1 modulates protein domain architecture of longin VAMP7/TI-VAMP, showing both non-SNARE and synaptobrevin-like isoforms.

Published in:

BMC Molecular Biology, 2011, v. 12, n. 1, p. 1, doi. 10.1186/1471-2199-12-26

By:

Vacca, Marcella;
Albania, Lara;
Ragione, Floriana Della;
Carpi, Andrea;
Rossi, Valeria;
Strazzullo, Maria;
De Franceschi, Nicola;
Rossetto, Ornella;
Filippini, Francesco;
D'Esposito, Maurizio

Publication type:

Article

Alternative splicing of the human gene SYBL1 modulates protein domain architecture of longin VAMP7/TI-VAMP, showing both non-SNARE and synaptobrevin-like isoforms.

Published in:

BMC Molecular Biology, 2011, v. 12, n. 1, p. 26, doi. 10.1186/1471-2199-12-26

By:

Vacca, Marcella;
Albania, Lara;
Ragione, Floriana Della;
Carpi, Andrea;
Rossi, Valeria;
Strazzullo, Maria;
De Franceschi, Nicola;
Rossetto, Ornella;
Filippini, Francesco;
D'Esposito, Maurizio

Publication type:

Article

Primary resistance of human patients to botulinum neurotoxins A and B.

Published in:

Annals of Clinical & Translational Neurology, 2018, v. 5, n. 8, p. 971, doi. 10.1002/acn3.586

By:

Pirazzini, Marco;
Carle, Stefan;
Barth, Holger;
Rossetto, Ornella;
Montecucco, Cesare

Publication type:

Article

An agonist of the CXCR4 receptor is therapeutic for the neuroparalysis induced by Bungarus snakes envenoming.

Published in:

Clinical & Translational Medicine, 2022, v. 12, n. 1, p. 1, doi. 10.1002/ctm2.651

By:

Stazi, Marco;
Fabris, Federico;
Tan, Kae Yi;
Megighian, Aram;
Rubini, Alessandro;
Mattarei, Andrea;
Negro, Samuele;
D'Este, Giorgia;
Lista, Florigio;
Rossetto, Ornella;
Tan, Choo Hock;
Montecucco, Cesare

Publication type:

Article

Tables of Toxicity of Botulinum and Tetanus Neurotoxins.

Published in:

Toxins, 2019, v. 11, n. 12, p. 686, doi. 10.3390/toxins11120686

By:

Rossetto, Ornella;
Montecucco, Cesare

Publication type:

Article

High Conservation of Tetanus and Botulinum Neurotoxins Cleavage Sites on Human SNARE Proteins Suggests That These Pathogens Exerted Little or No Evolutionary Pressure on Humans.

Published in:

Toxins, 2017, v. 9, n. 12, p. 404, doi. 10.3390/toxins9120404

By:

Carle, Stefan;
Pirazzini, Marco;
Rossetto, Ornella;
Barth, Holger;
Montecucco, Cesare

Publication type:

Article

Electrophysiological Characterization of the Antarease Metalloprotease from Tityus serrulatus Venom.

Published in:

Toxins, 2017, v. 9, n. 3, p. 81, doi. 10.3390/toxins9030081

By:

Zornetta, Irene;
Scorzeto, Michele;
Mendes Dos Reis, Pablo Victor;
De Lima, Maria E.;
Montecucco, Cesare;
Megighian, Aram;
Rossetto, Ornella

Publication type:

Article

Re-Assembled Botulinum Neurotoxin Inhibits CNS Functions without Systemic Toxicity.

Published in:

Toxins, 2011, v. 3, n. 4, p. 345, doi. 10.3390/toxins3040345

By:

Ferrari, Enrico;
Maywood, Elizabeth S.;
Restani, Laura;
Caleo, Matteo;
Pirazzini, Marco;
Rossetto, Ornella;
Hastings, Michael H.;
Niranjan, Dhevahi;
Schiavo, Giampietro;
Davletov, Bazbek

Publication type:

Article

Common and distinct fusion proteins in axonal growth and transmitter release.

Published in:

Journal of Comparative Neurology, 1996, v. 367, n. 2, p. 222, doi. 10.1002/(SICI)1096-9861(19960401)367:2<222::AID-CNE5>3.0.CO;2-7

By:

Osen-Sand, Astrid;
Staple, Julie K.;
Naldi, Ezio;
Schiavo, Giampietro;
Rossetto, Ornella;
Petitpierre, Sylvie;
Malgaroli, Antonio;
Montecucco, Cesare;
Catsicas, Stefan

Publication type:

Article

Tetanus and Botulinum Neurotoxins Are Zinc Proteases Specific for Components of the Neuroexocytosis Apparatus<sup>a</sup>.

Published in:

Annals of the New York Academy of Sciences, 1994, v. 710, n. 1, p. 65, doi. 10.1111/j.1749-6632.1994.tb26614.x

By:

SCHIAVO, GIAMPIETRO;
ROSSETTO, ORNELLA;
BENFENATI, FABIO;
POULAIN, BERNARD;
MONTECUCCO, CESARE

Publication type:

Article

Botulinum Neurotoxin Type A is Internalized and Translocated from Small Synaptic Vesicles at the Neuromuscular Junction.

Published in:

Molecular Neurobiology, 2013, v. 48, n. 1, p. 120, doi. 10.1007/s12035-013-8423-9

By:

Colasante, Cesare;
Rossetto, Ornella;
Morbiato, Laura;
Pirazzini, Marco;
Molgó, Jordi;
Montecucco, Cesare

Publication type:

Article

A Novel Inhibitor Prevents the Peripheral Neuroparalysis of Botulinum Neurotoxins.

Published in:

Scientific Reports, 2015, p. 17513, doi. 10.1038/srep17513

By:

Azarnia Tehran, Domenico;
Zanetti, Giulia;
Leka, Oneda;
Lista, Florigio;
Fillo, Silvia;
Binz, Thomas;
Shone, Clifford C.;
Rossetto, Ornella;
Montecucco, Cesare;
Paradisi, Cristina;
Mattarei, Andrea;
Pirazzini, Marco

Publication type:

Article

Neuromuscular paralysis and recovery in mice injected with botulinum neurotoxins A and C.

Published in:

European Journal of Neuroscience, 2007, v. 25, n. 9, p. 2697, doi. 10.1111/j.1460-9568.2007.05529.x

By:

Morbiato, Laura;
Carli, Luca;
Johnson, Eric A.;
Montecucco, Cesare;
Molgó, Jordi;
Rossetto, Ornella

Publication type:

Article

Glycogen synthase kinase 3 activation is essential for the snake phospholipase A2 neurotoxin-induced secretion in chromaffin cells.

Published in:

European Journal of Neuroscience, 2007, v. 25, n. 8, p. 2341, doi. 10.1111/j.1460-9568.2007.05497.x

By:

Giner, Daniel;
López, Inmaculada;
Ñeco, Patricia;
Rossetto, Ornella;
Montecucco, Cesare;
Gutiérrez, Luis M.

Publication type:

Article

Assay of diffusion of different botulinum neurotoxin type a formulations injected in the mouse leg.

Published in:

Muscle & Nerve, 2009, v. 40, n. 3, p. 374, doi. 10.1002/mus.21343

By:

Carli, Luca;
Montecucco, Cesare;
Rossetto, Ornella

Publication type:

Article