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The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.
Published in:
EMBO Reports, 2011, v. 12, n. 5, p. 463, doi. 10.1038/embor.2011.43
By:
- Chowdhury, Rasheduzzaman;
- Yeoh, Kar Kheng;
- Tian, Ya-Min;
- Hillringhaus, Lars;
- Bagg, Eleanor A;
- Rose, Nathan R;
- Leung, Ivanhoe K H;
- Li, Xuan S;
- Woon, Esther C Y;
- Yang, Ming;
- McDonough, Michael A;
- King, Oliver N;
- Clifton, Ian J;
- Klose, Robert J;
- Claridge, Timothy D W;
- Ratcliffe, Peter J;
- Schofield, Christopher J;
- Kawamura, Akane
Publication type:
Article
RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes.
Published in:
eLife, 2016, p. 1, doi. 10.7554/eLife.18591
By:
- Rose, Nathan R.;
- King, Hamish W.;
- Blackledge, Neil P.;
- Fursova, Nadezda A.;
- Ember, Katherine J. I.;
- Fischer, Roman;
- Kessler, Benedikt M.;
- Klose, Robert J.
Publication type:
Article
Is JmjC Oxygenase Catalysis Limited to Demethylation?
Published in:
Angewandte Chemie International Edition, 2013, v. 52, n. 30, p. 7709, doi. 10.1002/anie.201303282
By:
- Hopkinson, Richard J.;
- Walport, Louise J.;
- Münzel, Martin;
- Rose, Nathan R.;
- Smart, Tristan J.;
- Kawamura, Akane;
- Claridge, Timothy D. W.;
- Schofield, Christopher J.
Publication type:
Article
Conversion of Cysteine into Dehydroalanine Enables Access to Synthetic Histones Bearing Diverse Post-Translational Modifications.
Published in:
Angewandte Chemie International Edition, 2012, v. 51, n. 8, p. 1835, doi. 10.1002/anie.201106432
By:
- Chalker, Justin M.;
- Lercher, Lukas;
- Rose, Nathan R.;
- Schofield, Christopher J.;
- Davis, Benjamin G.
Publication type:
Article
Linking of 2-Oxoglutarate and Substrate Binding Sites Enables Potent and Highly Selective Inhibition of JmjC Histone Demethylases.
Published in:
Angewandte Chemie International Edition, 2012, v. 51, n. 7, p. 1631, doi. 10.1002/anie.201107833
By:
- Woon, Esther C. Y.;
- Tumber, Anthony;
- Kawamura, Akane;
- Hillringhaus, Lars;
- Ge, Wei;
- Rose, Nathan R.;
- Ma, Jerome H. Y.;
- Chan, Mun Chiang;
- Walport, Louise J.;
- Che, Ka Hing;
- Ng, Stanley S.;
- Marsden, Brian D.;
- Oppermann, Udo;
- McDonough, Michael A.;
- Schofield, Christopher J.
Publication type:
Article
Monitoring the Activity of 2-Oxoglutarate Dependent Histone Demethylases by NMR Spectroscopy: Direct Observation of Formaldehyde.
Published in:
ChemBioChem, 2010, v. 11, n. 4, p. 506, doi. 10.1002/cbic.200900713
By:
- Hopkinson, Richard J.;
- Hamed, Refaat B.;
- Rose, Nathan R.;
- Claridge, Timothy D. W.;
- Schofield, Christopher J.
Publication type:
Article
Conversion of Cysteine into Dehydroalanine Enables Access to Synthetic Histones Bearing Diverse Post-Translational Modifications.
Published in:
Angewandte Chemie, 2012, v. 124, n. 8, p. 1871, doi. 10.1002/ange.201106432
By:
- Chalker, Justin M.;
- Lercher, Lukas;
- Rose, Nathan R.;
- Schofield, Christopher J.;
- Davis, Benjamin G.
Publication type:
Article
Linking of 2-Oxoglutarate and Substrate Binding Sites Enables Potent and Highly Selective Inhibition of JmjC Histone Demethylases.
Published in:
Angewandte Chemie, 2012, v. 124, n. 7, p. 1663, doi. 10.1002/ange.201107833
By:
- Woon, Esther C. Y.;
- Tumber, Anthony;
- Kawamura, Akane;
- Hillringhaus, Lars;
- Ge, Wei;
- Rose, Nathan R.;
- Ma, Jerome H. Y.;
- Chan, Mun Chiang;
- Walport, Louise J.;
- Che, Ka Hing;
- Ng, Stanley S.;
- Marsden, Brian D.;
- Oppermann, Udo;
- McDonough, Michael A.;
- Schofield, Christopher J.
Publication type:
Article
Targeting Polycomb systems to regulate gene expression: modifications to a complex story.
Published in:
Nature Reviews Molecular Cell Biology, 2015, v. 16, n. 11, p. 643, doi. 10.1038/nrm4067
By:
- Blackledge, Neil P.;
- Rose, Nathan R.;
- Klose, Robert J.
Publication type:
Article
PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nε-dimethyl lysine demethylase.
Published in:
Human Molecular Genetics, 2010, v. 19, n. 2, p. 217, doi. 10.1093/hmg/ddp480
By:
- Loenarz, Christoph;
- Ge, Wei;
- Coleman, Mathew L.;
- Rose, Nathan R.;
- Cooper, Christopher D.O.;
- Klose, Robert J.;
- Ratcliffe, Peter J.;
- Schofield, Christopher J.
Publication type:
Article
2-Oxoglutarate oxygenases are inhibited by a range of transition metals.
Published in:
Metallomics, 2010, n. 6, p. 397, doi. 10.1039/c004952b
By:
- Sekirnik, Rok;
- Rose, Nathan R.;
- Mecinovic, Jasmin;
- Schofield, Christopher J.
Publication type:
Article
Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors.
Published in:
PLoS ONE, 2010, v. 5, n. 11, p. 1, doi. 10.1371/journal.pone.0015535
By:
- King, Oliver N. F.;
- Li, Xuan Shirley;
- Sakurai, Masaaki;
- Kawamura, Akane;
- Rose, Nathan R.;
- Ng, Stanley S.;
- Quinn, Amy M.;
- Rai, Ganesha;
- Mott, Bryan T.;
- Beswick, Paul;
- Klose, Robert J.;
- Oppermann, Udo;
- Jadhav, Ajit;
- Heightman, Tom D.;
- Maloney, David J.;
- Schofield, Christopher J.;
- Simeonov, Anton
Publication type:
Article
Is JmjC Oxygenase Catalysis Limited to Demethylation?
Published in:
Angewandte Chemie, 2013, v. 125, n. 30, p. 7863, doi. 10.1002/ange.201303282
By:
- Hopkinson, Richard J.;
- Walport, Louise J.;
- Münzel, Martin;
- Rose, Nathan R.;
- Smart, Tristan J.;
- Kawamura, Akane;
- Claridge, Timothy D. W.;
- Schofield, Christopher J.
Publication type:
Article
Inhibition of Histone Demethylases by 4-Carboxy-2,2′-Bipyridyl Compounds.
Published in:
ChemMedChem, 2011, v. 6, n. 5, p. 759, doi. 10.1002/cmdc.201100026
By:
- Chang, Kai-Hsuan;
- King, Oliver N. F.;
- Tumber, Anthony;
- Woon, Esther C. Y.;
- Heightman, Tom D.;
- McDonough, Michael A.;
- Schofield, Christopher J.;
- Rose, Nathan R.
Publication type:
Article
Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity.
Published in:
Nature, 2007, v. 448, n. 7149, p. 87, doi. 10.1038/nature05971
By:
- Ng, Stanley S.;
- Kavanagh, Kathryn L.;
- McDonough, Michael A.;
- Butler, Danica;
- Pilka, Ewa S.;
- Lienard, Benoit M. R.;
- Bray, James E.;
- Savitsky, Pavel;
- Gileadi, Opher;
- von Delft, Frank;
- Rose, Nathan R.;
- Offer, John;
- Scheinost, Johanna C.;
- Borowski, Tomasz;
- Sundstrom, Michael;
- Schofield, Christopher J.;
- Oppermann, Udo
Publication type:
Article
Studies on the Glutathione-Dependent Formaldehyde-Activating Enzyme from Paracoccus denitrificans.
Published in:
PLoS ONE, 2015, v. 10, n. 12, p. 1, doi. 10.1371/journal.pone.0145085
By:
- Hopkinson, Richard J.;
- Leung, Ivanhoe K. H.;
- Smart, Tristan J.;
- Rose, Nathan R.;
- Henry, Luc;
- Claridge, Timothy D. W.;
- Schofield, Christopher J.
Publication type:
Article

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