Works matching AU Rorsman, Patrik

Results: 102

Acetyl-CoA-carboxylase 1 (ACC1) plays a critical role in glucagon secretion.

Published in:

Communications Biology, 2022, v. 5, n. 1, p. 1, doi. 10.1038/s42003-022-03170-w

By:

Veprik, Anna;
Denwood, Geoffrey;
Liu, Dong;
Bany Bakar, Rula;
Morfin, Valentin;
McHugh, Kara;
Tebeka, Nchimunya N.;
Vetterli, Laurène;
Yonova-Doing, Ekaterina;
Gribble, Fiona;
Reimann, Frank;
Hoehn, Kyle L.;
Hemsley, Piers A.;
Ahnfelt-Rønne, Jonas;
Rorsman, Patrik;
Zhang, Quan;
de Wet, Heidi;
Cantley, James

Publication type:

Article

GABAB receptor activation inhibits exocytosis in rat pancreatic β-cells by G-protein-dependent activation of calcineurin.

Published in:

Journal of Physiology, 2004, v. 559, n. 2, p. 397, doi. 10.1113/jphysiol.2004.066563

By:

Braun, Matthias;
Wendt, Anna;
Buschard, Karsten;
Salehi, Albert;
Sewing, Sabine;
Gromada, Jesper;
Rorsman, Patrik

Publication type:

Article

Palmitate increases L-type Ca2+ currents and the size of the readily releasable granule pool in mouse pancreatic β-cells.

Published in:

Journal of Physiology, 2004, v. 557, n. 3, p. 935, doi. 10.1113/jphysiol.2004.066258

By:

Olofsson, Charlotta S.;
Salehi, Albert;
Holm, Cecilia;
Rorsman, Patrik

Publication type:

Article

Capacitance measurements of exocytosis in mouse pancreatic α-, β- and δ-cells within intact islets of Langerhans.

Published in:

Journal of Physiology, 2004, v. 556, n. 3, p. 711, doi. 10.1113/jphysiol.2003.059675

By:

Göpel, Sven;
Quan Zhang;
Eliasson, Lena;
Xiao-Song Ma;
Galvanovskis, Juris;
Kanno, Takahiro;
Salehi, Albert;
Rorsman, Patrik

Publication type:

Article

Somatostatin inhibits exocytosis in rat pancreatic α-cells by Gi2-dependent activation of calcineurin and depriming of secretory granules.

Published in:

Journal of Physiology, 2001, v. 535, n. 2, p. 519, doi. 10.1111/j.1469-7793.2001.00519.x

By:

Gromada, Jesper;
Høy, Marianne;
Buschard, Karsten;
Salehi, Albert;
Rorsman, Patrik

Publication type:

Article

Tolbutamide stimulates exocytosis of glucagon by inhibition of a mitochondrial-like ATP-sensitive K+ (KATP) conductance in rat pancreatic A-cells.

Published in:

Journal of Physiology, 2000, v. 527, n. 1, p. 109, doi. 10.1111/j.1469-7793.2000.00109.x

By:

Høy, Marianne;
Olsen, Hervør L.;
Bokvist, Krister;
Buschard, Karsten;
Barg, Sebastian;
Rorsman, Patrik;
Gromada, Jesper

Publication type:

Article

CaM kinase II-dependent mobilization of secretory granules underlies acetylcholine-induced stimulation of exocytosis in mouse pancreatic B-cells.

Published in:

Journal of Physiology, 1999, v. 518, n. 3, p. 745, doi. 10.1111/j.1469-7793.1999.0745p.x

By:

Gromada, Jesper;
Høy, Marianne;
Renström, Erik;
Bokvist, Krister;
Eliasson, Lena;
Göpel, Sven;
Rorsman, Patrik

Publication type:

Article

Rapid ATP-Dependent Priming of Secretory Granules Precedes Ca2+ -Induced Exocytosis in Mouse Pancreatic B-Cells.

Published in:

Journal of Physiology, 1997, v. 503, n. 2, p. 399, doi. 10.1111/j.1469-7793.1997.399bh.x

By:

Eliasson, Lena;
Renström, Erik;
Ding, Wei-Guang;
Proks, Peter;
Rorsman, Patrik

Publication type:

Article

Electrophysiological properties of human beta-cell lines EndoC-βH1 and -βH2 conform with human beta-cells.

Published in:

Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-34743-7

By:

Hastoy, Benoît;
Godazgar, Mahdieh;
Clark, Anne;
Nylander, Vibe;
Spiliotis, Ioannis;
van de Bunt, Martijn;
Chibalina, Margarita V.;
Barrett, Amy;
Burrows, Carla;
Tarasov, Andrei I.;
Scharfmann, Raphael;
Gloyn, Anna L.;
Rorsman, Patrik

Publication type:

Article

Short-term high glucose culture potentiates pancreatic beta cell function.

Published in:

Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-31325-5

By:

Rebelato, Eduardo;
Santos, Laila R.;
Carpinelli, Angelo R.;
Rorsman, Patrik;
Abdulkader, Fernando

Publication type:

Article

Quantal ATP release in rat β-cells by exocytosis of insulin-containing LDCVs.

Published in:

Pflügers Archiv: European Journal of Physiology, 2009, v. 458, n. 2, p. 389, doi. 10.1007/s00424-008-0610-6

By:

Karanauskaite, Jovita;
Hoppa, Michael B.;
Braun, Matthias;
Galvanovskis, Juris;
Rorsman, Patrik

Publication type:

Article

Kiss-and-run exocytosis and fusion pores of secretory vesicles in human β-cells.

Published in:

Pflügers Archiv: European Journal of Physiology, 2009, v. 457, n. 6, p. 1343, doi. 10.1007/s00424-008-0588-0

By:

Hanna, Salma T.;
Pigeau, Gary M.;
Galvanovskis, Juris;
Clark, Anne;
Rorsman, Patrik;
MacDonald, Patrick E.

Publication type:

Article

Matthias Braun, 23 July 1966-16 November 2013.

Published in:

2014

By:

Rorsman, Patrik;
Zhang, Quan

Publication type:

Editorial

ATP-regulated potassium channels and voltage-gated calcium channels in pancreatic alpha and beta cells: similar functions but reciprocal effects on secretion.

Published in:

Diabetologia, 2014, v. 57, n. 9, p. 1749, doi. 10.1007/s00125-014-3279-8

By:

Rorsman, Patrik;
Ramracheya, Reshma;
Rorsman, Nils;
Zhang, Quan

Publication type:

Article

Reducing hyperglucagonaemia in type 2 diabetes using low‐dose glibenclamide: Results of the LEGEND‐A pilot study.

Published in:

2022

By:

Spiliotis, Ioannis I.;
Chalk, Rod;
Gough, Stephen;
Rorsman, Patrik

Publication type:

Case Study

A critical role of the mechanosensor PIEZO1 in glucose-induced insulin secretion in pancreatic β-cells.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-31103-y

By:

Ye, Yingying;
Barghouth, Mohammad;
Dou, Haiqiang;
Luan, Cheng;
Wang, Yongzhi;
Karagiannopoulos, Alexandros;
Jiang, Xiaoping;
Krus, Ulrika;
Fex, Malin;
Zhang, Quan;
Eliasson, Lena;
Rorsman, Patrik;
Zhang, Enming;
Renström, Erik

Publication type:

Article

SEDLIN Forms Homodimers: Characterisation of SEDLIN Mutations and Their Interactions with Transcription Factors MBP1, PITX1 and SF1.

Published in:

PLoS ONE, 2010, v. 5, n. 5, p. 1, doi. 10.1371/journal.pone.0010646

By:

Jeyabalan, Jeshmi;
Nesbit, M. Andrew;
Galvanovskis, Juris;
Callaghan, Richard;
Rorsman, Patrik;
Thakker, Rajesh V.

Publication type:

Article

Defective Secretion of Islet Hormones in Chromogranin- B Deficient Mice.

Published in:

PLoS ONE, 2010, v. 5, n. 1, p. 1, doi. 10.1371/journal.pone.0008936

By:

Obermüller, Stefanie;
Calegari, Federico;
Angus King;
Lindqvist, Anders;
Lundquist, Ingmar;
Salehi, Albert;
Francolini, Maura;
Rosa, Patrizia;
Rorsman, Patrik;
Huttner, Wieland B.;
Barg, Sebastian

Publication type:

Article

Pathophysiological, Genetic and Gene Expression Features of a Novel Rodent Model of the Cardio- Metabolic Syndrome.

Published in:

PLoS ONE, 2008, v. 3, n. 8, p. 1, doi. 10.1371/journal.pone.0002962

By:

Wallis, Robert H.;
Collins, Stephan C.;
Kaisaki, Pamela J.;
Argoud, Karène;
Wilder, Steven P.;
Wallace, Karin J.;
Ria, Massimiliano;
Ktorza, Alain;
Rorsman, Patrik;
Bihoreau, Marie-Thérèse;
Gauguier, Dominique

Publication type:

Article

Mitochondrial matrix pH controls oxidative phosphorylation and metabolism-secretion coupling in INS-IE clonal β cells.

Published in:

FASEB Journal, 2010, v. 24, n. 11, p. 4613, doi. 10.1096/fj.10-162222

By:

Akhmedov, Dmitry;
Braun, Matthias;
Mataki, Chikage;
Park, Kyu-Sang;
Pozzan, Tullio;
Schoonjans, Kristina;
Rorsman, Patrik;
Wollheim, Claes B.;
Wiederkehr, Andreas

Publication type:

Article

Regulated exocytosis and kiss-and-run of synaptic-like microvesicles in INS-1 and primary rat beta-cells.

Published in:

2005

By:

MacDonald, Patrick E.;
Obermüller, Stefanie;
Vikman, Jenny;
Galvanovskis, Juris;
Rorsman, Patrik;
Eliasson, Lena;
Obermüller, Stefanie

Publication type:

journal article

ATP-Sensitive K[sup+] Channel--Dependent Regulation ofGlucagon Release and Electrical Activity by Glucose inWild-Type and SUR1[sup-/-] Mouse α-Cells.

Published in:

Diabetes, 2004, v. 53, p. S181, doi. 10.2337/diabetes.53.suppl_3.S181

By:

Gromada, Jesper;
Ma, Xiaosong;
Høy, Marianne;
Bokvist, Krister;
Salehi, Albert;
Berggren, Per-Olof;
Rorsman, Patrik

Publication type:

Article

Palmitate stimulation of glucagon secretion in mouse pancreatic alpha-cells results from activation of L-type calcium channels and elevation of cytoplasmic calcium.

Published in:

2004

By:

Olofsson, Charlotta S.;
Salehi, Albert;
Göpel, Sven O.;
Holm, Cecilia;
Rorsman, Patrik;
Göpel, Sven O

Publication type:

journal article

Glucose inhibition of glucagon secretion from rat alpha-cells is mediated by GABA released from neighboring beta-cells.

Published in:

2004

By:

Wendt, Anna;
Birnir, Bryndis;
Buschard, Karsten;
Gromada, Jesper;
Salehi, Albert;
Sewing, Sabine;
Rorsman, Patrik;
Braun, Matthias

Publication type:

journal article

Glucose Inhibition of Glucagon Secretion From Rat α-Cells Is Mediated by GABA Released From Neighboring β-Cells.

Published in:

Diabetes, 2004, v. 53, n. 4, p. 1038, doi. 10.2337/diabetes.53.4.1038

By:

Wendt, Anna;
Birnir, Bryndis;
Buschard, Karsten;
Gromada, Jesper;
Salehi, Albert;
Sewing, Sabine;
Rorsman, Patrik;
Braun, Matthias

Publication type:

Article

A subset of 50 secretory granules in close contact with L-type Ca2+ channels accounts for first-phase insulin secretion in mouse beta-cells.

Published in:

2002

By:

Barg, Sebastian;
Eliasson, Lena;
Renström, Erik;
Rorsman, Patrik;
Renström, Erik

Publication type:

journal article

Sulfonylurea-mediated stimulation of insulin exocytosis via an ATP-sensitive K+ channel-independent action.

Published in:

2002

By:

Renström, Erik;
Barg, Sebastian;
Thévenod, Frank;
Rorsman, Patrik;
Renström, Erik;
Thévenod, Frank

Publication type:

journal article

Tight coupling between electrical activity and exocytosis in mouse glucagon-secreting alpha-cells.

Published in:

2000

By:

Barg, Sebastian;
Galvanovskis, Juris;
Gopel, Sven O.;
Rorsman, Patrik;
Eliasson, Lena;
Barg, S;
Galvanovskis, J;
Göpel, S O;
Rorsman, P;
Eliasson, L

Publication type:

journal article

Hormone-sensitive lipase, the rate-limiting enzyme in triglyceride hydrolysis, is expressed and active in beta-cells.

Published in:

1999

By:

Mulder, Hindrik;
Hoist, Lena Stenson;
Svensson, Hakan;
Degerman, Eva;
Sundler, Frank;
Ahren, Bo;
Rorsman, Patrik;
Holm, Cecilia;
Mulder, H;
Holst, L S;
Svensson, H;
Degerman, E;
Sundler, F;
Ahrén, B;
Rorsman, P;
Holm, C

Publication type:

journal article

Glucagon-like peptide 1 (7-36) amide stimulates exocytosis in human pancreatic beta-cells by both proximal and distal regulatory steps in stimulus-secretion coupling.

Published in:

1998

By:

Gromada, Jesper;
Bokvist, Krister;
Ding, Wei-Guang;
Holst, Jens Juul;
Nielsen, Jens Hoiriis;
Rorsman, Patrik;
Gromada, J;
Bokvist, K;
Ding, W G;
Holst, J J;
Nielsen, J H;
Rorsman, P

Publication type:

journal article

Glucagon-Like Peptide I and Glucose-Dependent Insulinotropic Polypeptide Stimulate Ca2+ -Induced Secretion in Rat α-Cells by a Protein Kinase A-Mediated Mechanism.

Published in:

Diabetes, 1997, v. 46, n. 5, p. 792, doi. 10.2337/diab.46.5.792

By:

Wei-Guang Ding;
Renström, Erik;
Rorsman, Patrik;
Buschard, Karsten;
Gromada, Jesper

Publication type:

Article

Glucagon-like peptide I increases cytoplasmic calcium in insulin-secreting beta TC3-cells by enhancement of intracellular calcium mobilization.

Published in:

1995

By:

Gromada, Jesper;
Dissing, Steen;
Bokvist, Krister;
Renström, Erik;
Frøkjær-Jensen, Jørgen;
Wulff, Birgitte S.;
Rorsman, Patrik;
Gromada, J;
Dissing, S;
Bokvist, K;
Renström, E;
Frøkjaer-Jensen, J;
Wulff, B S;
Rorsman, P

Publication type:

journal article

An unclear role for the GLP-1 metabolite GLP-1(9–36) in human islet physiology. Reply to Matveyenko A, Vella A [letter].

Published in:

2024

By:

Gandasi, Nikhil R.;
Rorsman, Patrik

Publication type:

Letter

Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes.

Published in:

2009

By:

Girard, Christophe A.;
Wunderlich, F. Thomas;
Shimomura, Kenju;
Collins, Stephan;
Kaizik, Stephan;
Proks, Peter;
Abdulkader, Fernando;
Clark, Anne;
Ball, Vicky;
Zubcevic, Lejla;
Bentley, Liz;
Clark, Rebecca;
Church, Chris;
Hugill, Alison;
Galvanovskis, Juris;
Cox, Roger;
Rorsman, Patrik;
Brüning, Jens C.;
Ashcroft, Frances M.;
Brüning, Jens C

Publication type:

journal article

CaV2.3 calcium channels control second-phase insulin release.

Published in:

Journal of Clinical Investigation, 2005, v. 115, n. 1, p. 146, doi. 10.1172/JCI200522518

By:

Xingjun Jing;
Dai-Qing Li;
Olofsson, Charlotta S.;
Salehi, Albert;
Surve, Vikas V.;
Caballero, José;
Ivarsson, Rosita;
Lundquist, Ingmar;
Pereverzev, Alexey;
Schneider, Toni;
Rorsman, Patrik;
Renström, Erik

Publication type:

Article

Isoform-specific regulation of mood behavior and pancreatic β cell and cardiovascular function by L-type Ca2+channels.

Published in:

Journal of Clinical Investigation, 2004, v. 113, n. 10, p. 1430, doi. 10.1172/JCI200420208

By:

Sinnegger-Brauns, Martina J.;
Hetzenauer, Alfred;
Huber, Irene G.;
Rensträm, Erik;
Wietzorrek, Georg;
Berjukov, Stanislav;
Cavalli, Maurizio;
Walter, Doris;
Koschak, Alexandra;
Waldschutz, Ralph;
Hering, Steffen;
Bova, Sergio;
Rorsman, Patrik;
Pongs, Olaf;
Singewald, Nicolas;
Striessnig, Jörg

Publication type:

Article

Stimulus-secretion coupling in pancreatic β cells.

Published in:

Journal of Cellular Biochemistry, 1994, v. 55, p. 54, doi. 10.1002/jcb.240550007

By:

Ashcroft, Frances M.;
Proks, Peter;
Smith, Paul A.;
Ämmälä, Carina;
Bokvist, Krister;
Rorsman, Patrik

Publication type:

Article

Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion.

Published in:

Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-018-08193-8

By:

Vergari, Elisa;
Knudsen, Jakob G.;
Ramracheya, Reshma;
Salehi, Albert;
Zhang, Quan;
Adam, Julie;
Asterholm, Ingrid Wernstedt;
Benrick, Anna;
Briant, Linford J. B.;
Chibalina, Margarita V.;
Gribble, Fiona M.;
Hamilton, Alexander;
Hastoy, Benoit;
Reimann, Frank;
Rorsman, Nils J. G.;
Spiliotis, Ioannis I.;
Tarasov, Andrei;
Wu, Yanling;
Ashcroft, Frances M.;
Rorsman, Patrik

Publication type:

Article

α-cell glucokinase suppresses glucose-regulated glucagon secretion.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-03034-0

By:

Basco, Davide;
Quan Zhang;
Salehi, Albert;
Tarasov, Andrei;
Dolci, Wanda;
Herrera, Pedro;
Spiliotis, Ioannis;
Berney, Xavier;
Tarussio, David;
Rorsman, Patrik;
Thorens, Bernard

Publication type:

Article

A KATP Channel-Dependent Pathway within Cells Regulates Glucagon Release from Both Rodent and Human Islets of Langerhans.

Published in:

PLoS Biology, 2007, v. 5, n. 6, p. e143, doi. 10.1371/journal.pbio.0050143

By:

MacDonald, Patrick E.;
Marinis, Yang Zhang De;
Ramracheya, Reshma;
Salehi, Albert;
Ma, Xiaosong;
Johnson, Paul R. V.;
Cox, Roger;
Eliasson, Lena;
Rorsman, Patrik

Publication type:

Article

Oscillations, Intercellular Coupling, and Insulin Secretion in Pancreatic β Cells.

Published in:

PLoS Biology, 2006, v. 4, n. 2, p. e49, doi. 10.1371/journal.pbio.0040049

By:

MacDonald, Patrick E.;
Rorsman, Patrik

Publication type:

Article

NALCN: a regulated leak channel.

Published in:

EMBO Reports, 2009, v. 10, n. 9, p. 963, doi. 10.1038/embor.2009.185

By:

Gilon, Patrick;
Rorsman, Patrik

Publication type:

Article

GLP‐1 suppresses glucagon secretion in human pancreatic alpha‐cells by inhibition of P/Q‐type Ca2+ channels.

Published in:

Physiological Reports, 2018, v. 6, n. 17, p. 1, doi. 10.14814/phy2.13852

By:

Ramracheya, Reshma;
Chapman, Caroline;
Chibalina, Margarita;
Dou, Haiqiang;
Miranda, Caroline;
González, Alejandro;
Moritoh, Yusuke;
Shigeto, Makoto;
Zhang, Quan;
Braun, Matthias;
Clark, Anne;
Johnson, Paul R.;
Rorsman, Patrik;
Briant, Linford J. B.

Publication type:

Article

Uromodulin mutations causing familial juvenile hyperuricaemic nephropathy lead to protein maturation defects and retention in the endoplasmic reticulum.

Published in:

Human Molecular Genetics, 2009, v. 18, n. 16, p. 2963, doi. 10.1093/hmg/ddp235

By:

Williams, Siân E.;
Reed, Anita A.C.;
Galvanovskis, Juris;
Antignac, Corinne;
Goodship, Tim;
Karet, Fiona E.;
Kotanko, Peter;
Lhotta, Karl;
Morinière, Vincent;
Williams, Paul;
Wong, William;
Rorsman, Patrik;
Thakker, Rajesh V.

Publication type:

Article

Type 2 diabetes mellitus: not quite exciting enough?

Published in:

Human Molecular Genetics, 2004, v. 13, n. suppl_1, p. R21

By:

Ashcroft, Frances;
Rorsman, Patrik

Publication type:

Article

A method for the generation of human stem cell-derived alpha cells.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-16049-3

By:

Peterson, Quinn P.;
Veres, Adrian;
Chen, Lihua;
Slama, Michael Q.;
Kenty, Jennifer H. R.;
Hassoun, Shaimaa;
Brown, Matthew R.;
Dou, Haiqiang;
Duffy, Caden D.;
Zhou, Quan;
Matveyenko, Aleksey V.;
Tyrberg, Björn;
Sörhede-Winzell, Maria;
Rorsman, Patrik;
Melton, Douglas A.

Publication type:

Article

Impaired insulin secretion and glucose tolerance in ß cell-selective CaV1.2 Ca2+ channel null mice.

Published in:

EMBO Journal, 2003, v. 22, n. 15, p. 3844, doi. 10.1093/emboj/cdg389

By:

Schulla, Verena;
Renström, Erik;
Feil, Robert;
Feil, Susanne;
Franklin, Isobel;
Gjinovci, Aslian;
Xing-Jun Jing;
Laux, Dirk;
Lundquist, Ingmar;
Magnuson, Mark A.;
Obermüller, Stefanie;
Olofsson, Charlotta S.;
Salehi, Albert;
Wendt, Anna;
Klugbauer, Norbert;
Wollheim, Claes B.;
Rorsman, Patrik;
Hofmann, Franz

Publication type:

Article

Nateglinide, but not repaglinide, stimulates growth hormone release in rat pituitary cells by inhibition of K+ channels and stimulation of cyclic AMP-dependent exocytosis.

Published in:

European Journal of Endocrinology, 2002, v. 147, n. 1, p. 133

By:

Gromada, Jesper;
Bokvist, Krister;
Høy, Marianne;
Olsen, Hervør L.;
Lindström, Per;
Hansen, Birgit S.;
Gotfredsen, Carsten F.;
Rorsman, Patrik;
Thomsen, Mads Krogsgaard

Publication type:

Article

The insulinogenic effect of whey protein is partially mediated by a direct effect of amino acids and GIP on β-cells.

Published in:

Nutrition & Metabolism, 2012, v. 9, n. 1, p. 48, doi. 10.1186/1743-7075-9-48

By:

Albert Salehi, Albert Salehi;
Gunnerud, Ulrika;
Muhammed, Sarheed J.;
Östman, Elin;
Holst, Jens J.;
Björck, Inger;
Rorsman, Patrik

Publication type:

Article

Gs/Gq signaling switch in β cells defines incretin effectiveness in diabetes.

Published in:

2020

By:

Oduori, Okechi S.;
Naoya Murao;
Kenju Shimomura;
Harumi Takahashi;
Quan Zhang;
Haiqiang Dou;
Shihomi Sakai;
Kohtaro Minami;
Chanclon, Belen;
Guida, Claudia;
Kothegala, Lakshmi;
Tolö, Johan;
Yuko Maejima;
Norihide Yokoi;
Yasuhiro Minami;
Takashi Miki;
Rorsman, Patrik;
Susumu Seino;
Murao, Naoya;
Shimomura, Kenju

Publication type:

journal article