Found: 91
Select item for more details and to access through your institution.
Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof‐of‐Principle (Adv. Sci. 5/2023).
- Published in:
- Advanced Science, 2023, v. 10, n. 5, p. 1, doi. 10.1002/advs.202370027
- By:
- Publication type:
- Article
Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof‐of‐Principle.
- Published in:
- Advanced Science, 2023, v. 10, n. 5, p. 1, doi. 10.1002/advs.202204443
- By:
- Publication type:
- Article
Substratinspirierte Fragment‐Fusion und ‐Erweiterung führt zu wirksamen LasB‐Inhibitoren.
- Published in:
- Angewandte Chemie, 2022, v. 134, n. 5, p. 1, doi. 10.1002/ange.202112295
- By:
- Publication type:
- Article
Substrate‐Inspired Fragment Merging and Growing Affords Efficacious LasB Inhibitors.
- Published in:
- Angewandte Chemie International Edition, 2022, v. 61, n. 5, p. 1, doi. 10.1002/anie.202112295
- By:
- Publication type:
- Article
Structure‐Activity Relationship and Mode‐Of‐Action Studies Highlight 1‐(4‐Biphenylylmethyl)‐1H‐imidazole‐Derived Small Molecules as Potent CYP121 Inhibitors.
- Published in:
- ChemMedChem, 2021, v. 16, n. 18, p. 2786, doi. 10.1002/cmdc.202100283
- By:
- Publication type:
- Article
Front Cover: Phosphonate as a Stable Zinc‐Binding Group for "Pathoblocker" Inhibitors of Clostridial Collagenase H (ColH) (ChemMedChem 8/2021).
- Published in:
- ChemMedChem, 2021, v. 16, n. 8, p. 1198, doi. 10.1002/cmdc.202100229
- By:
- Publication type:
- Article
Phosphonate as a Stable Zinc‐Binding Group for "Pathoblocker" Inhibitors of Clostridial Collagenase H (ColH).
- Published in:
- ChemMedChem, 2021, v. 16, n. 8, p. 1257, doi. 10.1002/cmdc.202000994
- By:
- Publication type:
- Article
Micro-rheological properties of lung homogenates correlate with infection severity in a mouse model of Pseudomonas aeruginosa lung infection.
- Published in:
- Scientific Reports, 2020, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41598-020-73459-5
- By:
- Publication type:
- Article
Finding New Molecular Targets of Familiar Natural Products Using In Silico Target Prediction.
- Published in:
- International Journal of Molecular Sciences, 2020, v. 21, n. 19, p. 7102, doi. 10.3390/ijms21197102
- By:
- Publication type:
- Article
Synthesis, Optimization, Antifungal Activity, Selectivity, and CYP51 Binding of New 2-Aryl-3-azolyl-1-indolyl-propan-2-ols.
- Published in:
- Pharmaceuticals (14248247), 2020, v. 13, n. 8, p. 186, doi. 10.3390/ph13080186
- By:
- Publication type:
- Article
Titelbild: Squalenyl Hydrogen Sulfate Nanoparticles for Simultaneous Delivery of Tobramycin and an Alkylquinolone Quorum Sensing Inhibitor Enable the Eradication of P. aeruginosa Biofilm Infections (Angew. Chem. 26/2020).
- Published in:
- Angewandte Chemie, 2020, v. 132, n. 26, p. 10285, doi. 10.1002/ange.202005838
- By:
- Publication type:
- Article
Squalenyl Hydrogen Sulfate Nanoparticles for Simultaneous Delivery of Tobramycin and an Alkylquinolone Quorum Sensing Inhibitor Enable the Eradication of P. aeruginosa Biofilm Infections.
- Published in:
- Angewandte Chemie, 2020, v. 132, n. 26, p. 10378, doi. 10.1002/ange.202001407
- By:
- Publication type:
- Article
Cover Picture: Squalenyl Hydrogen Sulfate Nanoparticles for Simultaneous Delivery of Tobramycin and an Alkylquinolone Quorum Sensing Inhibitor Enable the Eradication of P. aeruginosa Biofilm Infections (Angew. Chem. Int. Ed. 26/2020).
- Published in:
- Angewandte Chemie International Edition, 2020, v. 59, n. 26, p. 10201, doi. 10.1002/anie.202005838
- By:
- Publication type:
- Article
Squalenyl Hydrogen Sulfate Nanoparticles for Simultaneous Delivery of Tobramycin and an Alkylquinolone Quorum Sensing Inhibitor Enable the Eradication of P. aeruginosa Biofilm Infections.
- Published in:
- Angewandte Chemie International Edition, 2020, v. 59, n. 26, p. 10292, doi. 10.1002/anie.202001407
- By:
- Publication type:
- Article
Cover Feature: Cystobactamid 507: Concise Synthesis, Mode of Action, and Optimization toward More Potent Antibiotics (Chem. Eur. J. 32/2020).
- Published in:
- Chemistry - A European Journal, 2020, v. 26, n. 32, p. 7141, doi. 10.1002/chem.202002127
- By:
- Publication type:
- Article
Cystobactamid 507: Concise Synthesis, Mode of Action, and Optimization toward More Potent Antibiotics.
- Published in:
- Chemistry - A European Journal, 2020, v. 26, n. 32, p. 7219, doi. 10.1002/chem.202000117
- By:
- Publication type:
- Article
Design and synthesis of novel annulated thienopyrimidines as phosphodiesterase 5 (PDE5) inhibitors.
- Published in:
- Archiv der Pharmazie, 2018, v. 351, n. 5, p. 1, doi. 10.1002/ardp.201800018
- By:
- Publication type:
- Article
Bacterial RNAP Inhibitors: Synthesis and Evaluation of Prodrugs of Aryl‐ureidothiophene‐carboxylic acids.
- Published in:
- ChemistrySelect, 2017, v. 2, n. 35, p. 11899, doi. 10.1002/slct.201702574
- By:
- Publication type:
- Article
Biophysical Screening of a Focused Library for the Discovery of CYP121 Inhibitors as Novel Antimycobacterials.
- Published in:
- ChemMedChem, 2017, v. 12, n. 19, p. 1616, doi. 10.1002/cmdc.201700363
- By:
- Publication type:
- Article
Regulation of Burkholderia cenocepacia biofilm formation by RpoN and the c-di-GMP effector BerB.
- Published in:
- MicrobiologyOpen, 2017, v. 6, n. 4, p. 1, doi. 10.1002/mbo3.480
- By:
- Publication type:
- Article
In-depth Profiling of MvfR-Regulated Small Molecules in Pseudomonas aeruginosa after Quorum Sensing Inhibitor Treatment.
- Published in:
- Frontiers in Microbiology, 2017, v. 8, p. 1, doi. 10.3389/fmicb.2017.00924
- By:
- Publication type:
- Article
Metallfreie meta-selektive Oxyarylierung von Alkinen mit Pyridin- N-oxiden: schnelle Synthese von Metyrapon-Analoga.
- Published in:
- Angewandte Chemie, 2016, v. 128, n. 49, p. 15650, doi. 10.1002/ange.201607988
- By:
- Publication type:
- Article
Metal-Free meta-Selective Alkyne Oxyarylation with Pyridine N-Oxides: Rapid Assembly of Metyrapone Analogues.
- Published in:
- Angewandte Chemie International Edition, 2016, v. 55, n. 49, p. 15424, doi. 10.1002/anie.201607988
- By:
- Publication type:
- Article
Structure-Activity Relationships of 2-Sufonylpyrimidines as Quorum-Sensing Inhibitors to Tackle Biofilm Formation and eDNA Release of Pseudomonas aeruginosa.
- Published in:
- ChemMedChem, 2016, v. 11, n. 22, p. 2522, doi. 10.1002/cmdc.201600419
- By:
- Publication type:
- Article
Discovery and Biophysical Evaluation of First Low Nanomolar Hits Targeting CYP125 of M. tuberculosis.
- Published in:
- ChemMedChem, 2016, v. 11, n. 21, p. 2385, doi. 10.1002/cmdc.201600361
- By:
- Publication type:
- Article
Back Cover: Discovery and Biophysical Evaluation of First Low Nanomolar Hits Targeting CYP125 of M. tuberculosis (ChemMedChem 21/2016).
- Published in:
- ChemMedChem, 2016, v. 11, n. 21, p. 2466, doi. 10.1002/cmdc.201600532
- By:
- Publication type:
- Article
Targeting Steroidogenic Cytochromes P450 (CYPs) with 6-Substituted 1-Imidazolylmethylxanthones.
- Published in:
- ChemMedChem, 2016, v. 11, n. 16, p. 1770, doi. 10.1002/cmdc.201600078
- By:
- Publication type:
- Article
17β-Hydroxysteroid Dehydrogenase Type 2 Inhibition: Discovery of Selective and Metabolically Stable Compounds Inhibiting Both the Human Enzyme and Its Murine Ortholog.
- Published in:
- PLoS ONE, 2015, v. 10, n. 7, p. 1, doi. 10.1371/journal.pone.0134754
- By:
- Publication type:
- Article
Advanced Mutasynthesis Studies on the Natural α-Pyrone Antibiotic Myxopyronin from Myxococcus fulvus.
- Published in:
- ChemBioChem, 2015, v. 16, n. 6, p. 946, doi. 10.1002/cbic.201402666
- By:
- Publication type:
- Article
New CYP17 Hydroxylase Inhibitors: Synthesis, Biological Evaluation, QSAR, and Molecular Docking Study of New Pregnenolone Analogs.
- Published in:
- Archiv der Pharmazie, 2014, v. 347, n. 12, p. 896, doi. 10.1002/ardp.201400255
- By:
- Publication type:
- Article
6-Hydroxybenzothiophene Ketones: Potent Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1) Owing to Favorable Molecule Geometry and Conformational Preorganization.
- Published in:
- ChemMedChem, 2014, v. 9, n. 10, p. 2294, doi. 10.1002/cmdc.201402050
- By:
- Publication type:
- Article
Design and Synthesis of a Library of Lead-Like 2,4-Bisheterocyclic Substituted Thiophenes as Selective Dyrk/Clk Inhibitors.
- Published in:
- PLoS ONE, 2014, v. 9, n. 3, p. 1, doi. 10.1371/journal.pone.0087851
- By:
- Publication type:
- Article
Overcoming the Unexpected Functional Inversion of a PqsR Antagonist in Pseudomonas aeruginosa: An In Vivo Potent Antivirulence Agent Targeting pqs Quorum Sensing.
- Published in:
- Angewandte Chemie, 2014, v. 126, n. 4, p. 1127, doi. 10.1002/ange.201307547
- By:
- Publication type:
- Article
Overcoming the Unexpected Functional Inversion of a PqsR Antagonist in Pseudomonas aeruginosa: An In Vivo Potent Antivirulence Agent Targeting pqs Quorum Sensing.
- Published in:
- Angewandte Chemie International Edition, 2014, v. 53, n. 4, p. 1109, doi. 10.1002/anie.201307547
- By:
- Publication type:
- Article
Rule–based regulatory and metabolic model for Quorum sensing in P. aeruginosa.
- Published in:
- BMC Systems Biology, 2013, v. 7, n. 1, p. 1, doi. 10.1186/1752-0509-7-81
- By:
- Publication type:
- Article
6-Aryl and Heterocycle Quinazoline Derivatives as Potent EGFR Inhibitors with Improved Activity toward Gefitinib-Sensitive and -Resistant Tumor Cell Lines.
- Published in:
- ChemMedChem, 2013, v. 8, n. 9, p. 1495, doi. 10.1002/cmdc.201300147
- By:
- Publication type:
- Article
Molecular basis of HHQ biosynthesis: molecular dynamics simulations, enzyme kinetic and surface plasmon resonance studies.
- Published in:
- BMC Biophysics, 2013, v. 6, n. 1, p. 1, doi. 10.1186/2046-1682-6-10
- By:
- Publication type:
- Article
Recent Progress in Pharmaceutical Therapies for Castration-Resistant Prostate Cancer.
- Published in:
- International Journal of Molecular Sciences, 2013, v. 14, n. 7, p. 13958, doi. 10.3390/ijms140713958
- By:
- Publication type:
- Article
A Detective Story in Drug Discovery: Elucidation of a Screening Artifact Reveals Polymeric Carboxylic Acids as Potent Inhibitors of RNA Polymerase.
- Published in:
- Chemistry - A European Journal, 2013, v. 19, n. 26, p. 8397, doi. 10.1002/chem.201301289
- By:
- Publication type:
- Article
Synthesis and Biological Evaluation of Thieno[3,2-d]-pyrimidinones, Thieno[3,2-d]pyrimidines and Quinazolinones: Conformationally Restricted 17β-Hydroxysteroid Dehydrogenase Type 2 (17β-HSD2) Inhibitors.
- Published in:
- Molecules, 2013, v. 18, n. 4, p. 4487, doi. 10.3390/molecules18044487
- By:
- Publication type:
- Article
Design of Novel β-Carboline Derivatives with Pendant 5-Bromothienyl and Their Evaluation as Phosphodiesterase-5 Inhibitors.
- Published in:
- Archiv der Pharmazie, 2013, v. 346, n. 1, p. 23, doi. 10.1002/ardp.201200334
- By:
- Publication type:
- Article
Mutation in Elongation Factor G Confers Resistance to the Antibiotic Argyrin in the Opportunistic Pathogen Pseudomonas aeruginosa.
- Published in:
- ChemBioChem, 2012, v. 13, n. 16, p. 2339, doi. 10.1002/cbic.201200479
- By:
- Publication type:
- Article
3-Pyridyl Substituted Aliphatic Cycles as CYP11B2 Inhibitors: Aromaticity Abolishment of the Core Significantly Increased Selectivity over CYP1A2.
- Published in:
- PLoS ONE, 2012, v. 7, n. 11, p. 1, doi. 10.1371/journal.pone.0048048
- By:
- Publication type:
- Article
Synthesis and Biological Evaluation of Phenyl Substituted 1 H-1,2,4-Triazoles as Non-Steroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 2.
- Published in:
- Archiv der Pharmazie, 2012, v. 345, n. 8, p. 610, doi. 10.1002/ardp.201200025
- By:
- Publication type:
- Article
Biosynthesis of 2-Alkyl-4(1 H)-Quinolones in Pseudomonas aeruginosa: Potential for Therapeutic Interference with Pathogenicity.
- Published in:
- ChemBioChem, 2011, v. 12, n. 6, p. 850, doi. 10.1002/cbic.201100014
- By:
- Publication type:
- Article
Bicyclic Substituted Hydroxyphenylmethanone Type Inhibitors of 17 β-Hydroxysteroid Dehydrogenase Type 1 (17 β-HSD1): The Role of the Bicyclic Moiety.
- Published in:
- ChemMedChem, 2011, v. 6, n. 3, p. 476, doi. 10.1002/cmdc.201000457
- By:
- Publication type:
- Article
Multi-Drug Resistance in Cancer. Edited by Jun Zhou.
- Published in:
- ChemMedChem, 2011, v. 6, n. 3, p. 570, doi. 10.1002/cmdc.201000501
- By:
- Publication type:
- Article
Predicting Putative Inhibitors of 17β-HSD1.
- Published in:
- Molecular Informatics, 2010, v. 29, n. 10, p. 695, doi. 10.1002/minf.201000015
- By:
- Publication type:
- Article
Insights in 17β-HSD1 Enzyme Kinetics and Ligand Binding by Dynamic Motion Investigation.
- Published in:
- PLoS ONE, 2010, v. 5, n. 8, p. 1, doi. 10.1371/journal.pone.0012026
- By:
- Publication type:
- Article
Synthesis and Antineoplastic Activity of O-Alkylated Derivatives of 7-Hydroximinoandrost-5-ene Steroids.
- Published in:
- Archiv der Pharmazie, 2010, v. 343, n. 7, p. 377, doi. 10.1002/ardp.200900258
- By:
- Publication type:
- Article