Works by Roep, Bart O.

Results: 118

Activated Mesenchymal Stromal Cells Process and Present Antigens Regulating Adaptive Immunity.

Published in:

Frontiers in Immunology, 2019, p. N.PAG, doi. 10.3389/fimmu.2019.00694

By:

van Megen, Kayleigh M.;
van 't Wout, Ernst-Jan T.;
Lages Motta, Julia;
Dekker, Bernice;
Nikolic, Tatjana;
Roep, Bart O.

Publication type:

Article

A Future for Autologous Hematopoietic Stem Cell Transplantation in Type 1 Diabetes.

Published in:

Frontiers in Immunology, 2018, p. 1, doi. 10.3389/fimmu.2018.00690

By:

van Megen, Kayleigh M.;
van ’t Wout, Ernst-Jan T.;
Forman, Stephen J.;
Roep, Bart O.

Publication type:

Article

Induction of Treg by monocyte-derived DC modulated by vitamin D.

Published in:

European Journal of Immunology, 2009, v. 39, n. 11, p. 3147, doi. 10.1002/eji.200839103

By:

Unger, Wendy W. J.;
Laban, Sandra;
Kleijwegt, Fleur S.;
van der Slik, Arno R.;
Roep, Bart O.

Publication type:

Article

The vitamin D receptor gene FokI polymorphism: Functional impact on the immune system.

Published in:

European Journal of Immunology, 2007, v. 37, n. 2, p. 395, doi. 10.1002/eji.200636043

By:

van Etten, Evelyne;
Verlinden, Lieve;
Giulietti, Annapaula;
Ramos-Lopez, Elizabeth;
Branisteanu, Dumitru D.;
Ferreira, Gabriela B.;
Overbergh, Lut;
Verstuyf, Annemieke;
Bouillon, Roger;
Roep, Bart O.;
Badenhoop, Klaus;
Mathieu, Chantal

Publication type:

Article

Quantitative determination of TCR cross-reactivity using peptide libraries and protein databases.

Published in:

European Journal of Immunology, 1999, v. 29, n. 8, p. 2385, doi. 10.1002/(SICI)1521-4141(199908)29:08<2385::AID-IMMU2385>3.0.CO;2-B

By:

Hiemstra, Hoebert S.;
van Veelen, Peter A.;
Willemen, Sabine J. M.;
Benckhuijsen, Willemien E.;
Geluk, Annemieke;
de Vries, René R. P.;
Roep, Bart O.;
Drijfhout, Jan W.

Publication type:

Article

HLA-associated inverse correlation between T cell and antibody responsiveness to islet autoantigen in recent-onset insulin-dependent diabetes mellitus.

Published in:

European Journal of Immunology, 1996, v. 26, n. 6, p. 1285, doi. 10.1002/eji.1830260616

By:

Roep, Bart O.;
Duinkerken, Gaby;
Schreuder, Geziena M. T.;
Kolb, Hubert;
de Vries, René R. P.;
Martin, Stephan

Publication type:

Article

Human T cell clones with specificity for insulinoma cell antigens.

Published in:

European Journal of Immunology, 1989, v. 19, n. 1, p. 213, doi. 10.1002/eji.1830190136

By:

Vliet, Els Van;
Roep, Bart O.;
Meulenbroek, Lex;
Jan Bruining, G.;
De Vries, René R. P.

Publication type:

Article

Intra-pancreatic tissue-derived mesenchymal stromal cells: a promising therapeutic potential with anti-inflammatory and pro-angiogenic profiles.

Published in:

Stem Cell Research & Therapy, 2019, v. 10, n. 1, p. 1, doi. 10.1186/s13287-019-1435-2

By:

Khiatah, Bashar;
Qi, Meirigeng;
Du, Weiting;
T-Chen, Kuan;
van Megen, Kayleigh M.;
Perez, Rachel G.;
Isenberg, Jeffrey S.;
Kandeel, Fouad;
Roep, Bart O.;
Ku, Hsun Teresa;
Al-Abdullah, Ismail H.

Publication type:

Article

Residual β-Cell Function Is Associated With Longer Time in Range in Individuals With Type 1 Diabetes.

Published in:

Diabetes Care, 2024, v. 47, n. 7, p. 1114, doi. 10.2337/dc23-0776

By:

Fuhri Snethlage, Coco M.;
McDonald, Timothy J.;
Oram, Richard D.;
de Groen, Pleun;
Rampanelli, Elena;
Schimmel, Alinda W. M.;
Holleman, Frits;
Siegelaar, Sarah;
Hoekstra, Joost;
Brouwer, Catherine B.;
Knop, Filip K.;
Verchere, C. Bruce;
van Raalte, Daniël H.;
Roep, Bart O.;
Nieuwdorp, Max;
Hanssen, Nordin M. J.

Publication type:

Article

Improving the Prediction of Type 1 Diabetes Across Ancestries.

Published in:

2022

By:

Kaddis, John S.;
Perry, Daniel J.;
Vu, Anh Nguyet;
Rich, Stephen S.;
Atkinson, Mark A.;
Schatz, Desmond A.;
Roep, Bart O.;
Brusko, Todd M.

Publication type:

journal article

There Is Something About Insulin Granules.

Published in:

2020

By:

Roep, Bart O.

Publication type:

journal article

Anti-PD-1 Therapy-Associated Type 1 Diabetes in a Pediatric Patient With Relapsed Classical Hodgkin Lymphoma.

Published in:

2020

By:

Samoa, Raynald A.;
Lee, Hayley S.;
Kil, Sung H.;
Roep, Bart O.

Publication type:

journal article

Improving Clinical Islet Transplantation Outcomes.

Published in:

2020

By:

Roep, Bart O.

Publication type:

journal article

HLA-A*24 Carrier Status and Autoantibody Surges Posttransplantation Associate With Poor Functional Outcome in Recipients of an Islet Allograft.

Published in:

2016

By:

Demeester, Simke;
Balke, Else M.;
Van der Auwera, Bart J.;
Gillard, Pieter;
Hilbrands, Robert;
Da Hae Lee;
de Velde, Ursule Van;
Zhidong Ling;
Roep, Bart O.;
Pipeleers, Daniel G.;
Gorus, Frans K.;
Keymeulen, Bart;
Lee, DaHae;
Van de Velde, Ursule;
Ling, Zhidong

Publication type:

journal article

T-cell recognition of β-cell autoantigens in insulin-dependent diabetes mellitus.

Published in:

APMIS, 1996, v. 104, n. 1-6, p. 3, doi. 10.1111/j.1699-0463.1996.tb00679.x

By:

KALLAN, ARAM A.;
VRIES, RENÉ R. P.;
ROEP, BART O.

Publication type:

Article

The need and benefit of immune monitoring to define patient and disease heterogeneity, mechanisms of therapeutic action and efficacy of intervention therapy for precision medicine in type 1 diabetes.

Published in:

Frontiers in Immunology, 2023, v. 13, p. 1, doi. 10.3389/fimmu.2023.1112858

By:

Roep, Bart O.

Publication type:

Article

Tolerogenic dendritic cells pulsed with islet antigen induce long-term reduction in T-cell autoreactivity in type 1 diabetes patients.

Published in:

Frontiers in Immunology, 2022, v. 13, p. 01, doi. 10.3389/fimmu.2022.1054968

By:

Nikolic, Tatjana;
Suwandi, Jessica S.;
Wesselius, Joris;
Laban, Sandra;
Joosten, Antoinette M.;
Sonneveld, Petra;
Mul, Dick;
Aanstoot, Henk-Jan;
Kaddis, John S.;
Zwaginga, Jaap Jan;
Roep, Bart O.

Publication type:

Article

Functional Impact of Risk Gene Variants on the Autoimmune Responses in Type 1 Diabetes.

Published in:

Frontiers in Immunology, 2022, v. 13, p. 1, doi. 10.3389/fimmu.2022.886736

By:

Gootjes, Chelsea;
Zwaginga, Jaap Jan;
Roep, Bart O.;
Nikolic, Tatjana

Publication type:

Article

The gut microbiome is associated with residual β-cell function and glycemic control in type 1 diabetes.

Published in:

Nederlands Tijdschrift voor Diabetologie (NTvD), 2023, v. 21, n. 4, p. 46

By:

Fuhri Snethlage, Coco M.;
Davids, Mark;
Rampanelli, Elena;
de Groen, Pleun;
Verdoes, Xanthe;
Herrema, Hilde J.;
van Raalte, Daniël H.;
Roep, Bart O.;
Nieuwdorp, Max;
Hanssen, Nordin M. J.

Publication type:

Article

β-Cell Antigen--Specific Lysis of Macrophages by CD4 T-Cell Clones From Newly Diagnosed IDDM Patient.

Published in:

Diabetes, 1992, v. 41, n. 11, p. 1380, doi. 10.2337/diab.41.11.1380

By:

Roep, Bart O.;
Kallan, Aram A.;
De Vries, Rene R. P.

Publication type:

Article

CTLA4 is differently associated with autoimmune diseases in the Dutch population.

Published in:

2006

By:

Zhernakova, Alexandra;
Eerligh, Peter;
Barrera, Pilar;
Weseloy, Joanna Z.;
Huizinga, Tom W. J.;
Roep, Bart O.;
Wijmenga, Cisca;
Koeleman, Bobby P. C.

Publication type:

Correction Notice

Choice of Antibody Immunotherapy Influences Cytomegalovirus Viremia in Simultaneous Pancreas-Kidney Transplant Recipients.

Published in:

Diabetes Care, 2006, v. 29, n. 4, p. 842, doi. 10.2337/diacare.29.04.06.dc05-1647

By:

Huurman, Volkert A. L.;
Kalpoe, Jayant S.;
Van De Linde, Pieter;
Vaessen, Norbert;
Ringers, Jan;
Kroes, Aloys C. M.;
Roep, Bart O.;
De Fijter, Johan W.

Publication type:

Article

Vitamin D receptor polymorphisms and growth until adulthood after very premature birth.

Published in:

2016

By:

Finken, Martijn;
Schrevel, Marlies;
Houwing-Duistermaat, Jeanine;
Kharagjitsingh, Aan;
Dekker, Friedo;
Koeleman, Bobby;
Roep, Bart;
Wit, Jan;
Finken, Martijn J J;
Houwing-Duistermaat, Jeanine J;
Kharagjitsingh, Aan V;
Dekker, Friedo W;
Koeleman, Bobby P;
Roep, Bart O;
Wit, Jan M

Publication type:

journal article

Associations between diabetes-related genetic risk scores and residual beta cell function in type 1 diabetes: the GUTDM1 study.

Published in:

Diabetologia, 2024, v. 67, n. 9, p. 1865, doi. 10.1007/s00125-024-06204-6

By:

Fuhri Snethlage, Coco M.;
Balvers, Manon;
Ferwerda, Bart;
Rampanelli, Elena;
de Groen, Pleun;
Roep, Bart O.;
Herrema, Hilde;
McDonald, Timothy J.;
van Raalte, Daniël H.;
Weedon, Michael N.;
Oram, Richard A.;
Nieuwdorp, Max;
Hanssen, Nordin M. J.

Publication type:

Article

IFNɣ but not IFNα increases recognition of insulin defective ribosomal product-derived antigen to amplify islet autoimmunity.

Published in:

Diabetologia, 2023, v. 66, n. 11, p. 2075, doi. 10.1007/s00125-023-05991-8

By:

Thomaidou, Sofia;
Munoz Garcia, Amadeo;
de Lange, Sabine;
Gan, Jin;
van der Slik, Arno R.;
Hoeben, Rob C.;
Roep, Bart O.;
Carlotti, Françoise;
Zaldumbide, Arnaud

Publication type:

Article

Presence of immunogenic alternatively spliced insulin gene product in human pancreatic delta cells.

Published in:

Diabetologia, 2023, v. 66, n. 5, p. 884, doi. 10.1007/s00125-023-05882-y

By:

van Tienhoven, René;
Kracht, Maria J. L.;
van der Slik, Arno R.;
Thomaidou, Sofia;
Wolters, Anouk H. G.;
Giepmans, Ben N. G.;
Riojas, Juan Pablo Romero;
Nelson, Michael S.;
Carlotti, Françoise;
de Koning, Eelco J. P.;
Hoeben, Rob C.;
Zaldumbide, Arnaud;
Roep, Bart O.

Publication type:

Article

Congenital beta cell defects are not associated with markers of islet autoimmunity, even in the context of high genetic risk for type 1 diabetes.

Published in:

Diabetologia, 2022, v. 65, n. 7, p. 1179, doi. 10.1007/s00125-022-05697-3

By:

Wyatt, Rebecca C.;
Hagopian, William A.;
Roep, Bart O.;
Patel, Kashyap A.;
Resnick, Brittany;
Dobbs, Rebecca;
Hudson, Michelle;
De Franco, Elisa;
Ellard, Sian;
Flanagan, Sarah E.;
Hattersley, Andrew T.;
Oram, Richard A.;
Johnson, Matthew B.

Publication type:

Article

A randomised, single-blind, placebo-controlled, dose-finding safety and tolerability study of the anti-CD3 monoclonal antibody otelixizumab in new-onset type 1 diabetes.

Published in:

Diabetologia, 2021, v. 64, n. 2, p. 313, doi. 10.1007/s00125-020-05317-y

By:

Keymeulen, Bart;
van Maurik, André;
Inman, Dave;
Oliveira, João;
McLaughlin, Rene;
Gittelman, Rachel M.;
Roep, Bart O.;
Gillard, Pieter;
Hilbrands, Robert;
Gorus, Frans;
Mathieu, Chantal;
Van de Velde, Ursule;
Wisniacki, Nicolas;
Napolitano, Antonella

Publication type:

Article

GAD-alum immunotherapy in type 1 diabetes expands bifunctional Th1/Th2 autoreactive CD4 T cells.

Published in:

Diabetologia, 2020, v. 63, n. 6, p. 1186, doi. 10.1007/s00125-020-05130-7

By:

Arif, Sefina;
Gomez-Tourino, Iria;
Kamra, Yogesh;
Pujol-Autonell, Irma;
Hanton, Emily;
Tree, Timothy;
Melandri, Daisy;
Hull, Caroline;
Wherrett, Diane K.;
Beam, Craig;
Roep, Bart O.;
Lorenc, Anna;
Peakman, Mark

Publication type:

Article

Studies of insulin and proinsulin in pancreas and serum support the existence of aetiopathological endotypes of type 1 diabetes associated with age at diagnosis.

Published in:

Diabetologia, 2020, v. 63, n. 6, p. 1258, doi. 10.1007/s00125-020-05115-6

By:

Leete, Pia;
Oram, Richard A.;
McDonald, Timothy J.;
Shields, Beverley M.;
Ziller, Clemens;
TIGI study team;
Roep, Bart O.;
Tree, Timothy I.;
Patel, Kashyap;
Hammersley, Suzy;
Bolt, Robert;
Hill, Anita V.;
Hattersley, Andrew T.;
Richardson, Sarah J.;
Morgan, Noel G.

Publication type:

Article

Clinical and genetic correlates of islet-autoimmune signatures in juvenile-onset type 1 diabetes.

Published in:

Diabetologia, 2020, v. 63, n. 2, p. 351, doi. 10.1007/s00125-019-05032-3

By:

Claessens, Laura A.;
Wesselius, Joris;
van Lummel, Menno;
Laban, Sandra;
Mulder, Flip;
Mul, Dick;
Nikolic, Tanja;
Aanstoot, Henk-Jan;
Koeleman, Bobby P. C.;
Roep, Bart O.

Publication type:

Article

Abnormal islet sphingolipid metabolism in type 1 diabetes.

Published in:

Diabetologia, 2018, v. 61, n. 7, p. 1650, doi. 10.1007/s00125-018-4614-2

By:

Holm, Laurits J.;
Krogvold, Lars;
Hasselby, Jane P.;
Kaur, Simranjeet;
Claessens, Laura A.;
Russell, Mark A.;
Mathews, Clayton E.;
Hanssen, Kristian F.;
Morgan, Noel G.;
Koeleman, Bobby P. C.;
Roep, Bart O.;
Gerling, Ivan C.;
Pociot, Flemming;
Dahl-Jørgensen, Knut;
Buschard, Karsten

Publication type:

Article

SLC30A8 polymorphism and BMI complement HLA-A*24 as risk factors for poor graft function in islet allograft recipients.

Published in:

Diabetologia, 2018, v. 61, n. 7, p. 1623, doi. 10.1007/s00125-018-4609-z

By:

Balke, Else M.;
Demeester, Simke;
Lee, DaHae;
Gillard, Pieter;
Hilbrands, Robert;
Van de Velde, Ursule;
Van der Auwera, Bart J.;
Ling, Zhidong;
Roep, Bart O.;
Pipeleers, Daniël G.;
Keymeulen, Bart;
Gorus, Frans K.

Publication type:

Article

Heterogeneity of circulating CD8 T-cells specific to islet, neo-antigen and virus in patients with type 1 diabetes mellitus.

Published in:

PLoS ONE, 2018, v. 13, n. 8, p. 1, doi. 10.1371/journal.pone.0200818

By:

Laban, Sandra;
Suwandi, Jessica S.;
van Unen, Vincent;
Pool, Jos;
Wesselius, Joris;
Höllt, Thomas;
Pezzotti, Nicola;
Vilanova, Anna;
Lelieveldt, Boudewijn P. F.;
Roep, Bart O.

Publication type:

Article

Acute Onset of Type I Diabetes Mellitus after Severe Echovirus 9 Infection: Putative Pathogenic...

Published in:

Clinical Infectious Diseases, 2000, v. 31, n. 4, p. 1025, doi. 10.1086/318159

By:

Vreugdenhil, Gienke R.;
Schloot, Nanette C.;
Hoorens, Anne;
Rongen, Ciska;
Pipeleers, Daniel G.;
Melchers, Willem J. G.;
Roep, Bart O.;
Galama, Jochem M. D.

Publication type:

Article

The problems and promises of research into human immunology and autoimmune disease.

Published in:

2012

By:

Roep, Bart O;
Buckner, Jane;
Sawcer, Stephen;
Toes, Rene;
Zipp, Frauke

Publication type:

Opinion

Type 1 Diabetes Genetic Risk Contributes to Phenotypic Presentation in Monogenic Autoimmune Diabetes.

Published in:

Diabetes, 2025, v. 74, n. 2, p. 243, doi. 10.2337/db24-0485

By:

Luckett, Amber M.;
Hawkes, Gareth;
Green, Harry D.;
De Franco, Elisa;
Hagopian, William A.;
Roep, Bart O.;
Weedon, Michael N.;
Oram, Richard A.;
Johnson, Matthew B.;
Dobbs, Rebecca A;
Domingo-Vila, Clara;
Gillespie, Kathleen M;
Hattersley, Andrew T;
Hudson, Michelle;
McDonald, Timothy J;
Morgan, Noel G;
Murrall, Kathryn;
Richardson, Sarah J;
Smithmyer, Megan E;
Speake, Cate

Publication type:

Article

Methylglyoxal Adducts Are Prognostic Biomarkers for Diabetic Kidney Disease in Patients With Type 1 Diabetes.

Published in:

Diabetes, 2024, v. 73, n. 4, p. 611, doi. 10.2337/db23-0277

By:

Seigmund Wai Tsuen Lai;
Hernandez-Castillo, Carlos;
Lopez Gonzalez, Edwin De Jesus;
Zoukari, Tala;
Talley, Min;
Paquin, Nadia;
Zhuo Chen;
Roep, Bart O.;
Kaddis, John S.;
Natarajan, Rama;
Termini, John;
Shuck, Sarah C.

Publication type:

Article

Syntaxin 4 Enrichment in β-Cells Prevents Conversion to Autoimmune Diabetes in Non-Obese Diabetic (NOD) Mice.

Published in:

2021

By:

Oh, Eunjin;
McCown, Erika M.;
Ahn, Miwon;
Garcia, Pablo A.;
Branciamore, Sergio;
Tang, Shanshan;
Zeng, De-Fu;
Roep, Bart O.;
Thurmond, Debbie C.

Publication type:

journal article

Long RNA Sequencing and Ribosome Profiling of Inflamed β-Cells Reveal an Extensive Translatome Landscape.

Published in:

2021

By:

Thomaidou, Sofia;
Slieker, Roderick C.;
van der Slik, Arno R.;
Boom, Jasper;
Mulder, Flip;
Munoz-Garcia, Amadeo;
't Hart, Leen M.;
Koeleman, Bobby;
Carlotti, Françoise;
Hoeben, Rob C.;
Roep, Bart O.;
Mei, Hailiang;
Zaldumbide, Arnaud

Publication type:

journal article

There Is Something About Insulin Granules.

Published in:

Diabetes, 2020, v. 69, n. 12, p. 2575, doi. 10.2337/dbi20-0039

By:

Roep, Bart O.

Publication type:

Article

β-Cell Stress Shapes CTL Immune Recognition of Preproinsulin Signal Peptide by Posttranscriptional Regulation of Endoplasmic Reticulum Aminopeptidase 1.

Published in:

2020

By:

Thomaidou, Sofia;
Kracht, Maria J. L.;
van der Slik, Arno;
Laban, Sandra;
de Koning, Eelco J.;
Carlotti, Francoise;
Hoeben, Rob C.;
Roep, Bart O.;
Zaldumbide, Arnaud

Publication type:

journal article

Standardizing T-Cell Biomarkers in Type 1 Diabetes: Challenges and Recent Advances.

Published in:

2019

By:

Ahmed, Simi;
Cerosaletti, Karen;
James, Eddie;
Long, S. Alice;
Mannering, Stuart;
Speake, Cate;
Nakayama, Maki;
Tree, Timothy;
Roep, Bart O.;
Herold, Kevan C.;
Brusko, Todd M.

Publication type:

journal article

Epitope Stealing as a Mechanism of Dominant Protection by HLA-DQ6 in Type 1 Diabetes.

Published in:

2019

By:

van Lummel, Menno;
Buis, David T. P.;
Ringeling, Cherish;
de Ru, Arnoud H.;
Pool, Jos;
Papadopoulos, George K.;
van Veelen, Peter A.;
Reijonen, Helena;
Drijfhout, Jan W.;
Roep, Bart O.

Publication type:

journal article

Syntaxin 4 Expression in Pancreatic β-Cells Promotes Islet Function and Protects Functional β-Cell Mass.

Published in:

2018

By:

Eunjin Oh;
Miwon Ahn;
Afelik, Solomon;
Becker, Thomas C.;
Roep, Bart O.;
Thurmond, Debbie C.;
Oh, Eunjin;
Ahn, Miwon

Publication type:

journal article

Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes.

Published in:

2017

By:

Michels, Aaron W.;
Landry, Laurie G.;
McDaniel, Kristen A.;
Liping Yu;
Martha Campbell-Thompson;
Kwok, William W.;
Jones, Kenneth L.;
Gottlieb, Peter A.;
Kappler, John W.;
Qizhi Tang;
Roep, Bart O.;
Atkinson, Mark A.;
Mathews, Clayton E.;
Maki Nakayama;
Yu, Liping;
Campbell-Thompson, Martha;
Tang, Qizhi;
Nakayama, Maki

Publication type:

journal article

Insulitis Revisited.

Published in:

2016

By:

Roep, Bart O.

Publication type:

journal article

Discovery of a Selective Islet Peptidome Presented by the Highest-Risk HLA-DQ8trans Molecule.

Published in:

2016

By:

van Lummel, Menno;
van Veelen, Peter A.;
de Ru, Arnoud H.;
Pool, Jos;
Nikolic, Tatjana;
Laban, Sandra;
Joosten, Antoinette;
Drijfhout, Jan W.;
Gómez-Touriño, Iria;
Arif, Sefina;
Aanstoot, Henk J.;
Peakman, Mark;
Roep, Bart O.

Publication type:

journal article

Regulatory multitasking of tolerogenic dendritic cells - lessons taken from vitamin D3-treated tolerogenic dendritic cells.

Published in:

Frontiers in Immunology, 2013, v. 4, p. 1, doi. 10.3389/fimmu.2013.00113

By:

Nikolic, Tatjana;
Roep, Bart O.

Publication type:

Article

Regulatory multitasking of tolerogenic dendritic cells - lessons taken from Vitamin D3-treated tolerogenic dendritic cells.

Published in:

Frontiers in Immunology, 2013, p. 1, doi. 10.3389/fimmu.2013.00113

By:

Nikolic, Tatjana;
Roep, Bart O.

Publication type:

Article